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8 results on '"Yin, Hailing"'

4. Comparing the Effectiveness and Safety of MedAn with the Nishikawa Blade and UE Videolaryngoscopes for Left-Sided Double-Lumen Endobronchial Tube Intubation: A Randomized Controlled Trial

Author

Zhang, Yong, primary, Zhang, Wenwen, additional, Wang, Shuai, additional, Yin, Hailing, additional, Xu, Yajie, additional, Fang, Zhaojing, additional, Bao, Hongguang, additional, Zhang, Chen, additional, Wang, Xiaoliang, additional, and Liu, Wentao, additional

Published
2023
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7. WDR34mutation from anencephaly patients impaired both SHH and PCP signaling pathways

Author

Yin, Hailing, Peng, Rui, Chen, Zhongzhong, Wang, Hongyan, Zhang, Ting, and Zheng, Yufang

Abstract

Neural tube defects (NTDs) are debilitating human congenital abnormalities due to failure of neural tube closure. Sonic Hedgehog (SHH) signaling is required for dorsal–ventral patterning of the neural tube. The loss of activation in SHH signaling normally causes holoprosencephaly while the loss of inhibition causes exencephaly due to failure in neural tube closure. WDR34 is a dynein intermedia chain component which is required for SHH activation. However, Wdr34knockout mouse exhibit exencephaly. Here we screened mutations in WDR34gene in 100 anencephaly patients of Chinese Han population. Compared to 1000 Genome Project data, two potentially disease causing missense mutations of WDR34gene (c.1177G>A; p.G393S and c.1310A>G; p.Y437C) were identified in anencephaly patients. These two mutations did not affect the protein expression level of WDR34. Luciferase reporter and endogenous target gene expression level showed that both mutations are lose-of-function mutations in SHH signaling. Surprisingly, WDR34 could promote planar cell polarity (PCP) signaling and the G393S lost this promoting effect on PCP signaling. Morpholino knockdown of wdr34in zebrafish caused severe convergent extension defects and pericardial abnormalities. The G393S mutant has less rescuing effects than both WT and Y437C WDR34 in zebrafish. Our results suggested that mutation in WDR34could contribute to human NTDs by affecting both SHH and PCP signaling.

Published
2020
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8. The Median Effective Volume of 0.375% Ropivacaine for Ultrasound-guided Anterior Suprascapular Nerve Block in Arthroscopic Shoulder Surgery.

Author

Pu J, Zhang Y, Chen W, Yin H, Bao H, Liu W, and Wang X

Subjects
Humans, Ropivacaine therapeutic use, Sufentanil therapeutic use, Prospective Studies, Analgesia, Patient-Controlled, Ultrasonography, Interventional, Analgesics, Pain, Postoperative etiology, Anesthetics, Local therapeutic use, Arthroscopy adverse effects, Shoulder surgery, Shoulder innervation, Brachial Plexus Block
Abstract

Background: The suprascapular nerve (SSN) is an important nerve that contributes to shoulder joint sensation and movement. The anterior suprascapular nerve block (aSSNB) has the potential for noninferior analgesic effect compared with the interscalene block while preserving respiratory function. This study investigated the median effective volume (MEV) of 0.375% ropivacaine in aSSNB for analgesic effect among patients undergoing arthroscopic shoulder surgery., Objectives: Our primary objective was the MEV. The secondary objectives included the 24 hour sufentanil consumption, 24 hour patient-controlled analgesia (PCA) presses, and incidences of diaphragm impairment., Study Design: Prospective registered (ChiCTR2300070129), single-armed, volume-finding study., Setting: This study was conducted in a tertiary, single center., Methods: There were 23 patients who completed the study. Using an up-and-down process, patients enrolled in the study received different volumes of 0.375% ropivacaine for an aSSNB adjusted based on the success or failure of the previous patient in the study's block by increasing or decreasing the volume by 3 mL. The first patient received 15 mL of 0.375% ropivacaine. The nerve blocks were evaluated by the sensory score of the C5 and C6 dermatomes., Results: MEV50 (50% of the patients) was 6 mL (95% CI, 5.78 - 6.78 mL), and MEV95 (95% of the patients) was 13.88 mL (95% CI, 13.37 - 14.87 mL). There was no significant difference in the PCA presses, 24 hour sufentanil consumption, and incidences of diaphragm impairments between successful and unsuccessful blocks., Limitations: Our study focused on the analgesic effect rather than hemi-diaphragmatic paralysis with 0.375% ropivacaine for an aSSNB. The study also did not test varying ropivacaine concentrations while keeping the volume constant. Further investigation with varying concentrations and a larger sample size is indicated to address the optimal volume and concentration to balance analgesia and diaphragm function., Conclusions: To produce effective analgesic effect, the MEV50 is 6 mL, and the MEV95 is 13.88 mL in patients undergoing arthroscopic shoulder surgery who receive an aSSNB using 0.375% ropivacaine for analgesia.

Published
2023

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