Search

Your search keyword '"Yen, B. Linju"' showing total 146 results
Start Over Author "Yen, B. Linju"
146 results on '"Yen, B. Linju"'

4. Correction: Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD+/ SIRT1 axis.

Author

Yen, B. Linju, Wang, Li‑Tzu, Wang, Hsiu‑Huang, Hung, Chin‑Pao, Hsu, Pei‑Ju, Chang, Chia‑Chi, Liao, Chien‑Yu, Sytwu, Huey‑Kang, and Yen, Men‑Luh

Subjects
*STEM cells, *SIRTUINS, *BONE growth, *MITOCHONDRIA, *GLUCOSE
Abstract

This document is a correction notice for an article titled "Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD+/ SIRT1 axis" published in the Journal of Biomedical Science. The correction addresses two figures in the original paper that still have revision red lettering on some legends. Additionally, the funding section of the article has been updated to reflect the correct year-based numbering of two grants. The original publication has been corrected. [Extracted from the article]

Published
2024
Full Text
View/download PDF

10. Supplementary Data from Upregulation of SOX9 in Lung Adenocarcinoma and Its Involvement in the Regulation of Cell Growth and Tumorigenicity

Author

Jiang, Shih Sheng, primary, Fang, Wen-Tsen, primary, Hou, Ya-Hsiue, primary, Huang, Shiu-Feng, primary, Yen, B. Linju, primary, Chang, Junn-Liang, primary, Li, Shih-Miao, primary, Liu, Hui-Ping, primary, Liu, Ying-Lan, primary, Huang, Chih-Ting, primary, Li, Yu-Wei, primary, Jang, Te-Hsuan, primary, Chan, Shih-Hsuan, primary, Yang, Su Jing, primary, Hsiung, Chao A., primary, Wu, Cheng-Wen, primary, Wang, Lu-Hai, primary, and Chang, I-Shou, primary

Published
2023
Full Text
View/download PDF

11. Clinical implications of differential functional capacity between tissue‐specific human mesenchymal stromal/stem cells.

Author

Yen, B. Linju, Liu, Ko‐Jiunn, Sytwu, Huey‐Kang, and Yen, Men‐Luh

Subjects
*STEM cells, *MESENCHYMAL stem cells, *BONE marrow, *ENDOMETRIUM, *ADIPOSE tissues, *CLINICAL trials
Abstract

Over the past two decades, there has been an explosion in the numbers of clinical trials using mesenchymal stem cells (MSCs). While the safety profile of MSC therapy has been excellent, therapeutic success has not been as robust as expected. In addition to variabilities inherent in all live‐cell products because of donor‐specific differences and manufacturing practices, MSCs may have an additional layer of complexity due to the availability of many tissues/organ sources for isolation. Since first isolation from the bone marrow (BM) over 50 years ago, human MSCs have been robustly found in multiple tissues/organs. The increased variety of MSC sources is reflected in clinical trials: while BMMSCs was used in nearly all trials prior to 2008, they are used in less than 50% of clinical trials in recent years. While the majority of single‐source MSC preclinical data accumulated over the past several decades do reveal biological differences between tissue‐specific sources of MSCs, studies directly comparing different MSC sources are relatively rare. In this Review, we summarise these past findings and also specifically focus on studies comparing MSCs isolated from the most commonly utilised sources of BM, adipose tissue and post‐partum discarded extraembryonic tissue. The MSC functions discussed here include paraxial mesodermal trilineage differentiation capacity, and also other well‐studied and translationally relevant MSC functions of haematopoietic support, immunomodulation and paracrine capacities. Finally, we will discuss the implications of tissue‐specific MSC functional differences on future research avenues, manufacturing practices, as well as clinical implementation. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

13. Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome.

Author

Li-Tzu Wang, Yen, B. Linju, Hsiu-Huan Wang, Ying-Yin Chao, Wei Lee, Li-Yueh Huang, Sheng-Kang Chiu, Siu, L. Kristopher, Ko-Jiunn Liu, Huey-Kang Sytwu, and Men-Luh Yen

Subjects
ADULT respiratory distress syndrome, MESENCHYMAL stem cells, KLEBSIELLA pneumoniae, MEDICAL sciences, BONE marrow, MACROPHAGES, PULMONARY fibrosis, ABRUPTIO placentae
Published
2023
Full Text
View/download PDF

14. Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome

Author

Wang, Li-Tzu, primary, Yen, B Linju, additional, Wang, Hsiu-Huan, additional, Chao, Ying-Yin, additional, Lee, Wei, additional, Huang, Li-Yueh, additional, Chiu, Sheng-Kang, additional, Siu, L. Kristopher, additional, Liu, Ko-Jiunn, additional, Sytwu, Huey-Kang, additional, and Yen, Men-Luh, additional

Published
2022
Full Text
View/download PDF

17. Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome

Author

Wang, Li-Tzu, Yen, B Linju, Wang, Hsiu-Huan, Chao, Ying-Yin, Lee, Wei, Huang, Li-Yueh, Chiu, Sheng-Kang, Siu, L. Kristopher, Liu, Ko-Jiunn, Sytwu, Huey-Kang, and Yen, Men-Luh

Abstract

RationaleAcute respiratory distress syndrome (ARDS) is a lethal complication of severe bacterial pneumonia due to the inability to dampen overexuberant immune responses without compromising pathogen clearance. Both of these processes involve tissue-resident and bone marrow (BM)–recruited macrophage (MΦ) populations which can be polarised to have divergent functions. Surprisingly, despite the known immunomodulatory properties of mesenchymal stem cells (MSCs), simultaneous interactions with tissue-resident and recruited BMMΦ populations are largely unexplored.ObjectivesWe assessed the therapeutic use of human placental MSCs (PMSCs) in severe bacterial pneumonia with elucidation of the roles of resident alveolar MΦs (AMΦs) and BMMΦs.MethodsWe developed a lethal, murine pneumonia model using intratracheal infection of a clinically relevant Klebsiella pneumoniae(KP) strain with subsequent intravenous human PMSC treatment. Pulmonary AMΦ and recruited BMMΦ analyses, histological evaluation, bacterial clearance and mice survival were assessed. To elucidate the role of resident AMΦs in improving outcome, we performed AMΦ depletion in the KP-pneumonia model with intratracheal clodronate pretreatment.Measurements and main resultsHuman PMSC treatment decreased tissue injury and improved survival of severe KP-pneumonia mice by decreasing the presence and function of recruited M1 BMMΦ while preserving M2 AMΦs and enhancing their antibacterial functions. Interestingly, PMSC therapy failed to rescue AMΦ-depleted mice with KP pneumonia, and PMSC-secreted IL-1β was identified as critical in increasing AMΦ antibacterial activities to significantly improve pathogen clearance—especially bacteraemia—and survival.ConclusionsHuman PMSC treatment preferentially rescued resident M2 AMΦs over recruited M1 BMMΦs with overall M2 polarisation to improve KP-related ARDS survival.

Published
2023
Full Text
View/download PDF

27. Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells

Author

Sytwu Huey-Kang, Liu Ko-Jiunn, Yen Men-Luh, Chen Pei-Min, and Yen B-Linju

Subjects
mesenchymal stem cells, bone marrow, fetal, multilineage differentiation, immunomodulation, T lymphocytes, natural killer lymphocytes, dendritic cells, major histocompatibility complex (MHC) molecules, Medicine
Abstract

Abstract In recent years, a large number of studies have contributed to our understanding of the immunomodulatory mechanisms used by multipotent mesenchymal stem cells (MSCs). Initially isolated from the bone marrow (BM), MSCs have been found in many tissues but the strong immunomodulatory properties are best studied in BM MSCs. The immunomodulatory effects of BM MSCs are wide, extending to T lymphocytes and dendritic cells, and are therapeutically useful for treatment of immune-related diseases including graft-versus-host disease as well as possibly autoimmune diseases. However, BM MSCs are very rare cells and require an invasive procedure for procurement. Recently, MSCs have also been found in fetal-stage embryo-proper and extra-embryonic tissues, and these human fetal MSCs (F-MSCs) have a higher proliferative profile, and are capable of multilineage differentiation as well as exert strong immunomodulatory effects. As such, these F-MSCs can be viewed as alternative sources of MSCs. We review here the current understanding of the mechanisms behind the immunomodulatory properties of BM MSCs and F-MSCs. An increase in our understanding of MSC suppressor mechanisms will offer insights for prevalent clinical use of these versatile adult stem cells in the near future.

Published
2011
Full Text
View/download PDF

37. Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small and Large Animal Myocardial Ischemia Studies

Author

Liu, Yuan-Hung, primary, Peng, Kai-Yen, additional, Chiu, Yu-Wei, additional, Ho, Yi-Lwun, additional, Wang, Yao-Horng, additional, Shun, Chia-Tung, additional, Huang, Shih-Yun, additional, Lin, Yi-Shuan, additional, De Vries, Antoine A. F., additional, Pijnappels, Daniël A., additional, Lee, Nan-Ting, additional, Yen, B. Linju, additional, and Yen, Men-Luh, additional

Published
2015
Full Text
View/download PDF

38. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses

Author

Wang, Wei-Bei, primary, Yen, Men-Luh, additional, Liu, Ko-Jiunn, additional, Hsu, Pei-Ju, additional, Lin, Ming-Hong, additional, Chen, Pei-Min, additional, Sudhir, Putty-Reddy, additional, Chen, Chein-Hung, additional, Chen, Chung-Hsuan, additional, Sytwu, Huei-Kang, additional, and Yen, B. Linju, additional

Published
2015
Full Text
View/download PDF

45. 14-3-3σ Regulates β-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3β

Author

Chang, Tzu-Ching, primary, Liu, Chia-Chia, additional, Hsing, En-Wei, additional, Liang, Shu-Man, additional, Chi, Ya-Hui, additional, Sung, Li-Ying, additional, Lin, Shau-Ping, additional, Shen, Tang-Long, additional, Ko, Bor-Sheng, additional, Yen, B. Linju, additional, Yet, Shaw-Fang, additional, Wu, Kenneth K., additional, and Liou, Jun-Yang, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results