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1. The effects of milled Tribulus terrestris, Avena sativa, and white ginseng powder on total cholesterol, free testosterone levels and testicular tissue in rats fed a high-cholesterol diet

Author

Yasemin Nasir, Nurettin Cengiz, Ali Bilgili, Mehmet Akdoğan, Akdogan, M, Nasir, Y, Cengiz, N, Bilgili, A, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, and Akdoğan, Mehmet

Subjects
medicine.medical_specialty, Tribulus terrestris, Cholesterol diet, Testicular tissue, food.ingredient, General Veterinary, Free testosterone, business.industry, Ginseng, Endocrinology, Avena, food, Internal medicine, Total cholesterol, Medicine, Animal Science and Zoology, Veterinary Sciences, business
Abstract

This study examines the effects of milled Tribulus terrestris (TT), Avena sativa (AS), white ginseng (WG) and triple-combination (TC) powders on sexual dysfunction parameters - such as serum total cholesterol, free testosterone levels and histopathological changes in testicular tissue - in rats fed a high-cholesterol diet. The study's animal matenal consisted of 42 male Wistar albino rats weighing 200-210 g divided into six groups. Group I was fed normal pellet feed, while the remaining groups were fed pellet feed containing 2% cholesterol. Group III, IV, V, and VI also received 0.6 g/kg/day of TT, 0.3 g/kg/day of AS, 0.2 g/kg/day of WG and 0.55 g/kg/day of TC (7.5% TT, 3.75% AS, 2.5% WG), respectively. After 90 days, the rats were sacrificed and blood and testicular tissue samples obtained. Serum total cholesterol and free testosterone levels were measured, and the Johnsen testicular biopsy score (JTBS) was calculated by a histopathological examination of testicular tissue samples. The high-cholesterol diet in Group II significantly caused increase in total cholesterol level and decrease in JTBS as compared to Group I. Although the groups' free testosterone levels were not statistically significant, WG and TC significantly prevented total cholesterol increase. TC significantly increased the JTBS compared to TT, AS and WG alone. Thus, it was concluded that TC might be particularly efficient for improving male sexual dysfunction.

Published
2018
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2. Effect of the Oxidant-Antioxidant System in Seminal Plasma on Varicocele and Idiopathic Infertility in Male Humans

Author

Hayrullah Yazar, Yasemin Nasir, Derya Guzel, Fikret Halis, Ahmet Gökçe, Mehmet Akdogan, Yazar, H, Halis, F, Nasir, Y, Guzel, D, Akdogan, M, Gokce, A, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Yazar, Hayrullah, Halis, Fikret, Nasır, Yasemin, Güzel, Derya, Akdoğan, Mehmet, and Gökçe, Ahmet

Subjects
Adult, Male, 0301 basic medicine, Infertility, medicine.medical_specialty, Varicocele, Urology, Physiology, Semen, AutoAnalyzer, Antioxidants, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Statistical significance, Humans, Medicine, Infertility, Male, 030219 obstetrics & reproductive medicine, biology, Aryldialkylphosphatase, business.industry, Paraoxonase, Oxidants, medicine.disease, PON1, Sperm, Oxidative Stress, Medical Laboratory Technology, 030104 developmental biology, biology.protein, business
Abstract

The aim of this study was to investigate seminal oxidant-antioxidant activity in idiopathic and varicocele infertility in men.Total anti-oxidant capacity (TAC), total oxidant status (TOS), paraoxonase (PON1), aryl esterase (ARE), and total thiol levels (TTL) were measured in seminal plasma with an autoanalyzer. The TOS/TAC ratio was determined as the oxidative stress index (OSI). A histopathological evaluation of the sperm was performed in the andrology laboratory of the hospital. Number, motility, morphology, volume, pH, and leukocytes were evaluated in all samples according to World Health Organization criteria. The three study groups were as follows: G1, males with idiopathic infertility; G2, males with varicocele infertility; and G3, normal healthy males (had fathered a child in the last 2 years). Each group was composed of 36 men (age, 25 - 40 years). The Rel Assay Diagnostics kit was used to determine the levels of the parameters. The study was conducted according to the principles of the declaration of Helsinki and was approved by Sakarya University Medicine Faculty Ethic Committee (e.n: 16214662/050.01.04/07). Statistical significance was assumed if p0.05. All statistical evaluations were performed using SPSS (version 20.0 for Windows; SPSS, Inc., Chicago, IL, USA).No differences were detected between the mean values of antioxidant parameters among the three groups (Kruskal-Wallis test). The p-values of the test parameters (TAC, TOS, PON1, ARE, TTL, OSI) are respectively: 0.494, 0.548, 0.068, 0.151, 0.202, 0.873. The antioxidant parameters of all subjects were compared using the MannWhitney U-test in both groups as fertile (G3) and infertile (G1 + G2). The PON1 levels in infertile subjects were significantly higher than those in fertile subjects. There was a statistically significant difference (p = 0.042). The other antioxidant parameters had no statistically significant difference (p0.05). The ARE was not performed in group 3 (control) due to a methodological problem.PON1 levels in infertile subjects were significantly higher than those of fertile subjects.

Published
2017
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3. Kuklacı

Author

Erbek, Yasemin Nasır, editör : Gonca Erkmen Gidenoğlu, Erbek, Yasemin Nasır, and editör : Gonca Erkmen Gidenoğlu

Subjects
Turkish fiction, Türk romani
Published
2016

4. Immunohistochemical evaluation of iron accumulation in term placenta of preeclamptic patients

Author

Ayfer Aktas, Nurten Akdeniz, Yasemin Nasir, and Yusuf Nergiz

Subjects
medicine.medical_specialty, biology, Preeclampsia, placenta, immunohistochemistry, iron accumulation, medicine.disease, Applied Microbiology and Biotechnology, Preeclampsia, Ferritin, Pathogenesis, Term placenta, Andrology, Endocrinology, medicine.anatomical_structure, Stroma, Internal medicine, Placenta, embryonic structures, Genetics, medicine, biology.protein, Immunohistochemistry, Agronomy and Crop Science, Molecular Biology, reproductive and urinary physiology, Immunostaining, Biotechnology
Abstract

Preeclampsia is a disease which involves hypertension and multisystem, it effects approximately 2 to 8% of all pregnancies and is a significant cause of maternal and newborn mortality and morbidity. It develops in the placenta and its pathogenesis is associated with placental abnormalities. Classical immunohistochemical studies on placenta have shown that there is a linear increase in iron storage in the placenta in the first half of a normal pregnancy, however, these stocks are decreased in normal 3 rd trimester placenta. Iron accumulation in term placentas of preeclamptic and normal pregnancies were evaluated in this study. Ferritin immunostaining was observed to be more intense in preeclamptic group than in the control group, especially in Hofbauer cells, subtrophoblastic areas of stem villous, perivasculer stroma and villous stroma. Statistical analysis of the data was performed using SPSS software. Mann Whitney U test was used in the analysis and P values below 0.05 were statistically significant. In this study, iron accumulations in normotensif and preeclamptic placentas were compared. Key words: Preeclampsia, placenta, immunohistochemistry, iron accumulation.

Published
2011
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5. Investigation of functional sperm membrane integrity after consequence of anti-hypoosmotic swelling test technique: an electron microscopic study

Author

Yekbun, Tutsi, Murat, Akkus, Selcuk, Tunik, Yusuf, Nergiz, Iskender, Kaplanoglu, and Yasemin, Nasir

Subjects
Male, Microscopy, Electron, Staining and Labeling, Asthenozoospermia, Osmotic Pressure, Cell Membrane, Eosine Yellowish-(YS), Humans, Oligospermia, Spermatozoa, Infertility, Male, Fluorescent Dyes
Abstract

Infertility is described as the inability of a couple to conceive after 1 year of unprotected intercourse. Male factor is assumed to be responsible for 50% of cases of infertile couples. It is a common clinical problem, affecting approximately 13-15% of couples worldwide. In this study we aimed to investigate the effects of hypoosmotic swelling (HOS) and anti-HOS tests on sperm membrane integrity at the ultrastructural level.Twenty-nine infertile and 10 fertile men were included in this study. The fertile and infertile subjects were classified according to Kruger and WHO criterion. All semen samples were examined and ana-yzed based on WHO guidelines. Sperm viability was determined by using the eosin Y staining method. After HOS and anti-HOS tests wore applied, the samples were evaluated at the ultrastructural level.Normal structural features of all regions of sperm were observed in sections of sham normospermia. Some histopathological changes wore seen in HOS and anti-HOS group sections.The HOS procedure was found not to cause degenerative changes in the sperm ultrastructure. The anti-HOS procedure can be applied in normospermic and oligospermic groups.

Published
2015

6. Poster presentations

Author

Funda Aksu, Hakan Topacoglu, Candan Arman, Aytul Atac, Suleyman Tetik, Aida Hasanovic, Amela Kulenovic, Zakira Mornjakovic, Branko Pikula, Aida Sarac-Hadzihalilovic, Alma Voljevica, Belgin Bamac, Tuncay Colak, Murat Alemdar, Gulmine Dundar, Macit Selekler, Ozgur Dincer, Enis Colak, Aydin Ozbek, Cenk Kilic, Kivanc Kamburoglu, Tuncer Ozen, Vatan Kavak, Yalcin Kirici, Emin Oztas, Handan Altinkaya Soysal, Erdogan Unur, Nihat Ekinci, Omur Karaca, Olga Malakhova, Murat Kocaoglu, Serdar Toker, Figen Taser, Volkan Kilincoglu, Mustafa Fahri Yurtgun, Cannur Dalcik, Ali Zeybek, Marc Baroncini, Johann Peltier, Patrice Jissendi, Jean-Pierre Pruvo, Jean-Paul Francke, Vincent Prevot, Rengin Kosif, Yasin Arifoglu, Murat Diramali, Mustafa Sarsilmaz, Evren Kose, Murat Ogeturk, Burhan Akpinar, Ilter Kus, Sedat Meydan, Alev Kara, Zeliha Kurtoglu, Ibrahim Tekdemir, Alaittin Elhan, Orhan Bas, Ersan Odaci, Hakan Mollaoglu, Kagan Ucok, Suleyman Kaplan, Mehmet Senoglu, Vedat Nacitarhan, Ergul Belge Kurutas, Nimet Senoglu, Idris Altun, Yalcin Atli, Davut Ozbag, Sacide Karakas, M. Dincer Bilgin, Ayfer Metin Tellioglu, Sercin Ozlem, Betul Akcanal, Yuksel Yildiz, Hakki Gunes, Hayrullah Kose, Ibrahim Uzum, Umit Naci Gundogmus, Cigdem Caglayan, Velichka Pavlova, Mashenka Dimitrova, Lilia Georgieva, Elena Nikolova, Deniz Uzmansel, Nail Can Ozturk, Canan Yurttas Saylam, Erkin Ozgiray, Mustafa Orhan, Sedat Cagli, Mehmet Zileli, Derya Ozkan, Taylan Akkaya, Ayhan Comert, Nilgun Balikci, Esra Ozdemir, Haluk Gumus, Zafer Ergul, Oskay Kaya, Serdar Altun, R. Erkin Unlu, Hakan Orbay, Deog-Im Kim, Seung-Ho Han, Yi-Suk Kim, Ho-Jeong Kim, Kyu-Seok Lee, Omur Elcioglu, Hilmi Ozden, Gul Guven, Nurcan Imre, Bulent Yalcin, Hasan Ozan, Pinar Akyer, Mustafa Guvencer, Vasfi Karatosun, Mandeep Gill Sagoo, Rachel Claire Aland, Derya Ustuner, M. Cengiz Ustuner, Jafar Ai, Seyed Reza Ghazi, Seyed Hadi Mansouri, Mehmet Cudi Tuncer, Mehmet Ufuk Aluclu, Ozlen Karabulut, Eyup Savas Hatipoglu, Hasan Nazaroglu, Cigdem Icke, Emrah Akbay, Turkan Gunay, Suleyman Icke, Selda Yildiz, Fatih Yazar, Barcin Orhan Barlas, Delia Elena Zahoi, Ahmet Kavakli, Ufuk Tas, Durrin Ozlem Dabak, Hilal Irmak Sapmaz, Necdet Kocabiyik, Cenk Murat Ozer, Ayhan Ozcan, Levent Elevli, Kadir Desdicioglu, Ibrahim Alanbay, Figen Govsa, Canan Y. Saylam, Ilgaz Akdogan, Yilmaz Kiroglu, Sule Onur, Emine Hilal Evcil, Neslihan Cankara, Mehmet Ali Malas, M. Tayyar Kalcioglu, Serdar Duman, Tufan Ulcay, Ahmet Uzun, Zulfu Karabulut, Cagatay Barut, Ozdemir Sevinc, Gamze Yurdakan, Dundar Kacar, Ali Riza Erdogan, Hulyam Kurt, Bunyamin Demir, Mustafa Saltan, Dilek Burukoglu, Mehmet Cengiz Ustuner, Irfan Degirmenci, Aliriza Erdogan, Ozlem Damar, Merih Is, Gokhan Bayramoglu, Sahin Kabay, Onur Uysal, Hakan Senturk, Aysegul Bayramoglu, Cansu Ozbayar, Ali Kutlu, Mediha Canbek, Salih Cenap Cevli, Oguz Hancerlioglu, Mustafa Koplay, Elif Aksakalli, Fatih Dikici, Aysin Kale, Ozcan Gayretli, Ilke Ali Gurses, Senem Turan Ozdemir, Ilker Ercan, Emel Bulbul Baskan, Mediha Yilmaz, Guven Ozkaya, Hayriye Saricaoglu, Mete Erturk, Gulgun Kayalioglu, Mehmet Uzel, Guler Kahraman, Ercan Tanyeli, Ali Ihsan Soyluoglu, Orhan Tacar, Ayda Demirant, Murat Bilgin, Aziz Karadede, Ayfer Aktas, E. Hilal Evcil, Esra Koyuncu, Osman Sulak, Soner Albay, Gulnur Ozguner, Ahmet Ozbek, Elvan Ozbek, A. Hakan Ozturk, Tuba Demirci, Engin Ciftcioglu, Mehmet Tevfik Demir, Cem Kopuz, Esra Eroglu, Semin Gedikli, Hamit Ozyurek, Mehmet Selim Nural, Lutfi Incesu, Gonul Ogur, Engin Kara, Baris Celebi, Altan Yildiz, B. Zuhal Altunkaynak, Samet Vasfi Kuvat, Suleyman Murat Tagil, Cumhur Ertekin, Hilmi Uysal, Fikret Bademkiran, Nural Albayrak, Ali Firat Esmer, Nigar Keles Coskun, Muzaffer Sindel, Ferah Kizilay, Sevket Yalin, Nevin Karapinar, Mehmet Tokdemir, Lokman Karakurt, Levent Tumkaya, Adnan Korkmaz, Bulent Ayas, Nusret Ciftci, Yuksel Terzi, Ozlem Baran, Yusuf Nergiz, Murat Akkus, Ufuk Aluclu, Askin Ender Topal, Dilek Yuksel, Halil Ibrahim Acar, Simel Kendir, Emre Hekimoglu, Deniz Basman, Sunay Duman, Baris Ozener, Can Pelin, Ragiba Zagyapan, Ayla Kurkcuoglu, Mustafa Koc, Meral Erdinc, Levent Erdinc, Ilker Kelle, Enver Sancakdar, Nil Cetin, Selcuk Tunik, Ayse Yildirim, Iskender Kaplanoglu, Ercan Ayaz, Necip Ilhan, Mehmet Okumus, Kasim Zafer Yuksel, Harun Ciralik, Zeki Yilmaz, Yakup Gumusalan, Mehmet Gamsizkan, Mustafa Kazkayasi, Nadire Unver Dogan, Ismihan Ilknur Uysal, Aylin Karalezli, Zeliha Fazliogullari, Mustafa Buyukmumcu, Mehmet Cem Bozkurt, Aynur Emine Cicekcibasi, Deniz Demiryurek, M. Hakan Ozsoy, Alp Bayramoglu, Eray Tuccar, Ozlem Pamukcu Baran, Sevda Soker, Selen Bahceci, Yasemin Nasir, Mehmet Tugrul Yilmaz, Emine Aynur Cicekcibasi, Mahinur Ulusoy, Pervin Gunaslan, Nuray Bilge, Muzaffer Akkaya, Abdurrahman Genc, Sezer Akcer, Yucel Gonul, Emine Cosar, Gulengul Koken, Ilknur Ari, Sinan Bakirci, Ilker Mustafa Kafa, Murat Uysal, Ahmet Kagan Karabulut, Bahar Keles, Dilek Emlik, Yavuz Uyar, Kayhan Ozturk, Neslihan Altuntas Yilmaz, Ahmet Salbacak, Burkay Kutluhan Kacira, Mehmet Arazi, Serafettin Demirci, Demet Kiresi, Serter Gumus, Muzaffer Seker, Mehmet Uyar, Mohammad Ebrahim Astaneh, Alireza Khorshid, Ramazan Uygur, Ahmet Songur, Osman Fikret Sonmez, Kamil Hakan Dogan, Giray Kolcu, Madalina Iliescu, Petru Bordei, Dan Iliescu, Camelia Ciobotaru, Viorel Lucescu, Anatoli Covaleov, Constantin Ionescu, Miguel Guirao, E. Páramo, R. Mutuberria, I. Sánchez-Montesinos, O. Roda, F. Girón, Miguel Lopez-Soler, Olga Roda, Raúl Campos-López, Miguel Guirao-Piñeiro, Maria Teresa Pascual-Morenilla, Indalecio Sanchez-Montesinos, Maria Teresa Pascual, I. Garzon, D. Serrato, R. Nieto-Aguilar, I. Sanchez-Montesinos, M. Sanchez-Quevedo, M. Bulent Ozdemir, R. Hakan Ozean, Dilek Bagdatli, Esat Adiguzel, Zumrut Dogan, Ozlem Aycan, Nigar Vardi, Haldun Sukru Erkal, Hakan Ozturk, S. Mocanu, C. Stefanescu, A. Ionescu, Raluca Talpes, Elena Sapte, Constantin Dina, Loredana Surdu, Ionut Bulbuc, M. T. Medina, J. Medina, M. López-Soler, Carlos Martin-Oviedo, Alejandro Lowy-Benoliel, Eva Maranillo, Tomas Martinez-Guirado, Jose Sañudo, Bartolome Scola, Teresa Vazquez, L. A. Arráez-Aybar, J. L. Conejo-Menor, C. C. Gonzáles-Gómez, A. J. Torres-García, Hisayo Nasu, Shoji Chiba, M. Gutierrez-Semillera, Yahya Paksoy, Ahmet Kalaycioglu, Mehmet Yildirim, Ali Ozyasar, Omer Ozdogmus, Yusuf Ozgur Cakmak, Ural Verimli, Safiye Cavdar, Begum Yildizhan, Z. Asli Aktan Ikiz, Hulya Ucerler, Zuhal Ozgur, Seher Yilmaz, Abdullah Demirtas, Ertugrul Mavili, Mehtap Hacialiogullari, Hatice Susar, Seda Arslan, Kenan Aycan, Vecihi Ozkaya, Mara Pilmane, Sarmite Boka, Gursel Ortug, Carlos Ramirez, Aran Pascual-Font, Francisco Valderrama-Canales, Abdulah Kucukalic, Eldan Kapur, Elvira Talovic, Vaclav Baca, Robert Grill, Zdenek Horak, David Kachlik, Valer Dzupa, Marek Konarik, Jakub Knize, Petr Veleminsky, Tereza Smrzova, Michal Otcenasek, Jana Chmelova, Michal Kheck, Tomas Cupka, Lukas Hnatek, Floris van der Meijs, Pavel Cech, Vladimir Musil, H. Mustafa Ozkan, S. Kivanc Muratli, Hamid Tayefi, Ipek Ergur, Amac Kiray, Muhsin Toktas, Ozan Alkoc, Tolgahan Acar, Ibrahim Uzun, Oguz Asian Ozen, Abdullah Aycicek, Ozan Alper Alkoc, Mehmet Unlu, Ufuk Corumlu, Ihsaniye Coskun Ikiz, I. Hakan Oygucu, Erdogan Sendemir, Tuncay Kaner, Veli Caglar, Olcay Eser, Mehmet T. Demir, Omer Iyigun, Gokhan Pirzirenli, Ahmet Hilmi Kaya, Mennan Ece Aydin, Fahrettin Celik, Hakan True, Sevket Ozkaya, Bekir Ugur Ergur, Gulsah Zeybek, Kadir Bacakoglu, Mina Tadjalli, Aghdas Poostpasand, Seid Hadi Mansouiri, Ozra Allahvaisi, Jafar Soleimanirad, Bahram Nikkhoo, Yasukazu Nagato, Yasuo Haruki, Komazo Yazawa, Tutomu Okazaki, Munetaka Haida, Yutaka Imai, Thmineh Peirouvi, Mehrzad Mahzad-Sadaghiani, Farahnaz Noroozinia, Salami Siamak, Gholamhosseine Farjah, Sima Mola, Ewa Biegaj, Tymon Skadorwa, Konrad Pawlewicz, Robert Kapolka, Agata Chachulska, Joanna Zabicka, Aleksandra Krasowska, Alicja Prusik, Grzegorz Jaczewski, Adam Kolesnik, M. Mohsen Taghavi, S. Hasan Alavi, S. Adel Moallem, Zahed Safikhani, Marzieh Panahi, Shahriar Dabiri, Majid Asadi Shekaari, Rafael Latorre, Federico Soria, Octavio Lopez-Albors, Ricardo Sarria, Inacio Ayala, Inma Serrano, Enrique Perez-Cuadrado, Vladimir Musienko, Dmitry Tkachenko, Neriman Colakoglu, Murat Abdulgani Kus, Mahdi Jalali, Mohammad Reza Nikravesh, Abbas Ali Moeen, Mohammad Hassan Karimfar, Houshang Rafighdoost, Shabnam Mohammadi, Marina Korneeva, Houshang Rafighdoust, Kvetuse Lovasova, Adriana Bolekova, Darina Kluchova, Igor Sulla, Marina Yurievna Kapitonova, Syed Baharom Syed Ahmad Fuad, Flossie Jayakaran, Ali Reza Shams, Fereshteh Aghaee, Zohreh Baqer, Mohamad Faroki, Srijit Das, Normadiah Kassim, Azian Latiff, Frihah Suhaimi, Norzana Ghafar, Khin Pa Pa Hlaing, Israa Maatoq, Faizah Othman, Muge Kiray, Husnu Alper Bagriyanik, Cetin Pekcetin, Candan Ozogul, Mustafa Fidan, Farihah Suhaimi, Fei Sun, Francisco Sanchez-Margallo, Francisco Gil, Verónica Crisostomo, Jesus Uson, Gegorio Ramirez, Ozan Turamanlar, Oguz Kirpiko, Alpay Haktanir, Salvador Climent, Sergio Losilla, Maria Climent, Levent Sarikcioglu, Yesim Senol, Fatos B. Yildirim, Arzu Utuk, Jacek Kunicki, Parichehr Pasbakhsh, Negar Omidi, Hamed Omidi, Fatemeh Dehghani Nazhvani, Seyed Razi Ghalebi, Nima Javan, Akrami Mohagery, Ali Reza Ebrahimzadeh Bideskan, Mohammad Mehdi Hassanzadeh Taheri, Ali Reza Fazel, Cesare Tiengo, Veronica Macchi, Carla Stecco, Andrea Porzionato, Franco Mazzoleni, Raffaele De Caro, Alberto Clemente, Aldo Morra, Pietro Greco, Piero Pavan, Arturo Natali, Mehmet Demir, Mehmet Dokur, Niyazi Acer, Ayfer Mavi, Niki Matveeva, Dobrila Lazarova, Kostandina Korneti, Svetlana Jovevska, Dragica Jurkovik, Meri Papazova, Masoumeh Havasi, Naeim Alboghobeish, Ahmad Savari, Negin Salamat, Mozafar Sharifi, Hyun-Ho Kwak, Kyung-Seok Hu, Gyoo-Cheon Kim, Bong-Soo Park, Hee-Jin Kim, Ahmet Sinav, Adarsh K. Gulati, Nidhi K. Gulati, Hussien Alshammary, Seifollah Dehghani Nazhvani, Amir Vafafar, Tahereh Esmaeilpour, Soghra Bahmanpour, Leila Elyasi, Ahmad Monabbati, M. Ghanadi, Mohammad Reza Paryani, Hassan Gilanpour, Banino Amirsam, Rodrigo Elizondo Omaña, Santos Guzmán López, Oscar De la Garza Castro, Edgar Urrutia Vega, Santos Guzman Lopez, Freshteh Talebpour, Rahim Golmohammadi, Golamreza Dashti, Mohammad Ali Atlasi, Mehdi Mehdizadeh, Mohammad Hadi Bahadori, Mohammad Taghi Joghataei, Leili Hatami, Mandana Beigi Boroujeni, Jasem Estakhr, Ebrahim Esfandiary, Mohsen Marzban, Mehrdad Bakhtiary, Navid Modiry, Mokhtar Jafarpur, Hassan Mofidpur, S. Hassan Alavi, Alareza Mahmoudian, Mohmmad Mohsen Taghavi, Mokhtar Jafarpour, Ali Reza Mahmoudian, Nasrin Sanjarmousavi, Ines Doassans, Natalia Sorrenti, German Decuadro, Andres Saibene, Marie Poumayrac, Sebastian Laza, Carina Almiron, Maria Elena Vergara, Victor Soria, Sebastian Lasa, Adolfo Perez, Gabriela Castro, Ana Santa Maria, Mansoureh Soleimani, Majid Katebi, Masoomeh Bakhshayesh, Mithat Oner, Mehmet Halici, Ali Yikilmaz, Ahmet Guney, Yildirim Turk, Mete Edizer, Umit Beden, Nihal Icten, Mohammad Afshar, Mohammad Mehdi Hasanzadeh Taheri, Adel Moalem, Mohammad Jafar Golalipour, Azadeh Tamizi, Mohammad Ahi, Shahram Mohammadpour, Ardeshir Maiery, Cengiz Acikel, Ersin Ulkur, Huseyin Karagoz, Bahattin Celikoz, Kuldip Bedi, Partadiredja Ginus, Mohammad Jafar Golalipoor, Mohammad Reza Mohammadi, Poya Jhand, Azad Reza Mansourian, Kanizreza Hosseinpoor, Abbas Ali Keshtkar, Raith Alsaffar, Babak Kabiri Balajadeh, Soraya Ghafari, Ramin Azarhosh, Seyyed Amirhossein Fazeli, Mehrdad Jahanshahi, Annen Mohammad Gharravi, Banu Alicioglu, Hakki Muammer Karakas, Ahmet Harma, Hun-Mu Yang, Sung-Yoon Won, Jae-Gi Lee, Ju-Young Lee, Jeong-Yong Lee, Yoo-Ri Kim, Wu-Chul Song, Ki-Seok Koh, Eu-Na Hwang, Hyun-Gon Choi, Soon-Heum Kim, Soo-Young Kim, Mi-Sun Hur, Enis Ulucam, Osman Celbis, Da-Hye Kim, Hee-Suk Hong, Hyun-Joo Kim, Jong-Hoon Choi, Jong-Tae Park, Hyeon-Cheol Kim, Hamed Abbasi, Seyed Mohammad Hosseinipanah, Mohammad Hosseini, A. Amani, H. R. Ashrafi, Mohsen Sadeghimehr, Hyun-Ju Kim, Vadim Sheverdin, Zahra Amani, Alireza Ashrafi, Ali Reza Ashrafi, Hami Javad, Mokhtar Jafarpoor Kachap, Sebastián Laza, Marie Catherine Poumayrac, Inés Doassans, María Elena Vergara, Carina Almirón, Víctor Soria, Alvaro Rivara, Angela Sirilo, Diego Freire, Angela Cirillo, Maria Elena Veragara, Vlado Krmek, Nikola Krmek, Ana Jo-Osvatic, Vasilije Nikolic, Radivoje Radic, R. Shane Tubbs, Marios Loukas, Quentin Fogg, Neil Ashwood, Serpil Cilingiroglu, Cemal Ozbakir, Tahereh Mazoochi, Vedat Sabanciogullari, Cesur Gumus, F. Hayat Erdil, Mehmet Cimen, Hesam Moodi, Fateme Ghiasi, Asghar Akbari, Javad Hami, Majid Khazei, Elham Haghparast, Ioannis Mitsakis, Aikaterini Anastasiou, Menelaos Mitsakis, Kyriaki Sianou, Roxani Hainoglou, Margarida Francisco, Charikleia Mitsaki, Maria Konstantinidi, Stamatia Prapa, Igor Leksan, Tomislav Mrcela, Robert Selthofer, Fatemeh Kermanian, Alireza Mahmoudian, Mahmood Erfanian Ahmadpoor, Naser Dalili, Amir Hossein Elian, Ardesheer Moaiery, Zahra Jamalpour, Mohammad Reza Nourani, Alireza Asgari, Alireza Ebrahimzadeh, Seyed Hasan Eftekharvaghefi, Abbas Mohammadi, Vahid Sheibani, Seyed Noureddin Nematollahi-Mahani, Mastafa Latifpour, Masood Deilami, Behzad Soroure-Azimzadeh, Fatemeh Nabipour, Hamid Najafipour, Nouzar Nakhaee, Mohammad Yaghoobi, Rana Eftekharvaghefi, Parvin Salehinejad, Hasan Azizi, Hamid Reza Riasi, Maliheh Nobakht, Sara Asalgoo, Roshanak Rahbar, Norooz Najafzadeh, Kazem Moosavizadeh, Massood Ezzatabadypour, Masoud Majidi, Reza Malekpor-Afshar, Fariba Karimzade, Mahmood Hoseini, Mohamad Bayat, Ali Gorgi, Akram Nezhadi, Mehrdad Bakhtiari, Homa Rasooli Jazi, Maryam Jafaryan, Hosein Haghir, Mahmood Hosseini, Sadegh Rahimi, Fatemeh Behnam Rassouli, Ali Gorji, Aliasghar Habibi, Fatemeh Pouya, Shahryar Dabiri, A. Mousavi, Saeed Rajabalian, A. Abolidokht, Neda Khanlarkhani, Homayoun Naderian, Nezamedin Berjis, Mohamad Reza Namavar, Tahereh Talaei, Zohreh Mazaheri, Ahmad Monabati, Mehmet Ilkay Kosar, Kezban Karacan, Hamidreza Chegini, Hossein Nikzad, Egemen Ayhan, Sinan Ustundag, Salih Murat Akkin, Tahir Ogut, Parviz Rayegan, Mohamad Ali Emami Meibodi, Reza Montazer Ghaem, Rosa Zargarpoor, Seyd Hasan Eftekhar Vaghefi, Ghazale Moshkdanian, Fateme Poya, Hamid Kohestani, Roozbeh Rayegan Abarghoeai, Parviz Rayegan Abarghoeai, Seyed Hasan Eftekhar Vaghefi, Abolghasem Amir Mahmodi, Ali Poraboli, Hamid Reza Kohestani, Raena Eftekhar Vaghefi, Seyed Hasan Eftekhar Vaghefy, Raena Eftekhar Vaghefy, Parviz Raygan Abarghoeai, Mohamad Saba, Anneh Mohammad Gharravi, Fatemeh Javadnia, Mohsen Zhaleh, Dariush Bijan Nezhad, Mohammad Reza Gholami, Maria Piagkou, Vassiliki Kouki Aikaterini, Giannoulis Piagkos, Stergios Douvetzemis, Panagiotis Skandalakis, Sophia Anagnostopoulou, Nikolaos Papadopoulos, H. Hamdi Celik, Ilkan Tatar, Emel Cadalli Tatar, Burce Ozgen Mocan, Mustafa F. Sargon, C. Cem Denk, Homa Rasoolijazi, Mohammad Taghi Joghataie, Mehrdad Roghani, Salin Murat Akkin, Gulten Dinc, Mustafa Kurklu, Sener Ozboluk, Mahmut Komurcu, Jürgen Koebke, Mehmet Bulent Balioglu, Mehmet Akif Kaygusuz, Ferdi Sefa Bozkus, Ozgur Korkmaz, Sule Biyik Bayram, Mehmet Ali Can, Ebrahim Nasiri, Koroush Jafar-Kazemi, Melina Hosseini, Shahin Maghoul, Mansooreh Soleimani, Abdollah Amini, Mohamad Mahdi Hassanzade, Mohammad Hossein Davari, Tom Van Hoof, Germano T. Gomes, Emmanuel Audenaert, Koenraad Verstraete, Ingrid Kerckaert, Katharina D’Herde, Brion Benninger, Gil Hedley, Florin Mihail Filipoiu, Eugen Tarta, Mihali Enyedi, Cosmin Pantu, Razvan Stanciulescu, Cezary Skobowiat, Jaroslaw Calka, Mariusz Majewski, Maryam Rezaian, Akbar Yaghoobfar, Somayeh Hamedi, and T. Shomali

Subjects
Radiology, Nuclear Medicine and imaging, Surgery, Anatomy, Pathology and Forensic Medicine
Published
2009

7. Ultrastructural effects of tamoxifen on uterus in rats

Author

Engin, Deveci, Yasemin, Nasir, and Senay, Deveci

Subjects
Tamoxifen, Antineoplastic Agents, Hormonal, Uterus, Animals, Humans, Breast Neoplasms, Female, Rats, Wistar, Rats
Abstract

Tamoxifen is a triphenylethylene derivative commonly used in the treatment of breast cancer The Wistar rats (9 weeks old, 180-200 g body weight) used in these trials were divided into two groups of 20 animals each (control and experimental group). Animals of the experimental group were given drinking water containing 200 μg/kg tamoxifen citrate for a period of 30 day. At the end of exposure, body and uterus weights were measured. There was no statistical difference in the uterus weights between the control and treated groups (p0,05). Squamous metaplasia, characterized by the presence of stratified squamous epithelium on the lumenal surface of the uterus and the lining of the luminal surface of uterine glands was seen in some animals that had received tamoxifen. Ultrastructural changes were revealed in the form of vacularization of cell cytoplasm and The cytoplasm contained areas of low electron density. Not only was the cytoplasm full with intense crystalized and degeneration in mitochondria.

Published
2009

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