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1. Incidence of sodium–glucose cotransporter-2 inhibitor-associated perioperative ketoacidosis in surgical patients: a prospective cohort study

Author

Seki, Hiroyuki, Kuratani, Norifumi, Shiga, Toshiya, Iwasaki, Yudai, Karita, Kanae, Yasuda, Kazuki, Yamamoto, Natsuko, Nakanishi, Yuko, Shigematsu, Kenji, Kobayashi, Kensuke, Saito, Junichi, Kondo, Ichiro, Yaida, Nozomu, Watanabe, Hidenobu, Higashi, Midoriko, Shirasaka, Tetsuro, Doshu-Kajiura, Akira, Edanaga, Mitsutaka, Tanaka, Satoshi, Ikumi, Saori, Ito, Shingo, Okada, Masayuki, and Yorozu, Tomoko

Published
2024
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2. Correction: New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)

Author

Shimada, Akira, Kawasaki, Eiji, Abiru, Norio, Awata, Takuya, Oikawa, Yoichi, Osawa, Haruhiko, Kajio, Hiroshi, Kozawa, Junji, Takahashi, Kazuma, Chujo, Daisuke, Noso, Shinsuke, Fukui, Tomoyasu, Miura, Junnosuke, Yasuda, Kazuki, Yasuda, Hisafumi, Imagawa, Akihisa, and Ikegami, Hiroshi

Published
2024
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3. New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)

Author

Shimada, Akira, Kawasaki, Eiji, Abiru, Norio, Awata, Takuya, Oikawa, Yoichi, Osawa, Haruhiko, Kajio, Hiroshi, Kozawa, Junji, Takahashi, Kazuma, Chujo, Daisuke, Noso, Shinsuke, Fukui, Tomoyasu, Miura, Junnosuke, Yasuda, Kazuki, Yasuda, Hisafumi, Imagawa, Akihisa, and Ikegami, Hiroshi

Published
2024
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7. Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments

Author

Fukuda, Hironori, primary, Arai, Kosuke, additional, Mizuno, Hideaki, additional, Nishito, Yukari, additional, Motoi, Noriko, additional, Arai, Yasuhito, additional, Hiraoka, Nobuyoshi, additional, Shibata, Tatsuhiro, additional, Sonobe, Yukiko, additional, Kayukawa, Yoko, additional, Hashimoto, Eri, additional, Takahashi, Mina, additional, Fujii, Etsuko, additional, Maruyama, Toru, additional, Kuwabara, Kenta, additional, Nishizawa, Takashi, additional, Mizoguchi, Yukihiro, additional, Yoshida, Yukihiro, additional, Watanabe, Shun‐ichi, additional, Yamashita, Makiko, additional, Kitano, Shigehisa, additional, Sakamoto, Hiromi, additional, Nagata, Yuki, additional, Mitsumori, Risa, additional, Ozaki, Kouichi, additional, Niida, Shumpei, additional, Kanai, Yae, additional, Hirayama, Akiyoshi, additional, Soga, Tomoyoshi, additional, Tsukada, Keisuke, additional, Yabuki, Nami, additional, Shimada, Mei, additional, Kitazawa, Takehisa, additional, Natori, Osamu, additional, Sawada, Noriaki, additional, Kato, Atsuhiko, additional, Yoshida, Teruhiko, additional, Yasuda, Kazuki, additional, Ochiai, Atsushi, additional, Tsunoda, Hiroyuki, additional, and Aoki, Kazunori, additional

Published
2024
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9. Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design

Author

Chujo, Daisuke, Imagawa, Akihisa, Yasuda, Kazuki, Abiru, Norio, Awata, Takuya, Fukui, Tomoyasu, Ikegami, Hiroshi, Kawasaki, Eiji, Katsuki, Takeshi, Kobayashi, Tetsuro, Kozawa, Junji, Nagasawa, Kan, Ohtsu, Hiroshi, Oikawa, Yoichi, Osawa, Haruhiko, Shimada, Akira, Shimoda, Masayuki, Takahashi, Kazuma, Tsuchiya, Kyoichiro, Tsujimoto, Tetsuro, Yasuda, Hisafumi, Hanafusa, Toshiaki, and Kajio, Hiroshi

Published
2022
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10. New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes of the Japan Diabetes Society (English version)

Author

Shimada, Akira, primary, Kawasaki, Eiji, additional, Abiru, Norio, additional, Awata, Takuya, additional, Oikawa, Yoichi, additional, Osawa, Haruhiko, additional, Kajio, Hiroshi, additional, Kozawa, Junji, additional, Takahashi, Kazuma, additional, Chujo, Daisuke, additional, Noso, Shinsuke, additional, Fukui, Tomoyasu, additional, Miura, Junnosuke, additional, Yasuda, Kazuki, additional, Yasuda, Hisafumi, additional, Imagawa, Akihisa, additional, and Ikegami, Hiroshi, additional

Published
2024
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11. FIGURE 5 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Author

Aoki, Kazunori, primary, Nishito, Yukari, primary, Motoi, Noriko, primary, Arai, Yasuhito, primary, Hiraoka, Nobuyoshi, primary, Shibata, Tatsuhiro, primary, Sonobe, Yukiko, primary, Kayukawa, Yoko, primary, Hashimoto, Eri, primary, Takahashi, Mina, primary, Fujii, Etsuko, primary, Nishizawa, Takashi, primary, Fukuda, Hironori, primary, Ohashi, Kana, primary, Arai, Kosuke, primary, Mizoguchi, Yukihiro, primary, Yoshida, Yukihiro, primary, Watanabe, Shun-ichi, primary, Yamashita, Makiko, primary, Kitano, Shigehisa, primary, Sakamoto, Hiromi, primary, Nagata, Yuki, primary, Mitsumori, Risa, primary, Ozaki, Kouichi, primary, Niida, Shumpei, primary, Kanai, Yae, primary, Hirayama, Akiyoshi, primary, Soga, Tomoyoshi, primary, Maruyama, Toru, primary, Tsukada, Keisuke, primary, Yabuki, Nami, primary, Shimada, Mei, primary, Kitazawa, Takehisa, primary, Natori, Osamu, primary, Sawada, Noriaki, primary, Kato, Atsuhiko, primary, Yoshida, Teruhiko, primary, Yasuda, Kazuki, primary, Mizuno, Hideaki, primary, Tsunoda, Hiroyuki, primary, and Ochiai, Atsushi, primary

Published
2023
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12. Table S3 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Author

Aoki, Kazunori, primary, Nishito, Yukari, primary, Motoi, Noriko, primary, Arai, Yasuhito, primary, Hiraoka, Nobuyoshi, primary, Shibata, Tatsuhiro, primary, Sonobe, Yukiko, primary, Kayukawa, Yoko, primary, Hashimoto, Eri, primary, Takahashi, Mina, primary, Fujii, Etsuko, primary, Nishizawa, Takashi, primary, Fukuda, Hironori, primary, Ohashi, Kana, primary, Arai, Kosuke, primary, Mizoguchi, Yukihiro, primary, Yoshida, Yukihiro, primary, Watanabe, Shun-ichi, primary, Yamashita, Makiko, primary, Kitano, Shigehisa, primary, Sakamoto, Hiromi, primary, Nagata, Yuki, primary, Mitsumori, Risa, primary, Ozaki, Kouichi, primary, Niida, Shumpei, primary, Kanai, Yae, primary, Hirayama, Akiyoshi, primary, Soga, Tomoyoshi, primary, Maruyama, Toru, primary, Tsukada, Keisuke, primary, Yabuki, Nami, primary, Shimada, Mei, primary, Kitazawa, Takehisa, primary, Natori, Osamu, primary, Sawada, Noriaki, primary, Kato, Atsuhiko, primary, Yoshida, Teruhiko, primary, Yasuda, Kazuki, primary, Mizuno, Hideaki, primary, Tsunoda, Hiroyuki, primary, and Ochiai, Atsushi, primary

Published
2023
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13. FIGURE 3 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

Author

Aoki, Kazunori, primary, Nishito, Yukari, primary, Motoi, Noriko, primary, Arai, Yasuhito, primary, Hiraoka, Nobuyoshi, primary, Shibata, Tatsuhiro, primary, Sonobe, Yukiko, primary, Kayukawa, Yoko, primary, Hashimoto, Eri, primary, Takahashi, Mina, primary, Fujii, Etsuko, primary, Nishizawa, Takashi, primary, Fukuda, Hironori, primary, Ohashi, Kana, primary, Arai, Kosuke, primary, Mizoguchi, Yukihiro, primary, Yoshida, Yukihiro, primary, Watanabe, Shun-ichi, primary, Yamashita, Makiko, primary, Kitano, Shigehisa, primary, Sakamoto, Hiromi, primary, Nagata, Yuki, primary, Mitsumori, Risa, primary, Ozaki, Kouichi, primary, Niida, Shumpei, primary, Kanai, Yae, primary, Hirayama, Akiyoshi, primary, Soga, Tomoyoshi, primary, Maruyama, Toru, primary, Tsukada, Keisuke, primary, Yabuki, Nami, primary, Shimada, Mei, primary, Kitazawa, Takehisa, primary, Natori, Osamu, primary, Sawada, Noriaki, primary, Kato, Atsuhiko, primary, Yoshida, Teruhiko, primary, Yasuda, Kazuki, primary, Mizuno, Hideaki, primary, Tsunoda, Hiroyuki, primary, and Ochiai, Atsushi, primary

Published
2023
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16. Diffusion-weighted magnetic resonance imaging in the pancreas of fulminant type 1 diabetes

Author

Tokunaga, Ayumi, Imagawa, Akihisa, Nishio, Hiroshi, Hayata, Satoshi, Shimomura, Iichiro, Abiru, Norio, Awata, Takuya, Ikegami, Hiroshi, Uchigata, Yasuko, Oikawa, Yoichi, Osawa, Haruhiko, Kajio, Hiroshi, Kawasaki, Eiji, Kawabata, Yumiko, Kozawa, Junji, Shimada, Akira, Takahashi, Kazuma, Tanaka, Shoichiro, Chujo, Daisuke, Fukui, Tomoyasu, Miura, Junnosuke, Yasuda, Kazuki, Yasuda, Hisafumi, Kobayashi, Tetsuro, Hanafusa, Toshiaki, and For the consultation of Japan Diabetes Society Committee on Fulminant Type 1 Diabetes Mellitus Research

Published
2018
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17. Tumor-infiltrating leukocyte profiling defines three immune subtypes of NSCLC with distinct signaling pathways and genetic alterations

Author

Aoki, Kazunori, primary, Nishito, Yukari, additional, Motoi, Noriko, additional, Arai, Yasuhito, additional, Hiraoka, Nobuyoshi, additional, Shibata, Tatsuhiro, additional, Sonobe, Yukiko, additional, Kayukawa, Yoko, additional, Hashimoto, Eri, additional, Takahashi, Mina, additional, Fujii, Etsuko, additional, Nishizawa, Takashi, additional, Fukuda, Hironori, additional, Ohashi, Kana, additional, Arai, Kosuke, additional, Mizoguchi, Yukihiro, additional, Yoshida, Yukihiro, additional, Watanabe, Shun-ichi, additional, Yamashita, Makiko, additional, Kitano, Shigehisa, additional, Sakamoto, Hiromi, additional, Nagata, Yuki, additional, Mitsumori, Risa, additional, Ozaki, Kouichi, additional, Niida, Shumpei, additional, Kanai, Yae, additional, Hirayama, Akiyoshi, additional, Soga, Tomoyoshi, additional, Maruyama, Toru, additional, Tsukada, Keisuke, additional, Yabuki, Nami, additional, Shimada, Mei, additional, Kitazawa, Takehisa, additional, Natori, Osamu, additional, Sawada, Noriaki, additional, Kato, Atsuhiko, additional, Yoshida, Teruhiko, additional, Yasuda, Kazuki, additional, Mizuno, Hideaki, additional, Tsunoda, Hiroyuki, additional, and Ochiai, Atsushi, additional

Published
2023
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18. Supplementary Figures 1 - 5 from Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

Author

Nakaoku, Takashi, primary, Tsuta, Koji, primary, Ichikawa, Hitoshi, primary, Shiraishi, Kouya, primary, Sakamoto, Hiromi, primary, Enari, Masato, primary, Furuta, Koh, primary, Shimada, Yoko, primary, Ogiwara, Hideaki, primary, Watanabe, Shun-ichi, primary, Nokihara, Hiroshi, primary, Yasuda, Kazuki, primary, Hiramoto, Masaki, primary, Nammo, Takao, primary, Ishigame, Teruhide, primary, Schetter, Aaron J., primary, Okayama, Hirokazu, primary, Harris, Curtis C., primary, Kim, Young Hak, primary, Mishima, Michiaki, primary, Yokota, Jun, primary, Yoshida, Teruhiko, primary, and Kohno, Takashi, primary

Published
2023
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19. Supplementary Materials and Methods from Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

Author

Nakaoku, Takashi, primary, Tsuta, Koji, primary, Ichikawa, Hitoshi, primary, Shiraishi, Kouya, primary, Sakamoto, Hiromi, primary, Enari, Masato, primary, Furuta, Koh, primary, Shimada, Yoko, primary, Ogiwara, Hideaki, primary, Watanabe, Shun-ichi, primary, Nokihara, Hiroshi, primary, Yasuda, Kazuki, primary, Hiramoto, Masaki, primary, Nammo, Takao, primary, Ishigame, Teruhide, primary, Schetter, Aaron J., primary, Okayama, Hirokazu, primary, Harris, Curtis C., primary, Kim, Young Hak, primary, Mishima, Michiaki, primary, Yokota, Jun, primary, Yoshida, Teruhiko, primary, and Kohno, Takashi, primary

Published
2023
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20. Supplementary Figure Legends from Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

Author

Nakaoku, Takashi, primary, Tsuta, Koji, primary, Ichikawa, Hitoshi, primary, Shiraishi, Kouya, primary, Sakamoto, Hiromi, primary, Enari, Masato, primary, Furuta, Koh, primary, Shimada, Yoko, primary, Ogiwara, Hideaki, primary, Watanabe, Shun-ichi, primary, Nokihara, Hiroshi, primary, Yasuda, Kazuki, primary, Hiramoto, Masaki, primary, Nammo, Takao, primary, Ishigame, Teruhide, primary, Schetter, Aaron J., primary, Okayama, Hirokazu, primary, Harris, Curtis C., primary, Kim, Young Hak, primary, Mishima, Michiaki, primary, Yokota, Jun, primary, Yoshida, Teruhiko, primary, and Kohno, Takashi, primary

Published
2023
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21. Supplementary Tables 1 - 2 from Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

Author

Nakaoku, Takashi, primary, Tsuta, Koji, primary, Ichikawa, Hitoshi, primary, Shiraishi, Kouya, primary, Sakamoto, Hiromi, primary, Enari, Masato, primary, Furuta, Koh, primary, Shimada, Yoko, primary, Ogiwara, Hideaki, primary, Watanabe, Shun-ichi, primary, Nokihara, Hiroshi, primary, Yasuda, Kazuki, primary, Hiramoto, Masaki, primary, Nammo, Takao, primary, Ishigame, Teruhide, primary, Schetter, Aaron J., primary, Okayama, Hirokazu, primary, Harris, Curtis C., primary, Kim, Young Hak, primary, Mishima, Michiaki, primary, Yokota, Jun, primary, Yoshida, Teruhiko, primary, and Kohno, Takashi, primary

Published
2023
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22. Supplementary Table Legends from Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma

Author

Nakaoku, Takashi, primary, Tsuta, Koji, primary, Ichikawa, Hitoshi, primary, Shiraishi, Kouya, primary, Sakamoto, Hiromi, primary, Enari, Masato, primary, Furuta, Koh, primary, Shimada, Yoko, primary, Ogiwara, Hideaki, primary, Watanabe, Shun-ichi, primary, Nokihara, Hiroshi, primary, Yasuda, Kazuki, primary, Hiramoto, Masaki, primary, Nammo, Takao, primary, Ishigame, Teruhide, primary, Schetter, Aaron J., primary, Okayama, Hirokazu, primary, Harris, Curtis C., primary, Kim, Young Hak, primary, Mishima, Michiaki, primary, Yokota, Jun, primary, Yoshida, Teruhiko, primary, and Kohno, Takashi, primary

Published
2023
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28. Clinical features of cases of seroconversion of anti-glutamic acid decarboxylase antibody during the clinical course of type 2 diabetes: a nationwide survey in Japan

Author

Oikawa, Yoichi, Shimada, Akira, Awata, Takuya, Fukui, Tomoyasu, Ikegami, Hiroshi, Imagawa, Akihisa, Kajio, Hiroshi, Kawabata, Yumiko, Kawasaki, Eiji, Miura, Junnosuke, Osawa, Haruhiko, Takahashi, Kazuma, Tanaka, Shoichiro, Uchigata, Yasuko, Yasuda, Hisafumi, Yasuda, Kazuki, Hanafusa, Toshiaki, Kobayashi, Tetsuro, and Research Committee on Type 1 Diabetes of the Japan Diabetes Society

Published
2017
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29. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c

Author

Asahara, Shun-ichiro, Etoh, Hiroaki, Inoue, Hiroyuki, Teruyama, Kyoko, Shibutani, Yuki, Ihara, Yuka, Kawada, Yukina, Bartolome, Alberto, Hashimoto, Naoko, Matsuda, Tomokazu, Koyanagi-Kimura, Maki, Kanno, Ayumi, Hirota, Yushi, Hosooka, Tetsuya, Nagashima, Kazuaki, Nishimura, Wataru, Inoue, Hiroshi, Matsumoto, Michihiro, Higgins, Michael J., Yasuda, Kazuki, Inagaki, Nobuya, Seinoa, Susumu, Kasuga, Masato, and Kido, Yoshiaki

Published
2015

31. Abstract 5703: Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis

Author

Kuramoto, Junko, primary, Arai, Eri, additional, Fujimoto, Mao, additional, Tian, Ying, additional, Yamada, Yuriko, additional, Yotani, Takuya, additional, Makiuchi, Satomi, additional, Tsuda, Noboru, additional, Ojima, Hidenori, additional, Fukai, Moto, additional, Seki, Yosuke, additional, Kasama, Kazunori, additional, Funahashi, Nobuaki, additional, Udagawa, Haruhide, additional, Nammo, Takao, additional, Yasuda, Kazuki, additional, Taketomi, Akinobu, additional, Kanto, Tatsuya, additional, and Kanai, Yae, additional

Published
2022
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32. Micro‐Doppler Radar‐Based Gait Classification of Common Pedestrians and Smartphone Zombies.

Author

Yasuda, Kazuki, Tsuyuhara, Teppei, Saho, Kenshi, and Masugi, Masao

Subjects
*DOPPLER radar, *CONVOLUTIONAL neural networks, *GAIT in humans, *SMARTPHONES, *PEDESTRIANS
Abstract

This paper proposes a micro‐Doppler radar‐based method to classify common pedestrians and pedestrians texting on a smartphone (called a smartphone zombies). We used a micro‐Doppler radar to collect motion data of the gait of participants texting on smartphones while walking, and then generated time‐frequency distribution images (spectrogram images). They were input into a convolutional neural network (CNN) to classify gait patterns. Results using measured data confirmed that the classification accuracy exceeded 90%, validating the effectiveness of the proposed method. Furthermore, by applying feature visualization by Grad‐Cam, we found that the motion of the leg swinging has essential features for the classification of smartphone zombies. © 2023 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Bivalent GAD autoantibody ELISA improves clinical utility and risk prediction for adult autoimmune diabetes.

Author

Kawasaki, Eiji, Shimada, Akira, Imagawa, Akihisa, Abiru, Norio, Awata, Takuya, Oikawa, Yoichi, Osawa, Haruhiko, Kawabata, Yumiko, Kozawa, Junji, Kobayashi, Tetsuro, Takahashi, Kazuma, Chujo, Daisuke, Fukui, Tomoyasu, Miura, Junnosuke, Yasuda, Kazuki, Yasuda, Hisafumi, Kajio, Hiroshi, Hanafusa, Toshiaki, and Ikegami, Hiroshi

Subjects
TYPE 1 diabetes, GLUTAMATE decarboxylase, AUTOANTIBODIES, DIABETIC acidosis, DIABETES
Abstract

Aim/Introduction: To investigate the differences in the clinical significance and glutamic acid decarboxylase autoantibody (GADA) affinity between RIA (RIA‐GADA) and ELISA (ELISA‐GADA) in patients with type 1 diabetes. Methods: A total of 415 patients with type 1 diabetes were enrolled, including 199 acute‐onset type 1 diabetes, 168 slowly progressive type 1 diabetes (SPIDDM), and 48 fulminant type 1 diabetes. GADA affinity was measured by a competitive binding experiment using unlabeled recombinant human GAD65 protein, and the diagnostic performance of both assays and the relationship between GADA affinity and the decline of fasting C‐peptide (F‐CPR) were examined. Results: While the ELISA‐GADA displayed a higher sensitivity than the RIA method in diagnosing type 1 diabetes in acute‐onset patients, about 40% of SPIDDM patients with low‐titer RIA‐GADA were determined as negative by the ELISA method. Patients with type 1 diabetes with RIA‐GADA alone had an older age of onset, less diabetic ketoacidosis, a higher BMI, and a higher F‐CPR compared with patients positive for both RIA‐GADA and ELISA‐GADA. Additionally, 36% of RIA‐GADA‐positive patients had low‐affinity GADA (<1010 L/mol), which was significantly higher than in the ELISA‐GADA‐positive patients (4%, P < 0.0001). Furthermore, over a 3 year monitoring period, F‐CPR levels decreased in ELISA‐GADA‐positive SPIDDM, whereas it was maintained in patients with RIA‐GADA alone, regardless of GADA affinity. Conclusions: These results suggest that bivalent ELISA for GADA is superior to the RIA method in diagnosing type 1 diabetes. Moreover, the diagnostic superiority of the ELISA‐GADA made possible the concurrent identification of SPIDDM patients at high‐risk of early progression, and allowed for more accurate clinical diagnosis and management. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Sodium-glucose cotransporter 2-associated perioperative ketoacidosis: a protocol for SAPKA systematic review

Author

Seki, Hiroyuki, primary, Ideno, Sathoshi, additional, Shiga, Toshiya, additional, Watanabe, Hidenobu, additional, Ono, Motoaki, additional, Motoyasu, Akira, additional, Noguchi, Hikari, additional, Kondo, Kazuya, additional, Yoshikawa, Takahiro, additional, Hoshijima, Hiroshi, additional, Hyuga, Shunsuke, additional, Shishii, Miho, additional, Nagai, Ai, additional, Higashi, Midoriko, additional, Ouchi, Takashi, additional, Yasuda, Kazuki, additional, and Kuratani, Norifumi, additional

Published
2022
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35. Development of Visualization System for Fuel Regression of Paraffin Wax in Acceleration Environments

Author

NEKI, Tomoya, OZAWA, Kohei, TSUBOI, Nobuyuki, NAKATA, Daisuke, UCHIUMI, Masaharu, and YASUDA, Kazuki

Subjects
Acceleration environment, Regression rate, Hybrid rocket, Wax fuel, Rocket sled
Abstract

第4回ハイブリッドロケットシンポジウム(2022年2月14日. オンライン開催), 4th Hybrid Rocket Symposium(February 14, 2022. Online Meeting), 資料番号: SA6000171015, HR-2021-15

Published
2022

36. PID Throttle Control of Self-pressurized Hybrid Rocket Engine

Author

YAMAGISHI, Kohki, NAKATA, Daisuke, YASUDA, Kazuki, SHIINA, Tatsuhiko, ANG, YiYong, TADA, Takuya, HASHIMOTO, Yuma, EGUCHI, Hikaru, and UCHIUMI, Masaharu

Subjects
PID controlle, Self-pressurization, Throttling, Hybrid Rocket, Thrust control
Abstract

第4回ハイブリッドロケットシンポジウム(2022年2月14日. オンライン開催), 4th Hybrid Rocket Symposium(February 14, 2022. Online Meeting), 資料番号: SA6000171010, HR-2021-10

Published
2022

37. ロケットスレッド実験におけるシステムインターフェース

Author

NAKATA, Daisuke, YASUDA, Kazuki, SHINA, Tatsuhiko, ANG, YiYong, YAMAGISHI, Koki, TADA, Takuya, HASHIMOTO, Yuma, EGUCHI, Hikaru, and UCHIUMI, Masaharu

Abstract

令和3年度宇宙輸送シンポジウム（2022年1月13日-14日. オンライン開催), Space Transportation Symposium FY2021 (January 13-14, 2022. Online Meeting), 資料番号: SA6000173039, STCP-2021-040

Published
2022

40. Comparing the clinical significance and antigen specificity of insulinoma‐associated antigen‐2 autoantibodies between radioimmunoassay and enzyme‐linked immunosorbent assay in Japanese patients with type 1 diabetes.

Author

Kawasaki, Eiji, Shimada, Akira, Imagawa, Akihisa, Abiru, Norio, Awata, Takuya, Oikawa, Yoichi, Osawa, Haruhiko, Kawabata, Yumiko, Kozawa, Junji, Kobayashi, Tetsuro, Takahashi, Kazuma, Chujo, Daisuke, Fukui, Tomoyasu, Miura, Junnosuke, Yasuda, Kazuki, Yasuda, Hisafumi, Kajio, Hiroshi, Hanafusa, Toshiaki, and Ikegami, Hiroshi

Subjects
TYPE 1 diabetes, ENZYME-linked immunosorbent assay, INSULINOMA, JAPANESE people, AUTOANTIBODIES, GLUTAMATE decarboxylase
Abstract

Aims/Introduction: This study aimed to investigate the clinical significance and antigen specificity of autoantibodies to insulinoma‐associated antigen‐2 (IA‐2A) by radioimmunoassay (RIA; IA‐2A‐RIA) and enzyme‐linked immunosorbent assay (ELISA; IA‐2A‐ELISA) in Japanese patients with type 1 diabetes. Materials and Methods: A total of 338 type 1 diabetic patients were enrolled, including 38 fulminant type 1 diabetes, 168 acute‐onset type 1 diabetes and 137 slowly‐progressive type 1 diabetes (SPIDDM). The concordance, correlation of autoantibody titer, and the relationship between IA‐2A and progression to the insulin‐deficient state were examined. Also, competitive assay was used to examine the antigen specificity. Results: The prevalence of IA‐2A‐ELISA was 4–5% lower than that of IA‐2A‐RIA in both the acute‐onset type 1 diabetes and SPIDDM, but the diagnostic sensitivities of both subtypes, when measured in combination with glutamic acid decarboxylase autoantibody, were comparable. The diagnosis of type 1 diabetes using either the RIA or ELISA methods showed substantial agreement with the exponential correlation of autoantibody titers detected by RIA and ELISA. Among the SPIDDM patients, the fasting C‐peptide for IA‐2A‐positive cases by ELISA, but not the RIA method, was significantly lower than in the negative cases (P < 0.05). Furthermore, IA‐2A‐ELISA proved superior to the RIA method in predicting the progression to insulin deficiency in SPIDDM. Competitive analysis showed that even sera with discrepant results by RIA and ELISA have IA‐2‐specific autoantibodies. Conclusion: These results suggest that IA‐2A‐ELISA is a reliable marker not only for the diagnosis of type 1 diabetes, but also for the prediction of future insulin dependency; that is, detection of IA‐2A‐ELISA helps identify a subtype of SPIDDM patients who would likely progress onto insulin‐deficient state. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of the Japan Diabetes Society

Author

Tanaka, Shoichiro, Ohmori, Masayuki, Awata, Takuya, Shimada, Akira, Murao, Satoshi, Maruyama, Taro, Kamoi, Kyuzi, Kawasaki, Eiji, Nakanishi, Koji, Nagata, Masao, Fujii, Sumie, Ikegami, Horoshi, Imagawa, Akihisa, Uchigata, Yasuko, Okubo, Minoru, Osawa, Haruhiko, Kajio, Horishi, Kawaguchi, Akio, Kawabata, Yumiko, Satoh, Jo, Shimizu, Ikki, Takahashi, Kazuma, Makino, Hideichi, Iwahashi, Hiromi, Miura, Junnosuke, Yasuda, Kazuki, Hanafusa, Toshiaki, Kobayashi, Tetsuro, and Committee on Type 1 Diabetes

Published
2015
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44. Aeroacoustics of Hybrid Rockets

Author

Nakamura, Shintaro, primary, Araki, Mikiya, additional, González Palencia, Juan C., additional, Yamagishi, Koki, additional, Yasuda, Kazuki, additional, Nakata, Daisuke, additional, and Uchiumi, Masaharu, additional

Published
2022
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45. Characterization of the taste receptor‐related G‐protein, α‐gustducin, in pancreatic β‐cells

Author

Udagawa, Haruhide, Hiramoto, Masaki, Kawaguchi, Miho, Uebanso, Takashi, Ohara‐Imaizumi, Mica, Nammo, Takao, Nishimura, Wataru, and Yasuda, Kazuki

Subjects
endocrine system, α-Gustducin, stomatognathic system, Insulin secretion, Taste receptor
Abstract

Aims/Introduction: Taste receptors, T1rs and T2rs, and the taste‐selective G‐protein, α‐gustducin, are expressed outside the taste‐sensing system, such as enteroendocrine L cells. Here, we examined whether α‐gustducin also affects nutrition sensing and insulin secretion by pancreatic β‐cells. Materials and Methods: The expression of α‐gustducin and taste receptors was evaluated in β‐cell lines, and in rat and mouse islets either by quantitative polymerase chain reaction or fluorescence immunostaining. The effects of α‐gustducin knockdown on insulin secretion and on cyclic adenosine monophosphate and intracellular Ca2+ levels in rat INS‐1 cells were estimated. Sucralose (taste receptor agonist)‐induced insulin secretion was investigated in INS‐1 cells with α‐gustducin suppression and in islets from mouse disease models. Results: The expression of Tas1r3 and α‐gustducin was confirmed in β‐cell lines and pancreatic islets. Basal levels of cyclic adenosine monophosphate, intracellular calcium and insulin secretion were significantly enhanced with α‐gustducin knockdown in INS‐1 cells. The expression of α‐gustducin was decreased in high‐fat diet‐fed mice and in diabetic db/db mice. Sucralose‐induced insulin secretion was not attenuated in INS‐1 cells with α‐gustducin knockdown or in mouse islets with decreased expression of α‐gustducin. Conclusions: α‐Gustducin is involved in the regulation of cyclic adenosine monophosphate, intracellular calcium levels and insulin secretion in pancreatic β‐cells in a manner independent of taste receptor signaling. α‐Gustducin might play a novel role in β‐cell physiology and the development of type 2 diabetes.

Published
2020

46. Spirituality in older men living alone near the end-of-life

Author

Hirakawa, Yoshihisa, Chiang, Chifa, Yasuda, Kazuki, Iwaki, Yoshinobu, Andoh, Hideaki, and Aoyama, Atsuko

Subjects
older people, palliative care, non-cancer patient, spiritual pain, community
Abstract

Older people living alone has been reported to be socially isolated and suffering from loneliness. Although spiritual care is a core element of end-of-life care for older people, a clear-cut definition of spirituality has not been established yet. It remains unclear how spirituality is perceived by heath care professionals and how spiritual care is delivered in the end of life. Also, most of the previous studies on perspective of older people living alone targeted women, while very few researches shed light on the experience of older men. The aim of the present study was to investigate the spirituality of older men living alone near the end-of-life. We conducted group interviews targeting 30 care managers and individual in-depth interviews to 15 older men living alone. Qualitative content analysis was used. Five main themes emerged: worthlessness and hopelessness, autonomy and independence, comfort and gratitude, past experiences, and well-being indicator. Our findings provide important additional information that can help clinicians, nurses and care managers achieve better patient-centered care for older men living alone and enhance their dignity. Our investigation found that Japanese older men living alone were enjoying their autonomous status and freedom, despite wide spread negative views of them. Their spiritual health was found to be enhanced through gratitude to everyone with whom they had crossed paths in their life, yearning for the presence of a female companion, and confirming their health measurements were comparative or better than those of others in the same age group., This work was supported by Sasakawa Memorial Health Foundation and Japan Grants-in-Aid for Scientific Research, Grant Number 26460596.

Published
2019

48. Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design

Author

Chujo, Daisuke, primary, Imagawa, Akihisa, additional, Yasuda, Kazuki, additional, Abiru, Norio, additional, Awata, Takuya, additional, Fukui, Tomoyasu, additional, Ikegami, Hiroshi, additional, Kawasaki, Eiji, additional, Katsuki, Takeshi, additional, Kobayashi, Tetsuro, additional, Kozawa, Junji, additional, Nagasawa, Kan, additional, Ohtsu, Hiroshi, additional, Oikawa, Yoichi, additional, Osawa, Haruhiko, additional, Shimada, Akira, additional, Shimoda, Masayuki, additional, Takahashi, Kazuma, additional, Tsuchiya, Kyoichiro, additional, Tsujimoto, Tetsuro, additional, Yasuda, Hisafumi, additional, Hanafusa, Toshiaki, additional, and Kajio, Hiroshi, additional

Published
2021
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