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2. Association between continuous cessation or reduction of drinking alcohol and improvement of multiple dysplastic lesions in patients with esophageal squamous cell carcinoma after endoscopic resection

Author

Hori, Keisuke, Katada, Chikatoshi, Okada, Hiroyuki, Katagiri, Atsushi, Matsuo, Yasumasa, Yokoyama, Tetsuji, Yano, Tomonori, Suzuki, Haruhisa, Shimizu, Yuichi, Furue, Yasuaki, Nakanishi, Hiroyoshi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Yoshii, Takako, Yamanouchi, Takenori, Kawakubo, Hirofumi, Kobayashi, Nozomu, Shimoda, Tadakazu, Ochiai, Atsushi, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu

Published
2024
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3. Case-control study of IL23R rs76418789 polymorphism, smoking, and ulcerative colitis in Japan

Author

Miyake, Yoshihiro, Tanaka, Keiko, Nagata, Chisato, Furukawa, Shinya, Andoh, Akira, Yokoyama, Tetsuji, Yoshimura, Naoki, Mori, Kenichiro, Ninomiya, Tomoyuki, Yamamoto, Yasunori, Takeshita, Eiji, Ikeda, Yoshio, Saito, Mitsuru, Ohashi, Katsuhisa, Imaeda, Hirotsugu, Kakimoto, Kazuki, Higuchi, Kazuhide, Nunoi, Hiroaki, Mizukami, Yuji, Suzuki, Seiyuu, Hiraoka, Sakiko, Okada, Hiroyuki, Kawasaki, Keitarou, Higashiyama, Masaaki, Hokari, Ryota, Miura, Hiromasa, Miyake, Teruki, Kumagi, Teru, Kato, Hiromasa, Hato, Naohito, Sayama, Koji, and Hiasa, Yoichi

Published
2024
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5. Metachronous primary gastric cancer after endoscopic resection in patients with esophageal squamous cell carcinoma

Author

Hirao, Motohiro, Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Suzuki, Haruhisa, Furue, Yasuaki, Yamamoto, Keiko, Doyama, Hisashi, Koike, Tomoyuki, Tamaoki, Masashi, Kawata, Noboru, Kawahara, Yoshiro, Katagiri, Atsushi, Ogata, Takashi, Yamanouchi, Takenori, Kiyokawa, Hirofumi, Kawakubo, Hirofumi, Konno, Maki, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu

Published
2023
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9. IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan

Author

Miyake, Yoshihiro, Tanaka, Keiko, Nagata, Chisato, Furukawa, Shinya, Andoh, Akira, Yokoyama, Tetsuji, Yoshimura, Naoki, Mori, Kenichiro, Ninomiya, Tomoyuki, Yamamoto, Yasunori, Takeshita, Eiji, Ikeda, Yoshio, Saito, Mitsuru, Ohashi, Katsuhisa, Imaeda, Hirotsugu, Kakimoto, Kazuki, Higuchi, Kazuhide, Nunoi, Hiroaki, Mizukami, Yuji, Suzuki, Seiyuu, Hiraoka, Sakiko, Okada, Hiroyuki, Kawasaki, Keitarou, Higashiyama, Masaaki, Hokari, Ryota, Miura, Hiromasa, Miyake, Teruki, Kumagi, Teru, Kato, Hiromasa, Hato, Naohito, Sayama, Koji, and Hiasa, Yoichi

Published
2022
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10. Optimizing Organ-Preservation Strategies Through Chemotherapy-Based Selection in Esophageal Squamous Cell Carcinoma: Results From the CROC Multi-Institutional Phase 2 Clinical Trial.

Author

Katada, Chikatoshi, Yokoyama, Tetsuji, Watanabe, Akinori, Hara, Hiroki, Yoshii, Takako, Fujii, Hirofumi, Yamaguchi, Hironori, Nakajima, Takako Eguchi, Izawa, Naoki, Ando, Takayuki, Nomura, Motoo, Kojima, Takashi, Yamashita, Keishi, Kawakami, Shogo, Ishiyama, Hiromichi, Inoue, Yusuke, Sakamoto, Yasutoshi, Sasaki, Hiroki, Ishikawa, Hideki, and Hosokawa, Ayumu

Subjects
*INDUCTION chemotherapy, *SQUAMOUS cell carcinoma, *PROGRESSION-free survival, *OVERALL survival, *CISPLATIN
Abstract

This study aimed to assess the viability of definitive chemoradiotherapy (dCRT) as an organ-preservation strategy for remarkable responders who were downstaged to stage IA after receiving induction chemotherapy for resectable esophageal squamous cell carcinoma (ESCC). Chemotherapy-naïve patients with resectable ESCC (stage IB-III, Union for International Cancer Control, International Cancer Control seventh edition) were eligible for the study. All patients received 3 cycles of docetaxel, cisplatin, and 5-FU (DCF) therapy (docetaxel 75 mg/m2 on day 1, cisplatin 75 mg/m2 on day 1, and 5-fluorouracil [5-FU] 750 mg/m2 on days 1-5, repeated every 3 weeks). Remarkable response was defined as a reduction in the tumor to T1, metastatic lymph nodes <1 cm on the short axis, and downstaging to stage IA after 3 cycles of DCF therapy. Remarkable responders then underwent dCRT, which included 2 courses of cisplatin 75 mg/m2 and 5-FU 1000 mg/m2 on days 1 to 4, repeated every 4 weeks, along with 50.4 Gy of concurrent radiation therapy. The primary endpoint was 1-year progression-free survival in remarkable responders following DCF therapy and subsequent dCRT. Secondary endpoints included 3-year overall survival (OS) and esophagectomy-free survival. Of the 92 patients registered, 90 were analyzed. A remarkable response to 3 courses of DCF therapy was observed in 58.4% of patients. Among these responders, 89.8% achieved a complete response after dCRT. During the median follow-up period of 33 months (range, 1-85 months), the 1-year progression-free survival was 89.8% (95% confidence interval [CI], 77.2%-95.6%, primary endpoint), and the 3-year OS was 83.7%. The 3-year OS and esophagectomy-free survival rates in the analysis group were 74.1% and 45.3%, respectively. An 18F-fluorodeoxyglucose-positron emission tomography response after 2 courses of DCF therapy was significantly associated with OS (P =.0049). In patients with resectable ESCC, dCRT for remarkable responders downstaging to stage IA after induction chemotherapy with 3 courses of DCF therapy is a feasible treatment option and provides an optimizing organ-preservation strategy of chemotherapy-based selection. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Field Effect of Alcohol, Cigarette Smoking, and Their Cessation on the Development of Multiple Dysplastic Lesions and Squamous Cell Carcinoma: A Long-term Multicenter Cohort Study

Author

Kaneko, Kazuhiro, Morita, Shuko, Funakoshi, Makiko, Horimatsu, Takahiro, Takahashi, Mari, Suzuki, Haruhisa, Abiko, Satoshi, Takemura, Kenichi, Nakanishi, Hiroyoshi, Saito, Masahiro, Ara, Nobuyuki, Kakushima, Naomi, Tanaka, Masaki, Hori, Keisuke, Tsuda, Takashi, Muto, Manabu, Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Ezoe, Yasumasa, Tanabe, Satoshi, Shimizu, Yuichi, Doyama, Hisashi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Ogata, Takashi, Katagiri, Atsushi, Yamanouchi, Takenori, Matsuo, Yasumasa, Kawakubo, Hirofumi, Omori, Tai, Kobayashi, Nozomu, Shimoda, Tadakazu, Ochiai, Atsushi, Ishikawa, Hideki, Baba, Kiichiro, Amanuna, Yusuke, Yokoyama, Akira, and Ohashi, Shinya

Published
2022
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12. Dietary intake of vegetables, fruit, and antioxidants and risk of ulcerative colitis: A case-control study in Japan

Author

Miyake, Yoshihiro, Tanaka, Keiko, Nagata, Chisato, Furukawa, Shinya, Andoh, Akira, Yokoyama, Tetsuji, Yoshimura, Naoki, Mori, Kenichiro, Ninomiya, Tomoyuki, Yamamoto, Yasunori, Takeshita, Eiji, Ikeda, Yoshio, Saito, Mitsuru, Ohashi, Katsuhisa, Imaeda, Hirotsugu, Kakimoto, Kazuki, Higuchi, Kazuhide, Nunoi, Hiroaki, Mizukami, Yuji, Suzuki, Seiyuu, Hiraoka, Sakiko, Okada, Hiroyuki, Kawasaki, Keitarou, Higashiyama, Masaaki, Hokari, Ryota, Miura, Hiromasa, Miyake, Teruki, Kumagi, Teru, Kato, Hiromasa, Hato, Naohito, Sayama, Koji, and Hiasa, Yoichi

Published
2021
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13. Tumor thickness as a novel risk factor for lymph node metastasis by superficial squamous cell carcinoma of head and neck.

Author

Fujii, Satoshi, Katada, Chikatoshi, Watanabe, Hidenobu, Shimoda, Tadakazu, Ochiai, Atsushi, Yokoyama, Tetsuji, Sakamoto, Yasutoshi, Kano, Koichi, Ichinoe, Masaaki, Nemoto, Tetsuo, Fujita, Masahiro, Tateishi, Yoko, Sugiura, Hitoshi, Mikami, Tetuo, Yano, Tomonori, Kato, Takakuni, Muto, Manabu, and Hayashi, Ryuichi

Abstract

Narrow‐band imaging combined with magnified endoscopy has enabled the detection of superficial squamous cell carcinoma of the head and neck (SSCCHN) that has been resected with minimally invasive treatment, preserving vocalization and swallowing functions. However, risk factors of lymph node metastasis (LNM) must be identified, as some patients with LNM have a poor prognosis. From an initial 599 patients with 700 lesions who underwent trans‐oral surgery in 27 Japanese hospitals (a nationwide registration survey), we enrolled 541 patients with 633 SSCCHNs, as indicated by central pathological diagnoses. All pathological specimens for each patient were examined using 20 pathological factors that are thought to affect the LNM of SSCCHN. In all, 24 (4.4%) of the 568 SSCCHNs exhibited LNM, and all 24 had at least one solitary nest of epithelial neoplastic cells present in the stroma, clearly separated from the intraepithelial carcinoma. Multivariate analysis also showed that tumor thickness (p = 0.0132, RR: 7.85, 95% confidence interval [CI]: 1.54–40.02), and an INFc pattern classified as infiltrating growth (INF) with unclear boundaries between tumor and non‐tumor tissues (p = 0.0003, RR: 14.47, 3.46–60.46), and tumor budding (p = 0.0019, RR: 4.35, CI: 1.72–11.01) were significantly associated with LNM. Solitary nests may be indicative of LNM. In addition, tumor thickness was revealed to be a risk factor for LNM in SSCCHNs using pT factors that do not include an invasion depth element because of the anatomical absence of the muscularis mucosae. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma

Author

Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Shimizu, Yuichi, Doyama, Hisashi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Yoshii, Takako, Kubota, Yutaro, Yamanouchi, Takenori, Tsuda, Takashi, Omori, Tai, Kobayashi, Nozomu, Suzuki, Haruhisa, Tanabe, Satoshi, Hori, Keisuke, Nakayama, Norisuke, Kawakubo, Hirofumi, Kakushima, Naomi, Matsuo, Yasumasa, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu

Published
2020
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18. Association between continuous cessation or reduction of drinking alcohol and improvement of multiple dysplastic lesions in patients with esophageal squamous cell carcinoma after endoscopic resection

Author

Hori, Keisuke, primary, Katada, Chikatoshi, additional, Okada, Hiroyuki, additional, Katagiri, Atsushi, additional, Matsuo, Yasumasa, additional, Yokoyama, Tetsuji, additional, Yano, Tomonori, additional, Suzuki, Haruhisa, additional, Shimizu, Yuichi, additional, Furue, Yasuaki, additional, Nakanishi, Hiroyoshi, additional, Koike, Tomoyuki, additional, Takizawa, Kohei, additional, Hirao, Motohiro, additional, Yoshii, Takako, additional, Yamanouchi, Takenori, additional, Kawakubo, Hirofumi, additional, Kobayashi, Nozomu, additional, Shimoda, Tadakazu, additional, Ochiai, Atsushi, additional, Ishikawa, Hideki, additional, Yokoyama, Akira, additional, and Muto, Manabu, additional

Published
2023
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19. Effect of a Community-Based Program to Accelerate Referral to Physicians for Individuals at High-Risk of Lifestyle-Related Diseases: A Cluster Randomized Trial

Author

Iso, Hiroyasu, primary, Noguchi, Midori, additional, Yokoyama, Tetsuji, additional, Yoshida, Toshiko, additional, Saito, Isao, additional, Shintani, Ayumi, additional, Sairenchi, Toshimi, additional, Nishizawa, Hitoshi, additional, Imano, Hironori, additional, Kitamura, Akihiko, additional, and Shimomura, Iichiro, additional

Published
2023
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22. Alcohol consumption, multiple Lugol‐voiding lesions, and field cancerization.

Author

Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Suzuki, Haruhisa, Furue, Yasuaki, Yamamoto, Keiko, Doyama, Hisashi, Koike, Tomoyuki, Tamaoki, Masashi, Kawata, Noboru, Hirao, Motohiro, Kawahara, Yoshiro, Ogata, Takashi, Katagiri, Atsushi, Yamanouchi, Takenori, Kiyokawa, Hirofumi, Kawakubo, Hirofumi, Konno, Maki, Yokoyama, Akira, and Ohashi, Shinya

Published
2024
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23. Coffee and caffeine intake reduces risk of ulcerative colitis: a case–control study in Japan.

Author

Tanaka, Keiko, Okubo, Hitomi, Miyake, Yoshihiro, Nagata, Chisato, Furukawa, Shinya, Andoh, Akira, Yokoyama, Tetsuji, Yoshimura, Naoki, Mori, Kenichiro, Ninomiya, Tomoyuki, Yamamoto, Yasunori, Takeshita, Eiji, Ikeda, Yoshio, Saito, Mitsuru, Ohashi, Katsuhisa, Imaeda, Hirotsugu, Kakimoto, Kazuki, Higuchi, Kazuhide, Nunoi, Hiroaki, and Mizukami, Yuji

Subjects
ULCERATIVE colitis, COFFEE, CAFFEINE, CASE-control method, BODY mass index
Abstract

Background and Aim: Although diet is one of the potential environmental factors affecting ulcerative colitis (UC), evidence is not sufficient to draw definitive conclusions. This Japanese case–control study examined the association between the consumption of coffee, other caffeine‐containing beverages and food, and total caffeine and the risk of UC. Methods: The study involved 384 UC cases and 665 control subjects. Intake of coffee, decaffeinated coffee, black tea, green tea, oolong tea, carbonated soft drinks, and chocolate snacks was measured with a semiquantitative food‐frequency questionnaire. Adjustments were made for sex, age, pack‐years of smoking, alcohol consumption, history of appendicitis, family history of UC, education level, body mass index, and intake of vitamin C, retinol, and total energy. Results: Higher consumption of coffee and carbonated soft drinks was associated with a reduced risk of UC with a significant dose–response relationship (P for trend for coffee and carbonated soft drinks were <0.0001 and 0.01, respectively), whereas higher consumption of chocolate snacks was significantly associated with an increased risk of UC. No association was observed between consumption of decaffeinated coffee, black tea, green tea, or oolong tea and the risk of UC. Total caffeine intake was inversely associated with the risk of UC; the adjusted odds ratio between extreme quartiles was 0.44 (95% confidence interval: 0.29–0.67; P for trend <0.0001). Conclusions: We confirmed that intake of coffee and caffeine is also associated with a reduced risk of UC in Japan where people consume relatively low quantities of coffee compared with Western countries. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes

Author

Matsumoto, Hisako, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Tomita, Katsuyuki, Yokoyama, Akihito, Ohnishi, Hiroshi, Nakano, Yasutaka, Oguma, Tetsuya, Hozawa, Soichiro, Izuhara, Yumi, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Iwata, Toshiyuki, Ono, Junya, Ohta, Shoichiro, Hirota, Tomomitsu, Kawaguchi, Takahisa, Tamari, Mayumi, Yokoyama, Tetsuji, Tabara, Yasuharu, Matsuda, Fumihiko, Izuhara, Kenji, Niimi, Akio, and Mishima, Michiaki

Published
2017
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27. Alcohol consumption, multiple Lugol‐voiding lesions, and field cancerization

Author

Katada, Chikatoshi, primary, Yokoyama, Tetsuji, additional, Yano, Tomonori, additional, Suzuki, Haruhisa, additional, Furue, Yasuaki, additional, Yamamoto, Keiko, additional, Doyama, Hisashi, additional, Koike, Tomoyuki, additional, Tamaoki, Masashi, additional, Kawata, Noboru, additional, Hirao, Motohiro, additional, Kawahara, Yoshiro, additional, Ogata, Takashi, additional, Katagiri, Atsushi, additional, Yamanouchi, Takenori, additional, Kiyokawa, Hirofumi, additional, Kawakubo, Hirofumi, additional, Konno, Maki, additional, Yokoyama, Akira, additional, Ohashi, Shinya, additional, Kondo, Yuki, additional, Kishimoto, Yo, additional, Kano, Koichi, additional, Mure, Kanae, additional, Hayashi, Ryuichi, additional, Ishikawa, Hideki, additional, and Muto, Manabu, additional

Published
2023
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28. Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck

Author

Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Kaneko, Kazuhiro, Oda, Ichiro, Shimizu, Yuichi, Doyama, Hisashi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Yoshii, Takako, Konishi, Kazuo, Yamanouchi, Takenori, Tsuda, Takashi, Omori, Tai, Kobayashi, Nozomu, Shimoda, Tadakazu, Ochiai, Atsushi, Amanuma, Yusuke, Ohashi, Shinya, Matsuda, Tomonari, Ishikawa, Hideki, Yokoyama, Akira, and Muto, Manabu

Published
2016
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29. Genetic Polymorphisms of Alcohol Dehydrogense-1B and Aldehyde Dehydrogenase-2, Alcohol Flushing, Mean Corpuscular Volume, and Aerodigestive Tract Neoplasia in Japanese Drinkers

Author

Yokoyama, Akira, Mizukami, Takeshi, Yokoyama, Tetsuji, Cohen, Irun R., Series editor, Lajtha, N.S. Abel, Series editor, Paoletti, Rodolfo, Series editor, Lambris, John D., Series editor, Vasiliou, Vasilis, editor, Zakhari, Samir, editor, Seitz, Helmut K., editor, and Hoek, Jan B., editor

Published
2015
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32. Validation of Dietary Intake Estimated by Web-Based Dietary Assessment Methods and Usability Using Dietary Records or 24-h Dietary Recalls: A Scoping Review

Author

Murai, Utako, primary, Tajima, Ryoko, additional, Matsumoto, Mai, additional, Sato, Yoko, additional, Horie, Saki, additional, Fujiwara, Aya, additional, Koshida, Emiko, additional, Okada, Emiko, additional, Sumikura, Tomoko, additional, Yokoyama, Tetsuji, additional, Ishikawa, Midori, additional, Kurotani, Kayo, additional, and Takimoto, Hidemi, additional

Published
2023
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33. Nonsmoking after simultaneous alcohol abstinence and smoking cessation program was associated with better drinking status outcome in Japanese alcohol-dependent men: A prospective follow-up study

Author

Yokoyama, Akira, primary, Kimura, Mitsuru, additional, Yoshimura, Atsushi, additional, Matsushita, Sachio, additional, Yoneda, Junichi, additional, Maesato, Hitoshi, additional, Komoto, Yasunobu, additional, Nakayama, Hideki, additional, Sakuma, Hiroshi, additional, Yumoto, Yosuke, additional, Takimura, Tsuyoshi, additional, Toyama, Tomomi, additional, Iwahara, Chie, additional, Mizukami, Takeshi, additional, Yokoyama, Tetsuji, additional, and Higuchi, Susumu, additional

Published
2023
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34. We Should Pay More Attention to Sex Differences to Predict the Risk of Severe COVID-19: Men Have the Same Risk of Worse Prognosis as Women More Than 10 Years Older

Author

Matsushita, Yumi, primary, Yokoyama, Tetsuji, additional, Hayakawa, Kayoko, additional, Matsunaga, Nobuaki, additional, Ohtsu, Hiroshi, additional, Saito, Sho, additional, Terada, Mari, additional, Suzuki, Setsuko, additional, Morioka, Shinichiro, additional, Kutsuna, Satoshi, additional, Tsuzuki, Shinya, additional, Hara, Hisao, additional, Kimura, Akio, additional, and Ohmagari, Norio, additional

Published
2023
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37. Curative Management After Endoscopic Resection for Esophageal Squamous Cell Carcinoma Invading Muscularis Mucosa or Shallow Submucosal Layer–Multicenter Real-World Survey in Japan

Author

Katada, Chikatoshi, primary, Yokoyama, Tetsuji, additional, Hirasawa, Dai, additional, Iizuka, Toshiro, additional, Kikuchi, Daisuke, additional, Yano, Tomonori, additional, Hombu, Takuya, additional, Yoshio, Toshiyuki, additional, Yoshimizu, Shoichi, additional, Ono, Hiroyuki, additional, Yabuuchi, Yohei, additional, Terai, Shuji, additional, Hashimoto, Satoru, additional, Takahashi, Kazuya, additional, Tanaka, Shinji, additional, Urabe, Yuji, additional, Arima, Miwako, additional, Tanabe, Satoshi, additional, Wada, Takuya, additional, Furue, Yasuaki, additional, Oyama, Tsuneo, additional, Takahashi, Akiko, additional, Sakamoto, Yasutoshi, additional, and Muto, Manabu, additional

Published
2022
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38. Risk factors for the development of second primary esophageal squamous-cell carcinoma after endoscopic resection for esophageal squamous-cell carcinoma according to genetic polymorphisms related to alcohol and nicotine metabolism.

Author

Katada, Chikatoshi, Yokoyama, Tetsuji, Mure, Kanae, Doyama, Hisashi, Nakanishi, Hiroyoshi, Shimizu, Yuichi, Yamamoto, Keiko, Furue, Yasuaki, Tamaoki, Masashi, Koike, Tomoyuki, Kawahara, Yoshiro, Kiyokawa, Hirofumi, Konno, Maki, Yokoyama, Akira, Ohashi, Shinya, Ishikawa, Hideki, and Muto, Manabu

Published
2023
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40. Factors associated with smoking behaviour changes during the COVID-19 pandemic in Japan: a 6-month follow-up study

Author

Yamamoto, Takafumi, Abbas, Hazem, Kanai, Makiko, Yokoyama, Tetsuji, and Tabuchi, Takahiro

Abstract

BackgroundSmoking behaviour may have changed due to the COVID-19 pandemic, the April 2020 revised smoke-free policy and the high prevalence of heated tobacco product (HTP) use in Japan (10.9% in 2020). This study examined the association between these three events and smoking behaviour changes using 6-month follow-up data from before and during the pandemic.MethodUsing longitudinal data from an internet survey conducted in February 2020 (baseline) and follow-up in August to September 2020, prevalence ratios (PR) and 95% confidence intervals (95% CIs) for smoking behaviour changes (increase and quit) were calculated using multivariable Poisson regression with adjustments for potential covariates including three event-related five factors: fear of COVID-19, living in a COVID-19 endemic area, workplace smoking rules, self-imposed smoking rules at home and type of tobacco use (cigarette only/HTP only/dual use). A smoker who reported an increase in smoking intensity in the last month was defined as an increase. A smoker who had stopped both cigarettes and HTPs at follow-up was defined as a quit.ResultsWe analysed 1810 tobacco users (1448 males (80%); mean age 50.8 years±13.2 SD). At baseline, 930 participants used cigarettes only, 293 HTPs only and 587 both. While 214 (11.8%) users increased smoking intensity, 259 (14.3%) quit both tobacco products. Those who feared COVID-19 were less likely to quit (PR=0.77, 95% CI 0.68 to 0.95), while living in a COVID-19 endemic area was not associated with either smoking behaviour change. Workplace smoking rules were not associated with either smoking behaviour change, but those with no home smoking ban were less likely to quit. Compared with cigarette-only users, HTP-only users were more likely to quit (PR=1.57, 95% CI 1.17 to 2.11), while dual users were more likely to increase smoking intensity (PR=1.35, 95% CI 1.01 to 1.79).ConclusionDuring the pandemic, dual cigarette and HTP use increased smoking intensity, whereas HTP-only use was associated with quitting but fear of COVID-19 and not having a home smoking ban made it harder to quit.

Published
2024
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44. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids

Author

Kanemitsu, Yoshihiro, Matsumoto, Hisako, Izuhara, Kenji, Tohda, Yuji, Kita, Hideo, Horiguchi, Takahiko, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Tomita, Katsuyuki, Yokoyama, Akihito, Ohnishi, Hiroshi, Nakano, Yasutaka, Oguma, Tetsuya, Hozawa, Soichiro, Nagasaki, Tadao, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Iwata, Toshiyuki, Izuhara, Yumi, Ono, Junya, Ohta, Shoichiro, Tamari, Mayumi, Hirota, Tomomitsu, Yokoyama, Tetsuji, Niimi, Akio, and Mishima, Michiaki

Published
2013
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49. Field Effect of Alcohol, Cigarette Smoking, and Their Cessation on the Development of Multiple Dysplastic Lesions and Squamous Cell Carcinoma: A Long-term Multicenter Cohort Study

Author

Muto, Manabu, Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Ezoe, Yasumasa, Tanabe, Satoshi, Shimizu, Yuichi, Doyama, Hisashi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Ogata, Takashi, Katagiri, Atsushi, Yamanouchi, Takenori, Matsuo, Yasumasa, Kawakubo, Hirofumi, Omori, Tai, Kobayashi, Nozomu, Shimoda, Tadakazu, Ochiai, Atsushi, Ishikawa, Hideki, Baba, Kiichiro, Amanuna, Yusuke, Yokoyama, Akira, Ohashi, Shinya, Kaneko, Kazuhiro, Morita, Shuko, Funakoshi, Makiko, Horimatsu, Takahiro, Takahashi, Mari, Suzuki, Haruhisa, Abiko, Satoshi, Takemura, Kenichi, Nakanishi, Hiroyoshi, Saito, Masahiro, Ara, Nobuyuki, Kakushima, Naomi, Tanaka, Masaki, Hori, Keisuke, Tsuda, Takashi, Muto, Manabu, Katada, Chikatoshi, Yokoyama, Tetsuji, Yano, Tomonori, Oda, Ichiro, Ezoe, Yasumasa, Tanabe, Satoshi, Shimizu, Yuichi, Doyama, Hisashi, Koike, Tomoyuki, Takizawa, Kohei, Hirao, Motohiro, Okada, Hiroyuki, Ogata, Takashi, Katagiri, Atsushi, Yamanouchi, Takenori, Matsuo, Yasumasa, Kawakubo, Hirofumi, Omori, Tai, Kobayashi, Nozomu, Shimoda, Tadakazu, Ochiai, Atsushi, Ishikawa, Hideki, Baba, Kiichiro, Amanuna, Yusuke, Yokoyama, Akira, Ohashi, Shinya, Kaneko, Kazuhiro, Morita, Shuko, Funakoshi, Makiko, Horimatsu, Takahiro, Takahashi, Mari, Suzuki, Haruhisa, Abiko, Satoshi, Takemura, Kenichi, Nakanishi, Hiroyoshi, Saito, Masahiro, Ara, Nobuyuki, Kakushima, Naomi, Tanaka, Masaki, Hori, Keisuke, and Tsuda, Takashi

Abstract

[Background and Aims] Multiple developments of squamous dysplasia and squamous cell carcinoma (SCC) in the upper aerodigestive tract have been explained by field cancerization phenomenon and were associated with alcohol and cigarette use. Second primary SCC development after curative treatment impairs patients’ quality of life and survival; however, how these consumption and cessation affect field cancerization is still unknown. [Methods] This is a multicenter cohort study including 331 patients with superficial esophageal SCC (ESCC) treated endoscopically and pooled data from 1022 healthy subjects for comparison. Physiological condition in the background esophageal mucosa was classified into 3 groups based on the number of Lugol-voiding lesions (LVLs) per endoscopic view: grade A, 0; grade B, 1–9; or grade C, ≥10 LVLs. Lifestyle surveys were conducted using a self-administered questionnaire. Patients were counseled on the need for alcohol and smoking cessation by physicians and were endoscopically surveyed every 6 months. [Results] LVL grades were positively associated with alcohol drinking intensity, flushing reactions, smoking, and high-temperature food and were negatively associated with eating green and yellow vegetables and fruit. Second primary ESCC and head/neck SCC were significantly more prevalent in the grade C LVL (cumulative 5-y incidences 47.1%, 95% confidence interval [CI] = 38.0–57.2 and 13.3%, 95% CI = 8.1–21.5, respectively). Alcohol and smoking cessation significantly reduced the development of second primary ESCC (adjusted hazard ratios 0.47, 95% = CI 0.26–0.85 and 0.49, 95% CI = 0.26–0.91, respectively). [Conclusion] Alcohol drinking, smoking, flushing reaction, and high-temperature food were closely associated with field cancerization, and cessation of alcohol and smoking significantly reduced the risk of development of second primary cancer. UMIN Clinical Trials Registry ID:UMIN000001676.

Published
2022

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