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Multi-dimensional coupling analysis is a research hot spot in nuclear reactor thermal hydraulic study and both the full-scale system transient response and local key three-dimensional thermal hydraulic phenomenon could be obtained simultaneously, which can achieve the balance between efficiency and accuracy in the numerical simulation of nuclear reactor. A one-dimensional to three-dimensional (1D-3D) coupling platform for the nuclear reactor multi-dimensional analysis is developed by XJTU-NuTheL (Nuclear Thermal-hydraulic Laboratory at Xi'an Jiaotong University) based on the CFD code Fluent and system code RELAP5 through the Dynamic Link Library (DLL) technology and Fluent user-defined functions (UDF). In this paper, the International Standard Problem (ISP) No. 43 is selected as the benchmark and the rapid boron dilution transient in the nuclear reactor is studied with the coupling code. The code validation is conducted first and the numerical simulation results show good agreement with the experimental data. The three-dimensional flow and temperature fields in the downcomer are analyzed in detail during the transient scenarios. The strong reverse flow is observed beneath the inlet cold leg, causing the de-borated water slug to mainly diffuse in the circumferential direction. The deviations between the experimental data and the transients predicted by the coupling code are also discussed.