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514 results on '"Yin, Xindao"'

39. Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space in presbycusis.

Author

Xu, Kaixi, Zhang, Juan, Xing, Chunhua, Xu, Xiaomin, Yin, Xindao, Wu, Yuanqing, Chen, Xinjian, and Chen, Yu‐Chen

Subjects
DIFFUSION tensor imaging, CALCULUS of tensors, PRESBYCUSIS, IMAGE analysis, HEARING disorders
Abstract

Purpose: Previous studies have suggested that presbycusis (age‐related hearing loss) is accompanied with cognitive decline and dementia. However, the neural mechanism underlying the cognitive decline in presbycusis remains unclear. This study aimed to evaluate the glymphatic system function in presbycusis patients compared to healthy controls using diffusion tensor imaging (DTI) with the perivascular space (DTI‐ALPS) method. Methods: DTI scans were obtained from 30 presbycusis patients with cognitive decline (PCD), 30 presbycusis patients with no cognitive decline (PNCD) and 40 age‐, gender‐, and education‐matched healthy controls (HCs). The DTI‐ALPS index was calculated for each group. We evaluated the differences in the DTI‐ALPS index among PCD, PNCD and HCs. In addition, we conducted a correlation analysis between the DTI‐ALPS index and cognitive performance. Results: There were significant differences of the DTI‐ALPS index among three groups. Post‐hoc analysis suggested that the DTI‐ALPS index in PCD was significantly lower patients in relative to PNCD and HCs (1.49147 vs. 1.57441 vs. 1.62020, p < 0.001). After correcting for age, gender, and education, the DTI‐ALPS index is positively correlated with the MoCA scores (rho = 0.426, p = 0.026). Conclusion: Presbycusis patients with cognitive impairment exhibited decreased glymphatic activity than those without cognitive impairment and HCs. The DTI‐ALPS index may provide useful disease progression or treatment biomarkers for patients with presbycusis as an indicator of modulation of glymphatic activity. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Abnormal causal connectivity of anterior cingulate cortex‐visual cortex circuit related to nonsteroidal anti‐inflammatory drug efficacy in migraine.

Author

Wei, Heng‐Le, Yang, Qian, Zhou, Gang‐Ping, Chen, Yu‐Chen, Yu, Yu‐Sheng, Yin, Xindao, Li, Junrong, and Zhang, Hong

Subjects
CINGULATE cortex, SUMATRIPTAN, DRUG efficacy, ANTI-inflammatory agents, FUNCTIONAL magnetic resonance imaging, MIGRAINE, MIGRAINE aura
Abstract

The anterior cingulate cortex (ACC) and visual cortex are integral components of the neurophysiological mechanisms underlying migraine, yet the impact of altered connectivity patterns between these regions on migraine treatment remains unknown. To elucidate this issue, we investigated the abnormal causal connectivity between the ACC and visual cortex in patients with migraine without aura (MwoA), based on the resting‐state functional magnetic resonance imaging data, and its predictive ability for the efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs). The results revealed increased causal connectivity from the bilateral ACC to the lingual gyrus (LG) and decreased connectivity in the opposite direction in nonresponders compared with the responders. Moreover, compared with the healthy controls, nonresponders exhibited heightened causal connectivity from the ACC to the LG, right inferior occipital gyrus (IOG) and left superior occipital gyrus, while connectivity patterns from the LG and right IOG to the ACC were diminished. Based on the observed abnormal connectivity patterns, the support vector machine (SVM) models showed that the area under the receiver operator characteristic curves for the ACC to LG, LG to ACC and bidirectional models were 0.857, 0.898, and 0.939, respectively. These findings indicate that neuroimaging markers of abnormal causal connectivity in the ACC‐visual cortex circuit may facilitate clinical decision‐making regarding NSAIDs administration for migraine management. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Disrupted Effective Connectivity within the Fronto-Thalamic Circuit in Pontine Infarction: A Spectral Dynamic Causal Modeling Study.

Author

Chen, Huiyou, Mao, Qianqian, Zhang, Yujie, Shi, Mengye, Geng, Wen, Ma, Yuehu, Chen, Yuchen, and Yin, Xindao

Subjects
CAUSAL models, MOTOR cortex, DYNAMIC models, INFARCTION, CINGULATE cortex
Abstract

This study aims to investigate alterations in effective connectivity (EC) within the fronto-thalamic circuit and their associations with motor and cognitive declines in pontine infarction (PI). A total of 33 right PI patients (RPIs), 38 left PI patients (LPIs), and 67 healthy controls (HCs) were recruited. The spectral dynamic causal modeling (spDCM) approach was used for EC analysis within the fronto-thalamic circuit, including the thalamus, caudate, supplementary motor area (SMA), medial prefrontal cortex (mPFC), and anterior cingulate cortex (ACC). The EC differences between different sides of the patients and HCs were assessed, and their correlations with motor and cognitive dysfunctions were analyzed. The LPIs showed increased EC from the mPFC to the R-SMA and decreased EC from the L-thalamus to the ACC, the L-SMA to the R-SMA, the R-caudate to the R-thalamus, and the R-thalamus to the ACC. For RPIs, the EC of the R-caudate to the mPFC, the L-thalamus and L-caudate to the L-SMA, and the L-caudate to the ACC increased obviously, while a lower EC strength was shown from the L-thalamus to the mPFC, the LSMA to the R-caudate, and the R-SMA to the L-thalamus. The EC from the R-caudate to the mPFC was negatively correlated with the MoCA score for RPIs, and the EC from the R-caudate to the R-thalamus was negatively correlated with the FMA score for LPIs. The results demonstrated EC within the fronto-thalamic circuit in PI-related functional impairments and reveal its potential as a novel imaging marker. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Development and Validation of CCTA-based Radiomics Signature for Predicting Coronary Plaques With Rapid Progression

Author

Chen, Qian, primary, Xie, Guanghui, additional, Tang, Chun Xiang, additional, Yang, Liu, additional, Xu, Pengpeng, additional, Gao, Xiaofei, additional, Lu, Mengjie, additional, Fu, Yunlei, additional, Huo, Yingsong, additional, Zheng, Shaoqing, additional, Tao, Xinwei, additional, Xu, Hui, additional, Yin, Xindao, additional, and Zhang, Long Jiang, additional

Published
2023
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48. The Relationship between Patterns of Remodeling and Degree of Enhancement in Patients with Atherosclerotic Middle Cerebral Artery Stenosis: A High-Resolution MRI Study

Author

Zhang, Dan-Feng, Wu, Xin-Ying, Zhang, Wei-Dong, Wang, Mi, Yin, Xindao, and Chen, Yu-Chen

Subjects
Arteries -- Stenosis, Magnetic resonance imaging -- Usage, Cerebrovascular disease -- Diagnosis -- Development and progression, Health
Abstract

Byline: Dan-Feng. Zhang, Xin-Ying. Wu, Wei-Dong. Zhang, Mi. Wang, Xindao. Yin, Yu-Chen. Chen Purpose: The aim of this research was to investigate the relationship between remodeling patterns and degree of [...]

Published
2021

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