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42 results on '"Yin, Haoyuan"'

11. Recent Advance in Biomarkers for Predicting Immune-related Adverse Events Caused by Immune Checkpoint Inhibitors

Author

LI Ying, YIN Haoyuan, PAN Li, and FENG Lei

Subjects
immune checkpoint inhibitors, immune-related adverse events, biomarkers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

In recent years, tumor immunotherapy with immune checkpoint as the target has attracted much attention because of its remarkable efficacy. However, with the application of immune-checkpoint inhibitors (ICIs), more and more immune-related adverse events (irAEs) have been reported. IrAEs impose an additional risk of death on tumor patients treated with ICIs, limiting the widespread use of ICIs. To help patients actively prevent irAEs, biomarkers with the predictive value of irAEs are of great significance. This paper reviews the biomarkers with predictive value for irAEs from the aspects of serology, genetics and microbiology.

Published
2021
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15. Soil Salinity Estimation Based on Sentinel-1/2 Texture Features and Machine Learning

Author

He, Yujie, Yin, Haoyuan, Chen, Yinwen, Xiang, Ru, Zhang, Zhitao, and Chen, Haiying

Abstract

Soil salinization is a vital factor in global land degradation, seriously affecting sustainable agricultural development. Efficient monitoring of soil salinity using satellite remote sensing is critical for saline soil management. Currently, research on soil salinity extraction using satellite remote sensing primarily relies on the spectral information of remote sensing images, but insufficient consideration was given to the texture features of the imagery and the integration of spectral and texture information. To fully explore the effectiveness of texture features and the integration of texture features and spectral information in soil salinity estimation, experiments were conducted in Shahaoqu Irrigation Area, Inner Monglia, China from April to August 2019. To this end, the experiments utilized measured soil salinity data and the textural and spectral data from Sentinel-1/2. The effectiveness of Sentinel-1/2 texture features in soil salinity estimation was examined using out-of-bag score, and soil salinity inversion models were constructed based on the texture features, spectral information, and four machine learning models [random forest, Cubist, support vector machines (SVMs), and backpropagation (BP)]. The results indicated that Sentinel-1 texture features were more sensible to bare soil salinity (the top four most sensible texture features were HOM, ENT, COR, and CON), while Sentinel-2 texture features were more sensible to vegetated soil salinity (the top four were VAR, CON, HOM, and ENT). In addition, when combining texture features and spectral information, the models exhibited improved performance, and random forest had the best performance in both bare soil ( ${R}^{{2}}$ = 0.688 and RMSE = 0.207) and vegetated soil ( ${R}^{{2}}$ = 0.494 and RMSE = 0.304).

Published
2024
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23. Multifunctional Hybrid Hydrogel System Enhanced the Therapeutic Efficacy of Treatments for Postoperative Glioma

Author

Cao, Xiang, primary, Li, Shengnan, additional, Chen, Wenli, additional, Lu, Hongdan, additional, Ye, Lu, additional, Min, Zhiyi, additional, Sun, Shanbo, additional, Teng, Chuanhui, additional, Yin, Haoyuan, additional, Zhang, Qi, additional, He, Weichong, additional, Wang, Xiuzhen, additional, Lv, Wei, additional, Lv, Lingyan, additional, and Xin, Hongliang, additional

Published
2022
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31. Enhanced Anti-Brain Metastasis from Non-Small Cell Lung Cancer of Osimertinib and Doxorubicin Co-Delivery Targeted Nanocarrier

Author

Wang, Xiaoqi, Mao, Wenxing, Wang, Zhi, Li, Xinrui, Xiong, Yaokun, Lu, Hongjin, Wang, Xiuzhen, Yin, Haoyuan, Cao, Xiang, and Xin, Hongliang

Subjects
Collagen Type IV, Male, Lung Neoplasms, AZD9291, Drug Delivery Systems, International Journal of Nanomedicine, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Receptors, Transferrin, Animals, Humans, Prodrugs, brain metastasis, brain targeted delivery system, Original Research, Acrylamides, Drug Carriers, Mice, Inbred BALB C, Aniline Compounds, Brain Neoplasms, Xenograft Model Antitumor Assays, Peptide Fragments, Nanostructures, Blood-Brain Barrier, Doxorubicin, drug delivery, redox-responsive
Abstract

Xiaoqi Wang1 ,* Wenxing Mao2 ,* Zhi Wang3 ,* Xinrui Li,1 Yaokun Xiong,4 Hongjin Lu,1 Xiuzhen Wang,1 Haoyuan Yin,1 Xiang Cao,1 Hongliang Xin1 1Department of Pharmaceutics and Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, People’s Republic of China; 2Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People’s Republic of China; 3Department of Pharmacy, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 4School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongliang Xin Fax +86 25 86868467; +86 25 86868477Email xhl@njmu.edu.cnPurpose: Currently, the treatment of brain metastases from non-small cell lung cancer (NSCLC) is rather difficult in the clinic. A combination of small molecule-targeted drug and chemo-drug is a promising therapeutic strategy for the treatment of NSCLC brain metastases. But the efficacy of this combination therapy is not satisfactory due to the blood–brain barrier (BBB). Therefore, it is urgent to develop a drug delivery system to enhance the synergistic therapeutic effects of small molecule–targeted drug and chemo-drug for the treatment of NSCLC brain metastases.Methods: T7 peptide installed and osimertinib (AZD9291) loaded intracellular glutathione (GSH) responsive doxorubicin prodrug self-assembly nanocarriers (T7-DSNPs/9291) have been developed as a targeted co-delivery system to enhance the combined therapeutic effect on brain metastases from NSCLC. In vitro cell experiments, including intracellular uptake assay, in vitro BBB transportation, and MTT assay were used to demonstrate the efficacy of T7-DSNPs/9291 in NSCLC brain metastasis in vitro. Real-time fluorescence imaging analysis, magnetic resonance imaging analysis, and Kaplan–Meier survival curves were used to study the effect of T7-DSNPs/9291 on an animal model in vivo.Results: T7-DSNPs/9291 could significantly enhance BBB penetration of AZD9291 and doxorubicin via transferrin receptor-mediated transcytosis. Moreover, T7-DSNPs/9291 showed significant anti-NSCLC brain metastasis effect and prolonged median survival of an intracranial NSCLC brain metastasis animal model.Conclusion: T7-DSNPs/9291 is a potential drug delivery system for the combined therapy of brain metastasis from NSCLC.Keywords: drug delivery, brain metastasis, AZD9291, redox-responsive, brain targeted delivery system

Published
2020

35. Development and Validation of a Nomogram to Predict the Individual Future Stroke Risk for Adult Patients With Moyamoya Disease: A Multicenter Retrospective Cohort Study in China

Author

Ye, Fei, primary, Wang, Tianzhu, additional, Yin, Haoyuan, additional, Li, Jiaoxing, additional, Li, Haiyan, additional, Guo, Tongli, additional, Zhang, Xiong, additional, Yang, Tingting, additional, Jie, Liang, additional, Wu, Xiaoxin, additional, Li, Qi, additional, and Sheng, Wenli, additional

Published
2021
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42. Two-Dimensional Hetero-structured TiO2/TiS2Nanosheets for Capacitive Deionization

Author

Yang, Zhengqu, Yang, Peiyu, Zhang, Xiaochen, Yin, Haoyuan, Yu, Fei, and Ma, Jie

Abstract

Capacitive deionization (CDI) is a low-cost, low-energy desalination technology, which is largely affected by electrode materials. Both TiO2and TiS2have good sodium storage capacity, however, TiO2has poor electrical conductivity, and TiS2has a strong stacking tendency. In this work, a typical transition metal carbide MXene (Ti3C2Tx) was used as the precursor to prepare hetero-structured TiO2/TiS2by the hydrothermal method. The rough particles between the layers provided a channel for the rapid transport of sodium ions and relieve the stacking state of nanosheets. The maximum desalination capacity of the TiO2/TiS2electrode was 36.45 mg g–1(NaCl), and the capacity retention rate was about 75% after 30 cycles. Based on the electrochemical quartz crystal microbalance, the migration behavior of ions in the desalination process was exhibited in situ. This work shows that TiO2/TiS2, as a heterojunction material obtained from MXene, offers a new idea to solve the problem of poor electrochemical properties of TiO2.

Published
2023
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