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Green technological innovation has the dual benefit of promoting economic development and limiting environmental pollution and is critical to sustainable development in developing countries. This study assessed the green innovation effects of ecological civilization pilot policies by using the difference-indifferences approach, mediating effects model, and causal forest algorithm. The results showed that: (1) The ecological civilization pilot policy increased the level of green technology innovation in the pilot area by 27.9 %. (2) Urbanization partially mediated the impact process of ecological civilization pilot policies on green technology innovation, and the green innovation effect transmitted through urbanization was about 28%. (3) When energy structure and financial support were taken as the conditions, the green innovation effect of the ecological civilization pilot policy respectively showed an S-shaped curve and an inverted U-shaped curve. The above results can provide a new scientific basis for promoting green development in developing countries. [ABSTRACT FROM AUTHOR]

With the in-depth promotion of low-carbon economic transformation and air pollution control, the role of synergetic control of CO2 and air pollutant emissions has begun to stand out. Based on panel data for 30 provinces in China from 2012 to 2020, we measured the coupling and coordination degree of CO2 and air pollutant emissions control (CCD) and revealed the direct effect of human capital on CCD, the heterogeneous effect, and the threshold effect of R&D intensity. The results of the study showed that, firstly, CCD at the provincial level in China showed a stepped-up trend and regional heterogeneity. Second, human capital had a significant positive effect on CCD, and this effect was stronger in the "Four Provinces of Shan-He" and Inland provinces. Third, R&D intensity played a significant threshold role in the impact of human capital on CCD, but there was a "medium-term trap". Therefore, based on the development of differentiated synergistic strategies for pollution and carbon reduction, financial investment in human capital and R&D activities should be increased. [ABSTRACT FROM AUTHOR]

To investigate the effect of propofol pretreatment on microglial pyroptosis in the ischemic penumbra of rats subjected to cerebral ischemia-reperfusion. 90 rats were randomly divided into Sham group, model group, nod-like receptor protein 3 inhibitor group, propofol low dose group and high dose group. Pathological changes in the hippocampal region of the ischemic penumbra of brain tissue were observed by hematoxylin and eosin staining; interleukin-1 beta and interleukin-18 levels were detected in the ischemic penumbra of cerebral tissue by enzyme-linked immunosorbent assay; immunofluorescence double staining was performed to detect the immunopositive co-expression of nod-like receptor protein 3, aspartate specific caspase 1 and ionized calcium adaptor protein 1 in the ischemic penumbra of cerebral tissue. Compared with the model group, the nod-like receptor protein 3 inhibitor group, propofol low dose group and propofol high dose group groups also had significantly lower neurological deficit scores, cerebral infarction volumes, and interleukin-1 beta and interleukin-18 levels, ionized calcium adaptor protein 1/nod-like receptor protein 3, ionized calcium adaptor protein 1/caspase 1 immunopositive co-expression, nod-like receptor protein 3, pro-caspase 1, P10, P20 and interleukin-1 beta protein expressions in the ischemic penumbra were significantly reduced (p<0.05), the pathological damage was improved to various degrees, and the number of nerve cells was increased. The neuroprotective effect of propofol pretreatment on cerebral ischemia-reperfusion injury may be related to the inhibition of microglial pyroptosis mediated by nod-like receptor protein 3 inflammasome. [ABSTRACT FROM AUTHOR]