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2. ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels

Author

Lin, Yang, Gil, Chang-Hyun, Banno, Kimihiko, Yokoyama, Masataka, Wingo, Matthew, Go, Ellen, Prasain, Nutan, Liu, Ying, Hato, Takashi, Naito, Hisamichi, Wakabayashi, Taku, Sominskaia, Musia, Gao, Meng, Chen, Kevin, Geng, Fuqiang, Gomez Salinero, Jesus Maria, Chen, Sisi, Shelley, W. Christopher, Yoshimoto, Momoko, Li Calzi, Sergio, Murphy, Michael P., Horie, Kyoji, Grant, Maria B., Schreiner, Ryan, Redmond, David, Basile, David P., Rafii, Shahin, and Yoder, Mervin C.

Published
2024
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3. Identification of genotype–biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency

Author

Sakuma, Ikki, Nagano, Hidekazu, Hashimoto, Naoko, Fujimoto, Masanori, Nakayama, Akitoshi, Fuchigami, Takahiro, Taki, Yuki, Matsuda, Tatsuma, Akamine, Hiroyuki, Kono, Satomi, Kono, Takashi, Yokoyama, Masataka, Nishimura, Motoi, Yokote, Koutaro, Ogasawara, Tatsuki, Fujii, Yoichi, Ogawa, Seishi, Lee, Eunyoung, Miki, Takashi, and Tanaka, Tomoaki

Published
2023
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7. Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Author

Fujimoto, Masanori, Yokoyama, Masataka, Kiuchi, Masahiro, Hosokawa, Hiroyuki, Nakayama, Akitoshi, Hashimoto, Naoko, Sakuma, Ikki, Nagano, Hidekazu, Yamagata, Kazuyuki, Kudo, Fujimi, Manabe, Ichiro, Lee, Eunyoung, Hatano, Ryo, Onodera, Atsushi, Hirahara, Kiyoshi, Yokote, Koutaro, Miki, Takashi, Nakayama, Toshinori, and Tanaka, Tomoaki

Published
2022
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8. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway

Author

Aersilan, Alimasi, Hashimoto, Naoko, Yamagata, Kazuyuki, Yokoyama, Masataka, Nakayama, Akitoshi, Shi, Xiaoyan, Nagano, Hidekazu, Sakuma, Ikki, Nohata, Nijiro, Kinoshita, Takashi, Seki, Naohiko, Rahmutulla, Bahityar, Kaneda, Atsushi, Zhahara, Siti Nurul, Gong, Yingbo, Nishimura, Motoi, Kawauchi, Shoichiro, Kawakami, Eiryo, and Tanaka, Tomoaki

Published
2022
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9. Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors

Author

Yamato, Azusa, Nagano, Hidekazu, Gao, Yue, Matsuda, Tatsuma, Hashimoto, Naoko, Nakayama, Akitoshi, Yamagata, Kazuyuki, Yokoyama, Masataka, Gong, Yingbo, Shi, Xiaoyan, Zhahara, Siti Nurul, Kono, Takashi, Taki, Yuki, Furuki, Naoto, Nishimura, Motoi, Horiguchi, Kentaro, Iwadate, Yasuo, Fukuyo, Masaki, Rahmutulla, Bahityar, Kaneda, Atsushi, Hasegawa, Yoshinori, Kawashima, Yusuke, Ohara, Osamu, Ishikawa, Tetsuo, Kawakami, Eiryo, Nakamura, Yasuhiro, Inoshita, Naoko, Yamada, Shozo, Fukuhara, Noriaki, Nishioka, Hiroshi, and Tanaka, Tomoaki

Published
2022
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14. TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia

Author

Ochiiwa, Hiroaki, Ailiken, Guzhanuer, Yokoyama, Masataka, Yamagata, Kazuyuki, Nagano, Hidekazu, Yoshimura, Chihoko, Muraoka, Hiromi, Ishida, Keiji, Haruma, Tomonori, Nakayama, Akitoshi, Hashimoto, Naoko, Murata, Kazutaka, Nishimura, Motoi, Kawashima, Yusuke, Ohara, Osamu, Ohkubo, Shuichi, and Tanaka, Tomoaki

Published
2021
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15. Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

Author

Palikuqi, Brisa, Nguyen, Duc-Huy T., Li, Ge, Schreiner, Ryan, Pellegata, Alessandro F., Liu, Ying, Redmond, David, Geng, Fuqiang, Lin, Yang, Gómez-Salinero, Jesus M., Yokoyama, Masataka, Zumbo, Paul, Zhang, Tuo, Kunar, Balvir, Witherspoon, Mavee, Han, Teng, Tedeschi, Alfonso M., Scottoni, Federico, Lipkin, Steven M., Dow, Lukas, Elemento, Olivier, Xiang, Jenny Z., Shido, Koji, Spence, Jason R., Zhou, Qiao J., Schwartz, Robert E., De Coppi, Paolo, Rabbany, Sina Y., and Rafii, Shahin

Published
2020
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32. Molecular determinants of nephron vascular specialization in the kidney

Author

Barry, David M., McMillan, Elizabeth A., Kunar, Balvir, Lis, Raphael, Zhang, Tuo, Lu, Tyler, Daniel, Edward, Yokoyama, Masataka, Gomez-Salinero, Jesus M., Sureshbabu, Angara, Cleaver, Ondine, Di Lorenzo, Annarita, Choi, Mary E., Xiang, Jenny, Redmond, David, Rabbany, Sina Y., Muthukumar, Thangamani, and Rafii, Shahin

Published
2019
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42. Current Ventilator and Oxygen Management during General Anesthesia: A Multicenter, Cross-sectional Observational Study

Author

Suzuki, Satoshi, Mihara, Yuko, Hikasa, Yukiko, Okahara, Shuji, Ishihara, Takuma, Shintani, Ayumi, Morimatsu, Hiroshi, Sato, Akiko, Kusume, Sachio, Hidaka, Hidekuni, Yatsuzuka, Hidehiko, Okawa, Masahiro, Takatori, Makoto, Saeki, Shinsei, Samuta, Takeshi, Tokioka, Hiroaki, Kurasako, Toshiaki, Maeda, Masato, Takeuchi, Mamoru, Hirasaki, Akihito, Kitaura, Michio, Kajiki, Hideki, Kobayashi, Osamu, Katayama, Hiroshi, Nakatsuka, Hideki, Mizobuchi, Satoshi, Sugimoto, Seiji, Yokoyama, Masataka, Kusudo, Kazuhito, Shiraishi, Kensuke, Iwaki, Toshio, Komatsu, Tatsuhiko, Hirai, Yasuo, Sato, Tetsufumi, Kimura, Masakazu, Yasukawa, Takeshi, Kimura, Motonobu, Taniguchi, Masahiro, Shimoda, Yutaka, Kobayashi, Yoji, Tsukioki, Mitsunori, Manabe, Nobuki, Ando, Eiji, Kosaka, Makoto, Tsukiji, Takashi, Tokura, Chika, Asao, Yasuhiro, Sugiyama, Masatoshi, and Seto, Kozo

Published
2018
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44. Intranasal midazolam administration enhances amnesic effect in rats

Author

Kadono, Takao, Kawano, Takashi, Yamanaka, Daiki, Tateiwa, Hiroki, Urakawa, Manami, Locatelli, Fabricio M., and Yokoyama, Masataka

Subjects
Complications and side effects, Physiological aspects, Research, Dosage and administration, Methods, Midazolam -- Dosage and administration -- Complications and side effects, Drug administration and dosage -- Methods -- Physiological aspects -- Research
Abstract

Author(s): Takao Kadono[sup.1] , Takashi Kawano[sup.1] , Daiki Yamanaka[sup.1] , Hiroki Tateiwa[sup.1] , Manami Urakawa[sup.1] , Fabricio M. Locatelli[sup.1] , Masataka Yokoyama[sup.1] Author Affiliations: (1) Department of Anesthesiology and Intensive [...], Intranasal (i.n.) administration of midazolam has been shown to be effective and safe for its sedative, anxiolytic, and anticonvulsant effects. However, there has been no investigation on the influence of i.n. administration on midazolam-induced anterograde amnesia. In addition, although the potential of direct drug delivery from the nose to the central nervous system (CNS) has recently become a topic of great interest, it remains unclear whether this pathway is also involved after i.n. midazolam. In this study, we examined the efficacy and the underlying mechanism of i.n. administration compared with intramuscular (i.m.) administration on midazolam-induced amnesia in rats. Equivalent doses of 0.6 mg/kg midazolam were administered via either the i.m or the i.n. route. Anterograde amnesia was assessed by a contextual/cued fear conditioning test. Each animal was conditioned 20 min after drug administration and then tested for a freezing response 24 h later. Midazolam administration by either route produced a similar level of light sedation (minimum spontaneous activity). However, i.n. administration of midazolam induced significantly less freezing behavior compared with i.m. midazolam. Furthermore, in rats with disrupted electrical input from the olfactory epithelium after an olfactotoxicant 3-methylindole administration, the i.n.-mediated enhanced amnesic effect of midazolam was not observed. Our findings indicate that i.n midazolam could probably generate olfactory signals to the brain via benzodiazepine receptors and, compared with i.m. administration, can produce a more significant amnesic effect without alteration in sedative levels. Further clinical studies are warranted.

Published
2016
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48. Effects of fentanyl on serotonin syndrome-like behaviors in rats

Author

Kitamura, Sonoe, Kawano, Takashi, Kaminaga, Satomi, Yamanaka, Daiki, Tateiwa, Hiroki, Locatelli, Fabricio M., and Yokoyama, Masataka

Subjects
Care and treatment, Complications and side effects, Development and progression, Research, Hallucinogenic drugs -- Research, Serotonin -- Research, Serotonin syndrome -- Research -- Development and progression -- Care and treatment -- Complications and side effects
Abstract

Author(s): Sonoe Kitamura[sup.1] , Takashi Kawano[sup.1] , Satomi Kaminaga[sup.1] , Daiki Yamanaka[sup.1] , Hiroki Tateiwa[sup.1] , Fabricio M. Locatelli[sup.1] , Masataka Yokoyama[sup.1] Author Affiliations: (1) Department of Anesthesiology and Intensive [...], Emerging evidence from case reports suggests that fentanyl may precipitate potentially life-threatening serotonin syndrome in patients taking serotonergic drugs. However, the underlying mechanism of the association between serotonin syndrome and fentanyl remains under investigation. We therefore investigated the pharmacological effects of an analgesic dose of fentanyl (0.2 mg/kg) injected subcutaneously (s.c.) on serotonergic toxicity-like responses in rats. Rats were s.c. injected with 0.75 mg/kg 8-OH-DPAT, a full 5-HT.sub.1A agonist, as an animal model of serotonin syndrome. The 8-OH-DPAT-treated rats showed well-characterized serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature. Rats injected s.c. with fentanyl alone showed no significant changes in any of the parameters measured, while concomitant administration of fentanyl + 8-OH-DPAT resulted in exaggerated 8-OH-DPAT-induced serototoxic responses. A separate dose-response experiment showed that the serototoxic effect of fentanyl was dose-dependent. Pretreatment with naloxone [2.0 mg/kg, intraperitoneal (i.p.) injection], an opioid receptor antagonist, failed to antagonize the fentanyl-induced exaggerated serotonin syndrome-like behaviors. In contrast, pretreatment with WAY-100653, a serotonin 5-HT.sub.1A receptor antagonist (0.5 mg/kg, i.p. injection) completely inhibited all responses. Our findings provide preclinical proof-of-concept that an analgesic dose of fentanyl enhances serotonin toxicity, likely via its serotonin-reuptake inhibitory activity, independently of interaction with the opioid receptors.

Published
2016
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49. Drug fever caused by propofol in the intensive care unit

Author

Yatabe, Tomoaki, Yamashita, Koichi, and Yokoyama, Masataka

Subjects
Drug therapy, Development and progression, Research, Case studies, Patient outcomes, Dosage and administration, Health aspects, Glycogen storage diseases -- Research -- Case studies -- Development and progression -- Drug therapy -- Patient outcomes, Critically ill persons -- Research -- Health aspects, Antibiotics -- Research -- Dosage and administration
Abstract

Author(s): Tomoaki Yatabe[sup.1] , Koichi Yamashita[sup.1] , Masataka Yokoyama[sup.1] Author Affiliations: (1) Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku, 783-8505, Kochi, Japan Introduction In [...], Few studies have reported that fever is caused by intravenous sedative drugs even though these agents are widely used. We present a case of propofol-induced drug fever. A 57-year-old woman underwent hepatic segmentectomy. Although she was diagnosed with type I glycogen storage disease when in her twenties, her liver function was normal. As the operative hemorrhage was high, the patient was transferred to the intensive care unit (ICU). Her temperature at ICU admission was 35.8 °C, and sedation with propofol and dexmedetomidine was initiated. Two hours after admission to the ICU, the patient had a fever of 38-39.5 °C. Remittent fever persisted until day 5 after surgery. Because of her persistent fever, pneumonia was suspected and antibiotics were initiated on day 4 after surgery. As the fever persisted after the initiation of antibiotics, drug fever was suspected. On day 5 after surgery, propofol infusion was discontinued and the patient was extubated. Her temperature of 37.7 °C at the discontinuation of propofol infusion, and rapidly decreased to 36.1 °C in the following 3 h. Propofol-induced drug fever must be considered in cases of fever of unknown origin when patients receive propofol and appear inappropriately well for the degree of fever that they have.

Published
2015
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50. A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats

Author

Kawano, Takashi, Takahashi, Tetsuya, Kaminaga, Satomi, Kadono, Takao, Yamanaka, Daiki, Iwata, Hideki, Eguchi, Satoru, and Yokoyama, Masataka

Subjects
Drug therapy, Complications and side effects, Research, Comparative analysis, Patient outcomes, Dosage and administration, Dexmedetomidine -- Comparative analysis -- Dosage and administration, Midazolam -- Dosage and administration -- Comparative analysis, Adrenergic alpha-agonists -- Comparative analysis -- Dosage and administration, Serotonin syndrome -- Research -- Drug therapy -- Patient outcomes -- Complications and side effects
Abstract

Author(s): Takashi Kawano[sup.1] [sup.2] , Tetsuya Takahashi[sup.1] , Satomi Kaminaga[sup.2] , Takao Kadono[sup.2] , Daiki Yamanaka[sup.1] , Hideki Iwata[sup.1] , Satoru Eguchi[sup.3] , Masataka Yokoyama[sup.1] [sup.2] Author Affiliations: (1) Department [...], Serotonin syndrome is a drug-related toxicity caused by excess serotonin within the central nervous system. We recently encountered a case of serotonin syndrome that developed in the early postoperative period that was successfully treated with intravenous dexmedetomidine. Although the prescriptive literature has commonly recommended sedation with benzodiazepines for controlling agitation in serotonin syndrome, the effectiveness of dexmedetomidine has also been reported in several clinical conditions. In the present study, we conducted a reverse translational experiment to compare the efficacy of dexmedetomidine and midazolam, at equi-sedative doses, on serotonergic toxicity-like responses in rats. Animals were subcutaneously injected with 0.75 mg/kg 8-OH-DPAT, a full 5-HT.sub.1A agonist. 8-OH-DPAT-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with WAY 100635, a selective 5-HT.sub.1A antagonist (n = 8). Intramuscular injection of midazolam (1.0 mg/kg) or dexmedetomidine (0.01 mg/kg), which comparably induced observable signs of sedation, was tested in the present study. Concomitant treatment with midazolam significantly attenuated the hyperlocomotion, but failed to affect traditional serotonin syndrome behaviors and body temperature in 8-OH-DPAT-treated rats (n = 8). On the other hand, concomitant treatment with dexmedetomidine significantly attenuated all of these parameters (n = 8). The present case and related reverse translational experiment demonstrate that dexmedetomidine may be more beneficial for the treatment of serotonin syndrome compared to the current recommended treatment with benzodiazepines. Electronic supplementary material The online version of this article (doi:10.1007/s00540-014-1973-9) contains supplementary material, which is available to authorized users.

Published
2015
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