29 results on '"Yelvington M"'
Search Results
2. 346 Elbow Contracture Severity at Hospital Discharge in Patients with Heterotopic Ossification
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Godleski, M, primary, Yelvington, M, additional, Lee, A, additional, Chouinard, A, additional, Simko, L C, additional, Herndon, D N, additional, Suman, O E, additional, Holavanahalli, R, additional, Kowalske, K, additional, Gibran, N S, additional, Esselman, P C, additional, Goverman, J, additional, Ryan, C M, additional, and Schneider, J C, additional
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- 2018
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3. Kinetics of the thermal decomposition of 3,3-diphenyl- and 3,3-dibenzyl-1,2-dioxetane. Consideration of stepwise and concerted mechanisms
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Richardson, W. H., primary, Montgomery, F. C., additional, Yelvington, M. B., additional, and O'Neal, H. E., additional
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- 1974
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4. ChemInform Abstract: 1,2‐DIOXETANE INTERMEDIATES IN THE BASE CATALYZED DECOMPOSITION OF ALPHA‐HYDROPEROXY KETONES
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RICHARDSON, W. H., primary, HODGE, V. F., additional, STIGGALL, D. L., additional, YELVINGTON, M. B., additional, and MONTGOMERY, F. C., additional
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- 1974
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5. 1,2-Dioxetane intermediates in the base catalyzed decomposition of .alpha.-hydroperoxy ketones
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Richardson, W. H., primary, Hodge, V. F., additional, Stiggall, D. L., additional, Yelvington, M. B., additional, and Montgomery, F. C., additional
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- 1974
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6. Generation of bradykinin during incubation of hereditary angioedema plasma
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Curd, J.G., primary, Yelvington, M., additional, Burridge, N., additional, Stimler, N.P., additional, Gerard, C., additional, Prograis, L.J., additional, Cochrane, C.G., additional, and Müller-Eberhard, H.J., additional
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- 1982
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7. Solvent and substituent effects in the thermolysis of 1,2-dioxetanes
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Richardson, W. H., primary, Montgomery, F. C., additional, Slusser, P., additional, and Yelvington, M. B., additional
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- 1975
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8. ChemInform Abstract: SOLVENT AND SUBSTITUENT EFFECTS IN THE THERMOLYSIS OF 1,2-DIOXETANES
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RICHARDSON, W. H., primary, MONTGOMERY, F. C., additional, SLUSSER, P., additional, and YELVINGTON, M. B., additional
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- 1975
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9. ChemInform Abstract: KINETICS OF THE THERMAL DECOMPOSITION OF 3,3‐DIPHENYL‐ AND 3,3‐DIBENZYL‐1,2‐DIOXETANE, A CONSIDERATION OF STEPWISE AND CONCERTED MECHANISMS
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RICHARDSON, W. H., primary, MONTGOMERY, F. C., additional, YELVINGTON, M. B., additional, and O'NEAL, H. E., additional
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- 1975
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10. ChemInform Abstract: THERMAL DECOMPOSITION OF TERTIARY ALKYL PEROXIDES, SUBSTITUENT EFFECTS IN PEROXIDE BOND HOMOLYSIS AND BETA SCISSION OF ALKOXY RADICALS
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RICHARDSON, W. H., primary, YELVINGTON, M. B., additional, ANDRIST, A. H., additional, ERTLEY, E. W., additional, SMITH, R. S., additional, and JOHNSON, T. D., additional
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- 1974
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11. Thermal decomposition of tertiary alkyl peroxides. Substituent effects in peroxide bond homolysis and .beta. scission of alkoxy radicals
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Richardson, W. H., primary, Yelvington, M. B., additional, Andrist, A. H., additional, Ertley, E. W., additional, Smith, R. S., additional, and Johnson, T. D., additional
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- 1973
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12. ChemInform Abstract: DIE BLDG. BENACHBARTER OXID-IONEN UND FRAGMENTIERUNGSRK. VON 1,3-CHLORHYDRINEN
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RICHARDSON, W. H., primary, GOLINO, C. M., additional, WACHS, R. H., additional, and YELVINGTON, M. B., additional
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- 1971
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13. Neighboring oxide ion and fragmentation reactions of 1,3-chlorohydrins
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Richardson, William Harry, primary, Golino, C. M., additional, Wachs, R. H., additional, and Yelvington, M. B., additional
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- 1971
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14. An Exploration of the Knowledge and Current Practices of Frontline Workers Regarding Elder Abuse.
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Marrs SA, Yelvington M, Rhodes A, O'Hara C, MacDonald C, and Gendron T
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- Humans, Aged, Female, Male, Middle Aged, Interviews as Topic, United States, Elder Abuse prevention & control, Health Knowledge, Attitudes, Practice, Focus Groups, Qualitative Research
- Abstract
Annually, approximately 16% of adults aged 60 and older are victims of abuse in community settings. A critical first step toward effectively intervening and reducing the prevalence of elder abuse is to better understand the current state of knowledge, beliefs, and practices. This qualitative descriptive study explored the perceptions of US frontline community workers regarding elder abuse through focus groups and interviews conducted in the spring and summer of 2021. Participants represented various aging and victim services ( n = 9), healthcare ( n = 7), and law enforcement ( n = 8). Thematic data analysis led to the emergence of three major themes in our data: societal influence, individual circumstances, and nature of abuse. Our findings point out several directions in which researchers and policymakers can begin moving the field forward. These include the need to focus on prevention strategies as well as the need to reduce ageist beliefs and attitudes., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2025
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15. Impact of animal-assisted intervention on therapy engagement in hospitalized children with traumatic brain injuries.
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Yelvington M, Spray B, Bregy F, Ramick A, Lovenstein A, and Walden M
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Background: Individuals who sustained traumatic brain injuries in childhood may experience global challenges including disorders of consciousness, motor dysfunctions, and sensory impairments. Occupational and physical therapy are important parts of recovery from an acute brain injury, addressing deficits that directly affect functional recovery and return to age-appropriate activities of daily living. Difficulty with active engagement in therapy tasks can limit the effectiveness of therapeutic interventions. Therapists search for methods to increase patient engagement to bolster patient progress., Objective: To examine the effect of animal-assisted interventions on patient engagement and therapy participation in children with traumatic brain injuries., Design: Prospective, crossover design observational study with each patient serving as their own control., Setting: This study was conducted in a pediatric acute rehabilitation unit., Participants: Nine participants completed all study sessions., Intervention: Study participants completed four visits, two with animal-assisted intervention and two without animal-assisted intervention., Outcomes and Measures: The Pediatric Rehabilitation Intervention Measure of Engagement, length of session, breaks needed., Results: The use of animal-assisted intervention resulted in significantly greater mean engagement scores and significantly greater affective and behavioral engagement scores. No significant differences were found with cognitive engagement score, length of session tolerated, or number of breaks required. No participants had decreased engagement when animal-assisted intervention was used., Conclusions: Animal-assisted intervention has the potential to increase therapy engagement in acute rehabilitation with children recovering from traumatic brain injuries., (© 2025 American Academy of Physical Medicine and Rehabilitation.)
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- 2025
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16. Comparison of Different Methods of Measuring Finger Range of Motion via Telehealth.
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Bettencourt K, Parry I, Yelvington M, Taylor S, Greenhalgh D, and James MA
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- Humans, Reproducibility of Results, Finger Joint physiology, Manikins, Range of Motion, Articular physiology, Telemedicine, Arthrometry, Articular methods
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Purpose: This study examined the accuracy and reliability of measuring total motion of the fingers via telehealth using the following three different methods: (1) goniometry, (2) visual estimation, and (3) electronic protractor. Measurements were compared with in-person measurement, which was assumed to be the reference standard., Methods: Thirty clinicians measured finger range of motion from prerecorded videos of a mannequin hand with articulating fingers, which was posed in extension and flexion that simulated a telehealth visit, using a goniometer with results blinded to the clinician (blinded goniometry), visual estimation, and an electronic protractor, in random order. Total motion was calculated for each finger and for all four fingers in sum. The experience level, familiarity with measuring finger range of motion, and opinions of measurement difficulty were assessed., Results: Measurement with the electronic protractor was the only method equivalent to the reference standard within 20°. Remote goniometer and visual estimation did not fall within the acceptable error margin of equivalence, and both underestimated total motion. Electronic protractor also had the highest interrater reliability (intraclass correlation [upper limit, lower limit], 0.95 [0.92, 0.95]); goniometry (intraclass correlation, 0.94 [0.91, 0.97]) was nearly identical, whereas visual estimation (intraclass correlation, 0.82 [0.74, 0.89]) was much lower. Clinicians' experience and familiarity with range of motion measurements had no relationship with the findings. Clinicians reported visual estimation as the most difficult (80%) and electronic protractor as the easiest method (73%)., Conclusions: This study showed that traditional in-person forms of measurement underestimate finger range of motion via telehealth; a new computer-based method (ie, electronic protractor) was found to be more accurate., Clinical Relevance: The use of an electronic protractor can be beneficial to clinicians measuring range of motion in patients virtually., (Copyright © 2024 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.)
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- 2024
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17. Comparing novel virtual reality and nursing standard care on burn wound care pain in adolescents: A randomized controlled trial.
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Jeffs DA, Spray BJ, Baxley L, Braden E, Files A, Marrero E, Teague T, Teo E, and Yelvington M
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- Humans, Adolescent, Child, Pain etiology, Pain Management methods, Pain, Procedural prevention & control, Burns therapy, Burns complications, Virtual Reality
- Abstract
Purpose: This study compared the effectiveness of age-appropriate, high technology, interactive virtual reality (VR) distraction with standard care (SC) provided by the nurse on adolescents' acute procedural pain intensity perception during burn wound care treatment in the ambulatory clinic setting., Design: This randomized controlled trial included 43 adolescents ages 10-21 from the ambulatory burn clinic of a large children's hospital., Methods: Blinded study participants were randomly assigned to either VR or SC (non-significantly different, current mean burn surface area, 1.3 and 1.7, respectively) during the first burn wound care procedure in the burn clinic. Blinded research staff collected pre-procedure data including Spielberger's State-Trait Anxiety Inventory and postprocedure wound care pain intensity using the Adolescent Pediatric Pain Tool. A total of 41 participants completed all study procedures., Results: No statistically significant difference in burn wound care procedural pain was noted between the VR and SC groups after adjusting for several factors. Pre-procedure state and trait anxiety correlated with reported pre-procedure pain. Wound care pain was found to be significantly associated with pre-wound care pain score, time from original burn to clinic burn care treatment, and length of wound care treatment. These factors accounted for approximately 45% of the variation in pain scores during wound care treatment., Practice Implications: VR distraction can be a useful pain management strategy but may not take the place of the unique nurse-patient relationship that occurs during clinical encounters. Tailoring pain management during burn wound care requires consideration of anxiety, time from the burn injury to the wound care procedure, length of time of the wound care procedure, and pretreatment pain level. Knowing patients' needs, desires, and temperaments along with the specifics about the healthcare procedures are critical to formulating individualized care plans that may or may not include VR. Newer technology, such as easier-to-use, less expensive VR, may assist with translation into practice making its clinical use more routine., (© 2023 Wiley Periodicals LLC.)
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- 2024
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18. Special Considerations for Pediatric Burn Injuries.
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Yelvington M, Whitehead C, and Turgeon L
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- Child, Humans, Survivors psychology, Burns rehabilitation, Burns therapy
- Abstract
Burns are the fifth leading cause of non-fatal childhood injuries. Physiological differences between children and adults lead to unique considerations when treating young burn survivors. In addition to the physical and psychological concerns which must be considered in adult burn rehabilitation, pediatric burn rehabilitation must also consider the developmental stage of the child, preexisting developmental delays, and the impact of scaring on growth and motor skill attainment. Treatment of pediatric burn survivors requires a multidisciplinary approach centered around caring for not only the child but also for their parents, siblings, and other caregivers. For children who sustain burns early in life, long-term follow-up is essential and should be conducted under the guidance of a burn center for the early identification of needed interventions during periods of growth and development. This article considers pediatric-specific factors, which may present during the rehabilitation of a child with a burn injury., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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19. Burn Injury Complications Impacting Rehabilitation.
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Godleski M, Yelvington M, and Jean S
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- Humans, Recovery of Function, Quality of Life, Contracture etiology, Contracture prevention & control, Contracture rehabilitation
- Abstract
Successful post-burn rehabilitation requires an understanding of a wide range of complications to maximize functional recovery. This article reviews a range of potential challenges including burn scar contracture, amputation, peripheral nerve injury, heterotopic ossification, dysphagia, altered skin physiology, pain, and pruritis. The overall focus is to serve as a guide for post-injury therapy and rehabilitation spanning the phases of care and considering evidence-based approaches, prevention, and treatment with an ultimate goal of aiding in the functional recovery and long-term quality of life for burn survivors., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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20. Contracture Severity at Hospital Discharge in Children: A Burn Model System Database Study.
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Yelvington M, Godleski M, Lee AF, Goverman J, Parry I, Herndon DN, Suman OE, Kowalske K, Holavanahalli R, Gibran NS, Esselman PC, Ryan CM, and Schneider JC
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- Adolescent, Child, Child, Hospitalized, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Length of Stay statistics & numerical data, Male, Patient Discharge, Severity of Illness Index, Burns complications, Contracture etiology, Contracture physiopathology
- Abstract
Contractures can complicate burn recovery. There are limited studies examining the prevalence of contractures following burns in pediatrics. This study investigates contracture outcomes by location, injury, severity, length of stay, and developmental stage. Data were obtained from the Burn Model System between 1994 and 2003. All patients younger than the age of 18 with at least one joint contracture at hospital discharge were included. Sixteen areas of impaired movement from the shoulder, elbow, wrist, hand, hip, knee, and ankle joints were examined. Analysis of variance was used to assess the association between contracture severity, burn size, and length of stay. Age groupings were evaluated for developmental patterns. A P value of less than .05 was considered statistically significant. Data from 225 patients yielded 1597 contractures (758 in the hand) with a mean of 7.1 contractures (median 4) per patient. Mean contracture severity ranged from 17% (elbow extension) to 41% (ankle plantarflexion) loss of movement. Statistically significant associations were found between active range of motion loss and burn size, length of stay, and age groupings. The data illustrate quantitative assessment of burn contractures in pediatric patients at discharge in a multicenter database. Size of injury correlates with range of motion loss for many joint motions, reflecting the anticipated morbidity of contracture for pediatric burn survivors. These results serve as a potential reference for range of motion outcomes in the pediatric burn population, which could serve as a comparison for local practices, quality improvement measures, and future research., (© The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2021
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21. Systematic Review and Expert Consensus on the Use of Orthoses (Splints and Casts) with Adults and Children after Burn Injury to Determine Practice Guidelines.
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Parry IS, Schneider JC, Yelvington M, Sharp P, Serghiou M, Ryan CM, Richardson E, Pontius K, Niszczak J, McMahon M, MacDonald LE, Lorello D, Kehrer CK, Godleski M, Forbes L, Duch S, Crump D, Chouinard A, Calva V, Bills S, Benavides L, Acharya HJ, De Oliveira A, Boruff J, and Nedelec B
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- Adult, Casts, Surgical, Child, Consensus, Evidence-Based Medicine, Humans, Practice Guidelines as Topic, Splints, Survivors, Burns rehabilitation, Contracture rehabilitation, Orthotic Devices
- Abstract
The objective of this review was to systematically evaluate the available literature addressing the use of orthoses (splints and casts) with adult and pediatric burn survivors and determine whether practice guidelines could be proposed. This review provides evidence-based recommendations specifically for rehabilitation professionals who are responsible for burn survivor rehabilitation. A summary recommendation was made after the literature was retrieved using a systematic review and critical appraisal by multiple authors. The level of evidence of the literature was determined in accordance with the Oxford Centre for Evidence-based Medicine criteria. Due to the low level of evidence in the available literature, only one practice guideline could be recommended: orthotic use should be considered as a treatment choice for improving range of motion or reducing contracture in adults who have sustained a burn injury. To address the rehabilitation-specific gaps found in the literature regarding orthotic use in burn rehabilitation and provide guidance to clinicians, a formal expert consensus exercise was conducted as a final step to the project. The resultant manuscript provides a summary of the literature regarding orthotic use with burn patients, one practice guideline, proposed orthotic terminology and additional practice recommendations based on expert opinion. The limitations in the current literature are also discussed, and suggestions are made for future studies in the area of orthotic use after burn injury., (© American Burn Association 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2020
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22. An Examination of Follow-up Services Received by Vulnerable Burn Populations: A Burn Model System National Database Study.
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Benavides L, Shie V, Yee B, Yelvington M, Simko LC, Wolfe AE, McMullen K, Epp J, Parry I, Shon R, Holavanahalli R, Herndon D, Rosenberg M, Rosenberg L, Meyer W, Gibran N, Wiechman S, Ryan CM, and Schneider JC
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- Aged, Burns ethnology, Databases, Factual, Persons with Disabilities, Female, Follow-Up Studies, Humans, Male, Medically Uninsured, Mental Disorders complications, Peer Group, Substance-Related Disorders complications, United States, Burns therapy, Occupational Therapy, Physical Therapy Modalities, Psychotherapy, Vulnerable Populations
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While disparities in healthcare outcomes and services for vulnerable populations have been documented, the extent to which vulnerable burn populations demonstrate disparities in long-term care is relatively underexplored. This study's goal was to assess for differences in long-term occupational or physical therapy (OT/PT) and psychological service use after burn injury in vulnerable populations. Data from the Burn Model System National Database (2006-2015) were analyzed. The vulnerable group included participants in one or more of these categories: 65 years of age or older, nonwhite, no insurance or Medicaid insurance, preinjury receipt of psychological therapy or counseling, preinjury alcohol and/or drug misuse, or with a preexisting disability. Primary outcomes investigated were receipt of OT/PT and psychological services. Secondary outcomes included nine OT/PT subcategories. Outcomes were examined at 6, 12, and 24 months postinjury. One thousand one hundred thirty-six burn survivors (692 vulnerable; 444 nonvulnerable) were included. The vulnerable group was mostly female, unemployed at time of injury, and with smaller burns. Both groups received similar OT/PT and psychological services at all time points. Adjusted regression analyses found that while the groups received similar amounts services, some vulnerable subgroups received significantly more services. Participants 65 years of age or older, who received psychological therapy or counseling prior to injury, and with a preexisting disability received more OT/PT and psychological or peer support services at follow-up. Overall, vulnerable and nonvulnerable groups received comparable OT/PT and psychological services. The importance of long-term care among vulnerable subgroups of the burn population is highlighted by this study. Future work is needed to determine adequate levels of follow-up services., (© American Burn Association 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2020
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23. Goniometric Measurement of Burn Scar Contracture: A Paradigm Shift Challenging the Standard.
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Parry I, Richard R, Aden JK, Yelvington M, Ware L, Dewey W, Jacobson K, Caffrey J, and Sen S
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- Adult, Burns complications, Cicatrix etiology, Contracture etiology, Female, Humans, Male, Prospective Studies, Recovery of Function, Severity of Illness Index, Arthrometry, Articular methods, Burns rehabilitation, Cicatrix physiopathology, Contracture physiopathology, Range of Motion, Articular physiology
- Abstract
Standard goniometry is the most commonly used method of assessing the range of motion (ROM) in patients with burn scar contracture. However, standard goniometry was founded on arthrokinematic principles and doesn't consider the cutaneous biomechanical influence between adjacent joint positions and skin pliability to accommodate motion. Therefore, the use of standard goniometry to measure burn scar contracture is called into question. This prospective, multicenter, comparative study investigated the difference between standard goniometry, based on arthrokinematics and a revised goniometry protocol, based on principles of cutaneokinematics and functional positions to measure ROM outcome in burn survivors. Data were collected for 174 joints from 66 subjects at seven burn centers totaling 1044 measurements for comparison. ROM findings using the revised protocol demonstrated significantly more limitation in motion 38.8 ± 15.2% than the standard protocol 32.1 ± 13.4% (p < .0001). Individual analyses of the motions likewise showed significantly more limitation with revised goniometry compared with standard goniometry for 9/11 joint motions. Pearson's correlation showed a significant positive correlation between the percentage of cutaneous functional units scarred and ROM outcome for the revised protocol (R2 = .05, p = .0008) and the Δ between the revised and standard protocols (R2 = .04, p = .0025) but no correlation was found with the standard goniometric protocol (R2 = .015, p = .065). The results of this study support the hypothesis that standard goniometry underestimates the ROM impairment for individuals whose motion is limited by burn scars. Having measurement methods that consider the unique characteristics of skin impairment and the impact on functional positions is an important priority for both clinical reporting and future research in burn rehabilitation., (© American Burn Association 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2019
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24. A Child With a Burn-Related Foot and Ankle Contracture Treated With Multiple Modalities.
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Yelvington M, Scoggins M, and White L
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- Child, Combined Modality Therapy, Female, Humans, Range of Motion, Articular, Ankle, Burns complications, Cicatrix, Hypertrophic complications, Contracture etiology, Contracture rehabilitation, Physical Therapy Modalities
- Abstract
Purpose: The presence of hypertrophic scars, which cross lower extremity joints, can often result in decreased range of motion, limitations in functional mobility, and gait deviations. This article reviews a case and describes a multimodal treatment approach., Summary of Key Points: A 6-year-old girl developed aggressive hypertrophic scars following a burn injury. A multimodal treatment approach, including splinting, elastomers, and physical therapy, was developed., Conclusions: Rapid improvements were demonstrated in measured objective outcomes., Recommendations for Clinical Practice: Early multimodal intervention, in addition to range of motion, stretching, massage, and compression garments, is recommended when treating hypertrophic scars. This case suggests that further study into a multimodal treatment approach may be beneficial to develop a standardized protocol for more efficient scar management.
- Published
- 2017
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25. Practice Guidelines for Cardiovascular Fitness and Strengthening Exercise Prescription After Burn Injury.
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Nedelec B, Parry I, Acharya H, Benavides L, Bills S, Bucher JL, Cheal J, Chouinard A, Crump D, Duch S, Godleski M, Guenther J, Knox C, LaBonte E, Lorello D, Lucio JX, Macdonald LE, Kemp-Offenberg J, Osborne C, Pontius K, Yelvington M, de Oliveira A, and Kloda LA
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- Adult, Cardiorespiratory Fitness, Child, Evidence-Based Medicine, Humans, Survivors, Burns therapy, Exercise Therapy, Practice Guidelines as Topic, Resistance Training
- Abstract
The objective of this review was to systematically evaluate the available clinical evidence for the prescription of strength training and cardiovascular endurance exercise programs for pediatric and adult burn survivors so that practice guidelines could be proposed. This review provides evidence-based recommendations specifically for rehabilitation professionals who are responsible for burn survivor rehabilitation. Summary recommendations were made after the literature was retrieved by systematic review, was critically appraised by multiple authors and the level of evidence determined in accordance with the Oxford Centre for Evidence-based Medicine criteria. Although gaps in the literature persist and should be addressed in future research projects, currently, strong research evidence supports the prescription of strength training and aerobic conditioning exercise programs for both adult and pediatric burn survivors when in the presence of strength limitations and/or decreased cardiovascular endurance after evaluation.
- Published
- 2016
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26. Ablative fractional photothermolysis for the treatment of hypertrophic burn scars in adult and pediatric patients: a single surgeon's experience.
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Khandelwal A, Yelvington M, Tang X, and Brown S
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- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Burns complications, Cicatrix, Hypertrophic etiology, Cicatrix, Hypertrophic surgery, Laser Therapy methods, Lasers, Gas therapeutic use
- Abstract
Many patients develop hypertrophic scarring after a burn injury. Numerous treatment modalities have been described and are currently in practice. Photothermolysis or laser therapy has been recently described as an adjunct for management of hypertrophic burn scars. This study is a retrospective chart review of adult and pediatric patients undergoing fractional photothermolysis at a verified burn center examining treatment parameters as well as pre- and post-Vancouver Scar Scale scores. Forty-four patients underwent fractional photothermolysis during the study period of 8 months. Mean pretreatment score was 7.6, and mean posttreatment score was 5.4. The mean decrease in score was 2.2, which was found to be statistically significant. There were no complications. Fractional photothermolysis is a safe and efficacious adjunct therapy for hypertrophic burn scars. Prospective trials would be beneficial to determine optimal therapeutic strategies.
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- 2014
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27. The use of neoprene as a scar management modality.
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Yelvington M, Brown S, Castro MM, and Nick TG
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- Adolescent, Adult, Child, Child, Preschool, Combined Modality Therapy, Female, Humans, Infant, Male, Regression Analysis, Retrospective Studies, Severity of Illness Index, Splints, Young Adult, Bandages, Cicatrix, Hypertrophic therapy, Neoprene therapeutic use
- Abstract
Purpose: Scar formation is one of the most functionally and cosmetically debilitating results of thermal injuries. Burn team members continuously search for new, cost effective, ways to prevent and treat hypertrophic scar formation. This study is a retrospective review of one facility's use of neoprene based products as an adjunct to, or in place of, traditional scar management techniques., Methods: Records of all patients treated with neoprene patches or neoprene splints from March 2008 through April 2011 were retrospectively reviewed. Vancouver Scar Scores (VSS) were collected, photographs were reviewed and any documented problems reported by the patients were noted., Results: Mean VSS scores were significantly lower at follow-up (5.3, SD 2.8) than at initial appointment (11.7, SD 1.4) with an estimated mean difference of 6.3 (P=0.0001). A 95% confidence interval for this mean difference is 3.9-8.7., Conclusions: In the reviewed cases, the use of neoprene inserts or splints resulted in a statistically significant reduction in hypertrophic scars with no secondary complications., (Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.)
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- 2013
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28. Immunodiffusion assay of C1 inhibitor function in serum: prospective analysis in angioedema-urticaria.
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Yelvington M, Prograis LJ Jr, Pizzo CJ, and Curd JG
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- Angioedema drug therapy, Angioedema genetics, Complement C1 Inactivator Proteins blood, Danazol therapeutic use, Humans, Immunodiffusion, Prospective Studies, Stanozolol therapeutic use, Urticaria immunology, Vasculitis diagnosis, Vasculitis immunology, Angioedema diagnosis, Complement C1 Inactivator Proteins deficiency, Urticaria diagnosis
- Abstract
An immunodiffusion assay for detecting C1 inhibitor function in human serum was described recently by Ziccardi and Cooper. In our present study, the applicability of this assay for C1 inhibitor deficiency or C1 inhibitor dysfunction was evaluated. Of the 39 patients evaluated, all eight patients with the common (C1 inhibitor deficiency) form of hereditary angioedema and all three patients with the variant (dysfunctional C1 inhibitor) form of hereditary angioedema were identified correctly. Treatment of patients with hereditary angioedema with stanozolol or danocrine increased their serum C1 inhibitor concentrations and normalized the immunodiffusion assay for C1 inhibitor function. In addition, the assay allowed the correct identification of three patients with the acquired form of C1 inhibitor deficiency, because the sera of these patients exhibited a distinctive pattern. The 25 samples from patients (chronic angioedema, chronic urticaria, or hypocomplementemic vasculitis) without C1 inhibitor deficiency had normal assays.
- Published
- 1983
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29. Purification and characterization of two functionally distinct forms of C1 inhibitor from a patient with angioedema.
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Curd JG, Yelvington M, Ziccardi RJ, Mathison DA, and Griffin JH
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- Adult, Amino Acids analysis, Angioedema drug therapy, Angioedema genetics, Complement Activating Enzymes antagonists & inhibitors, Complement C1s, Factor XII antagonists & inhibitors, Female, Humans, Kallikreins antagonists & inhibitors, Stanozolol therapeutic use, Angioedema immunology, Complement C1 Inactivator Proteins isolation & purification
- Abstract
A minority of patients with hereditary angioedema (HAE) have normal concentrations of a dysfunctional C1 inhibitor protein (C1INH) in their plasmas. We purified C1INH from the plasmas of one such patient before and during treatment with the anabolic steroid stanozolol. Both the pretreatment plasma and plasma obtained during stanozolol treatment contained varying amounts of two extremely similar C1INH proteins that were functionally distinct. The pretreatment plasma contained primarily (94%) dysfunctional C1INH that did not inactivate or complex with either purified C1s, activated Hageman factor, or kallikrein and small amounts (6%) of functionally normal C1INH. Stanozolol treatment increased the plasma concentrations of both of these proteins as well as the proportion (23%) of functional C1INH in the plasma. The purified dysfunctional and functional C1INHs had identical or nearly identical molecular sizes, charges, amino acid compositions, and amino sugar contents, and could not be distinguished physicochemically from each other or from normal C1INH. From these studies of purified C1INH proteins we concluded that HAE associated with dysfunctional C1INH is due to a defect at the structural locus for one C1INH gene and that both the dysfunctional C1INH gene and the normal C1INH gene products are present in the plasma of the affected subject. Treatment with stanozolol comparably increased the synthesis of both C1INH proteins. The disproportionate rise in the level of the normal C1INH protein is consistent with the view that it is more rapidly catabolized as a consequence of its interaction with the proteases it inactivates.
- Published
- 1981
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