25 results on '"Ying-Hua Song"'
Search Results
2. Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma
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Ying-Hua Song, Cai-Qing Zhang, Fang-Fang Chen, and Xiao-Yan Lin
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Chemoresistance ,Lung Adenocarcinoma ,NEDD4-1 ,PTEN 10 ,Prognosis ,Medicine - Abstract
Background: The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear. This study investigated the expression and the role of NEDD4-1 in tumor development and chemosensitivity of lung adenocarcinoma (ADC). Methods: We retrospectively investigated the expression and significance of NEDD4-1, PTEN, and p-Akt proteins in 135 paired ADC and adjacent noncancerous tissue specimens using immunohistochemistry. Furthermore, we evaluated the relationship between NEDD4-1 expression and clinicopathologic characteristics and prognosis. The effects of small interfering RNA against NEDD4-1 on proliferation and chemosensitivity were examined in A549 cells in vitro using 3- (4,5-dimethylthiazol-2-yl) -5-(3-carboxymethoxyphenyl) -2-(4-sulfophenyl)- 2H-tetrazolium method. The ability of migration and invasion of A549 cells was tested by transwell assay. Moreover, reverse-transcription quantitative polymerase chain reaction and Western blotting analyses were used to determine the expression of NEDD4-1, PTEN, phosphoinositide 3-kinase (PI3K)/Akt activity, and its downstream target proteins. Results: NEDD4-1 protein was significantly upregulated in lung ADC tissues, whereas it was weak or negative in normal lung epithelial cells. The expression of NEDD4-1 in ADC (78.5%, 106/135) was significantly much higher than that in adjacent normal lung tissue (13.3%, 29/135, P < 0.01), and it was associated with lymph node metastasis, tumor-node-metastasis (TNM) stage, and chemotherapy resistance. PTEN expression was downregulated in lung ADC (60.7% vs. 100.0% in noncancerous specimens, P = 0.007), and was negatively correlated with lymph node metastasis, histological variants, clinical stage, chemoresistance. In addition, expression of p-Akt in ADC tissues (71.1% 96/135) was much higher than that in adjacent lung epithelial cells (6.7%, 9/135, P < 0.01). Kaplan-Meier and multivariate analysis demonstrated that expressions of NEDD4-1 and PTEN were both independent risk factors for survival in patients with lung ADC. NEDD4-1 knockdown in vivo decreased proliferation, migration, and invasion and improved chemosensitivity to cisplatin and paclitaxel in A549 cells. NEDD4-1 knockdown also significantly enhanced PTEN expression and inhibited p-Akt activity and downstream target proteins. Conclusions: NEDD4-1 upregulation may contribute to the progression of lung ADC. NEDD4-1 may regulate the proliferation, invasion, migration, and chemoresistance of lung ADC cells through the PI3K/Akt pathway, suggesting that it may be regarded as a therapeutic target for the treatment of lung ADC.
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- 2018
- Full Text
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3. Pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe
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Xiao-yan LIN, Ying-ming LI, Ying-hua SONG, Ji-qing SONG, Ying-chao LIU, and Jia-yao WANG
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Adenocarcinoma, papillary ,Lung neoplasms ,Neoplasm metastasis ,Frontal lobe ,Immunohistochemistry ,Pathology ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective To investigate the clinical manifestations and pathological characteristics of pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe of brain. Methods The clinical manifestations, pathological features and differential diagnosis were studied in one case of pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe. Related literatures were also reviewed. Results A 56-year-old male suffered from intermittent headache for 3 years in fronto-occipital region without significant incentives. Cranial MRI examination revealed a space-occupying lesion in right frontal lobe, which was considered as meningioma. In operation, the tumor located in the right frontal lobe was tough and red-grey in color, with clear boundary and abundant blood supply. Histopathological examination revealed the tumor was arranged in papillary pattern. The tumor cells were large, with eosinophilic cytoplasm, round or oval nuclei and small red nucleoli. Especially, a plenty of psammoma bodies were found in tumor tissue and mesenchymal tissue. Immunohistochemical staining found that the tumor cells were positively expressed for cytokeratin (CK), epithelial membrane antigen (EMA), CK19, thyroid transcription factor-1 (TTF-1) and Napsin A, and showed focal positive expression of P53. Ki-67 labeling index was 5%-10%. The tumor cells were negative for glial fibrillary acidic protein (GFAP), S-100 protein (S-100), thyroglobulin (TG), Galectin-3 protein, progestrone receptor (PR) and vimentin (Vim). Combined with the results of chest 18F-FDG-PET CT, the final diagnosis was pulmonary papillary adenocarcinoma with psammoma bodies metastasis to right frontal lobe. The patient underwent auxiliary radiotherapy and chemotherapy after operation. The patient was followed for 12 months and no recurrence was seen. Conclusions This case is very rare. Understanding the patient's history and differentiating from other primary intracalvarium tumors is one of the key steps to give the right pathological diagnosis and clinical therapy. In order to avoid disdiagnosis, the diagnosis needs to be differentiated from other primary intracalvarium tumors, including papillary meningioma, papillary tumor of choroid plexus, papillary ependymoma, papillary glioneuronal tumors as well as metastatic papillary thyroid carcinoma. DOI: 10.3969/j.issn.1672-6731.2015.06.009
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- 2015
4. Acinic cell carcinoma of parotid gland metastasis to left cavernous sinus: a case report and review of literature
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Xiao-yan LIN, Ying-hua SONG, and Jia-yao WANG
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Carcinoma, acinar cell ,Parotid gland ,Neoplasm metastasis ,Cavernous sinus ,Immunohistochemistry ,Pathology ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective To investigate the clinical manifestations and pathological features of parotid gland papillary acinic cell carcinoma metastasis to left cavernous sinus. Methods The clinical manifestations, pathological features and differential diagnosis were studied in one case of parotid papillary acinic cell carcinoma metastasis to left cavernous sinus. Related literatures were also reviewed. Results The patient was a 50-year-old female who presented paroxysmal dizziness for 5 months and blurred vision in her left eye for 10 months. The MRI examination showed left parasellar space-occupying mass in the cavernous sinus. In operation, the tumor was located in the superior wall of left cavernous sinus, soft and red-grey in color, with abundant blood supply. The histomorphological examination revealed the tumor cells were arranged in solid, acinar or papillary pattern. The tumor cells were large, with eosinophilic cytoplasm, round or oval nuclei and small nucleoli. Immunohistochemical staining found that the tumor cells expressed cytokeratin (CK), epithelial membrane antigen (EMA), vimentin (Vim) and S-100 protein (S-100), and showed weak positive expression of glial fibrillary acidic protein (GFAP) and focal positive expression of P53 protein. Ki-67 labeling index was about 5%-10% . The tumor cells were negative for neuroendocrine markers and pituitary hormone protein markers. This case was difficult to differentiate from other primary intracalvarium tumors, including papillary meningioma, papillary tumor of choroid plexus, papillary ependymoma, papillary glioneuronal tumors as well as chordoma. According to the medical history and the comparison of histomorphology and immunophenotyping between parotid gland tumor cells and left cavernous sinus tumor cells, the final diagnosis was metastatic papillary parotid acinar cell carcinoma of the left cavernous sinus. The patient was followed for 21 months and no recurrence was seen. Conclusion It is very rare and to our knowlege it is the second case with metastasic papillary parotid acinar cell carcinoma in the cavernous sinus. Understanding the patient's history and differentiating from other primary intracalvarium tumors is one of the key steps to give right pathological diagnosis and clinical therapy. doi:10.3969/j.issn.1672-6731.2013.12.008
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- 2013
5. Study on Critical Density of Percolation in Crowds in Public Areas.
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Hui Guo, Ying-Hua Song, Wei Lv, Xin-Yao Guo, and Zhi-Wu Lei
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- 2020
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6. Risk analysis of dairy safety incidents in China
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Hui-Qin Yu, Wei Lv, and Ying-Hua Song
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Fault tree analysis ,Risk analysis ,Government ,business.industry ,020209 energy ,Supply chain ,020101 civil engineering ,Sample (statistics) ,02 engineering and technology ,Food safety ,0201 civil engineering ,Order (business) ,0202 electrical engineering, electronic engineering, information engineering ,Production (economics) ,Business ,Marketing ,Food Science ,Biotechnology - Abstract
In order to improve the condition of food safety management and prevent the dairy safety incidents effectively, supply chain and fault tree analysis (FTA) can be integrated to analyze the cause of such issues comprehensively. As a result, the main cause of the dairy incident can be found. Based on the analysis and identification of hazards in dairy foods across the entire supply chain from raw material sources to end-customers, the basic events which can lead to dairy incidents are given, and the accident tree of dairy foods is constructed. After a qualitative and quantitative analysis on the tree on the tree, the minimum cut sets and path sets are calculated. Then, the accidents mode and the accidents control mode are obtained, respectively. The Sanlu milk powder incident and the Fuyang milk powder affair are selected as the cases to prove the feasibility of FTA. We have analyzed 34 basic events quantitatively. Then 114 minimum cut sets and 78 minimum path sets are obtained. From the analysis of structure importance degree of the basic events, the most critical factors are production enterprises lack feedback mechanism (X1), Food and Drug Administration failed to sample (X33), Ministry of Health and other government departments overlook or don't have a good supervision (X34), supermarkets and other distributors make a wrong judgement and sell unsafe dairy (X32), the industrial and commercial department failed to sample (X31), personal preference (X2), family members need dairy (X3), supermarkets and other dealers promote unsafe dairy (X4), and their structural importance coefficients are 1, 1, 1, 0.567, 0.5, 0.25, 0.25, and 0.25, respectively. The corresponding dairy safety strategies are discussed qualitatively, which include: dairy enterprise establishes a feedback mechanism and strengthens industry self-regulation; regulatory authorities strengthen supervision; supermarket and other dealers enhance self-construction; consumers learn how to differentiate between unhealthy and healthy dairy foods; the government makes related food safety laws.
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- 2018
7. Superficial Radiation Therapy (SRT-100) for Hypertrophic Neurodermatitis.
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Ying-Hua Song, Dan Chen, Wei-Na Cai, and Liang Zhang
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SKIN inflammation diagnosis , *SKIN inflammation , *RADIOTHERAPY , *DERMATOLOGIC agents , *IMMUNOSUPPRESSIVE agents , *PATIENT safety , *RADIATION doses , *GLUCOCORTICOIDS , *DISEASE risk factors - Abstract
The article focuses on the successful treatment of hypertrophic neurodermatitis using superficial radiation therapy (SRT‑100), resulting in significant improvement and lesion disappearance. Topics include the challenges in managing neurodermatitis, the efficacy of superficial radiation therapy, and the development of a treatment plan based on existing literature and safe radiotherapy doses.
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- 2024
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8. Similarity matching of food safety incidents in China: Aspects of rapid emergency response and food safety
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Dan Liu, Wei Lv, Hui-Qin Yu, Dan-Hui Fang, Ying-Hua Song, and Yih-chi Tan
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medicine.medical_specialty ,Food poisoning ,Computer science ,business.industry ,Process (engineering) ,Public health ,digestive, oral, and skin physiology ,010401 analytical chemistry ,Cosine similarity ,04 agricultural and veterinary sciences ,medicine.disease ,Food safety ,040401 food science ,01 natural sciences ,0104 chemical sciences ,0404 agricultural biotechnology ,Emergency response ,Risk analysis (engineering) ,Similarity matching ,medicine ,China ,business ,Food Science ,Biotechnology - Abstract
Because food safety risks are becoming increasingly complex, food regulators and public health professionals should improve their ability in food safety management process. This study used the Carrado food poisoning incident in China as a case study to assist related managers in food safety assurance. The indicator system was established by extracting the descriptive information about food safety incidents, including ex-ante and ex-post information. In total, 295 food safety incident cases based on the characteristic attributes since 2000 were collected to establish a case database. We applied the algorithms of information entropy and cosine similarity to build the similarity matching model, and determined the degree of similarity between historical cases and the target case using MATLAB. By referring to the experiences of similar historical cases and the food safety accident emergency response plan, the emergency response was made. After the attribute difference analysis between similar historical cases and the target case was performed, the root causes of the target case were found. Finally, preventive measures were suggested. These results may provide a reference for food regulators to make rapid emergency response in the food safety incident and avoid the recurrence of similar incidents.
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- 2020
9. Investigation of crowd’s aggregation measurement based on an entropy model
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Guo Hui, Xinyao Guo, Wei Lv, and Ying-Hua Song
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Injury control ,Entropy model ,Public place ,Computer science ,Accident prevention ,05 social sciences ,0211 other engineering and technologies ,Public Health, Environmental and Occupational Health ,Poison control ,02 engineering and technology ,Data_GENERAL ,021105 building & construction ,Low density ,Econometrics ,Entropy (information theory) ,0501 psychology and cognitive sciences ,Safety, Risk, Reliability and Quality ,Safety Research ,050107 human factors ,Randomness - Abstract
Mass events have led to many deadly crowd crushes and crowd disasters. In order to avoid crowd accidents, a number of the studies have been conducted. For the people in public place, even a low density crowd can cause risk due to individual’s local aggregation. The local aggregation process is the crowd distribution of deviating from random distribution process. Therefore, it is particularly important to measure the degree of randomness or degree of aggregation of crowd distribution. Entropy can be used to quantitatively describe the number of microscopic states in a certain macroscopic state. A crowd entropy model is built to reveal the degree of aggregation crowd or the degree of deviation from random distribution based on entropy difference. The fluctuation of the entropy is used to reflect the disturbance caused by random movement of individual. The research shows that we can judge whether the crowd is aggregating by comparing the entropy difference and the fluctuation value under a certain confidence level. The entropy variation regularity shows that the larger the entropy difference is, the more obvious the crowd aggregation is. It will provide a new perspective and tool for crowd managers to monitor the changes in the degree of crowd gathering.
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- 2020
10. Study on Critical Density of Percolation in Crowds in Public Areas
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Guo Hui, Ying-Hua Song, Wei Lv, Zhi-Wu Lei, and Xin-Yao Guo
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050210 logistics & transportation ,Computer science ,business.industry ,05 social sciences ,01 natural sciences ,010305 fluids & plasmas ,Crowds ,Artificial Intelligence ,Data_GENERAL ,Percolation ,0502 economics and business ,0103 physical sciences ,Fluid dynamics ,Cluster (physics) ,Computer Vision and Pattern Recognition ,Statistical physics ,Artificial intelligence ,business ,Software - Abstract
The percolation model is an effective tool to solve the problem of fluid flow in the pores; the situation of outsiders crossing the crowd is similar. This paper verifies the obvious percolation phenomenon in the randomly distributed crowd by [Formula: see text] simulation and reveals several characteristics and laws of the crowd percolation phenomena. Studies have shown that sites with different spatial dimensions have different densities of crowd percolation: when the actual density of the crowd is greater than the critical density of the crowd percolation, the outsider is difficult to pass through the crowd; otherwise, the outsider can pass through the crowd easily. Therefore, the critical density of crowd percolation can be one of the indicators of crowd management in public areas, which will provide important guidance for the design of public areas, site selection of public activities and crowd management.
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- 2020
11. Applied Technology and Evaluation on Emergency Management Capability of Coal Mine Accidents Based on AHP and the Fuzzy Comprehensive Evaluation Method
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Ying Hua Song and Jing Jing Wan
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Engineering ,Emergency management ,Index system ,business.industry ,Evaluation methods ,General Engineering ,Coal mining ,Analytic hierarchy process ,business ,Civil engineering ,Fuzzy logic ,Construction engineering - Abstract
This paper has put forward a comprehensive assessment model of the emergency management capability of the coal mine accidents which is based on AHP and fuzzy comprehensive evaluation, and has made an empirical analysis. Firstly, the meaning and the key contents of the emergency management capability of coal mine accidents was elaborated. Secondly, the comprehensive evaluation index system of coal mine accidents emergency management capability was established. And then, the first class index weights were determined by AHP. Finally, this paper made a comprehensive evaluation of a certain regions emergency management capability of coal mine accidents by means of the fuzzy comprehensive evaluation.
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- 2013
12. Synthesis and Properties of Lithium Ion-sieve Precursor Li4Mn5O12
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Hui XU, Chang-Guo CHEN, and Ying-Hua SONG
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Inorganic Chemistry ,General Materials Science - Abstract
吸附法是目前从低锂浓度的盐湖卤水中提取锂的最有前途的方法。采用EDTA-柠檬酸络合法制备了Li 4 Mn 5 O 12 前驱体, 经酸浸脱锂后得到对Li + 具有特殊选择性的锰氧化物锂离子筛。通过热重、XRD、SEM、FT-IR、化学组成、吸附动力学及共存金属离子的分配系数等手段对样品的晶相结构和Li + 选择性吸附性能进行了研究。结果表明: 煅烧时间对Li 4 Mn 5 O 12 前驱体生成有较大影响, 由400℃煅烧24 h所得的前驱体几乎为纯相的Li 4 Mn 5 O 12 化合物, 经酸浸脱锂后的离子筛仍保持着与前驱体相同的尖晶石结构; 前驱体Li 4 Mn 5 O 12 和离子筛MnO 2 均为 200 nm左右的球状颗粒; 离子筛的最大吸附容量为43.1 mg/g, 并具有较好的Li + 选择性。
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- 2013
13. Fuchsine Adsorption from Aqueous Solution by Epichlorohydrin Crosslinked Peanut Husk
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Ying Hua Song, Jian Min Ren, Hui Xu, Sheng Ming Chen, and Yuan Gao
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Fuchsine ,chemistry.chemical_compound ,Langmuir ,Adsorption ,Aqueous solution ,Chemistry ,General Engineering ,Organic chemistry ,Freundlich equation ,Epichlorohydrin ,Endothermic process ,Husk ,Nuclear chemistry - Abstract
The adsorption of fuchsine by peanut husk, which was crosslinked by epichlorohydrin was studied with variation in the parameters of contact time, pH, initial fuchsine concentration and temperature. They were used for equilibrium adsorption uptake studies with fuchsine. The results indicate that adsorption equilibrium could be well described by both the Langmuir and the Freundlich isotherm equation. The adsorption followed the pseudo-second order model. The thermodynamic constants of the adsorption process were also evaluated, which suggest an endothermic adsorption process which runs spontaneously.
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- 2012
14. Evaluation of the City Integrated Emergency Response System Based on the Analytic Hierarchy Process
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Jing Jing Wan and Ying Hua Song
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Transport engineering ,Engineering ,Emergency response ,Operations research ,Index system ,business.industry ,General Engineering ,Analytic hierarchy process ,Emergency rescue ,business - Abstract
The city integrated emergency response system achieved consolidated receive alarm and command which cross-regional, inter-departmental and cross-force, it can conduct emergency rescue or relief disaster timely, orderly and efficiently. This paper mainly used the method of analytic hierarchy process (AHP), analysis the city integrated emergency response system through the establishment of evaluation index system, get the calculation formula of its comprehensive score, and take Nanning city integrated emergency response system for example, apply and prove the index system and calculation formula.
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- 2012
15. Research of a De-Noising Algorithm Based on Sliding Window
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Ting Xi Gou, Wen Chuan Yang, and Ying Hua Song
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Engineering ,Service (systems architecture) ,Focus (computing) ,business.industry ,De noising ,General Engineering ,computer.software_genre ,Data set ,Knowledge extraction ,Sliding window protocol ,Data mining ,business ,computer ,Algorithm - Abstract
Top-quality and efficient service increases in importance in the telecom service. One of its challenging issues is to deal with the atypical incidents. While the traditional mining algorithms are focus on the high-frequent item sets, a de-noising algorithm related to the atypical incidents still remains unsettled. This paper proposed a de-noising model based on the sliding window. In this model, FP-tree and multi-association rules are introduced to fix the thresholds of the sliding window. Experimental results demonstrate that the proposed algorithm can apply an appropriate data set to the knowledge discovery of the atypical incidents
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- 2012
16. Adsorption of Grape Seed Procyanidins on Macroporous Adsorbent Resin: Isotherms and Thermodynamics
- Author
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Gui Zhi Zhang and Ying Hua Song
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Langmuir ,Adsorption ,Macroporous resin ,Materials science ,General Engineering ,Thermodynamics ,Freundlich equation ,Endothermic process ,Grape seed - Abstract
The adsorption properties,including the adsorption isotherms,thermodynamics,of grape seed procyanidins onto macroporous resin HZ818 are investigated.Both the Langmuir and Freundlich equations can provide a good fit to the adsorption isotherms, which indicates an endothermic and a favorable process in our study.The capacities of the adsorption increase with temperature. The negative values of ΔG and values of ΔH lower than 40 kJ/mol indicate a spontaneous physical adsorption, and the positive values of ΔS show the increased randomness at the solid/solution interface during the adsorption process.
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- 2011
17. Kinetics of the Adsorption for Naphthol Green by Epichlorohydrin Modified Peanut Shell
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Ying Hua Song
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Langmuir ,chemistry.chemical_compound ,Adsorption ,Chemistry ,Kinetics ,Inorganic chemistry ,General Engineering ,Shell (structure) ,Freundlich equation ,Epichlorohydrin ,Diffusion (business) ,Kinetic energy - Abstract
The adsorption of naphthol green by peanut shell, which was chemically-modified by cross-linking with epichlorohydrin was studied with variation in the parameters of contact time and temperature. They were used for equilibrium adsorption uptake studies with naphthol green. The results revealed that adsorption equilibriums were rapidly established in about 3h. Three different kinetic models (i.e.,intraparticular diffusion model, Lagergren-first-order and second-order equations) were used to describe the adsorption kinetic mechanisms. The adsorption of naphthol green on epichlorohydrin modified peanut shell(EMPS) was not controlled by intraparticular diffusion. The kinetic adsorption data can be well simulated by the second-order equation and the adsorption might be rate-limiting controlled. The suitability of the adsorbent was evaluated by fitting the equilibrium data with Langmuir and Freundlich isotherms, which gave good fits with both isotherms.
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- 2011
18. Kinetic Studies of Adsorption of Chrome Blue-Black by Modified Peanut Husk
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Mei Ye, Yuan Gao, and Ying Hua Song
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Langmuir ,Aqueous solution ,Adsorption ,Materials science ,Waste management ,Adsorption kinetics ,Chemical engineering ,Freundlich equation ,General Medicine ,Diffusion (business) ,Kinetic energy ,Husk - Abstract
Modified peanut husk was used as an adsorbent to remove chrome blue-black from its aqueous solution. Results of kinetic experiments demonstrated that the adsorption was effective and rapid.Three different kinetic models (i.e.,intraparticular diffusion model, Lagergren-first-order and second-order equations) were used to describe the adsorption mechanisms. The adsorption of chrome blue-black on modified peanut husk was not controlled by intraparticular diffusion. The kinetic adsorption data can be well simulated by the second-order equation and the adsorption might be rate-limiting controlled. The suitability of the adsorbent was tested by fitting the equilibrium data with Langmuir and Freundlich isotherms, which gave good fits with both isotherms.
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- 2011
19. Biosorption of Eosin by Chemically Modified Peanut Husk
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Ying Hua Song and Sheng Ming Chen
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chemistry.chemical_compound ,Chromatography ,Eosin ,chemistry ,Chemical engineering ,Diffusion ,Mass transfer ,General Engineering ,Biosorption ,Sorption ,Freundlich equation ,Endothermic process ,Husk - Abstract
The sorption of eosin by peanut husk, which was chemically modified by formaldehyde in acidic medium was studied with variation in the parameters of contact time, pH, initial eosin concentration and temperature. They were used for equilibrium sorption uptake studies with eosin. The results indicate that sorption equilibrium could be well described by the Freundlich isotherm equation. The sorption followed the pseudo-second order model. The mass transfer model as intraparticle diffusion was applied to the experimental data to examine the mechanisms of the rate controlling step. It was found that the intraparticle diffusion is becoming the significant controlling step under the experimental conditions. The thermodynamic constants of the sorption process were also evaluated, which suggest an endothermic physical sorption process which runs spontaneously.
- Published
- 2011
20. Study on the fractal characteristics of rock in the prediction of rockburst
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Mo-xiao, Li, primary, Ying-hua, Song, additional, and Guang, Zhang, additional
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- 2017
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21. Research on the Surface Fractal Characteristic of the Rock with Rockburst Proneness
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Guang Zhang, Ying-hua Song, Moxiao Li, and Jing-xi Chen
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Surface (mathematics) ,Fractal ,General Engineering ,Uniaxial compression ,Geotechnical engineering ,Fractal dimension ,Geology - Abstract
In order to strengthen the prediction of rockburst and inquire the relationship between the rockburst proneness of rock and its surface fractal characteristic, the surface fractal of the rock was studied by fractal method and uniaxial compression test. The change rules of surface fractal of different types of rock were compared by calculating its fractal dimension of rock before experiment and after experiment. Based on the prediction results, we found that the dimension after test is bigger than before test for four kinds of rocks. The rock with stronger rockburst proneness has more intense failure in the loading process and its crack morphology is more complex.
- Published
- 2016
22. Upregulation of glucosylceramide synthase protein in papillary thyroid carcinoma
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Ke, Zhang, Ying-Hua, Song, Xiao-Yan, Lin, Qiang-Xiu, Wang, Hua-Wei, Zhang, and Jia-Wen, Xu
- Subjects
Adult ,Male ,Blotting, Western ,Carcinoma ,Prognosis ,Immunohistochemistry ,Carcinoma, Papillary ,Up-Regulation ,Glucosyltransferases ,Thyroid Cancer, Papillary ,Humans ,Female ,Thyroid Neoplasms ,Retrospective Studies - Abstract
Glucosylceramide synthase (GCS) can reduce ceramide levels and help cells escape ceramide-induced apoptosis, thus leading to multidrug resistance (MDR). However, its expression and clinical significance in thyroid neoplasms still remain unclear. We aimed to elucidate the expression of GCS and explore its correlation with the clinicopathological characteristics in papillary thyroid carcinomas (PTCs).We retrospectively investigated GCS protein expression level in tissue specimens obtained from 108 consecutive PTC patients by immunohistochemistry and Western blotting.GCS was weakly positive or negative in normal follicular cells, but it was frequently overexpressed in PTC cells. GCS overexpression was associated with primary tumor size, local infiltration, lymph node metastasis, and local recurrence, but not associated with gender, age, pathological variants, tumor multifocality, tumor stage or distant metastasis. Western blotting also showed that GCS protein levels were much higher in PTCs' tissues than in normal thyroid tissues.GCS was upregulated in PTCs and might be an independent factor affecting prognosis.
- Published
- 2013
23. Diagnostic accuracy of fiberoptic ductoscopy plus in vivo iodine staining for intraductal proliferative lesions
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Xin-zhi, Feng, Ying-hua, Song, Feng-xia, Zhang, Chuan-wu, Jiang, Hong, Mei, and Bin, Zhao
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Adult ,Hyperplasia ,Staining and Labeling ,Carcinoma, Ductal, Breast ,Breast Neoplasms ,Middle Aged ,Periodic Acid-Schiff Reaction ,Carcinoma, Intraductal, Noninfiltrating ,Fiber Optic Technology ,Humans ,Female ,Breast ,Aged ,Iodine - Abstract
Iodine staining during endoscopy has been successfully used to detect early carcinomatous and precancerous lesions in the esophagus, cervix, and oral cavity. The objective of this study was to determine the diagnostic accuracy of fiberoptic ductoscopy (FDS) plus in vivo iodine staining for intraductal proliferative lesions of the breast.We performed periodic acid-Schiff (PAS) and in vitro iodine staining on 52 and 64 specimens of benign mammary hyperplasia, respectively, and 57 and 53 specimens of ductal carcinoma in situ (DCIS), respectively. Next, FDS was performed on 177 recurrent nipple discharge patients who were randomly divided into two groups. One group was iodine-staining group in which 92 patients were randomly selected to undergo iodine staining during FDS, and the remaining 85 were assigned to the control group. Biopsy specimens of suspicious lesions were obtained and subjected to histopathological examination.Following PAS staining, benign mammary hyperplasia lesions were positively stained, while negligible PAS positivity was observed in the DCIS lesions (P0.05). Following in vitro iodine staining, benign mammary hyperplasia specimens appeared dark brown, whereas DCIS samples appeared significantly lighter or unstained. Compared with the pathological examination results, FDS with iodine staining showed an agreement rate in the diagnosis of ductal intraepithelial neoplasia (DIN), sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and Youden index of 97.82%, 98.83%, 83.33%, 5.93, 0.014, and 0.8216, respectively; the corresponding values for FDS without iodine staining were 88.24%, 89.16%, 50.00%, 1.78, 0.217, and 0.3916, respectively.FDS with iodine staining was superior to conventional FDS for the diagnosis of DIN and is valuable for breast cancer prevention.
- Published
- 2013
24. IL-25 Involved in Airway Inflammation of OVA-Induced Asthmatic Mice and the Inhibitory Effect of Glucocorticoid
- Author
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De-Gan Lu, Fen Liu, Chao Wang, Cai-qing Zhang, Liang Dong, Ying-hua Song, Jiping Zhao, Hong-jia Li, and Jin-Xiang Wu
- Subjects
medicine.medical_specialty ,Lung ,biology ,business.industry ,Inflammation ,respiratory system ,Immunoglobulin E ,Proinflammatory cytokine ,Ovalbumin ,Endocrinology ,medicine.anatomical_structure ,Internal medicine ,Immunology ,medicine ,biology.protein ,Immunohistochemistry ,medicine.symptom ,business ,Glucocorticoid ,Sensitization ,medicine.drug - Abstract
Objective: To study the expression of IL-25 in airway inflammation of OVA-induced asthmatic mice and the effects of glucocorticoid. Methods: The asthmatic mice were induced by ovalbumin (OVA) sensitization and challenge. This model was confirmed by detecting airway responsiveness, serum levels of IgE and lung histopathology. We also detected the inflammatory cells by cell counting plate and cytokines by ELISA, respectively. We also detected the expression of IL-25 by quantitative real-time PCR and immunohistochemistry. Results: Compared with the mice in control group, the asthmatic mice showed elevated airway responsiveness and high serum levels of IgE. We also detected more inflammatory cells and high level of inflammatory cytokines in mice of OVA group. The expression of IL-25 was also significantly increased in both mRNA and protein levels in OVA group. Furthermore, treating mice with glucocorticoid could inhibit inflammatory cells and cytokines infiltration and reduce IL-25 expression. Conclusion: IL-25 level is increased in OVA-induced asthmatic airway inflammation and glucocorticoid is capable of inhibiting IL-25 expression as well as other Th2 cytokines, thus presents a promising strategy for the treatment of asthma.
- Published
- 2013
25. Current Evidence on the Association between Mmp-7 (-181a>G) Polymorphism and Digestive System Cancer Risk
- Author
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Zhong De Wu, Pan Ke, primary and Miao Xiong Ying, Hua Song Wen, additional
- Published
- 2013
- Full Text
- View/download PDF
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