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It is becoming increasingly crucial to develop methods and strategies to assess building performance under the changing climate and to yield a more sustainable and resilient design. However, the outputs of climate models have a coarse spatial and temporal resolution and cannot be used directly in building energy simulation tools. This paper reviews methods to develop fine spatial and temporal weather files that incorporate climate emissions scenarios by means of downscaling. An overview of the climate change impact on building energy performance is given, and potential adaptation and mitigation factors in response to the changing climate in the building sector are presented. Also, methods to reflect, propagate, and partition main sources of uncertainties in both weather files and buildings are summarized, and a sample approach to propagate the uncertainties is demonstrated. [ABSTRACT FROM AUTHOR]