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1. Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

Author

Holbrook, Janet T, Sugar, Elizabeth A, Burke, Alyce E, Vitale, Albert T, Thorne, Jennifer E, Davis, Janet L, Jabs, Douglas A, Jaffe, Glenn J, Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora M, Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha, Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A, Scott, Adrienne Williams, See, Robert F, Shuler, Robert K, Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F, Srivastava, Sunil, Dunn, James P, Begum, Hosne, Boring, Jeff, Brotherson, Kristen L, Burkholder, Bryn, Butler, Nicholas J, Cain, Dennis, Cook, Mary A, Emmert, David, Graul, Janis R, Herring, Mark, Laing, Ashley, Leung, Theresa G, Mahon, Michael C, Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L, Reed, Terry, Arnold, Ellen, Barnabie, Patricia M, Belair, Marie-Lynn, Bolton, Stephen G, Brodine, Joseph B, Brown, Diane M, Brune, Lisa M, Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A, Livingston, Alison G, Morton, Yavette, Nolan, Kisten, Peters, George B, Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C Stephen, Anesi, Stephen D, Bruner, Linda, Ceron, Olga, Hinkle, David M, Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q, Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S, Sprague, Janet, and Yilmaz, Taygan

Subjects
Clinical Trials and Supportive Activities, Brain Disorders, Eye Disease and Disorders of Vision, Bioengineering, Clinical Research, Prevention, Neurosciences, Eye, Adolescent, Adult, Aged, Aged, 80 and over, Drug Implants, Equipment Failure, Female, Fluocinolone Acetonide, Follow-Up Studies, Foreign-Body Migration, Glucocorticoids, Humans, Intravitreal Injections, Male, Middle Aged, Postoperative Complications, Reoperation, Risk Factors, Time Factors, Uveitis, Visual Acuity, Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial.DesignRandomized clinical trial with extended follow-up.MethodsReview of data collected on the first implant in the eye(s) of participants. Dissociation was defined as the drug pellet no longer being affixed to the strut and categorized as spontaneous or surgically related.ResultsA total of 250 eyes (146 patients) had at least 1 implant placed. Median follow-up time after implant placement was 6 years (range 0.5-9.2 years). Thirty-four dissociations were reported in 30 participants. There were 22 spontaneous events in 22 participants; 6-year cumulative risk of a spontaneous dissociation was 4.8% (95% confidence interval [CI]: 2.4%-9.1%). The earliest event occurred 4.8 years after placement. Nine of 22 eyes with data had a decline in visual acuity ≥5 letters temporally related to the dissociation. Thirty-nine implant removal surgeries were performed, 33 with replacement. Twelve dissociations were noted during implant removal surgeries in 10 participants (26%, 95% CI 15%-48%); 5 of these eyes had a decline in visual acuity ≥5 letters after surgery. The time from implant placement to removal surgery was longer for the surgeries at which dissociated implants were identified than for those without one (5.7 vs 3.7 years, P < .001). Overall, visual acuity declined 15 or more letters from pre-implant values in 22% of affected eyes; declines were frequently associated with complications of uveitis or its treatment.ConclusionThere is an increasing risk of dissociation of Retisert implants during follow-up; the risk is greater with removal/exchange surgeries, but the risk of both spontaneous and surgically related events increases with longevity of the implants. In 22% of affected eyes visual acuity declined by 15 letters. In the context of eyes with moderate to severe uveitis for years, this rate is not unexpected.

Published
2016

2. The application of the retraction watch database in eye research-based studies

Author

Barton, Andrew, Cordero-Coma, Miguel, Gallagher, Micheal, and Yilmaz, Taygan

Subjects
Health
Abstract

Byline: Andrew. Barton, Miguel. Cordero-Coma, Micheal. Gallagher, Taygan. Yilmaz Dear Editor, There has been a steady rise in the number of scientific journal article retractions.[1] Previously, others have tried to [...]

Published
2021

3. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Jaffe, Glenn J., Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora (Nora) M., Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha (Shah), Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A., Scott, Adrienne Williams, See, Robert F., Shuler, Robert K., Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F., Srivastava, Sunil, Dunn, James P., Begum, Hosne, Boring, Jeff, Brotherson, Kristen L., Burkholder, Bryn, Butler, Nicholas J., Cain, Dennis, Cook, Mary A., Emmert, David, Graul, Janis R., Herring, Mark, Laing, Ashley, Leung, Theresa G., Mahon, Michael C., Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L., Reed, Terry, Arnold, Ellen, Barnabie, Patricia M., Belair, Marie-Lynn, Bolton, Stephen G., Brodine, Joseph B., Brown, Diane M., Brune, Lisa M., Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A., Livingston, Alison G., Morton, Yavette, Nolan, Kisten, Peters, George B., Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C. Stephen, Anesi, Stephen D., Bruner, Linda, Ceron, Olga, Hinkle, David M., Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q., Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S., Sprague, Janet, Yilmaz, Taygan, Sen, H. Nida, Bono, Michael, Cunningham, Denise, Hayes, Darryl, Koutsandreas, Dessie, Nussenblatt, Robert B., Sherry, Patti R., Short, Gregory L., Smith, Wendy, Temple, Alana, Bamji, Allison, Coleman, Hanna, Davuluri, Geetaniali, Faia, Lisa, Gottlieb, Chloe, Jirawuthiworavong, Guy V., Lew, Julie C., Mercer, Richard, Obiyor, Dominic, Perry, Cheryl H., Potapova, Natalia, Weichel, Eric, Wroblewski, Keith J., Latkany, Paul A., Coonan, Corinne, Honda, Andrea, Lorenzo-Latkany, Monica, Masini, Robert, Morell, Susan, Nguyen, Angela, Badamo, Jason, Boyd, Kenneth M., Enos, Matthew, Gallardo, Jenny, Jarczynski, Jacek, Lee, Ji Yun, McGrosky, Mirjana, Nour, Ann, Sanchez, Meredith, Steinberg, Kate, Stawell, Richard J., Breayley, Lisa, D'Sylva, Carly, Glatz, Elizabeth, Hodgson, Lauren, Lim, Lyndell, Ling, Cecilia, McIntosh, Rachel, Morrison (Ewing), Julie, Newton, Andrew, Sanmugasundram, Sutha, Smallwood, Richard, Zamir, Ehud, Hunt, Nicola, Jones, Lisa, Koukouras, Ignatios, Williams, Suzanne, Merrill, Pauline T., Carns, Danielle, Richine, Len, Voskuil-Marre, Denise L., Woo, Kisung, Gaynes, Bruce, Giannoulis, Christina, Hulvey, Pam, Kernbauer, Elaine, Khan, Heena S., Levine, Sarah J., Toennessen, Scott, Tonner, Eileen, Wang, Robert C., Aguado, Hank, Arceneaux, Sally, Duignan, Karen, Fish, Gary E., Hesse, Nick, Jaramillo, Diana, Mackens, Michael, Arnwine, Jean, Callanan, David, Cummings, Kimberly, Gray, Keith, Howden, Susie, Mutz, Karin, Sanchez, Brenda, Lightman, Susan, Ismetova, Filis, Prytherch, Ashley, Seguin-Greenstein, Sophie, Tomkins, Oren, Bar, Asat, Edwards, Kate, Joshi, Lavanish, Moraji, Jiten, Samy, Ahmed, Stubbs, Timothy, Taylor, Simon, Towler, Hamish, Tronnberg, Rebecca, Holland, Gary N., Almanzor, Robert D., Castellanos, Jose, Hubschman, Jean Pierre, Johiro, Ann K., Kukuyev, Alla, Levinson, Ralph D., McCannel, Colin A., Ransome, Susan S., Gonzales, Christine R., Gupta, Anurag, Kalyani, Partho S., Kapamajian, Michael A., Kappel, Peter J., Arcinue, Cheryl, Chuang, Janne, Barteselli, Giulio, Currie, Glenn, Mendoza, Veronica, Powell, Debbie, Clark, Tom, Cochran, Denine E., Freeman, William R., Hedaya, Joshua, Kemper, Tiara, Kozak, Igor, LeMoine, Jacqueline M., Loughran, Megan E., Magana, Luzandra, Mojana, Francesca, Morrison, Victoria, Nguyen, Vivian, Oster, Stephen F., Acharya, Nisha, Clay, David, Lee, Salena, Lew, Mary, Margolis, Todd P., Stewart, Jay, Wong, Ira G., Brown, Debra, Khouri, Claire M., Goldstein, Debra A., Birnbaum, Andrea, Degillio, Andrea, Rosa, Gemma De la, Ramirez, Carmen, Simjanowski, Evica, Skelly, Mariner, Castro-Malek, Anna L., Crooke, Catherine E., Huntley, Melody, Nash, Katrina, Niec, Marcia, Pyatetsky, Dimitry, Ramirez, Misel, Rozenbajgier, Zuzanna, Tessler, Howard H., Davis, Janet L., Albini, Thomas A., Chin, Marie, Castaño, Daniela, Elizondo, Ariana, Ho, Macy, Kovach, Jaclyn L., Lin, Richard C-S., Mandelcorn, Efrem, Nguyen, Jackie K-D., Pacini, Aura, Pineda, Susan, Pinto, David A., Rebimbas, Jose, Stepien, Kimberly E., Teran, Claudia, Elner, Susan G., Bernard, Hillary, Fournier, Linda, Godsey, Lindsay, Goings, Linda, Hackel, Richard, Hesselgrave, Moella, Jayasundera, K. Thiran, Prusak, Robert, Titus, Pamela, Bergeron, Melissa, Blosser, Reneé, Brown, Rebecca, Chrisman-McClure, Carrie, Gothrup, Julie R., Saxe, Stephen J., Sizemore, Deanna, Kempen, John H., Berger, James, Drossner, Sheri, DuPont, Joan C., Maguire, Albert M., Petner, Janice, Engelhard, Stephanie, Hopkins, Tim, Lo, Jonathan, McCall, Dawn, McRay, Monique, Salvo, Rebecca, Will, Daniel, Xu, Wei, Windsor, Elizabeth, Weeney, Laurel, Pavan, Peter R., Albritton, Ken, Leto, JoAnn, Madow, Brian, Mayor, Lori, Pautler, Scott E., Saxon, Wyatt, Soto, Judy, Goldstein, Burton, Klukoff, Amy, Lambright, Lucy, McDonald, Kim, Ortiz, Maria, Scymanky, Susan, Szalay, Dee Dee, Rao, Narsing, Davis, Tamara, Douglass, Jackie, Linton, Judith, Padilla, Margaret, Ramos, Sylvia, Rao, Narsing A., Aguirre, Alexia, Chong, Lawrence, Cisneros, Lupe, Corona, Elizabeth, Eliott, Dean, Fawzi, Amani, Garcia, Jesse, Khurana, Rahul, Lim, Jennifer, Mead, Rachel, Tsai, Julie H., Vitale, Albert, Bernstein, Paul S., Carlstrom, Bonnie, Gilman, James, Hanseen, Sandra, Morris, Paula, Ramirez, Diana, Wegner, Kimberley, Sheppard, John D., Anthony, Brianne, Casper, Amber, Felix-Kent, Lisa, Fernandez, Jeanette, Johnson, Tari, Scoper, Stephen V., Cole, R. Denise, Crawford, Nancy, Franklin, Lisa, Hamelin, Krista, Martin, Jen, Marx, Rebecca, Schultz, Gregory, Webb, Joseph, Yeager, Pamela, Kim, Rosa Y., Benz, Matthew S., Brown, David M., Chen, Eric, Fish, Richard H., Kegley, Eric, Shawver, Laura, Wong, Tien P., De La Garza, Rebecca, Friday (Hay), Shayla, Rao, P. Kumar, Adcock, Eve, Apte, Rajendra S., Baladenski, Amy, Curtis, Rhonda, Gould, Sarah, Hebden, Amanda, Kambarian, Jamie, Meyer, Charla, Pistorius, Sam, Quinn, Melanie, Rathert, Greg, Blinder, Kevin J., Hartz, Ashley, Light, Pam, Shah, Gaurav K., VanGelder, Russell, Jabs, Douglas A., Altaweel, Michael M., Holbrook, Janet T., Kurinij, Natalie, Brown, Diane, Prusakowski, Nancy, Thorne, Jennifer E., Hubbard, Larry, Wittes, Janet, Barlow, William E., Hochberg, Marc, Lyon, Alice T., Palestine, Alan G., Simon, Lee S., Rosenbaum, James T., Smith, Harmon, Davis, Janet, Thorne, Jennifer, Acharya, Nisha R., Vitale, Albert T., Boring, Jeffrey A., Alexander, Judith, Ng, Wai Ping, Friedman, David S., Adler, Anna, Burke, Alyce, Katz, Joanne, Reed, Susan, Ansari, Husam, Cohen, Nicholas, Modak, Sanjukta, Sugar, Elizabeth A., Burke, Alyce E., Drye, Lea T., Van Natta, Mark L., Frick, Kevin, Katz, JoAnn, Louis, Thomas A., Shade, David, Pascual, Karen, Slutsky-Sanon, Jill S., Allen, Amanda, Glomp, Colby, Hilal, Yasmin, Nieves, Melissa A., Stevens, Maria, Abreu, Francis, Casper, Anne Shanklin, Ewing, Cathleen, Hart, Adante, Lears, Andrea, Li, Shirley, Meinert, Jill, Morrison, Vinnette, Nowakowski, Deborah, Reyes, Girlie, Shade, Dave M., Smith, Jacqueline, Steuernagle, Karen, Van Natta, Mark, Venugopal, Vidya, Yu, Tsung, Chen, Paul, Collins, Karen, Dodge, John, Frick, Kevin D., Jackson, Rosetta, Jimenez, Christian, Landers, Ariel, Livingston, Hope, Meinert, Curtis L., Rayapudi, Sobharani, Shen, Weijiang, Shiflett, Charles, Smith, Rochelle, Tieman, Ada, Tonascia, James A., Zheng, Richard, Allan, James, Benz, Wendy K., Domalpally, Amitha, Johnson, Kristine A., Myers, Dawn J., Won Pak, Jeong, Reimers, James L., Chambers, Geoffrey, Christianson, Debra J., Fleischli, Margaret A., Freund, Jacquelyn, Gama, Vonnie, Gangaputra, Sapna, Glander, Kathleen E., Goulding, Anne, Hafford, Dennis, Harris, Susan E., Hubbard, Larry D., Joyce, Jeffrey M., Kruse, Christina N., Nagle, Lauren, Padden-Lechten, Gwyn E., Pohlman, Alyson, Remm, Amy, Shaw, Ruth A., Sivesind, Peggy, Thayer, Dennis, Treichel, Erika, Warren, Kelly J., Watson, Sheila M., Webster, Mary K., White, James K., Wilhelmson, Tara, Zhang, Grace, and Lightman, Susan L.

Published
2015
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4. Comparison of Retinal Imaging Techniques in Individuals with Pulmonary Artery Hypertension Using Vessel Generation Analysis

Author

DuPont, Mariana, primary, Hunsicker, John, additional, Shirley, Simona, additional, Warriner, William, additional, Rowland, Annabelle, additional, Taylor, Reddhyia, additional, DuPont, Michael, additional, Lagatuz, Mark, additional, Yilmaz, Taygan, additional, Foderaro, Andrew, additional, Lahm, Tim, additional, Ventetuolo, Corey E., additional, and Grant, Maria B., additional

Published
2022
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8. Retinal vessel changes in pulmonary arterial hypertension

Author

DuPont, Mariana, primary, Lambert, Savanna, additional, Rodriguez‐Martin, Antonio, additional, Hernandez, Okaeri, additional, Lagatuz, Mark, additional, Yilmaz, Taygan, additional, Foderaro, Andrew, additional, Baird, Grayson L., additional, Parsons‐Wingerter, Patricia, additional, Lahm, Tim, additional, Grant, Maria B., additional, and Ventetuolo, Corey E., additional

Published
2022
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12. Biological response modifier therapy for refractory childhood uveitis

Author

Gallagher, Michael, Quinones, Karina, Cervantes-Castaneda, Rene Antonio, Yilmaz, Taygan, and Foster, C. Stephen

Subjects
Uveitis -- Care and treatment, Biological response modifiers -- Usage, Biological response modifiers -- Research, Children -- Diseases, Children -- Care and treatment, Health
Published
2007

24. Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema

Author

Jampol, Lee M., primary, Glassman, Adam R., additional, Liu, Danni, additional, Aiello, Lloyd Paul, additional, Bressler, Neil M., additional, Duh, Elia J., additional, Quaggin, Susan, additional, Wells, John A., additional, Wykoff, Charles C., additional, Browning, David, additional, Antoszyk, Andrew N., additional, Price, Angela K., additional, Fredenberg, Sherry L., additional, Herby, Jenna T., additional, Fleming, Christina J., additional, McClain, Ashley A., additional, Ennis, Sarah A., additional, Gallagher, Kelly R., additional, Karow, Angella S., additional, Grupp, Autumn C., additional, Puskas, Danielle, additional, Watson, Lynn, additional, Bojaj, Swann J., additional, Balasubramaniam, Uma M., additional, McClain, Donna, additional, Styles, Donna R., additional, Kuopus, Jeff A., additional, Kimrey, Kathryn, additional, Clark, Loraine M., additional, Jackson, Lisa A., additional, McOwen, Michael D., additional, Dunlap, Matt, additional, Held, Susannah J., additional, Pieramici, Dante J., additional, Nasir, Ma'an A., additional, Castellarin, Alessandro A., additional, Dhoot, Dilsher, additional, Fishbein, Sarah, additional, Giust, Jack, additional, Wan, Lisha, additional, Hanna, Michelle S., additional, Rabena, Melvin D., additional, Smith, Jerry, additional, Bone, Layne J., additional, Avery, Kelly, additional, Giust, Matthew, additional, Walker, Aimee, additional, Shook, Aimee H., additional, Esau, Sara, additional, Ruvalcaba, Nitce L., additional, Clark, W. Lloyd, additional, Johnson, David L., additional, Payne, John F., additional, Swinford, Tiffany R., additional, Taylor, Mallie M., additional, Garrison, Cassandra L., additional, Miller, Peggy D., additional, Houlahan, Amber R., additional, O'Neill, Charlotte A., additional, Floyd, Ashley, additional, Parker, Crystal C., additional, Sease, Courtney, additional, Graham, Tara, additional, Spencer, Robin, additional, Ogbuewu, Tiffany N., additional, Studebaker, Ashley, additional, Huggins, Tyler, additional, Spivey, Robbin, additional, Jones, Brian, additional, Williams, Ashley, additional, Petty, Ron, additional, Poston, Erin L., additional, Ward, G. Michael, additional, Baker, Carl W., additional, Tilford, Ron H., additional, Caldwell, Tracey M., additional, Lambert, Lynnette F., additional, Palmer, Mary J., additional, Martin, Tracey R., additional, Williams, Tana R., additional, Kettler, Samantha, additional, Camp, Alecia B., additional, Silva, Paolo S., additional, Arrigg, Paul G., additional, Sharuk, George S., additional, Shah, Sabera T., additional, Sun, Jennifer K., additional, Westerfeld, Corey, additional, Andreoli, Christopher Michael, additional, Schlossman, Deborah, additional, Murtha, Timothy, additional, Kwak, Hanna, additional, Flores, Flor M., additional, Stockman, Margaret E., additional, Kieser, Troy, additional, Krigman, Michael N., additional, Bestourous, Leila, additional, Weimann, Elizabeth S., additional, Cavallerano, Jerry D., additional, Hock, Kristen M., additional, Robertson, Mary Ann, additional, Kirby, Rita K., additional, Papaconstantinou, Steve L., additional, Madigan, Kylie M., additional, Cavicchi, Robert W., additional, Palitsch, Kate A., additional, Yilmaz, Taygan, additional, Berger, Brian B., additional, Jhaveri, Chirag D., additional, Moore, Tori, additional, Manhart, Ginger J., additional, Walsh, Rachel A., additional, Gunderson, Ivana, additional, Riepen, Dietrich, additional, Bravenec, Chelsey A., additional, Reid, Ryan M., additional, Ren, Yong, additional, Ostrander, Ben, additional, Stovall, Christopher C., additional, Elman, Michael J., additional, Liss, Robert A., additional, Leder, Henry A., additional, Starr, JoAnn, additional, Belz, Jennifer L., additional, Putzulo, Charlene K., additional, Sandler, Dallas R., additional, Simmons, Jennifer L., additional, Singletary, Pamela V., additional, Davis, Ashley, additional, Simpson, Perel M., additional, Coffey, Teresa, additional, Ketner, Daniel J., additional, Cain, Terri, additional, Metzger, Ashley M., additional, Sotirakos, Peter, additional, Marcus, Dennis M., additional, Singh, Harinderjit, additional, Roberts, Courtney N., additional, Floyd, Geri L., additional, Ortiz, Siobhan O., additional, Mims, Virginia, additional, Foster, L. Allison, additional, Coursey, Christy, additional, Gardner, Jared C., additional, Ivey, Ken, additional, O'Keefe, John Stewart, additional, Astruc, Juan A., additional, Schwent, Bryan J., additional, Tabassian, Ali R., additional, Rosen, Suzette A., additional, Vaughan, David C., additional, Michaels, Jeffrey, additional, Arndt, Natalie J., additional, Maziarz, John J., additional, Friedman, Scott M., additional, Moinfar, Nader, additional, Williamson, Kimberly A., additional, Fagan, Damanda F., additional, Dawson, Katrina L., additional, Walters, Paige N., additional, McKinney, Allen, additional, Carlton, Steve, additional, Kwun, Robert C., additional, Knudsen, Victoria L., additional, Winward, Kirk E., additional, Swartz, Mano, additional, Howard, James G., additional, Riley, Michelle, additional, Taylor, Gena, additional, Holt, Michelle, additional, Winward, Jason G., additional, Walsh, Adam, additional, Taylor, Teresa, additional, Walsh, Daniel, additional, Hampton, G. Robert, additional, Brown, Jamin S., additional, Seth, Rajeev K., additional, Sienkiewycz, Laurie J., additional, Appleton, Deborah A., additional, Grinnell, Cindy J., additional, Cowley, Charity A., additional, Kwasniewski, Lynn M., additional, Manley, Michelle L., additional, Robarge, Nicole E., additional, DeSantis, Stefanie R., additional, Hay, Peter B., additional, DeForge, Teresa M., additional, Wong, Tien P., additional, Chen, Eric, additional, Brown, David M., additional, Kim, Rosa Y., additional, Major, James C., additional, Schefler, Amy C., additional, Fish, Richard H., additional, Benz, Matthew S., additional, Lipman, Meredith, additional, Hutson, Amy, additional, Landaverde, Nubia, additional, Chancey, Ashley E., additional, Cone, Cassie, additional, Royse, Tressa, additional, Sneed, Veronica A., additional, Almanza, Belinda A., additional, Dives, Brenda, additional, Richter, Beau A., additional, Kegley, Eric N., additional, Lauer, Andreas K., additional, Flaxel, Christina J., additional, Bailey, Steven T., additional, Schain, Mitchell, additional, Lundquist, Ann D., additional, Hanel, Shelley A., additional, Ira, Shirley D., additional, Nolte, Susan K., additional, Steinkamp, Peter N., additional, Ryan, Dawn M., additional, Pickell, Scott R., additional, Hui, Jocelyn T., additional, Brix, Michelle, additional, Barth, Jordan, additional, Howell, Chris S., additional, Fox, Gregory M., additional, Cooper, Blake A., additional, Batlle, Ivan R., additional, Manning, Lexie R., additional, Batlle, Karla A., additional, Wyrick, Holly, additional, Pippin, Katherine, additional, Perkins, Samantha, additional, Yeager, Frank T., additional, Rush, Ryan B., additional, Gardner, Glenn R., additional, Rush, Christi, additional, Hawkins, Johnathan R., additional, Dumas, Brenda, additional, Ysasaga, Ben, additional, Shah, Chirag P., additional, Morley, Michael G., additional, Wiegand, Torsten W., additional, Cleary, Tina S., additional, Topping, Trexler M., additional, Colegrove, Lindsey, additional, Bechtel, Katharine, additional, Johnson, Britta, additional, Lebedew, Lisa, additional, Lorius, Natacha, additional, Chong, Sandy G., additional, Stone, Jennifer L., additional, Jones, Michael Cullen, additional, Donovan, Dennis, additional, Malone, Sherry, additional, Graham, Margie, additional, Santos, Audrey, additional, Bennett, Steve A., additional, Blinder, Kevin J., additional, Smith, Bradley T., additional, Nobel, Ginny S., additional, Weeks, Rhonda F., additional, Hoehn, Erika A., additional, Stuart, Maria A., additional, Pepple, Kelly E., additional, Boyd, Lynda K., additional, Pulliam, Brook G., additional, Schremp, Steve A., additional, Guevara, Stephanie L., additional, Wehmeier, Jarrod, additional, Wright, Timothy L., additional, Gabel, Dana L., additional, Miller, David G., additional, Schartman, Jerome P., additional, Singerman, Lawrence J., additional, Coney, Joseph M., additional, Novak, Michael A., additional, Rao, Llewelyn J., additional, Rath, Susan C., additional, McNamara, Elizabeth, additional, Stone, Larraine, additional, Smith, Veronica A., additional, Rykena, Cecelia, additional, DuBois, Kimberly A., additional, Ilc, Mary A., additional, Tanner, Vivian, additional, Drury, Kim, additional, Nitzsche, Trina M., additional, Greanoff, Gregg A., additional, DuBois, John C., additional, Burgess, Stuart K., additional, Lara, Tirso M., additional, Pereda, Noel H., additional, Fernandez, Cindy V., additional, Davis, Deborah, additional, Quinchia, Evelyn, additional, Workman, Karen, additional, Nielsen, Jared S., additional, Sohn, Jeong-Hyeon, additional, Alliman, Kyle J., additional, Saggau, David D., additional, Parker, Marianne, additional, George, Bethany, additional, Eastvold, Carrie L., additional, Sells, Kristin, additional, Woehl, Tami Jo, additional, Johnson, Marilyn A., additional, Keenan, Holly, additional, Coleman, Jennifer L., additional, Spillman, Jamie, additional, Freeman, Shannon, additional, Schmidt, Leigh S., additional, Boender, Lisa M., additional, Partin, Jill L., additional, Bennett, Bailey R., additional, Rostvold, Jay, additional, McLure Stone, Cameron, additional, Raymer, Lea R., additional, Menzel, Andrea K., additional, Rickman, Leslie D., additional, Campbell, Barbara, additional, Sherlin, Lorraine P., additional, Hawkins, Lisa H., additional, Buckner, Melissa L., additional, Matsipura, Olesya N., additional, Price, Paula A., additional, Ghuman, A. Thomas, additional, Raskauskas, Paul A., additional, Sharma, Ashish G., additional, Wing, Glenn, additional, Walker, Joseph P., additional, Knips, Eileen, additional, Kiesel, Cheryl, additional, Peters, Crystal Y., additional, Ryan, Cheryl, additional, Greenhoe, Laura, additional, Torres, Natalie N., additional, Youngblood, Rebecca J., additional, Turnbo, Danielle, additional, Leslie, Anita H., additional, Schoeman, Etienne C., additional, Kiesel, Raymond K., additional, Kingsley, Ronald M., additional, Shah, Vinay A., additional, Leonard, Robert E., additional, Miller, Heather R., additional, Icks, Sonny, additional, Bergman, Vanessa A., additional, Drummond, Vanessa K., additional, Ross, Brittany L., additional, Ellis, Reshial D., additional, Whittington, Tina R., additional, Almeida, Shannon R., additional, Butt, Amanda M., additional, Burris, Russ, additional, Peters, Mark A., additional, Lee, Michael S., additional, Tlucek, Paul S., additional, Ma, Colin, additional, Hobbs, Stephen, additional, Milliron, Amanda C., additional, Ho, Stephanie L., additional, Kopfer, Marcia, additional, Logan, Joe, additional, Hoerner, Christine, additional, Khawly, Joseph A., additional, Rahman, Hassan T., additional, Abdelgani, Diana, additional, Miller, Pam S., additional, Fredrickson, Debbie, additional, Pineda, Erica, additional, Lopez, Desiree, additional, Lowd, Donald K., additional, Blank, Colin, additional, Martinez, Lorena R., additional, Muniz, Jason E., additional, Gottlieb, Justin, additional, Ip, Michael S., additional, Blodi, Barbara A., additional, Dietzman, Kristine A., additional, Burke, Kathryn F., additional, Smith, Christopher M., additional, Olson, Shelly R., additional, Wealti, Angela M., additional, Reed, Sandie L., additional, Krolnik, Denise A., additional, Peterson, John C., additional, Gonzalez, Victor Hugo, additional, Diaz-Rohena, Roberto, additional, Santiago, Juan G., additional, Adyanthaya, Rohit, additional, Patel, Nehal R., additional, Anaya, Deyla, additional, Garcia, Dina, additional, Cruz, Edna E., additional, Alvarez, Crystal A., additional, Iracheta, Ruth, additional, Rodriguez, Jessica, additional, Cantu, Monica R., additional, Flores, Rebecca R., additional, Jasso, Hector, additional, Rodriguez, Rachel, additional, Miranda, Karina, additional, Lozano, Krystle R., additional, Garza, Maricela, additional, Aguero, Lazaro, additional, Sandoval, Amanda L., additional, Montemayor, Monique, additional, Alonso, Samuel, additional, Garza, Santos, additional, DiLoreto, David Allen, additional, Ramchandran, Rajeev S., additional, Kleinman, David M., additional, O'Gara, George W., additional, Czubinski, Andrea M., additional, MacDowell, Peter, additional, Steinmetz, Kari M., additional, Castillo, Dan A., additional, Yu, Yvonne F., additional, Tongue, Salina M., additional, Keim, Melissa S., additional, Hollar, Rachel, additional, Deats, Brandi N., additional, Richardson, Brittany S., additional, Singer, Lynn, additional, Pannell, Taylor A., additional, Daniels, Stewart A., additional, Ranchod, Tushar M., additional, Leong, Craig J., additional, Touson, Stacey, additional, Earl, Shannon R., additional, Bartlett, Melissa C., additional, Fernando, Christine, additional, Factor, Djorella, additional, Garcia, Jessica, additional, Nguyen, Anna K., additional, Hom, Betty, additional, Walker, Cathy, additional, Marudo, Grace M., additional, Suazo, Jose Carlos, additional, McNeil, Leah M., additional, Hanamoto, Fred, additional, Hughes, Matthew D., additional, Ross, Robin D., additional, Sanford, Susan M., additional, Markiewicz, Nicole Martini, additional, Utley, Tracy M., additional, Henderson, Shannon, additional, Lippincott, Joanie H., additional, Streasick, Patricia, additional, Glazer, Louis C., additional, Garber, Frank W., additional, Zheutlin, Jeffrey D., additional, Listerman, Angela D., additional, Feehan, Christine E., additional, Cruz, Heather L., additional, Kuitula, Donald E., additional, Rainey, Olivia P., additional, Weatherbee, Sue, additional, Googe, Joseph M., additional, Shuler, R. Keith, additional, Anderson, Nicholas G., additional, Perkins, Stephen L., additional, Oliver, Kristina, additional, Grindall, Nicole, additional, Arnold, Ann, additional, Beerbower, Jennifer, additional, Hunt, Cecile, additional, Schulz, Kathy L., additional, Oelrich, Sarah M., additional, Whetstone, Jerry K., additional, Walsh, Justin, additional, Morris, Chris, additional, Wong, Robert W., additional, Nixon, Peter A., additional, Leon, Jeni L., additional, Montesclaros, Chris A., additional, Leung, Carrie E., additional, Le, Phill, additional, Harborth, Codey L., additional, Rodriguez, Margaret A., additional, Mangham, Cory, additional, Aaberg, Thomas M., additional, Westhouse, Scott J., additional, Vincent, Holly L., additional, Malone, Rebecca, additional, Karsten, Kathy L., additional, Maturi, Raj K., additional, Harless, Ashley M., additional, Novak, Carolee K., additional, Bleau, Laura A., additional, Steele, Thomas, additional, Harris, Charlotte, additional, Bildner, Alisha, additional, Maple, Abby, additional, Stone, Thomas W., additional, Isernhagen, Rick D., additional, Kitchens, John W., additional, Holcomb, Diana M., additional, Van Arsdall, Jeanne, additional, Buck, Michelle, additional, Slade, Edward A., additional, Chiu, Mark T., additional, Reddy, Ashok K., additional, Wyant, Frank W., additional, Montano-Niles, Mary M., additional, Carter, Lorraine J., additional, Maerki, Shirley, additional, Tartaglia, Laura, additional, Gomez, Paul P., additional, Maestas, Stephen A., additional, Shanta, Camille, additional, Jimenez, Lisbrenda M., additional, Stoltz, Robert A., additional, Vanderveldt, Stephanie L., additional, Lampert, Scott I., additional, Marcus, Leslie G., additional, Fulbright, Shelly, additional, Martin, James P., additional, Novack, Roger L., additional, Liao, David S., additional, Lo, Tammy Eileen, additional, Kurokouchi, Janet, additional, Ngo, Richard, additional, Hoang, Connie V., additional, Sierra, Julio, additional, Zamboni, Adam, additional, Protacio, Eric G., additional, Kessinger, Jeff, additional, Garg, Seema, additional, Houghton, Odette M., additional, Ulrich, Jan Niklas, additional, Chavala, Sai H., additional, DuBose, Elizabeth L., additional, Barnhart, Cassandra J., additional, Karmalkar, Megha, additional, Jani, Pooja D., additional, Goble, Justin, additional, Cantrell, Debra, additional, Esquejo, Rona Lyn, additional, Shah, Sandeep N., additional, Harmon, Natasha, additional, Dhalla, Mandeep S., additional, del Cid, Mario R., additional, Halperin, Lawrence S., additional, Brady, Jaclyn A., additional, Hamlin, Monica, additional, Lopez, Monica L., additional, Mariano, Jamie, additional, Neale, Candace M., additional, Veksler, Rita R., additional, Mannarelli, Angelica, additional, Coffee, Robert E., additional, Carvounis, Petros Euthymiou, additional, Hemati, Pejman, additional, Dorenbach, Cindy J., additional, Joshi, Annika S., additional, Leger, April, additional, Barnett, Dana B., additional, Morales, Joseph F., additional, Mansour, Sam E., additional, Choyce, Cathy, additional, Dirawatun, Aissa L., additional, Nagy, Emma A., additional, Kerkstra, Jamie C., additional, Fan, Joseph T., additional, Suthar, Mukesh Bhogilal, additional, Rauser, Michael E., additional, Santiago, Gisela, additional, Marvyn Cerdenio, Liel, additional, Perez, Brandi J., additional, Halsey, Kara E., additional, Kiernan, William H., additional, Knabb, Jesse, additional, Catren, Rachel, additional, Shami, Michel, additional, Arrington, Brenda K., additional, Neuling, Keri S., additional, Meeks, Ashaki, additional, Garcia, Natalie R., additional, Blair, Kayla, additional, Rhymes, Ginger K., additional, Medrano, Janet, additional, Kim, Judy E., additional, Weinberg, David V., additional, Stepien, Kimberly E., additional, Connor, Thomas B., additional, Williams, Vesper V., additional, Kaczanowski, Tracy L., additional, Packard, Krissa L., additional, Flanders, Judy, additional, Barwick, Vicki, additional, Winter, Pat A., additional, Beringer, Joseph R., additional, Selchert, Kathy J., additional, Lehr, John T., additional, Rodriguez-Roman, Elaine, additional, Jones, Teri, additional, Haddox, Martha Eileen, additional, Pena, Mark, additional, Hernandez, Brenda, additional, Chan, Clement K., additional, Lalezary, Maziar, additional, Lin, Steven G., additional, Walther, Kimberly S., additional, Gonzales, Tiana, additional, Myers, Lenise E., additional, Huff, Kenneth M., additional, Chace, Richard, additional, Kallay, Sunny, additional, Stevens, Kirsten, additional, Dolbec, Nicole, additional, Baker-Hill, Ronda, additional, Surette, Janea, additional, Rose, Steven J., additional, Connolly, Brian P., additional, Guillet, Ernest G., additional, Hall, Edward F., additional, Yagoda, Margaret M., additional, Doran, Mary Jo, additional, Burgess, Mindy, additional, Reynard, Ann, additional, Powers, Margaret, additional, Territo, Joe, additional, Mein, Calvin E., additional, Chica, Moises A., additional, Lane, R. Gary, additional, Holy, Sarah Elizabeth, additional, Kirschbaum, Lita, additional, Martinez, Vanessa D., additional, Baker, Jaynee, additional, Kincaid, Christa G., additional, Castillo, Elaine, additional, Wienecke, Christopher Sean, additional, Schlichting, Sara L., additional, Nakoski, Brenda, additional, Diddie, Kenneth R., additional, Cadwell, Deborah M., additional, Van Arsdale, Louise, additional, Boisvert, Taryn F., additional, Galonsky, Joyce, additional, O'Hayer, Susie, additional, Johnson, Melissa L., additional, McCabe, Frank J., additional, Baker, Brad J., additional, Defrin, Melvyn H., additional, Lampson, Marie V., additional, Pratte, Heather, additional, Baron, Selena A., additional, Borelli, Aundrea S., additional, Davidorf, Frederick H., additional, Wells, Michael B., additional, Chang, Susie, additional, Christoforidis, John Byron, additional, Letson, Alan D., additional, Salerno, Jill A., additional, Perry, Jerilyn G., additional, Shelley, Stephen E., additional, Fish, Patrick J., additional, Scott, Michael H., additional, Dixon, James A., additional, Walsh, Shannon R., additional, Ozpirincci, Philomina M., additional, Tebon, Brenda L., additional, Moyle, Marcia J., additional, Pavlica, Michael R., additional, Matta, Noelle S., additional, Brubaker, Cristina M., additional, Backer, Alyson B., additional, Bhagat, Neelakshi, additional, Fay, Catherine, additional, Mikheyeva, Tatiana, additional, Lazar, Michael, additional, Ellenberger, Janie D., additional, Malpica, Beth, additional, Brucker, Alexander J., additional, Kim, Benjamin J., additional, VanderBeek, Brian L., additional, Drossner, Sheri, additional, DuPont, Joan C., additional, Salvo, Rebecca, additional, Engelhard, Stephanie B., additional, Berger, Jim M., additional, Morales, Sara, additional, Serpentine, Beth, additional, Kaufman, Paul L., additional, McCluskey, Jessica D., additional, Wynne, Kathy T., additional, Jordan, Julian, additional, Watson, Brandun, additional, Wirthlin, Robert S., additional, Guglielmo, Eric S., additional, Dittman, Eileen A., additional, Waidelich, Dylan C., additional, Garza, Cristofer J., additional, Stone, Adeline M., additional, Oakes, Ashley Nicole, additional, Suner, Ivan J., additional, Hammer, Mark E., additional, Peden, Marc C., additional, Traynom, Janet R., additional, DenBoer, Rochelle, additional, Vargo, Heidi, additional, Ramsey, Susan, additional, Malzahn, Anita Kim, additional, Jeffres, Debra, additional, Chaudhry, Nauman A., additional, Shah, Sumit P., additional, Haffner, Gregory M., additional, German, Emiliya, additional, Moreau, Shannan, additional, Fox, Laura A., additional, Matteson, Jennifer M., additional, Pelletier, JoAnna L., additional, Fontecchio, Alison, additional, Morse, Emily, additional, McNamara, Greg, additional, Laglivia, Marie Grace, additional, Scherf, Marissa L., additional, LaPre, Angela, additional, Cocilo, Justin A., additional, Das, Arup, additional, Friesen, Linda, additional, Franco, Michele, additional, Lucero, Johnny, additional, Frazier, Melissa, additional, Laviolette, Robert, additional, Mian, Umar Khalil, additional, Riemer, Rebecca L., additional, Koestenblatt, Evelyn, additional, Wolf, Louise V., additional, Kim, Christine, additional, Katkovskaya, Irina, additional, Otoo, Erica, additional, Ellerbe, Kevin A., additional, Boyd, Kenneth, additional, Costa, Caroline, additional, Edwards, Paul Andrew, additional, Gao, Hua, additional, Hessburg, Thomas, additional, Desai, Uday, additional, Murphy, Janet, additional, Monk, Mary K., additional, Hall, Julianne, additional, Mazurek, Melina, additional, Ventimiglia, Katie M., additional, Rusinek, Brian A., additional, Stern, Bradley A., additional, Brouhard, Kris, additional, Weier, Katie M., additional, Allis, Megan, additional, Shaken, Jenny, additional, Massu, Nicole M., additional, Troszak, Tracy A., additional, Burley, David, additional, Bhavsar, Abdhish R., additional, Emerson, Geoffrey G., additional, Jones, Jacob M., additional, Anderson, Tracy A., additional, Gilchrist, Andrea, additional, Peloquin, Matt D., additional, Gaid, Gaid, additional, Vang, Yang, additional, Ryan, Samantha, additional, Vang, Denise, additional, Evans, Alanna C., additional, Scherer, Tonja, additional, Lazarus, Howard S., additional, Bunch, Debra Paige, additional, Davis, Liana C., additional, Booth, Kelly, additional, Trimble, Margaret, additional, Bledsaw, Mary A., additional, Moore, Jay, additional, Rosberger, Daniel F., additional, Groeschel, Sandra, additional, Madry, Miriam A., additional, DiGirolamo, Nikoletta, additional, Pressley, Dustin, additional, Santora, Robert, additional, Gomez, Yenelda M., additional, Olsen, Karl R., additional, Bergren, Robert L., additional, Conrad, P. William, additional, Rath, Pamela P., additional, Vyas, Avni Patel, additional, Liu, Judy C., additional, Merlotti, Lori A., additional, Chamberlin, Jennifer L., additional, Mechling, Holly M., additional, Kelly, Mary E., additional, Marfisi, Kellianne, additional, Yeckel, Kimberly A., additional, Bennett, Veronica L., additional, Schultz, Christina M., additional, Rigoni, Grace A., additional, Walter, Julie, additional, Forish, Missy A., additional, Fec, Amanda, additional, Foreman, Courtney L., additional, Steinberg, David, additional, McBroom, Keith D., additional, Chen, Melvin C., additional, Levy, Marc H., additional, Torres, Waldemar, additional, Jelemensky, Peggy, additional, Raphael, Tara L., additional, Rich, Joann, additional, Sneath, Mark, additional, Kinyoun, James L., additional, Vemulakonda, Gurunadh Atmaram, additional, Rath, Susan A., additional, Ernst, Patricia K., additional, Pettingill, Juli A., additional, Jones, Ronald C., additional, Clifton, Brad C., additional, Leslie, James D., additional, Solomon, Sharon D., additional, Levin, Lisa K., additional, Donohue, Deborah, additional, Frey, Mary, additional, Larez, Lorena, additional, Murray, Keisha, additional, Denbow, Rita L., additional, Graul, Janis, additional, Emmert, David, additional, Herring, Charles, additional, Rhoton, Nick, additional, Belz, Joe, additional, Lyon, Alice T., additional, Mirza, Rukhsana G., additional, Krug, Amanda M., additional, Ramirez, Carmen, additional, Kaminski, Lori, additional, Castro-Malek, Anna Liza M., additional, Mills, Amber N., additional, Rozenbajgier, Zuzanna, additional, Skelly, Marriner L., additional, Simjanoski, Evica, additional, Degillio, Andrea R., additional, Lim, Jennifer I., additional, Chau, Felix Y., additional, Niec, Marcia, additional, Johnson, Tametha, additional, Ovando, Yesenia, additional, Janowicz, Mark, additional, Carroll, Catherine, additional, Gross, Jeffrey G., additional, Fishburne, Barron C., additional, Flowers, Amy M., additional, Stroman, Riley, additional, Ochieng, Christen, additional, McDowell, Angelique S.A., additional, Paul, Ally M., additional, Price, Randall L., additional, Drouilhet, John H., additional, Lacaden, Erica N., additional, Nobler, Deborah J., additional, Cummings, Howard L., additional, Long, Deanna Jo, additional, McCord, Ben, additional, Robinson, Jason, additional, Swift, Jamie, additional, Maynard, Julie P., additional, Pahk, Patricia J., additional, Palmer-Dwore, Hannah, additional, Dave, Dipali H., additional, Pacheco, Mariebelle, additional, Galati, Barbara A., additional, Simpson, Eneil, additional, Barkmeier, Andrew J., additional, Vogen, Diane L., additional, Berg, Karin A., additional, Howard, Shannon L., additional, Burrington, Jean M., additional, Morgan, Jessica Ann, additional, Overend, Joan T., additional, Goddard, Shannon, additional, Lewison, Denise M., additional, Tesmer, Jaime L., additional, Greven, Craig Michael, additional, Fish, Joan, additional, Everhart, Cara, additional, Clark, Mark D., additional, Miller, David T., additional, Hubbard, George Baker, additional, Yan, Jiong, additional, Cribbs, Blaine E., additional, Curtis, Linda T., additional, Brower, Judy L., additional, Dobbs, Jannah L., additional, Jordan, Debora J., additional, Ahmad, Baseer U., additional, Huang, Suber S., additional, Sedlacek, Hillary M., additional, Hornsby, Cherie L., additional, Ferguson, Lisa P., additional, Carlton, Kathy, additional, Sholtis, Kelly A., additional, Allchin, Peggy, additional, Clow, Claudia, additional, Harrod, Mark A., additional, Pankhurst, Geoffrey, additional, Baum-Rawraway, Irit, additional, Hrvatin, Stacie A., additional, Gentile, Ronald C., additional, Yang, Alex, additional, Carrasquillo-Boyd, Wanda, additional, Masini, Robert, additional, Samy, Chander N., additional, Kraut, Robert J., additional, Shirley, Kathy, additional, Corso, Linsey, additional, Ely, Karen, additional, Scala, Elizabeth, additional, Gross, Stewart, additional, Alava, Vanessa, additional, Margalit, Eyal, additional, Neely, Donna G., additional, Blaiotta, Maria, additional, Hagensen, Lori, additional, Harris, April E., additional, Lennon, Rita L., additional, Cota, Denice R., additional, Wilson, Larry, additional, Aiello, Lloyd P., additional, Beck, Roy W., additional, Bressler, Susan B., additional, Chalam, Kakarla V., additional, Danis, Ronald P., additional, Arnold-Bush, Bambi J., additional, Ferris, Frederick, additional, Almukhtar, Talat, additional, Dale, Brian B., additional, Baptista, Alyssa, additional, Connor, Crystal, additional, Conner, Jasmine, additional, Constantine, Sharon R., additional, Dowling, Kimberly, additional, Dupre, Simone S., additional, Ayala, Allison R., additional, Huggins, Meagan L., additional, Inusah, Seidu, additional, Johnson, Paula A., additional, Loggins, Brenda L., additional, McClellan, Shannon L., additional, Melia, Michele, additional, Battle, Eureca, additional, Stockdale, Cynthia R., additional, Stanley, Danielle, additional, Jaffe, Glenn, additional, Balsley, Brannon, additional, Barbas, Michael, additional, Burns, Russell, additional, Busian, Dee, additional, Ebersohl, Ryan, additional, Heydary, Cynthia, additional, McEwan, Sasha, additional, Myers, Justin, additional, Robertson, Amanda, additional, Shields, Kelly, additional, Thompson, Garrett, additional, Winter, Katrina, additional, Young, Ellen, additional, Davis, Matthew D., additional, Huang, Yijun, additional, Blodi, Barbara, additional, Domalpally, Amitha, additional, Reimers, James, additional, Vargo, Pamela, additional, Wabers, Hugh, additional, Myers, Dawn, additional, Lawrence, Daniel, additional, Allan, James, additional, Jampol, Lee M., additional, Antoszyk, Andrew, additional, Friedman, Scott, additional, Scott, Ingrid U., additional, Schron, Eleanor, additional, Everett, Donald F., additional, Miskala, Päivi H., additional, Connett, John, additional, Abrams, Gary, additional, Barnbaum, Deborah R., additional, Flynn, Harry, additional, Weinstock, Ruth S., additional, Wilkinson, Charles P., additional, Wisniewski, Stephen, additional, Genuth, Saul, additional, Frank, Robert, additional, Ferris, Frederick L., additional, Jaffe, Glenn J., additional, Bhavsar, Abdhish, additional, Googe, Joseph, additional, Lauer, Andreas, additional, and McClain, Ashley, additional

Published
2018
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25. Localized bi-nasal macular edema in optic chiasmal syndrome

Author

Lavaque, Alejandro, Yilmaz, Taygan, and Cordero-Coma, Miguel

Subjects
Blindness -- Diagnosis -- Case studies -- Risk factors, Eye diseases -- Diagnosis -- Case studies -- Care and treatment -- Patient outcomes, Health
Abstract

Byline: Alejandro. Lavaque, Taygan. Yilmaz, Miguel. Cordero-Coma A 28-year-old healthy male complaining of vision loss in his right eye was discovered to have localized bi-nasal macular edema in the presence [...]

Published
2013

27. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Kempen, John H., primary, Van Natta, Mark L., additional, Altaweel, Michael M., additional, Dunn, James P., additional, Jabs, Douglas A., additional, Lightman, Susan L., additional, Thorne, Jennifer E., additional, Holbrook, Janet T., additional, Jaffe, Glenn J., additional, Branchaud, Brenda, additional, Hahn, Paul, additional, Koreen, Larry, additional, Lad, Eleonora (Nora) M., additional, Lin, Phoebe, additional, Martel, Joseph Nissim, additional, Serrano, Neha (Shah), additional, Skalak, Cindy, additional, Vajzovic, Lejla, additional, Baer, Claxton, additional, Bryant, Joyce, additional, Chavala, Sai, additional, Cusick, Michael, additional, Day, Shelley, additional, Dayani, Pouya, additional, Ehlers, Justis, additional, Kesen, Muge, additional, Lee, Annie, additional, Melamud, Alex, additional, Qureshi, Jawad A., additional, Scott, Adrienne Williams, additional, See, Robert F., additional, Shuler, Robert K., additional, Wood, Megan, additional, Yeh, Steven, additional, Fernandes, Alcides, additional, Gibbs, Deborah, additional, Leef, Donna, additional, Martin, Daniel F., additional, Srivastava, Sunil, additional, Begum, Hosne, additional, Boring, Jeff, additional, Brotherson, Kristen L., additional, Burkholder, Bryn, additional, Butler, Nicholas J., additional, Cain, Dennis, additional, Cook, Mary A., additional, Emmert, David, additional, Graul, Janis R., additional, Herring, Mark, additional, Laing, Ashley, additional, Leung, Theresa G., additional, Mahon, Michael C., additional, Moradi, Ahmafreza, additional, Nwankwo, Antonia, additional, Ostheimer, Trucian L., additional, Reed, Terry, additional, Arnold, Ellen, additional, Barnabie, Patricia M., additional, Belair, Marie-Lynn, additional, Bolton, Stephen G., additional, Brodine, Joseph B., additional, Brown, Diane M., additional, Brune, Lisa M., additional, Galor, Anat, additional, Gan, Theresa, additional, Jacobowitz, Adam, additional, Kapoor, Meera, additional, Kedhar, Sanjay, additional, Kim, Stephen, additional, Leder, Henry A., additional, Livingston, Alison G., additional, Morton, Yavette, additional, Nolan, Kisten, additional, Peters, George B., additional, Soto, Priscilla, additional, Stevenson, Ricardo, additional, Tarver-Carr, Michelle, additional, Wang, Yue, additional, Foster, C. Stephen, additional, Anesi, Stephen D., additional, Bruner, Linda, additional, Ceron, Olga, additional, Hinkle, David M., additional, Persons, Nancy, additional, Wentworth, Bailey, additional, Acevedo, Sarah, additional, Anzaar, Fahd, additional, Cesca, Tom, additional, Contero, Angelica, additional, Fitzpatrick, Kayleigh, additional, Goronga, Faith, additional, Johnson, Jyothir, additional, Lebron, Karina Q., additional, Marvell, Danielle, additional, Morgan, Chandra, additional, Patel, Nita, additional, Pinto, Jennifer, additional, Siddique, Sana S., additional, Sprague, Janet, additional, Yilmaz, Taygan, additional, Sen, H. Nida, additional, Bono, Michael, additional, Cunningham, Denise, additional, Hayes, Darryl, additional, Koutsandreas, Dessie, additional, Nussenblatt, Robert B., additional, Sherry, Patti R., additional, Short, Gregory L., additional, Smith, Wendy, additional, Temple, Alana, additional, Bamji, Allison, additional, Coleman, Hanna, additional, Davuluri, Geetaniali, additional, Faia, Lisa, additional, Gottlieb, Chloe, additional, Jirawuthiworavong, Guy V., additional, Lew, Julie C., additional, Mercer, Richard, additional, Obiyor, Dominic, additional, Perry, Cheryl H., additional, Potapova, Natalia, additional, Weichel, Eric, additional, Wroblewski, Keith J., additional, Latkany, Paul A., additional, Coonan, Corinne, additional, Honda, Andrea, additional, Lorenzo-Latkany, Monica, additional, Masini, Robert, additional, Morell, Susan, additional, Nguyen, Angela, additional, Badamo, Jason, additional, Boyd, Kenneth M., additional, Enos, Matthew, additional, Gallardo, Jenny, additional, Jarczynski, Jacek, additional, Lee, Ji Yun, additional, McGrosky, Mirjana, additional, Nour, Ann, additional, Sanchez, Meredith, additional, Steinberg, Kate, additional, Stawell, Richard J., additional, Breayley, Lisa, additional, D'Sylva, Carly, additional, Glatz, Elizabeth, additional, Hodgson, Lauren, additional, Lim, Lyndell, additional, Ling, Cecilia, additional, McIntosh, Rachel, additional, Morrison (Ewing), Julie, additional, Newton, Andrew, additional, Sanmugasundram, Sutha, additional, Smallwood, Richard, additional, Zamir, Ehud, additional, Hunt, Nicola, additional, Jones, Lisa, additional, Koukouras, Ignatios, additional, Williams, Suzanne, additional, Merrill, Pauline T., additional, Carns, Danielle, additional, Richine, Len, additional, Voskuil-Marre, Denise L., additional, Woo, Kisung, additional, Gaynes, Bruce, additional, Giannoulis, Christina, additional, Hulvey, Pam, additional, Kernbauer, Elaine, additional, Khan, Heena S., additional, Levine, Sarah J., additional, Toennessen, Scott, additional, Tonner, Eileen, additional, Wang, Robert C., additional, Aguado, Hank, additional, Arceneaux, Sally, additional, Duignan, Karen, additional, Fish, Gary E., additional, Hesse, Nick, additional, Jaramillo, Diana, additional, Mackens, Michael, additional, Arnwine, Jean, additional, Callanan, David, additional, Cummings, Kimberly, additional, Gray, Keith, additional, Howden, Susie, additional, Mutz, Karin, additional, Sanchez, Brenda, additional, Lightman, Susan, additional, Ismetova, Filis, additional, Prytherch, Ashley, additional, Seguin-Greenstein, Sophie, additional, Tomkins, Oren, additional, Bar, Asat, additional, Edwards, Kate, additional, Joshi, Lavanish, additional, Moraji, Jiten, additional, Samy, Ahmed, additional, Stubbs, Timothy, additional, Taylor, Simon, additional, Towler, Hamish, additional, Tronnberg, Rebecca, additional, Holland, Gary N., additional, Almanzor, Robert D., additional, Castellanos, Jose, additional, Hubschman, Jean Pierre, additional, Johiro, Ann K., additional, Kukuyev, Alla, additional, Levinson, Ralph D., additional, McCannel, Colin A., additional, Ransome, Susan S., additional, Gonzales, Christine R., additional, Gupta, Anurag, additional, Kalyani, Partho S., additional, Kapamajian, Michael A., additional, Kappel, Peter J., additional, Arcinue, Cheryl, additional, Chuang, Janne, additional, Barteselli, Giulio, additional, Currie, Glenn, additional, Mendoza, Veronica, additional, Powell, Debbie, additional, Clark, Tom, additional, Cochran, Denine E., additional, Freeman, William R., additional, Hedaya, Joshua, additional, Kemper, Tiara, additional, Kozak, Igor, additional, LeMoine, Jacqueline M., additional, Loughran, Megan E., additional, Magana, Luzandra, additional, Mojana, Francesca, additional, Morrison, Victoria, additional, Nguyen, Vivian, additional, Oster, Stephen F., additional, Acharya, Nisha, additional, Clay, David, additional, Lee, Salena, additional, Lew, Mary, additional, Margolis, Todd P., additional, Stewart, Jay, additional, Wong, Ira G., additional, Brown, Debra, additional, Khouri, Claire M., additional, Goldstein, Debra A., additional, Birnbaum, Andrea, additional, Degillio, Andrea, additional, Rosa, Gemma De la, additional, Ramirez, Carmen, additional, Simjanowski, Evica, additional, Skelly, Mariner, additional, Castro-Malek, Anna L., additional, Crooke, Catherine E., additional, Huntley, Melody, additional, Nash, Katrina, additional, Niec, Marcia, additional, Pyatetsky, Dimitry, additional, Ramirez, Misel, additional, Rozenbajgier, Zuzanna, additional, Tessler, Howard H., additional, Davis, Janet L., additional, Albini, Thomas A., additional, Chin, Marie, additional, Castaño, Daniela, additional, Elizondo, Ariana, additional, Ho, Macy, additional, Kovach, Jaclyn L., additional, Lin, Richard C-S., additional, Mandelcorn, Efrem, additional, Nguyen, Jackie K-D., additional, Pacini, Aura, additional, Pineda, Susan, additional, Pinto, David A., additional, Rebimbas, Jose, additional, Stepien, Kimberly E., additional, Teran, Claudia, additional, Elner, Susan G., additional, Bernard, Hillary, additional, Fournier, Linda, additional, Godsey, Lindsay, additional, Goings, Linda, additional, Hackel, Richard, additional, Hesselgrave, Moella, additional, Jayasundera, K. Thiran, additional, Prusak, Robert, additional, Titus, Pamela, additional, Bergeron, Melissa, additional, Blosser, Reneé, additional, Brown, Rebecca, additional, Chrisman-McClure, Carrie, additional, Gothrup, Julie R., additional, Saxe, Stephen J., additional, Sizemore, Deanna, additional, Kempen, John H., additional, Berger, James, additional, Drossner, Sheri, additional, DuPont, Joan C., additional, Maguire, Albert M., additional, Petner, Janice, additional, Engelhard, Stephanie, additional, Hopkins, Tim, additional, Lo, Jonathan, additional, McCall, Dawn, additional, McRay, Monique, additional, Salvo, Rebecca, additional, Will, Daniel, additional, Xu, Wei, additional, Windsor, Elizabeth, additional, Weeney, Laurel, additional, Pavan, Peter R., additional, Albritton, Ken, additional, Leto, JoAnn, additional, Madow, Brian, additional, Mayor, Lori, additional, Pautler, Scott E., additional, Saxon, Wyatt, additional, Soto, Judy, additional, Goldstein, Burton, additional, Klukoff, Amy, additional, Lambright, Lucy, additional, McDonald, Kim, additional, Ortiz, Maria, additional, Scymanky, Susan, additional, Szalay, Dee Dee, additional, Rao, Narsing, additional, Davis, Tamara, additional, Douglass, Jackie, additional, Linton, Judith, additional, Padilla, Margaret, additional, Ramos, Sylvia, additional, Rao, Narsing A., additional, Aguirre, Alexia, additional, Chong, Lawrence, additional, Cisneros, Lupe, additional, Corona, Elizabeth, additional, Eliott, Dean, additional, Fawzi, Amani, additional, Garcia, Jesse, additional, Khurana, Rahul, additional, Lim, Jennifer, additional, Mead, Rachel, additional, Tsai, Julie H., additional, Vitale, Albert, additional, Bernstein, Paul S., additional, Carlstrom, Bonnie, additional, Gilman, James, additional, Hanseen, Sandra, additional, Morris, Paula, additional, Ramirez, Diana, additional, Wegner, Kimberley, additional, Sheppard, John D., additional, Anthony, Brianne, additional, Casper, Amber, additional, Felix-Kent, Lisa, additional, Fernandez, Jeanette, additional, Johnson, Tari, additional, Scoper, Stephen V., additional, Cole, R. Denise, additional, Crawford, Nancy, additional, Franklin, Lisa, additional, Hamelin, Krista, additional, Martin, Jen, additional, Marx, Rebecca, additional, Schultz, Gregory, additional, Webb, Joseph, additional, Yeager, Pamela, additional, Kim, Rosa Y., additional, Benz, Matthew S., additional, Brown, David M., additional, Chen, Eric, additional, Fish, Richard H., additional, Kegley, Eric, additional, Shawver, Laura, additional, Wong, Tien P., additional, De La Garza, Rebecca, additional, Friday (Hay), Shayla, additional, Rao, P. Kumar, additional, Adcock, Eve, additional, Apte, Rajendra S., additional, Baladenski, Amy, additional, Curtis, Rhonda, additional, Gould, Sarah, additional, Hebden, Amanda, additional, Kambarian, Jamie, additional, Meyer, Charla, additional, Pistorius, Sam, additional, Quinn, Melanie, additional, Rathert, Greg, additional, Blinder, Kevin J., additional, Hartz, Ashley, additional, Light, Pam, additional, Shah, Gaurav K., additional, VanGelder, Russell, additional, Kurinij, Natalie, additional, Brown, Diane, additional, Prusakowski, Nancy, additional, Hubbard, Larry, additional, Wittes, Janet, additional, Barlow, William E., additional, Hochberg, Marc, additional, Lyon, Alice T., additional, Palestine, Alan G., additional, Simon, Lee S., additional, Rosenbaum, James T., additional, Smith, Harmon, additional, Davis, Janet, additional, Thorne, Jennifer, additional, Acharya, Nisha R., additional, Vitale, Albert T., additional, Boring, Jeffrey A., additional, Alexander, Judith, additional, Ng, Wai Ping, additional, Friedman, David S., additional, Adler, Anna, additional, Burke, Alyce, additional, Katz, Joanne, additional, Reed, Susan, additional, Ansari, Husam, additional, Cohen, Nicholas, additional, Modak, Sanjukta, additional, Sugar, Elizabeth A., additional, Burke, Alyce E., additional, Drye, Lea T., additional, Frick, Kevin, additional, Katz, JoAnn, additional, Louis, Thomas A., additional, Shade, David, additional, Pascual, Karen, additional, Slutsky-Sanon, Jill S., additional, Allen, Amanda, additional, Glomp, Colby, additional, Hilal, Yasmin, additional, Nieves, Melissa A., additional, Stevens, Maria, additional, Abreu, Francis, additional, Casper, Anne Shanklin, additional, Ewing, Cathleen, additional, Hart, Adante, additional, Lears, Andrea, additional, Li, Shirley, additional, Meinert, Jill, additional, Morrison, Vinnette, additional, Nowakowski, Deborah, additional, Reyes, Girlie, additional, Shade, Dave M., additional, Smith, Jacqueline, additional, Steuernagle, Karen, additional, Van Natta, Mark, additional, Venugopal, Vidya, additional, Yu, Tsung, additional, Chen, Paul, additional, Collins, Karen, additional, Dodge, John, additional, Frick, Kevin D., additional, Jackson, Rosetta, additional, Jimenez, Christian, additional, Landers, Ariel, additional, Livingston, Hope, additional, Meinert, Curtis L., additional, Rayapudi, Sobharani, additional, Shen, Weijiang, additional, Shiflett, Charles, additional, Smith, Rochelle, additional, Tieman, Ada, additional, Tonascia, James A., additional, Zheng, Richard, additional, Allan, James, additional, Benz, Wendy K., additional, Domalpally, Amitha, additional, Johnson, Kristine A., additional, Myers, Dawn J., additional, Won Pak, Jeong, additional, Reimers, James L., additional, Chambers, Geoffrey, additional, Christianson, Debra J., additional, Fleischli, Margaret A., additional, Freund, Jacquelyn, additional, Gama, Vonnie, additional, Gangaputra, Sapna, additional, Glander, Kathleen E., additional, Goulding, Anne, additional, Hafford, Dennis, additional, Harris, Susan E., additional, Hubbard, Larry D., additional, Joyce, Jeffrey M., additional, Kruse, Christina N., additional, Nagle, Lauren, additional, Padden-Lechten, Gwyn E., additional, Pohlman, Alyson, additional, Remm, Amy, additional, Shaw, Ruth A., additional, Sivesind, Peggy, additional, Thayer, Dennis, additional, Treichel, Erika, additional, Warren, Kelly J., additional, Watson, Sheila M., additional, Webster, Mary K., additional, White, James K., additional, Wilhelmson, Tara, additional, and Zhang, Grace, additional

Published
2015
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28. Sarcoid-like reaction in a patient with uveitis and underlying cancer.

Author

Pascual-Camps, Isabel, Alonso-Orcajo, Nieves, de la Fuente, Juan, Yilmaz, Taygan, and Cordero-Coma, Miguel

Abstract

Purpose: Sarcoidosis is a granulomatous disease of unknown etiology. Occasionally, triggering causes are identified, such as neoplasms, and they are termed sarcoid-like reactions, which may appear in any sarcoidotic target tissue. Choroidal metastases appear as part of widespread metastatic disease or as the first suggestion of neoplastic disease. They can also be a part of the differential diagnosis of a spectrum of inflammatory eye diseases. We present a case in which a lung carcinoma, pulmonary and eye sarcoid-like reactions, and choroidal metastasis take place in the same patient. Case report: A 60-year-old male with a past history of pulmonary sarcoidosis and associated anterior uveitis was diagnosed with a lung carcinoma with no regional lymph nodes extension, so that the resection surgery was performed without additional systemic treatment. At the same time, he complained of visual acuity loss and pain in his right eye. An intense ocular inflammatory reaction and a choroidal mass compatible with metastasis were identified. A vitrectomy with an accompanied histological exam of the lesion was deemed inconclusive. Ocular symptoms progressively worsened showing mass growth, and as a result, an enucleation was performed and the histological study subsequently revealed metastasis from his lung carcinoma. Conclusion: Sarcoid-like reactions may be due to incipient malignancies. Any diagnosis of sarcoidosis requires ruling out other diseases that can produce secondary sarcoid-like reactions. In addition, any choroidal mass suggestive of metastasis requires exclusion of metastatic disease even in the absence of clinical signs indicating tumor extension. [ABSTRACT FROM AUTHOR]

Published
2017
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33. Drug-induced uveitis

Author

Cordero-Coma, Miguel, primary, Salazar-Méndez, Raquel, additional, Garzo-García, Irene, additional, and Yilmaz, Taygan, additional

Published
2014
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44. Drug-induced uveitis

Author

Cordero-Coma, Miguel, Salazar-Méndez, Raquel, Garzo-García, Irene, and Yilmaz, Taygan

Abstract

Introduction:Drug-induced uveitis is a well described but often overlooked and/or misdiagnosed adverse reaction to medication. There are an increasing number of medications that have been related to the onset of intraocular inflammation. Identification of these inciting agents may decisively help the diagnostic algorithm involving new cases of uveitis.Areas covered:This review intends to be an updated comprehensive, practical guide for practitioners regarding the main drugs that have been associated with uveitis. A classification proposed by Naranjo et al.in 1981 for establishing potential causality is applied examining possible mechanisms of action. A guide for clinicians about the rationale of these observations when dealing with patients with uveitis is provided.Expert opinion:Several agents with different routes of administration (systemic, topical and/or intraocular) may cause intraocular inflammation. The mechanism behind ocular inflammation is frequently unknown. Clinicians should be aware of the potential drug effect to optimize diagnosis and management of such patients.

Published
2015
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46. Bilateral Occlusive Retinal Vasculitis in a Patient with Dermatomyositis.

Author

Loporchio D, Gealy D, Yilmaz T, Barton AT, Thakuria P, and Janigian R

Subjects
Female, Humans, Middle Aged, Vision Disorders, Blindness, Retinal Vasculitis complications, Retinal Vasculitis diagnosis, Dermatomyositis complications, Dermatomyositis diagnosis, Macular Edema diagnosis, Macular Edema drug therapy, Macular Edema etiology
Abstract

A 48-year-old woman with a history of dermatomyositis (DMS) presented with 2 weeks of worsening myalgias, weakness, and diffuse edema following cessation of her systemic immunosuppression and subsequently developed severe bilateral vision loss consistent with bilateral frosted branch angiitis. Multimodal imaging was performed, and the patient was successfully treated with pulse-dose steroids and intravenous immunoglobulin, as well as intravitreal aflibercept. Ophthalmic involvement of DMS is typically limited to episcleritis, conjunctivitis, and uveitis. We present an uncommon case of bilateral occlusive retinal vasculitis with frosted branch angiitis in a patient with DMS. The significant improvement anatomically and in visual acuity in our patient suggests a role of combined anti-vascular endothelial growth factor and systemic immunosuppression in the management of DMS -related frosted branch angiitis. We suggest that retinal vasculitis should be considered in patients with known DMS and acute vision loss, with prompt referral for ophthalmologic evaluation., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Middle East African Journal of Ophthalmology.)

Published
2023
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47. Moving forward in uveitis therapy: preclinical to phase II clinical trial drug development.

Author

Salazar-Méndez R, Yilmaz T, and Cordero-Coma M

Subjects
Administration, Ophthalmic, Animals, Clinical Trials, Phase II as Topic, Drug Delivery Systems, Drug Evaluation, Preclinical, Humans, Prognosis, Uveitis diagnosis, Uveitis immunology, Drug Design, Molecular Targeted Therapy, Uveitis drug therapy
Abstract

Introduction: Several advances have been made in the diagnostic approach and therapeutic management of patients with immune-mediated uveitis over the last few decades, which have to lead to an improvement in the visual prognosis of patients. However, the use of available therapies, including steroids and immunosuppressive drugs, is still associated with limited efficacy and potentially serious side effects. Consequently, efforts have been made to develop novel therapeutic alternatives including new molecules and innovative therapeutic approaches., Areas Covered: Herein, the authors provide an updated review of those drugs in the initial phases of evaluation for the treatment of immune-mediated uveitides as well as the latest evidence from basic research., Expert Opinion: Enhanced understanding of the pathogenic mechanisms leading to immune-mediated uveitis has led to the identification of new therapeutic targets and thus to the development of more specific drugs. In addition, considering that the eye is a semi-enclosed chamber and that local therapy has the benefit of sparing the rest of the body from potentially toxic exposure, several attempts of establishing direct ophthalmologic avenues for delivery of the established and emerging drugs have also been made. All these advances have been an unquestionable step forward in the challenging management of uveitis patients.

Published
2016
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48. Building information for systematic improvement of the prevention of hospital-acquired pressure ulcers with statistical process control charts and regression.

Author

Padula WV, Mishra MK, Weaver CD, Yilmaz T, and Splaine ME

Subjects
Cohort Studies, Female, Hospitals, Humans, Incidence, Male, Prospective Studies, United States, Iatrogenic Disease prevention & control, Pressure Ulcer prevention & control, Quality Assurance, Health Care organization & administration
Abstract

Objectives: To demonstrate complementary results of regression and statistical process control (SPC) chart analyses for hospital-acquired pressure ulcers (HAPUs), and identify possible links between changes and opportunities for improvement between hospital microsystems and macrosystems., Methods: Ordinary least squares and panel data regression of retrospective hospital billing data, and SPC charts of prospective patient records for a US tertiary-care facility (2004-2007). A prospective cohort of hospital inpatients at risk for HAPUs was the study population., Results: There were 337 HAPU incidences hospital wide among 43 844 inpatients. A probit regression model predicted the correlation of age, gender and length of stay on HAPU incidence (pseudo R(2)=0.096). Panel data analysis determined that for each additional day in the hospital, there was a 0.28% increase in the likelihood of HAPU incidence. A p-chart of HAPU incidence showed a mean incidence rate of 1.17% remaining in statistical control. A t-chart showed the average time between events for the last 25 HAPUs was 13.25 days. There was one 57-day period between two incidences during the observation period. A p-chart addressing Braden scale assessments showed that 40.5% of all patients were risk stratified for HAPUs upon admission., Conclusion: SPC charts complement standard regression analysis. SPC amplifies patient outcomes at the microsystem level and is useful for guiding quality improvement. Macrosystems should monitor effective quality improvement initiatives in microsystems and aid the spread of successful initiatives to other microsystems, followed by system-wide analysis with regression. Although HAPU incidence in this study is below the national mean, there is still room to improve HAPU incidence in this hospital setting since 0% incidence is theoretically achievable. Further assessment of pressure ulcer incidence could illustrate improvement in the quality of care and prevent HAPUs.

Published
2012
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49. Tumour necrosis factor-alpha in conjunctivae affected by ocular cicatricial pemphigoid.

Author

Cordero Coma M, Yilmaz T, and Foster CS

Subjects
Biopsy, Humans, Immunoenzyme Techniques, Conjunctiva metabolism, Conjunctivitis, Allergic metabolism, Pemphigoid, Benign Mucous Membrane metabolism, Tumor Necrosis Factor-alpha metabolism
Abstract

Purpose: The presence of tumour necrosis factor-alpha (TNF-alpha) in conjunctivae affected by ocular cicatricial pemphigoid (OCP) was investigated., Methods: Biopsy specimens from the conjunctivae of eight patients with OCP, three patients with atopic keratoconjunctivitis (AKC) and two normal subjects were studied for the expression of TNF-alpha by immunohistochemistry. Two independent, masked investigators evaluated the specimens. All samples were similarly processed by a third investigator., Results: No TNF-alpha was discerned in the normal conjunctival sections; small amounts of TNF-alpha were observed in the atopic keratoconjunctivitis specimens. TNF-alpha was present in substantial amounts in conjunctival sections of patients with OCP. The expression of TNF-alpha was detected in both epithelial and stromal cells of conjunctivae from OCP patients., Conclusions: The presence of TNF-alpha in conjunctivae affected by OCP may indicate that this cytokine plays an important role in the production and maintenance of conjuctival inflammation response and subsequent conjunctival scarring in patients with OCP. Further studies clarifying this potential role are warranted.

Published
2007
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50. Herpetic retinitis.

Author

Cordero-Coma M, Anzaar F, Yilmaz T, and Foster CS

Subjects
Antiviral Agents therapeutic use, Cytomegalovirus Retinitis drug therapy, Herpes Simplex drug therapy, Herpes Zoster Ophthalmicus drug therapy, Herpes Zoster Ophthalmicus virology, Humans, Retinal Necrosis Syndrome, Acute drug therapy, Retinal Necrosis Syndrome, Acute virology, Retinitis drug therapy, Retinitis pathology, Cytomegalovirus Retinitis pathology, Herpes Simplex pathology, Herpes Zoster Ophthalmicus pathology, Retinal Necrosis Syndrome, Acute pathology, Retinitis virology
Abstract

This paper provides an appreciation of the various forms and consequences of retinal inflammation caused by human herpesviruses. Herpes simplex virus types 1 and 2, varicella zoster virus, cytomegalovirus and Epstein-Barr virus are known to cause retinitis. The prognosis of herpetic retinitis remains poor because it is associated with a high incidence of complications, both during and after the acute disease phase. On diagnosis of retinal necrosis, antiviral treatment must be started promptly to limit disease progression; following this, prophylactic maintenance therapy may be required.

Published
2007

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