Search

Molecular isomeric engineering is employed to construct efficient orange-red Ir(iii) complexes for WOLEDs and understand the intrinsic structure–property relationship.

We analytically and numerically study the local dynamical characteristics of the Bessel beams reflected from an air—glass interface near the Brewster angle. A Taylor series expansion based on the angular spectrum component is applied to correct the reflection coefficients near the Brewster angle. Using a hybrid angular spectrum representation and vector potential method, the explicit expressions for the electric and magnetic field components of the reflected Bessel beams are derived analytically under paraxial approximation. The local energy, momentum, spin, and orbital angular momentum of the Bessel beams upon reflection near the Brewster angle are examined numerically by utilizing a canonical approach. Numerical simulation results show that the properties of these dynamical quantities for the Bessel beams near Brewster angle incidence change abruptly, and are significantly affected by their topological charge, half-cone angle, and polarization state. The present study has its importance in understanding the dynamical aspects of optical beams with vortex structure and diffraction-free nature during the reflection process.

Three novel 17

In this paper, the characteristics of Gaussian beam propagation through turbulent plasma sheath are studied. According to the generalized Huygens-Fresnel principle, the random phase screen is generated by power spectrum inversion method based on the fast Fourier transform. The random phase screen is used to simulate turbulence effect. The thickness of the plasma sheath is of about centimeter order of magnitude. Compared with the single fast Fourier transform algorithm, the double fast Fourier transform algorithm is not prone to under-sampling and can obtain good image results, even if the diffraction distance is 1 mm. Therefore, double fast Fourier transform algorithm is used for investigating the beam propagation between two phase screens. The turbulence effect of the plasma sheath surrounding a hypersonic vehicle is simulated by the multi-random phase screens. When the flight altitude is 45 km and the flight speed is 18 Mach, the intensity of refractive index fluctuation variance ranges from \begin{document}${10}^{ - 11} $\end{document} to \begin{document}$ {10}^{ - 14} $\end{document} indicated by analyzing the plasma flow field around the hypersonic vehicle. The characteristics of the Gaussian beam propagation through the turbulent plasma are numerically simulated. The results show that the refractive index fluctuation, wavelength and transmission distance are important factors affecting the Gaussian beam quality. The larger the refractive index variance, the more severe the spot dispersion and the more obvious the light intensity fluctuation. As wavelength is longer, the ability of the Gaussian beam to resist turbulence becomes stronger and the dispersion of the light spot and the intensity fluctuation are smaller. The beam distortion and the spot dispersion become more severe as the transmission distance is longer.

A dispersive conformal FDTD method has been proposed to accurately model the interface between two adjacent dispersive mediums and implemented to study the scattering of THz electromag- netic (EM) waves by inhomogeneous collisional plasma cylinder array. The method is based on the technology of area average, which is dif- ferent from existing dispersive conformal FDTD schemes. Numerical results show that the proposed method enhances the accuracy level compared to the staircasing FDTD scheme involved in the inhomoge- neous plasma. It is interesting to flnd that the THz EM waves can propagate through the plasma array more easily with higher frequen- cies or larger separations, hence the scattering width in the backward direction becomes smaller, and the forward scattering exhibits a little difierent. This study will be useful for further designing intelligent plasma antenna arrays in the THz band and terahertz reentry teleme- try through plasma.

An efficient domain decomposition method (DDM) is employed to improve upon the efficiency and capability of the finite element-boundary integral (FE-BI) method for calculation of electromagnetic (EM) scattering from deep cavities. This method first subdivides the original cavity into many sub-domains along its depth and classifies these sub-domains into a few building blocks. It then employs the substructuring method to deal with the different types of sub-domains. The resulting Schur complement system is solved by a special method which has low memory requirements because the formation of the global Schur complement matrix is not necessary. Numerical results indicate that the presented method is an effective approach for scattering by deep cavities.

Objective: Previous studies have shown that Astragalus polysaccharide (APS) can be applied to anti-cancer. However, the mechanism by which APS mediate this effect is unclear. In the present study, APS-mediated NSCLC cell apoptosis was investigated through the regulation of the notch signaling pathway. Methods: The cell viability was detected by the CCK8 assay. The mRNA and protein expression of notch1/3 and tumor suppressors were analyzed by RT-PCR and western blotting, respectively. Results: The mRNA and protein of notch1 and notch3 were significantly up-regulated in tumor tissues as compared to non-tumor adjacent tissues. Treatment of human NSCLC cells with APS induced cell death in a dose-and time-dependent manner by using CCK8 assay. The mRNA and protein expression of notch1 and notch3 were significantly lower in NSCLC cells with APS treatment than that in control group. Moreover, western blotting analysis showed that treatment of H460 cells with APS significantly increased the pro-apoptotic Bax and caspase 8 levels, decreased the anti-apoptotic Bcl-2 level. Furthermore, p53, p21 and p16 were obviously up-regulated by APS treatment in H460 cell. Conclusions: This study demonstrated that APS-treated could inhibit proliferation and promote cell apoptosis, at least partially, through suppressing the expression of notch1 and notch3 and up-regulating the expression of tumor suppressors in H460 NSCLC cell lines.

Rationale: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. Patient concers: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. Diagnoses: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. Intervations: We send the biopsy of the lung and the tongue lesions for gene sequencing. Outcomes: He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later. Lessons: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis.

To investigate the effect of co-stimulation of mimic viral infection [polyinosinic: polycytidylic acid, poly(I:C)] and endotoxin (lipopolysaccharide, LPS) on chemotactic factors production of human bronchial epithelial cells and explore its related mechanism.Human bronchial epithelial cells (16HBE) were challenged by co-stimulation of different concentrations of poly(I:C) and LPS. Some other 16HBE cells, before the co-stimulation of poly(I:C) and LPS, were pretreated with dexamethasone and p38MAPK specific inhibitor (SB203580), respectively. The levels of IL-8/CXCL8 and IP-10/CXCL1 mRNA transcription were detected by RT-PCR after 6 h challenge. The contents of IL-8 and IP-10 proteins were detected by ELISA after 24 h challenge.(1) The mRNA and protein expression of IL-8, not IP-10, increased under 10 μg/mL LPS stimulation compared with control group. The mRNA and protein expressions of both IL-8 and IP-10 were elevated significantly by the co-stimulation of LPS and 0.1 μg/mL poly (I:C) compared with control group and simple LPS groups. (2) The mRNA and protein expressions of IL-8 and IP-10 increased under the challenge of different concentrations of poly(I:C) (0.001, 0.01, 0.1 μg/mL) in a concentration-dependent manner, which showed no change after adding 10 μg/mL LPS. (3) Dexamethasone (1 μmol/L) and SB203580 (20 μmol/L) significantly decreased both the mRNA and protein production of IL-8 and IP-10 induced by co-stimulation of 0.1 μg/mL poly (I:C) and 10 μg/mL LPS compared with the control group and control+DMSO group respectively (P0.01 and P0.05). Inhibitive effect of dexamethasone was stronger than that of p38MAPK inhibitor.The co-stimulation of poly(I:C) and LPS can induce chemokine expression of airway epithelial cells. Poly(I:C) enhances the IL-8 expression induced by single LPS challenge, which suggests that viral infection could enhance the inflammation resulted from bacterial colonization in airway. Glucocorticoid has the greater effect on the inhibition of chemotactic factors production than p38MAPK inhibitor. These two drugs have a potential therapeutic effect on AECOPD caused by viral infection.

Although bronchoscopy has been widely performed in China, little has been known about its current state and development. In order to investigate the clinical application of bronchoscopy and make instructions for future education and development, the Chinese Society of Respiratory Diseases conducted postal surveys in both 2008 and 2010 in China.Questionnaires were sent to 40 tertiary grade A hospitals in 2008 and 58 tertiary grade A hospitals in 2010 to investigate bronchoscopies performed in 2007 and 2009 respectively.Thirty (75%) hospitals returned the completed questionnaires in 2008 and forty-one (71%) hospitals in 2010. All the respondents possessed flexible bronchoscopes. Fifty percent of the respondents had less than five in 2007, while more than 50% of the respondents had 5-9 bronchoscopes in 2009. All the respondents performed a radiograph or CT scan before bronchoscopy. Percentage of general anesthesia and no pre-medication before bronchoscopy increased, while atropine usage decreased in 2009 compared to 2007. During bronchoscopy, pulse oximetry was the most widely used monitoring method. Most respondents used the nasal route to perform routine bronchoscopy. After the procedure, they used sinks to wash and glutaraldehyde to disinfect the bronchoscopes. The total number of flexible bronchoscopies performed during 2007 was 37 874 and the average was 1262. Whereas in 2009, the total number was 60 178 and the average was 1468. Diagnostic bronchoscopy was more widely used than therapeutic bronchoscopy. The mortality rate was 0.076‰ in 2007 and 0.032‰ in 2009.The two surveys, to some extent, reflected the current status and development of bronchoscopy in China. The results are worthy of future education and developing of new guidelines. Regular surveys and monitoring of bronchoscopies across China are needed.

We report the case of a 53-year-old woman who initially presented with an intermittent dry cough that had lasted for 6 months. An investigation into these symptoms with thoracic computed tomography demonstrated hyperdense shadows in her lungs, and ultrasonography showed the presence of multiple hypoechoic nodules on her spleen. A lung biopsy was then performed, which revealed noncaseating epithelioid cell granulomas. Magnetic resonance imagining of her spleen was performed, which showed low signal intensity. The patient was treated with glucocorticoids, and 3 months later the lesions in her lungs had disappeared completely. Five months later, the lesions in her spleen had disappeared also. However, after 13 months of low-dose prednisone, a miliary pattern was observed on the patient's chest x-ray, although no lesions were observed in her spleen. Laboratory tests demonstrated that her blood level of angiotensin-converting enzyme had increased to 96 IU/L. The dose of prednisone was then increased, and the lung images returned to normal after 2 months of therapy.

To describe the clinical features and imaging characteristics of nodular splenic sarcoidosis.We describe a patient with splenic sarcoidosis and review the related medical literature, the etiology, symptomatology, pathology, diagnosis, differential diagnosis, management and prognosis of splenic sarcoidosis.The etiology of this rare disease remains unknown. Symptoms are scanty and usually mild; computed tomography usually reveals splenomegaly or the presence of multiple nodules, confusing with metastatic tumor in spleen. On histopathologic examination, sarcoid produces noncaseating granulomas. Sarcoid is typically treated only when symptomatic. Oral corticosteroids is the most important method of treatment in patients with progressive loss of organ functions. Prognosis has closed relationship with early clinical manifestation.Splenic sarcoidosis is rare and often misdiagnosis as other diseases.

To report the diagnostic experience for broncholithiasis, and to evaluate the value of flexible bronchoscopic management for the disease.The clinical data, radiological features, bronchoscopy findings, the effect and complications of bronchoscopic management in 31 patients with broncholithiasis admitted to changhai hospital of second military medical university and zhejiang Taizhou Hospital between 2000 and 2007 were retrospectively reviewed.There were 19 men and 12 women, the mean age was 58.6 +/- 12.6. There were 26 cases missed diagnosis, and 19 cases were misdiagnosis. The diagnosis was confirmed by chest CT combined with bronchoscopy in all the patients. Thirty-six broncholiths were revealed, of which 26 were intraluminal, 9 eroding in the bronchial wall, and 1 peribronchial. In 26 patients, 31 broncholiths were managed by flexible bronchoscope, and 25 broncholiths were successfully removed. The success rate for intraluminal free broncholiths was higher (23/25). One patient experienced hemoptysis of 300 ml after therapy, but no significant complications occurred in other patients.The diagnosis of broncholithiasis can be easily missed or misdiagnosed. Chest CT combined with bronchoscopy were useful methods for the diagnosis of the disease. Extraction of broncholiths with flexible bronchoscope is a safe and effective management, especially for intraluminal broncholiths.