1. Reflection-based thin-core modal interferometry optical fiber functionalized with PAA-PBA/PVA for glucose detection under physiological pH
- Author
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Yan Ru Wang, Chi Chiu Chan, Zhe Wen Ding, Chun Liu Zhao, Yi Yin Lim, R.V.S.S.N. Ravikumar, Ping Lam So, Zhi Qiang Tou, School of Chemical and Biomedical Engineering, and School of Electrical and Electronic Engineering
- Subjects
Vinyl alcohol ,Materials science ,Optical fiber ,Chemical engineering [Engineering] ,Michelson interferometer ,Biological Sensing and Sensors ,02 engineering and technology ,biochemical phenomena, metabolism, and nutrition ,Atomic and Molecular Physics, and Optics ,Fiber Optics ,law.invention ,Core (optical fiber) ,chemistry.chemical_compound ,Interferometry ,020210 optoelectronics & photonics ,chemistry ,Chemical engineering ,Fiber optic sensor ,law ,parasitic diseases ,0202 electrical engineering, electronic engineering, information engineering ,Fiber ,Acrylic acid - Abstract
A phenylboronic-acid-derivatized poly (acrylic acid) (PAA-PBA)/poly(vinyl alcohol) (PVA) functionalized thin-core fiber (TCF) optical sensor is proposed for glucose detection. The unique Michelson-type fiber interferometer sensor was fabricated by splicing a short segment of TCF with a single-mode fiber, where the tip of TCF was melted into a rounded shape. PAA-PBA was synthesized by grafting PBA onto the PAA chain using N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as coupling reagent. Multilayer films of PAA-PBA and PVA were subsequently functionalized onto the fiber-optic Michelson interferometer structure through layer-by-layer assembly. Experiments showed that the PAA-PBA/PVA functionalized fiber-optic probe exhibits glucose-sensitive behavior under physiological pH. The proposed sensor offers benefits such as simple fabrication, compact size, and glucose selectivity and has potential applications, such as insulin release system, in a biodevice. Accepted version
- Published
- 2019