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Your search keyword '"Yokota, Jumpei"' showing total 14 results
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14 results on '"Yokota, Jumpei"'

8. Regional Transcriptomics and Proteomics of Pharmacokinetics-Related Genes in Human Intestine

Author

Murata, Michika, primary, Fujioka, Hijiri, additional, Yokota, Jumpei, additional, Okada, Kentaro, additional, Yamashita, Tomoki, additional, Hirayama, Daisuke, additional, Kawakami, Kentaro, additional, Morinaga, Gaku, additional, Saito, Asami, additional, Nakase, Hiroshi, additional, Kishimoto, Wataru, additional, and Mizuguchi, Hiroyuki, additional

Published
2023
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9. Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

Author

Yamashita, Tomoki, primary, Inui, Tatsuya, additional, Yokota, Jumpei, additional, Kawakami, Kentaro, additional, Morinaga, Gaku, additional, Takatani, Masahito, additional, Hirayama, Daisuke, additional, Nomoto, Ryuga, additional, Ito, Kohei, additional, Cui, Yunhai, additional, Ruez, Stephanie, additional, Harada, Kazuo, additional, Kishimoto, Wataru, additional, Nakase, Hiroshi, additional, and Mizuguchi, Hiroyuki, additional

Published
2021
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13. 単一磁束量子デバイスを用いた次世代プロセッサのマイクロアーキテクチャ探索

Author

YOKOTA, Jumpei, TSUHATA, Tomonori, INOUE, Koji, and TANAKA, Masami

Subjects
Microprocessor, SFQ, マイクロプロセッサ, 性能モデリング, Performance Modeling, Hardware_ARITHMETICANDLOGICSTRUCTURES, アーキテクチャ, SFQ回路, Architectuire
Abstract

単一磁束量子(Single-Flux-Quantum;SFQ)マイクロプロセッサは,超伝導体素子によって構成され,極めて低消費電力で動作する次世代プロセッサである.デバイスの特性上,CMOSプロセッサと異なる新たなパイプライン構成およびビット幅の設計空間が考えられる.そこで,本稿ではSFQマイクロプロセッサの性能モデリングを行い,モデルに基づくマイクロアーキテクチャ探索を行う., Single-Flux-Quantum (SFQ) is a promising device technology to implement high-performance low-power microprocessors. Since it operates at the superconductive condition, the negative impact of resistance can dramatically reduced. Previous design of a SFQ microprocessor employs a bit-serial implementation for instruction pipelining. However, since there is a trade-off between bit-level parallelism and operation frequency, it is still not clear that this kind of bit-level operation is suitable for SFQ microprocessors. To answer this question, this paper explore the SFQ pipeline micro-architecture and evaluates their performance., IEICE Technical Report;CPM2013-115, IEICE Technical Report;ICD2013-92

Published
2013

14. Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research.

Author

Yamashita T, Inui T, Yokota J, Kawakami K, Morinaga G, Takatani M, Hirayama D, Nomoto R, Ito K, Cui Y, Ruez S, Harada K, Kishimoto W, Nakase H, and Mizuguchi H

Abstract

The human small intestine is the key organ for absorption, metabolism, and excretion of orally administered drugs. To preclinically predict these reactions in drug discovery research, a cell model that can precisely recapitulate the in vivo human intestinal monolayer is desired. In this study, we developed a monolayer platform using human biopsy-derived duodenal organoids for application to pharmacokinetic studies. The human duodenal organoid-derived monolayer was prepared by a simple method in 3-8 days. It consisted of polarized absorptive cells and had tight junctions. It showed much higher cytochrome P450 (CYP)3A4 and carboxylesterase (CES)2 activities than did the existing models (Caco-2 cells). It also showed efflux activity of P-glycoprotein (P-gp) and inducibility of CYP3A4. Finally, its gene expression profile was closer to the adult human duodenum, compared to the profile of Caco-2 cells. Based on these findings, this monolayer assay system using biopsy-derived human intestinal organoids is likely to be widely adopted., Competing Interests: The authors declare no competing interests., (© 2021 The Authors.)

Published
2021
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