Search

Objective: This study aims to determine the difference in the coronavirus disease 2019 incidence between our patient group performing home dialysis, including home hemodialysis and peritoneal dialysis, and our patient group performing in-center hemodialysis. Methods: The study consists of the patients followed up in our center: 58 scheduled hemodialysis, 9 home hemodialysis, and 54 peritoneal dialysis patients. All the patients were closely followed for the coronavirus disease 2019 symptoms between March 2020 and May 2020. The follow-up intervals of our patients who underwent peritoneal dialysis and home hemodialysis were increased from 1 month to 2 months; all of them were contacted over the phone at the beginning of the pandemic and 2 months later, and the patients were questioned in terms of the coronavirus disease 2019 symptoms. Relevant descriptive statistics were presented. Binary logistic regression model was applied to compare the development of coronavirus disease 2019 in the patient group who performed home dialysis (home hemodialysis and peritoneal dialysis) and in the patient group who performed in-center hemodialysis via the glm function in R that fits generalized linear models. Age and the number of critical comorbidities (diabetes mellitus, hypertension, coronary artery disease, congestive heart failure, and chronic obstructive lung disease) were employed as the other independent variables in the model. Results: Three of the 58 patients who underwent dialysis in our center were followed up in our pandemic service with the diagnosis of coronavirus disease 2019. Coronavirus disease 2019 positivity was not detected in any patient who applied dialysis methods at home. The number of critical comorbidities appeared as the only significant variable in explaining the development of COVID-19 (P = .0569<0.10). The non-reflection of the difference of the applied methods (in-center hemodialysis vs. home dialysis (home hemodialysis and peritoneal dialysis)) in coronavirus disease 2019 development to the statistics may be due to the somewhat low number of total observations. Conclusion: In our study, we observed no peritoneal dialysis or home hemodialysis patient diagnosed with coronavirus disease 2019 in our center during the pandemic period. Home dialysis methods may prove to be the gold standard treatment, especially during the pandemic period. [ABSTRACT FROM AUTHOR]

Background/aim: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. Materials and methods: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was carried out by measuring serum creatinine (sCr) and uNGAL at the time of diagnosis [0th min (T0)]. We followed the study group for three months. Results: At the time of diagnosis, sCr (T0) was highest in the postrenal AKI and AKI groups in contrast to stable chronic kidney disease patients and healthy subjects (P < 0.001), as expected. T0 median uNGAL was highest in the postrenal group (P < 0.001). Area under curve (AUC) of uNGAL to estimate postrenal AKI presence was 0.957 (95% CI, 0.897–1.000; P < 0.001). The cut-off point of uNGAL was 42.625 ng/mL for this estimation. Conclusion: Patients with AKI must be classified according to the underlying etiologies as soon as possible. uNGAL may be useful to estimate the etiologies, and whether the problem is acute or chronic in the course. In postrenal kidney problems, to plan the urgency of the urologic procedures, it is crucial. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Biochemistry / Turk Biyokimya Dergisi is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Chronic kidney disease (CKD) is associated with increased mortality and high cardiovascular (CV) risk. Slow heart rate recovery (HRR) is an index of cardiac autonomic dysfunction and also a prognostic tool for cardiac and all-cause mortality in high-risk groups. In this study, we aimed to investigate the subclinical CV risk factor in different stages of CKD. Materials and Methods: Fifty-one patients with stage 1–5 CKD (mean age, 42.5±8.1 years) and 42 healthy individuals (mean age, 36.0±7.9 years) were included in the study. The HRR was calculated by subtracting the heart rates in the 1st, 2nd, and 3rd minute of the recovery period from the maximum heart rate attained during the exercise stress test. Results: The HRR in the 1st minute was significantly slower in the CKD group compared with that in the control group (22.4±11.3 and 32.4±11.1, respectively; p<0.001). The HRR in the 2nd and 3rd minute was also slower in the patient group, but the difference was not statistically significant. Seventeen patients with the 1st minute HRR ≤18 beats/min were mainly distributed in CKD stages 4 and 5. Conclusion: Patients with CKD with no known cardiac disease and no structural cardiac changes were at risk of CV events with a slow HRR in the exercise test. Clinicians should be careful not to underestimate CV events in this group of patients. [ABSTRACT FROM AUTHOR]

Copyright of Ortadogu Medical Journal / Ortadogu Tip Dergisi is the property of Bastas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Pulmonary system is a target organ for microangiopathic damage in patients with diabetes mellitus (DM). In the present study, the relationships of pulmonary functions with glycemic control, duration of diabetes, and microangiopathic complications have been assessed in type II diabetic patients. Methods: Thirty-one type II diabetic patients with no history of either smoking or cardiopulmonary diseases were enrolled into the study. Blood tests including glycosylated hemoglobin (HbA1c) were performed. Pulmonary functions were assessed with spirometry and carbon monoxide (CO) diffusion capacity. Results: Pulmonary functions were as follows: FEV1 (%): 93.88±16.12; FVC (%): 86.48±15.76; FEV1/FVC: 94.79±12.34; DLCO (mL/min/mm Hg): 104.13±15.00; and DLVA (mL/min/mmHg/lt): 103.26±13.00. Eleven patients (35.4%) had diabetic nephropathy, 11 patients (35.4%) had retinopathy, 10 patients (32.3%) had sensorimotor neuropathy, and 10 patients (32.3%) did not have any microangiopathic complications. After adjustment for age, gender, and body mass index, there were significant associations between HbA1c and FEV1 (p=0.024; r=-0.426), FVC (p=0.009, r=-0.482), and FEV1/FVC ratio (p=0.028, r=0.415). No association was observed between HbA1c and CO diffusion capacity measurements (for all p>0.05). There was no significant relationship between the duration of diabetes and pulmonary functions (for all p>0.05). Pulmonary function tests were found similar between patients having microangiopathic complications and those without them. Conclusion: Poor glycemic control may cause functional alterations of restrictive type in patients with type II DM. [ABSTRACT FROM AUTHOR]

Objective: Platelet functions have important roles in the development of vascular complications in diabetic patients. Platelets with increased volume have increased activity compared to smaller ones; therefore, mean platelet volume (MPV) is used as a marker for platelet activity. In the present study, we evaluated MPV in patients with type II diabetes mellitus (DM) and its associations with diabetic microvascular and macrovascular complications. Methods: Consecutive type II diabetic patients were screened from outpatient clinic of Internal Medicine Department of Diskapi Yildirim Beyazit Education and Researsch Hospital, Ankara, Turkey. A total of 48 patients with type II DM and 30 age and gender matched healthy subjects constituted the study population. For all subjects a complete blood count including MPV, fasting blood glucose level and lipid parameters were studied. In diabetic patients, duration of diabetes and HbA1C level, presence of microvascular and macrovascular complications were noted additively. Mean platelet volume was compared between diabetic patients and healthy counterparents. Then, among diabetic patients, MPV was compared between the ones with and without microvascular and macrovascular complications. Results: Mean platelet volume was found significantly higher in diabetic patients compared to non-diabetic healthy subjects. Diabetic patients with at least one of the microvascular complications had significantly higher MPV than those without microvascular damage.Higher MPV levels have also been shown in diabetics with macrovascular complications compared to the ones without macrovascular disease. Conclusion: Mean platelet volume was found to be higher in type II diabetics and those having any of microvascular or macrovascular diabetic complications. [ABSTRACT FROM AUTHOR]

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome of patients with chronic liver disease. In addition to ammonia levels, increased manganese levels in the brain are also considered as having role in the pathogenesis of HE. On cranial T1-weighted magnetic resonance imaging (MRI), hyperintense and symmetrical globus pallidi linked to the manganese deposition are characteristic for patients with cirrhosis of the liver. We presented here a case of portal-systemic encephalopathy demonstrated with typical MR images and increased blood manganese concentration. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Osteoporosis / Turk Osteoporoz Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Osteoporosis / Turk Osteoporoz Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)