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The asymmetric conjugate addition of diethyl malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase was developed and used in the chemoenzymatic synthesis of (+)-femoxetine.

Cement mortar is the most commonly used cement-based material, which widely used in construction materials, filling materials and other fields. The aim of this paper is to study the compressive strength and wave velocity characteristic in different particle sizes and sand/cement ratio. The uniaxial compressive strength test and wave velocity test were carried out in different particle size and sand content of mortar samples, respectively. It was found that the compressive strength and wave velocity decrease with the increase of sand/cement ratio. It is interesting that compressive strength and wave velocity in all specimens gradually increases with the increase of particles sizes. The compressive strength of cement mortar is related to the wave velocity. In detailed, the compressive strength and wave velocity was fit to linear relationship. It could thus be used to predict the compressive strength of cement mortar by wave velocity.

Physical activity plays an important role in the recovery of breast cancer survivors. However, previous studies have shown that most breast cancer survivors have inadequate levels of physical activity.This study aimed to explore the influencing factors of physical activity in breast cancer survivors.Twelve participants aged 38 to 65 years who had completed surgery and related treatment for breast cancer were recruited from the outpatient service of a hospital in Daqing, China. The phenomenological method was used in this qualitative research. Semistructured interviews were conducted to explore the influencing factors of physical activity in breast cancer survivors. Colaizzi's 7-step analysis method was used to code the data and identify descriptive themes.Four themes affecting the daily physical activity of breast cancer patients were extracted: perception and motivation (knowledge about benefits, goals, and motivation for physical activity), symptom burden (psychological and physical symptoms), social support (support from oncology staff, family, and peers) and environmental resources (seasonal impact, community resources).The physical activity of breast cancer survivors is affected by many factors. Oncology providers need to strengthen assessment, identify barriers, and provide interventions to promote the patients' participation in physical activity and to improve their quality of life.It is necessary for providers to integrate medical and social support resources, use strategies to enhance motivation, and effectively solve barriers to increase physical activity in breast cancer survivors.

We aimed to describe the initial experience of mechanical thrombectomy using tandem double stent retrievers combined with intermediate catheter aspiration to treat refractory severe hemorrhagic (SH)-cerebral venous sinus thrombosis (CVST).All refractory SH-CVST patients treated with mechanical thrombectomy using tandem double stent retriever (SR) combined with intermediate catheter aspiration (MT-TDSA) in our institution were retrospectively reviewed. MT-TDSA is a technique that fully engages the clot with double SRs and retrieves the clot using a double SR in combination with aspiration from an intermediate catheter. Demographics, clinical manifestation, medical history, the location of the occluded venous sinus, intraoperative details, procedure-related complications, and modified Rankin Scale (1, 6, 12 months postoperatively) were collected and analyzed.Fourteen patients (median age, 43 years) with refractory SH-CVST were treated with MT-TDSA between January 2016 and January 2020. Ten of 14 (71.4%) had a successful intraoperative recanalization rate (90%) using MT-TDSA. No procedure-related complications occurred. Eleven patients had good clinical outcomes (modified Rankin Scale score 0-2 at 12 months postoperatively).MT-TDSA for refractory SH-CVST might improve clot-capturing ability and remove blood clots from cerebral venous sinuses effectively and safely, achieving good clinical outcomes.

The relationship between neutrophil-lymphocyte ratio (NLR) and the occurrence of rebleeding in aneurysmal subarachnoid hemorrhage (aSAH) is poorly understood. Our study aimed to investigate the association between NLR on admission and rebleeding following aSAH.Clinical and laboratorial data from patients with aSAH were retrospectively collected, including leukocyte, neutrophil, lymphocyte, and NLR. Univariate and multivariate analyses were performed to assess for the association of NLR with rebleeding. We performed propensity-score matching analyses to correct imbalances in patient characteristics between the rebleeding group and nonrebleeding group.Rebleeding occurred in 30 of 716 (4.19%) patients with aSAH in this cohort. Patients with rebleeding had significantly higher NLR comparing with patients without rebleeding (11.27 vs. 5.5; P0.05) in the univariate analysis. In the multivariate analysis, NLR was considered as a risk factor of rebleeding (odds ratio, 0.283; 95% confidence interval, 0.130-0.620; P = 0.002), as well as Fisher grade (odds ratio, 0.353, 95% confidence interval, 0.151-0.824; P = 0.016). The area under the curve of the NLR and combined NLR-Fisher grade model was 0.702 and 0.744 (sensitivity was 39.94%, and specificity was 100%) for predicting rebleeding, respectively. After propensity-score matching, the optimal cutoff value for NLR as a predictor for rebleeding following aSAH was determined as 5.4 (sensitivity was 83.33%, and the specificity was 63.33%).Higher NLR predicts the occurrence of rebleeding and poor outcome, and NLR combined with Fisher grade significantly improves the prediction of rebleeding following aSAH.

The present study aimed to explore whether a higher serum lactate dehydrogenase (sLDH) level on admission is associated with hematoma expansion (HE) in patients with primary intracerebral hemorrhage (ICH).This single-center prospective observational study of patients with primary ICH aged 19 years or older was conducted at the Dehua County Hospital from January 2018 to May 2021. Clinical data and demographic information and outcomes were collected and analyzed. The association between increased sLDH levels and HE was assessed in univariate and multivariate analyses. Propensity-score matching (PSM) analysis was implemented to reduce baseline differences between the groups.Of 609 patients with ICH screened, 360 who met all eligibility criteria were enrolled in the study (mean age, 59.83 ± 12.64 years; 60.28% female patients), of whom 69 (19.17%) developed early HE. sLDH levels were statistically higher in the HE group compared with the non-HE group (236.0 [222.30-275.50] U/L vs. 209.6 [179.30-253.8] U/L; P0.001). Multivariable analysis showed that higher sLDH levels were still statistically associated with HE (odds ratio [OR], 0.08; 95% confidence interval, 0.03-0.210; P0.001). After PSM, the matched HE group had a significantly higher sLDH level than did the matched non-HE group (236.0 [222.0-279.10] vs. 216.30 [173.0-278.7] U/L; P = 0.003). The area under the curve of 0.704 (95% confidence interval, 0.654-0.751; P0.0001) (sensitivity, 92.75%; specificity, 52.58%), and the optimal cutoff value for sLDH level as a predictor for HE in patients with primary ICH was determined as 211.0U/L. The area under the curve of the logistic regression model based on these predictors (the TsL (time from onset to initial computed tomography,sLDH) modelbased on these predictors: sLDH, time from onset to initial computed tomography) was 0.817, with a sensitivity of 84.06% and specificity of 72.51% for HE. The TsL model produced the best ability to predict HE compared with single sLDH. sLDH levels were statistically correlated with poor outcome.The current PSM analysis study shows that increased serum LDH level is statistically associated with HE. Our findings indicate that the TsL model constructed by sLDH and time from onset to initial computed tomography markedly enhances the prediction of HE after ICH.

Background: The relationship between serum phosphate ion (sPi) and the occurrence of acute hydrocephalus (aHCP) in aneurysmal subarachnoid hemorrhage (aSAH) remains largely unknown and controversial. The primary aim of this study was to evaluate the association between sPi on admission and aHCP following aSAH. Methods: A prospective study was conducted on six hundred thirty-five patients over the age of 19 years diagnosed with aSAH in our institution from January 21, 2012, to December 30, 2019. Data on clinical characteristics, laboratory parameters, treatments, and outcomes were collected and analyzed. The association between lower sPi levels and aHCP was assessed in univariate and multivariate analyses. Propensity-score matching (PSM) analyses were adopted to reduce the baseline differences between the non-HCP group and HCP group. Results: The overall incidence of aHCP following aSAH was 19.37% (123/512). Lower sPi levels were detected in patients with aHCP compared with those without [0.86(0.67-1.06) mmol/L vs. 1.04(0.84-1.21)] mmol/L in the univariate analysis. In the multivariate analysis, lower sPi, high modified Fisher (mFisher) grade, and high Hunt-Hess grade were associated with aHCP [odds ratios (OR) 1.729, 95% CI 1.139–2.623, P=0.01; mFisher OR 0.097,95%CI 0.055-0.172, pConclusion: Lower sPi levels at admission were observed in patients with unfavorable outcomes. Lower sPi levels were associated with aHCP and poor prognosis, and the model constructed by sPi levels, Hunt-Hess grade, and mFisher grade significantly improves the prediction of aHCP after aSAH.

The aim of the study is to investigate the value of serum iron and hemoglobin levels for predicting acute seizures following aneurysmal subarachnoid hemorrhage (aSAH). Clinical and laboratorial data from patients with ruptured intracranial aneurysms were collected in the retrospective study. Age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt–Hess grade, Fisher grade, aneurysm location, hemoglobin, serum potassium, sodium, calcium, phosphorus, and iron were collected. Acute seizures were determined as seizures within 1 week following aSAH. Propensity score matching (PSM) analyses were performed to correct imbalances in patient characteristics between seizure and non-seizure groups. A total of 760 patients were included. Incidence of acute seizures following aSAH was 6.4%. In the univariate analysis, significant differences were detected in age, admission Hunt–Hess grade, Fisher grade, hemoglobin, serum sodium, and serum iron between seizure and non-seizure groups. In multivariate logistic regression model, lower serum iron was considered as a risk factor for acute seizures (OR 0.182, 95% CI 0.084–0.393, p = 0.000), as well as lower hemoglobin (OR 0.977, 95% CI 0.962–0.993, p = 0.004) and higher serum sodium (OR 1.072, 95% CI 1.003–1.145, p = 0.039). After PSM, there were no significant differences in age, admission Hunt–Hess grade, Fisher grade, and serum sodium between seizure and non-seizure groups. The matched seizure group had lower serum iron and hemoglobin levels compared with the matched non-seizure group (p

Objective We tested the hypothesis that low serum iron levels are associated with acute hydrocephalus following aneurysmal subarachnoid hemorrhage (aSAH). Methods Patients presenting with ruptured intracranial aneurysms were enrolled in the prospective observational study. Age, sex, history of diabetes, hypertension and hyperlipidemia, symptom onset, Fisher grade, Hunt-Hess grade, aneurysm location, hemoglobin, and serum iron were collected. Acute hydrocephalus was determined within 72 hours after subarachnoid hemorrhage. A propensity-score matching analysis was performed to correct imbalances in patient characteristics between hydrocephalus and non-hydrocephalus groups. Results A total of 535 patients were included. Incidence of acute hydrocephalus was 20.0%. In multivariate logistic regression analysis, lower serum iron was considered as a risk factor of acute hydrocephalus, as well as delayed ischemic neurologic deficit and lower hemoglobin (P = 0.000). After propensity-score matching, lower serum iron was considered as an independent risk factor for acute hydrocephalus, whereas hemoglobin and delayed ischemic neurologic deficit were not. The matched hydrocephalus group had lower serum iron comparing with the matched non-hydrocephalus group (10.26 ± 5.33 mmol/L vs. 13.44 ± 5.18 mmol/L; P = 0.000). The optimal cut-off value for serum iron levels as a predictor for acute hydrocephalus in patients with aSAH was determined as 13.1 mmol/L in the receiver operating characteristic curve. Furthermore, lower serum iron levels (odds ratio 0.305; 95% confidence interval, 0.178–0.524; P = 0.000) and acute hydrocephalus (odds ratio 0.372; 95% confidence interval, 0.202–0.684; P = 0.001) were predictors of poor outcome, as well as higher Hunt-Hess grade and Fisher grade. Conclusions Lower serum iron levels after aSAH was a predictor of acute hydrocephalus and unfavorable outcome.

Objectives: To evaluate the prognostic significance of Adult Comorbidity Evaluation-27 (ACE-27) for elderly patients (age ≥70 years) with locoregionally advanced nasopharyngeal carcinoma (NPC) treated with Intensity-Modulated Radiotherapy (IMRT), with or without chemotherapy. Methods: 206 elderly patients with locoregionally advanced NPC treated from December 2006 to December 2016 were involved into analysis as the training cohort. Besides, a separate cohort of 72 patients from the same cancer center collected between January 2003 and October 2006 served as the validation cohort. By using propensity score matching (PSM), we created a balanced cohort by matching patients who received chemoradiotherapy with patients who received IMRT alone. Treatment toxicities were calculated between CRT and RT groups using the χ2 test. The primary endpoint was cancer-specific survival (CSS). Multivariate analysis was performed to assess the relative risk for each factor by using a Cox's proportional hazards regression model. Results: The median follow-up was 39.0 months (range = 3-137 months). In the PSM cohort, patients in the CRT group achieved comparable survival compared with patients in the RT group. The 3-year CSS rate was 64.3% and 65.2%, respectively (P =0.764). In multivariate analysis, the addition of chemotherapy to IMRT was not an independent prognostic factor for CSS, whereas a high ACE-27 score was an independent risk factor. In subgroup analysis with ACE-27 score ≥ 2, the 3-year CSS rate was worse in patients from the CRT group (63.5% vs. 46.3%, P = 0.041). Conclusions: CRT is comparable to IMRT alone for elderly patients with locoregionally advanced NPC. The ACE-27 tool may help to identify high-risk subgroup for poor disease outcome and tailor individualized treatment.

The emergence of wall-climbing robots alleviates the limitations of traditional manual flaw detection, and the autonomous positioning and marking system is its core research problem. By installing a three-axis accelerometer and a three-axis gyroscope on the wall-climbing robot, this paper firstly establishes a 3D model of the oil storage tank and stores its data in a database, then realizes the autonomous positioning of the wall-climbing robot on the oil storage tank, and finally marks the unqualified weld seam points.

Objective We tested the hypothesis that low hemoglobin levels are associated with acute seizures after aneurysmal subarachnoid hemorrhage (aSAH). Methods Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale. Acute seizures were determined as seizures within 1 week after aSAH. Results We included 554 patients with requisite data for analysis in the prospective study. Incidence of acute seizures following aSAH was 3.61%. In the univariate analysis, significant differences were detected in admission Hunt-Hess grade, Fisher grade, hemoglobin, and serum iron between epilepsy and nonepilepsy groups. Furthermore, acute seizures were associated with higher modified Rankin Scale score and poor outcome (P = 0.004). Serum hemoglobin levels were 114.30 ± 20.08 g/L in the epilepsy group, which were lower than those in the nonepilepsy group (128.64 ± 17.94 mmol/L, P = 0.001). Serum iron levels were 8.89 ± 5.03 g/L in the epilepsy group, which were also lower than those in the nonepilepsy group (13.71 ± 6.70 mmol/L, P = 0.002). The hemoglobin level was positively correlated with serum iron on admission (ρ = 0.321, P = 0.000). In the multivariate logistic regression model, lower hemoglobin was considered as an independent risk factor of acute seizures (odds ratio 4.286, 95% confidence interval 1.492–12.315, P = 0.007). The optimal cutoff value for hemoglobin level as a predictor for acute epilepsy after aSAH was determined as 119 g/L in the receiver operating characteristic curve (sensitivity was 75.00%, and specificity was 69.48%). Conclusions These data support the hypothesis that hemoglobin was inversely associated with acute seizures following aSAH.

Objective We tested the hypothesis that cerebellopontine angle (CPA) tumors are associated with a greater incidence of unruptured intracranial aneurysms (IAs). Methods Patients with intracranial tumors (ITs) undergoing computed tomography angiography and magnetic resonance imaging were enrolled in an observational cohort study that prospectively collected age, sex, hypertension, diabetes, cerebral arteriosclerosis, tumor type, tumor location, hydrocephalus, smoking, alcohol intake, CPA tumor size, cerebral aneurysms, and cerebral arteriosclerosis. Patients with the coexistence of IA and IT were classified as group II, whereas the others with IT as group I. Results We included 1218 patients with IT for analysis. The incidence of IA was 7.1% (86/1218). A total of 31% of patients with aneurysms had CPA tumors. In a multivariate logistic regression model, a greater incidence of IA was found in female patients (odds ratio [OR] 1.726, 95% confidence interval [CI] 1.050–2.836, P = 0.031) and in patients with CPA tumors (OR 3.002, 95% CI 1.822–4.947, P = 0.000) after adjustment for tumor type, cerebral arteriosclerosis, and age. In female patients, CPA tumors were a unique independent risk factor of a greater incidence of IA (OR 2.270, 95% CI 1.194–4.317, P = 0.012). Furthermore, cerebral arteriosclerosis was a unique independent risk factor of IA in patients with CPA tumors (OR 7.626, 95% CI 2.928–19.860, P = 0.000). Conclusions These data support the hypothesis that CPA tumors are associated with a greater incidence of unruptured IAs, especially in female patients. Cerebral arteriosclerosis contributed to elevated risk of IA in patients with CPA tumors.

We tested the hypothesis that ionized calcium levels at admission are associated with early hematoma expansion and functional outcome in patients with hypertensive intracerebral hemorrhage (HICH).Patients presenting with HICH were enrolled in the observational cohort study that prospectively collected age, sex, blood pressure, history of diabetes and smoking, time from symptom onset to initial computed tomography (CT), admission ionized calcium (iCa) and total calcium (tCa), coagulation function, Glasgow Coma Scale (GCS), and postoperative modified Rankin Scale score. Hematoma reconstruction on CT was performed to measure hematoma volumes. Hematoma expansion (HE) was defined as an increase of more than 30% or 6 mL in HICH volume. We performed univariate and multivariate analyses to assess for association of iCa level with early HE and functional outcome.We included 111 patients with HICH for analysis. Admission serum iCa was 1.10 mmol/L in patients with HE and 1.17 in patients without HE. Univariate analysis indicated significant difference of GCS, initial HICH volume, iCa, and tCa between the HE and non-HE groups (P0.05). Lower admission iCa (less than 1.12 mmol/L) was associated with HE (odds ratio [OR] 0.300, 95% confidence interval [CI] 0.095-0.951, P = 0.041) after adjustment for age, blood pressure, GCS score, time to initial CT scan, baseline HICH volume, prothrombin time, and tCa. Furthermore, predictive factors of poor outcome included iCa (OR 0.192, 95% CI 0.067-0.554, P = 0.002) and GCS score (OR 0.832, 95% CI 0.722-0.959, P = 0.011).These data support the hypothesis that lower ionized calcium is associated with early hematoma expansion and poor outcome in patients with hypertensive intracerebral hemorrhage.

Post-harvest low-temperature management is essential to maintain the quality of raw soybeans. In this study, we applied a ground source heat pump (GSHP) cooling system to a large warehouse and compared the physiological and physical changes of soybeans stored in this warehouse with those stored in a traditional warehouse with mechanical ventilation (control warehouse). The temperature of the soybeans was measured once every three months. The results showed that the average temperature the soybeans in the GSHP warehouse and traditional warehouses was 13.9 and 18.7 °C, respectively. The temperatures in GSHP warehouse were 4.9–6.1 °C lower than that in the control warehouse for most of the summer period. Compared with the control warehouse, the soybeans stored in the GSHP warehouse for 12 months had a notably lower level of the free fatty acid content, microbial load and respiration rate, and a higher level of water solute protein content. Our study suggests that large warehouses using with the GSHP system is a promising approach to improve the quality of stored soybeans.

We consider the boundary value problem \(\Delta u + \left| x \right|^{2\alpha } \left| u \right|^{p - 1} u = 0, - 1 < \alpha \ne 0\), in the unit ball B with the homogeneous Dirichlet boundary condition, when p is a large exponent. By a constructive way, we prove that for any positive integer m, there exists a multi-peak nodal solution up whose maxima and minima are located alternately near the origin and the other m points \(\widetilde{q_l } = (\lambda \cos \frac{{2\pi (l - 1)}} {m},\lambda \sin \frac{{2\pi (l - 1)}} {m}),l = 2, \cdots ,m + 1 \), such that as p goes to +∞, $$p\left| x \right|^{2\alpha } \left| {u_p } \right|^{p - 1} u_p \rightharpoonup 8\pi e(1 + \alpha )\delta _0 + \sum\limits_{l = 2}^{m + 1} {8\pi e( - 1)^{l - 1} \delta _{\widetilde{q_l }} } $$ , where λ ∈ (0, 1), m is an odd number with (1+α)(m+2)−1 > 0, or m is an even number. The same techniques lead also to a more general result on general domains.

This paper first describes the basic theory of BP neural network algorithm, defects and improved methods, establishes a computer network security evaluation index system, explores the computer network security evaluation method based on BP neural network, and has designed to build the evaluation model, and shows that the method is feasible through the MATLAB simulation experiments.

With the increasing investment of power grid enterprise, grid infrastructure projects, especially the main network project investment, has begun to play an increasingly important role. This paper studies the whole life cycle of the main network investment projects, from pre-evaluation, interim evaluation and post-evaluation of the project to set up a complete technical and economic evaluation index system for the investment of the main network projects and achieve the overall project evaluation, making the main grid network investment have a more reasonable basis and get rid of the previous single and imperfect evaluation system of main network investment. Simultaneously, establishing a scientific evaluation system and a database of evaluation index can help to track the main network project investment to achieve more reasonable assessment reporting projects.

Red wines were made from Vitis vinifera cv. Cabernet Sauvignon in China at different methods of maceration. The effects of using different winemaking technologies during maceration on the quality characteristics, in terms of colour, aroma profile and sensory characteristics, of the wines before bottling were evaluated, and made a comparison with the effects of adding skins. Seed contact treatments raised wine colour intensity, proanthocyanidins, tannins, and polyphenols content in comparison to the control wines. However, as indicated in the sensory evolution, the significant increase in astringency intensity was found in the wines with seed contact. Besides, the bitterness of the red wine also increased in the wines with seed contact, but it was not significantly.

Red wines were made from Vitis vinifera cv. Cabernet Sauvignon in China at different methods of maceration. The effects of adding seeds during maceration on the quality characteristics, in terms of colour, and functional characteristics, of the wines before bottling were evaluated, and made a comparison with the effects of adding skins. Seed contact treatments raised wine colour intensity, anthocyanidins, and tannins in comparison to the control wine.

Effects of different methods of gas package on freshness of harvested waxy maize at room temperature in its shelf life were investigated. The harvested waxy maize were packaged under vacuum, air, N2 or CO2, respectively, and then stored 90 days at 30°Cafter the high temperature sterilization. After the sterilization and during storage, the changes of aerobic plate count, water content, soluble sugar content, and sensory evaluation were determined. The results showed that compared with others, the package with N2 could inhibit the growth of microorganisms, kept the content of water, soluble sugar and fat. After 90 days, the sensory evaluation could show that waxy maize of N2 package had better tasty and aroma.

Red wines were made from Vitis vinifera cv. Cabernet Sauvignon in China at different methods of maceration. The effects of adding seeds during maceration on the quality characteristics, in terms of colour, aroma profile and sensory characteristics, of the wines before bottling were evaluated, and made a comparison with the effects of adding skins. Seed contact treatments raised wine colour intensity, proanthocyanidins, tannins, and polyphenols content in comparison to the control wines. However, as indicated in the sensory evolution, the significant increase in astringency intensity was found in the wines with seed contact. Besides, the bitterness of the red wine also increased in the wines with seed contact, but it was not significantly

Abnormalities in glutamate signaling and glutamate toxicity are thought to be important in the pathophysiology of bipolar disorder (BD). Whilst previous studies have found brain white matter changes in BD, there is paucity of data about how glutamatergic genes affect brain white matter integrity in BD. Based on extant neuroimaging data, we hypothesized that GRIN2B risk allele is associated with reductions of brain white matter integrity in the frontal, parietal, temporal, and occipital regions and cingulate gyrus in BD. Fourteen patients with BD and 22 healthy controls matched in terms of age, gender and handedness were genotyped using blood samples and underwent diffusion tensor imaging. Compared to G allele, brain FA values were significantly lower in BD patients with risk T allele in left frontal region (P=0.001), right frontal region (P=0.002), left parietal region (P=0.001), left occipital region (P=0.001), right occipital region (P<0.001), and left cingulate gyrus (P=0.001). Further elucidation of the interactions between different glutamate genes and their relationships with such structural, functional brain substrates will enhance our understanding of the link between dysregulated glutamatergic neurotransmission and neuroimaging endophenotypes in BD.

Accurately defining the radiation scope of the logistics park is the basis of the rational planning of the logistics park as well as further improvement of the regional logistics efficiency, but currently there is still a lack of scientific and systematical theory focusing on the research of defining the radiation scope of the logistics park. Therefore the concept of ‘hinterland’ was introduced into the research of the radiation scope of the logistics park, and the concept of ‘logistics park hinterland’ was particularly proposed. Subsequently, based on the Voronoi diagram theory in computational geometry which reflects the advantage of the continuity of space division, and by introducing the ‘scale’ parameter in the breaking-point model into weighted Voronoi diagram, the model based on weighted Voronoi diagram to define the logistics park hinterland was built. Finally, this model was practically applied to the planning example of ‘Four logistics centers’ of Chengdu, and also by means of GIS software the respective hinterlands of ‘Four logistics centers’ of Chengdu were defined. It practically proves that this model overcomes the shortcomings existing in the conventional single space division theories and methods such as the breaking-point model and the ordinary Voronoi diagram theory, which makes the definition of the logistics park hinterland more reasonable and scientific.

Different clustering methods featuring varied principles needed being comparatively opted. Clustering effect estimation coefficient was adopted to highway transportation research, and the best one out of clustering methods was evaluated as well as chose after comparing their findings. True as empirical analyses prove, this method is simple yet feasible, and its results are in accordance with the real conditions as well.

To improve the level of ship monitoring, ease the engineer’s working strength, improve the level of the shipping company regulation, the remote fault diagnosis system of ship’s engine room is designed with the comprehensive utilization of neural network, SQL Sever database, C/S structure, the Inmarsat system, etc. The system includes the data acquisition, data storage, the display and control of interface and wireless transmission. The results of application show that the system is stable, easy to use, modification with low cost, helpful for engineer knowing the state of engine room, convenient for unified supervision of the shipping company, improves the work efficiency, safeguards the shipping service.

This paper presents a frequency-tunable bandpass fllter with constant absolute bandwidth and improved linearity. The proposed resonator is composed of an open-ended transmission line with back-to-back varactor diodes loaded at one end. The back-to-back varactor diodes are used to enhance the linearity of the fllter, which is better than that of the single varactor counterparts. A mixed electric and magnetic coupling scheme is utilized to control the overall coupling coe-cients so that the absolute bandwidth can be kept constant when the frequency is tuned. For validation, two frequency-tuning fllters with 30-MHz and 44-MHz absolute bandwidth are implemented. The experimental and simulated results are presented to verify the proposed design.

Wind power, strong and smart grid (SSG), analysis model, coordinated development Abstract. Chinese wind power industry has been experiencing a booming development in recent years and will keep the strong momentum of development through 2020. Some key problems are facing China’s wind power industry, which requires the innovation in technology and management. Fortunately, China is constructing Strong and Smart Grid which addresses the development of renewables. In this scenario, after analyzing some major wind-power related bottlenecks in China, the paper gives an in-depth introduction to the Strong and Smart Grid strategy. Finally, the paper presents a novel model for studying the coordinated development of wind power and grid.

The introduction of the thought of supply chain management into the construction industry can improve the competitiveness of enterprises. Based on the integration of both the effect of the supply chain as well as supply chain management and the actual situation, this paper analyzed the necessity of the construction and implementation of supply chain management of the construction enterprise. Compared with the supply chain of manufacturing industry, we found it feasible to implement supply chain management in the construction industry and analyzed the obstacles in it. Finally, it pointed out that the clustering of construction materials, information technology, business process reengineering, outsourcing of projects logistics and so on were the basis of constructing supply chain management of the construction enterprise, and accordingly the joint-design supply chain model of the project cost-oriented and the responsiveness-oriented was established.

A series of novel 7-(3-alkoxyimino-4-amino-4-methylpiperidin-1-yl)fluoroquinolone derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity and cytotoxicity. All of the target compounds have potent antibacterial activity against the tested Gram-positive and Gram-negative strains, and exhibit good potency in inhibiting the growth of Staphylococcus aureus including MRSA, Staphylococcus epidermidis including MRSE and Streptococcus pneumoniae (MICs: 0.125-4 μg/mL). Compound 22, with the best activity against Gram-positive strains, is 4-16 fold more potent than gemifloxacin, gatifloxacin and levofloxacin against Enterococcus faecalis, and 16- and 4-fold more potent than levofloxacin against S. epidermidis 09-6 and S. pneumoniae 08-4, respectively.

We report herein the design and synthesis of novel 7-(3-alkoxyimino-5-amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives based on the structures of new fluoroquinolones IMB and DZH. The antibacterial activity of these newly synthesized compounds was also evaluated and compared with gemifloxacin, ciprofloxacin, and levofloxacin. Results revealed that all of the target compounds 10–27 have good potency in inhibiting the growth of Staphylococcus aureus including MSSA (MIC: 0.125–8 μg/mL), Staphylococcus epidermidis including MRSE (MIC: 0.25–16 μg/mL), Streptococcus pneumoniae (MIC: 0.125–4 μg/mL), and Escherichia coli (MIC: 0.25–0.5 μg/mL). In particular, some compounds showed useful activity against several fluoroquinolone-resistant strains, and the most active compound 15 was found to be 16–128, 2–32, and 4–8-fold more potent than the three reference drugs against fluoroquinolone-resistant MSSA, MRSA, and MRSE.

A series of novel 7-[3-( N ′-alkoxycarbamimidoyl)-4-(alkoxyimino)pyrrolidin-1-yl] fluoroquinolone derivatives were designed, synthesized and characterized by 1 H NMR, MS and HRMS. These fluoroquinolones were screened for their in vitro antibacterial activity. Most of them exhibit good potency in inhibiting the growth of Staphylococcus aureus and Staphylococcus epidermidis (MIC: 0.06–4.00 μg/mL). The activity of compounds 33 and 43 against S. aureus including MRSA and S. epidermidis including MRSE (MIC: 0.06–0.125 μg/mL) is more than or comparable to the reference drugs levofloxacin and gemifloxacin. In addition, compound 33 is 32 and 16–32 fold more potent than both the reference drugs against Enterococcus faecium 08-7 and Klebsiella pneumoniae 09-22, respectively.

Atemoyacin A, a new annonaceous acetogenin was isolated from the alcoholic extract of the seeds of Annona atemoya Hort (Annonaceae). Its structure and relative configuration were elucidated on the basis of the spectral analysis.

La1-xCaxVO3 composition-spread films were fabricated by combinatorial pulsed laser deposition and their thermoelectric properties were evaluated paralelly by the multi-channel thermoelectric measurement system. Concurrent X-ray analysis verified the formation of solid solution films in the full composition range (0≤x≤1) as judged from the linear variation of the lattice constants. The power factor of 0.6 µW/cm K2 was achieved in LaVO3 film at 800°C.Large thermoelectric properties in vanadium oxide system can be expected with the change of vanadium ion valence from 3+ to 2+.

(Ca1-xAx)3Co4O9 (A: Sr, Ba) composition-spread films were fabricated successfully on TiO2 (100) substrate by combinatorial pulsed laser deposition (CPLD), and their thermoelectric (TE) properties and structure were evaluated by the multi-channel thermoelectric measurement system and concurrent X-ray analysis respectively. The largest power factor in (Ca1-xSrx)3Co4O9 film library was achieved as 1.67µW/cmK2. The influence of substitution on TE properties was investigated by doping Sr2+ and Ba2+ ions into Ca3Co4O9. However, there was little change of Seebeck coefficient in the range of 0≤x≤0.1 for (Ca1-xAx)3Co4O9 (A: Sr, Ba) films, which suggested that the substitution ions with smaller size were potential candidates for good TE properties.

A series of novel 7-(3-alkoxyimino-4-methyl-4-methylaminopiperidin-1-yl)fluoroquinolone derivatives were designed, synthesized, and characterized by 1H-NMR, MS, and HRMS. These fluoroquinolones were evaluated for their in-vitro antibacterial activity against representative Gram-positive and Gram-negative strains. Generally, all of the target compounds have considerable antibacterial activity against the tested forty strains, and exhibit exceptional potency in inhibiting the growth of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) ATCC33591 (MICs: 0.06 to 2 microg/mL). In particular, compounds 14, 19, 28, and 29 are fourfold more potent than ciprofloxacin against MSSA 08-49. Compounds 23, 26, and 27 are twofold more potent than ciprofloxacin against MRSA ATCC33591 and MSSA ATCC29213. In addition, compound 14 exhibits excellent activity (MIC: 0.06 microg/mL) against Acinetobactes calcoaceticus, which is two- to 16-fold more potent than the reference drugs gemifloxacin, levofloxacin, and ciprofloxacin.

Stronger (0001) basal plane textures mainly include two types: and in AZ31 magnesium alloy thin sheet were formed after hot-rolling. The texture types of hot-rolled AZ31 magnesium alloy thin sheet after annealing at 523K and 673K respectively were as same as that of hot-rolled thin sheet without annealing, but texture intensities became weaker, especially after annealing at 673K. The strong texture of hot-rolled thin sheet caused anisotropy of mechanical properties (tensile strength b, yield strength s and elongation ) significantly , and the anisotropy reduced with the decrease of texture intensity after annealing. Besides texture, the grain shape also effects anisotropy of mechanical properties. The anisotropy becames more significantly with the increase of relative difference of grain diameter between transverse and longitudinal directions.

N-methyl-D-aspartate (NMDA) receptors have been implicated in many neurological disorders. Although NMDA receptors are best known for their high calcium permeability, the recently discovered NR3 subunits, NR3A and NR3B, have been shown to reduce the calcium permeability of the NMDA receptor. Thus, NR3 subunits may be important players in modulating synaptic plasticity in neurons. Although NR3B expression in the rodent and human brain has been studied, little is known about its distribution in different cell types. Here we used immunolabeling with a specific NR3B antibody together with antibodies against established neurochemical markers to determine the cellular and subcellular localization of NR3B. The nucleus was concurrently stained with NR3B immunolabeling to show that NR3B is widely expressed by many cells in each brain region. Our findings indicate that NR3B is widely expressed in the structures examined in the rat forebrain (hippocampus, cerebral cortex, caudoputamen, and nucleus accumbens), cerebellum, and lumbar sections of the spinal cord. Within these regions NR3B was found to be expressed in all the substructures of the hippocampus (CA1, CA3, dentate gyrus), the various layers of the cerebral cortex, projection neurons and interneurons of the striatum, different cell types of the cerebellum, and motor neurons of the spinal cord. Furthermore, when stained with NR1-the obligatory subunit responsible for forming functional NMDA receptors-the distribution of NR3B appears to be as ubiquitous as NR1. Taken together, our data suggest that there may be a population of NR3B-containing NMDA receptors conferring new functional roles in the mammalian central nervous system.

A new ursane-based compound, astilbotriterpenic acid (1), was isolated from the rhizomes of Astilbe chinensis. Its structure was determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D- and 2D-NMR. The pentacyclic triterpenoid 1 was assayed for its in vitro cytotoxicity against Bcap37, HeLa, HepG2, HO-8910, K562, PAA, SGC7901, and P388 cancer cells, as well as for its apoptosis-inducing activity in HeLa cells. Compound 1 was found to strongly inhibit tumor-cell growth through induction of apoptosis and may, thus, be further evaluated as a novel chemotherapeutic agent.