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Kurarinone is a major component found in the dried roots of Sophora flavescens Ait. that participates in vital pharmacological activities. Recombinant CYP450 supersomes and liver microsomes were used to study the metabolic profiles of kurarinone and its inhibitory actions against cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes. 100 μM of kurarinone strongly inhibited more than 90% of UGT1A1, UGT1A6, CYP1A2, and CYP2C9. CYP1A2 and CYP2D6 played important roles in catalyzing the biotransformation of kurarinone. Moreover, metabolism of kurarinone considerably differs among species, and metabolic characteristics were similar between monkey and human. Kurarinone demonstrated moderate permeability at values of pH 4.0 and 7.4. Our findings offer a clearer idea to understand the pharmacological and toxicological mechanisms of kurarinone.

In view of the current problems caused by UHV voltage data monitoring, the voltage and data warnings are often artificially set to the upper and lower limit voltage values, so that in any case, the artificially set warning value is used. For the basis of judgment, it creates many security risks. The big data fusion and BP neural network are used to analyze the detected voltage data, and the temperature is introduced to further influence the influence of the voltage data, so that when judging the warning voltage value , more intelligent, which is more reliable than the result of manually setting the warning voltage value.

Background Potential effects of resveratrol consumption on cardiovascular disease risk factors and body weight in overweight/obese adults have not been fully elucidated. Our present analysis was to evaluate the effects of resveratrol consumption on risk markers related to cardiovascular health in overweight/obese Individuals. Methods Multiple literature databases were systematically searched, and 21 studies were included. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI), and heterogeneity was assessed with the I2 test. Publication bias and subgroup analyses were also performed. Results There were variations in reporting quality of included studies. Resveratrol intervention significantly lowered total cholesterol (WMD, –0.19 mmol/L; 95% CI, –0.32 to –0.06; P = 0.004), systolic blood pressure (WMD, –2.26 mmHg; 95% CI, –4.82 to –0.49; P = 0.02), and fasting glucose (WMD, –0.22 mmol/L; 95% CI, –0.42 to –0.03; P = 0.03). Heterogeneity was noted for these outcomes (35.6%, 38.7% and 71.4%, respectively). Our subgroup analysis showed significant reductions in total cholesterol, systolic blood pressure, diastolic blood pressure, glucose, and insulin in subjects ingesting higher dose of resveratrol (≥300 mg/day). Conclusion Our finding provides evidence that daily resveratrol consumption might be a candidate as an adjunct to pharmacological management to better prevent and control cardiovascular disease in overweight/obese individuals.

Metal ion or non-metal ion doping is a simple and effective method to improve the photocatalytic efficiency. The previous research showed that metal ion and non-metal ion could enhance the photocatalytic efficiency of BiOCl through different mechanisms. Since aluminum is an amphoteric metal elemental, Al3+ doping may exhibit special properties. To study the effect of Al3+ doping on the structure of BiOCl and its photocatalytic performance, Al-doped BiOCl microspheres which were assembled by nanosheets with exposed (0 0 1) crystal plane were prepared by solvothermal method. The prepared samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS). The degradation results displayed that Al-10.0-BiOCl with a doping amount of 10 atom% (Al: Bi = 1:10) was the optimized sample and it could degrade 91.1% of tetracycline hydrochloride (TC, 100 mg/L) within 60 min under simulated sunlight irradiation. It was confirmed ·O2– was the main active substance during the catalytic degradation of TC and the high photocatalytic performance may be mainly attributed to the large specific surface area, wide range of sunlight absorption and high charge separation efficiency. To study the effect of the Al3+ doping on the structure of BiOCl and its photocatalytic performance, novel Al-doped BiOCl microspheres assembled by nanosheets with exposed (0 0 1) crystal plane were prepared by a solvothermal method. The samples were characterized and the photocatalytic activity was evaluated by degradating tetracycline hydrochloride under simulated sunlight irradiation. The results showed that Al-BiOCl with a doping content of 10 at% (Al: Bi = 1:10) exhibited optimal photocatalytic performance, and the high photocatalytic performance of Al-BiOCl may be mainly attributed to the large specific surface area, wide range of sunlight absorption and high charge separation efficiency.

GRADE Evidence Profile. (DOC 38Â kb)

The effects of berries consumption on cardiovascular disease (CVD) risk factors have not been systematically examined. Here, we aimed to conduct a meta-analysis with trial sequential analysis to estimate the effect of berries consumption on CVD risk factors. PubMed, Embase and CENTRAL were searched for randomized controlled trials (RCTs) that regarding the effects of berries consumption in either healthy participants or patients with CVD. Twenty-two eligible RCTs representing 1,251 subjects were enrolled. The pooled result showed that berries consumption significantly lowered the low density lipoprotein (LDL)-cholesterol [weighted mean difference (WMD), −0.21 mmol/L; 95% confidence interval (CI), −0.34 to −0.07; P = 0.003], systolic blood pressure (SBP) (WMD, −2.72 mmHg; 95% CI, −5.32 to −0.12; P = 0.04), fasting glucose (WMD, −0.10 mmol/L; 95% CI, −0.17 to −0.03; P = 0.004), body mass index (BMI) (WMD, −0.36 kg/m2; 95% CI, −0.54 to −0.18, P P = 0.04) and tumor necrosis factor-α (TNF-α) (WMD, −0.99 ρg/mL; 95% CI, −1.96 to −0.02; P = 0.04). However, no significant changes were seen in other markers. The current evidence suggests that berries consumption might be utilized as a possible new effective and safe supplementary option to better prevent and control CVD in humans.

cope : We conducted a pooled analysis of randomized controlled trials to evaluate the effects of chromium supplementation on clinically relevant metabolic biomarkers in type 2 diabetes mellitus (T2DM) patients. Methods and results : Electronic searches were conducted and the bibliographies of located articles were searched, and 28 studies were suitable for statistical pooling. Endpoints were calculated as weighted mean differences (WMDs) with 95% confidence intervals (CIs) by using fixed-effects or random-effects models. Statistical heterogeneity, publication bias, subgroup analyses, sensitivity analysis and meta-regression assessments were also assessed. Chromium reduced levels of fasting plasma glucose (WMD, -0.99 mmol/L; 95% CI, -1.72 to -0.25; P = 0.008), hemoglobin A1c (WMD, -0.54 %; 95% CI, -0.82 to -0.25; P = 0.0002), triglycerides (WMD, -11.71 mg/dL; 95% CI, -18.38 to -5.04; P = 0.0006). Chromium also increased levels of high-density lipoprotein cholesterol (WMD, 1.73 mg/dL; 95% CI, 0.50 to 2.96; P = 0.006). These results were robust in sensitivity analysis and were not dependent on the chromium dose and duration of supplementation. Subgroup analyses indicated that these notably favorable effects were presented in T2DM subjects ingesting chromium chloride and chromium picolinate formulations. Conclusion : Our pooled analysis suggested that chromium supplementation might be a candidate as an adjunct to pharmacological management in patients with T2DM. This article is protected by copyright. All rights reserved