Search

Your search keyword '"Yoo, K. -h."' showing total 652 results
Start Over Author "Yoo, K. -h."
652 results on '"Yoo, K. -h."'

1. Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud

Author

Adrich, P., Blumer, P., Caratsch, G., Chung, M., Cladé, P., Comini, P., Crivelli, P., Dalkarov, O., Debu, P., Douillet, A., Drapier, D., Froelich, P., Garroum, N., Guellati-Khelifa, S., Guyomard, J., Hervieux, P-A., Hilico, L., Indelicato, P., Jonsell, S., Karr, J-P., Kim, B., Kim, S., Kim, E-S., Ko, Y. J., Kosinski, T., Kuroda, N., Latacz, B. M., Lee, B., Lee, H., Lee, J., Lim, E., Liszkay, L., Lunney, D., Manfredi, G., Mansoulié, B., Matusiak, M., Nesvizhevsky, V., Nez, F., Niang, S., Ohayon, B., Park, K., Paul, N., Pérez, P., Regenfus, C., Reynaud, S., Roumegou, C., Roussé, J-Y., Sacquin, Y., Sadowski, G., Sarkisyan, J., Sato, M., Schmidt-Kaler, F., Staszczak, M., Szymczyk, K., Tanaka, T. A., Tuchming, B., Vallage, B., Voronin, A., van der Werf, D. P., Won, D., Wronka, S., Yamazaki, Y., Yoo, K-H., and Yzombard, P.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report on the first production of an antihydrogen beam by charge exchange of 6.1 keV antiprotons with a cloud of positronium in the GBAR experiment at CERN. The antiproton beam was delivered by the AD/ELENA facility. The positronium target was produced from a positron beam itself obtained from an electron linear accelerator. We observe an excess over background indicating antihydrogen production with a significance of 3-4 standard deviations.

Published
2023
Full Text
View/download PDF

2. Erratum to: Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud

Author

Adrich, P., Blumer, P., Caratsch, G., Chung, M., Cladé, P., Comini, P., Crivelli, P., Dalkarov, O., Debu, P., Douillet, A., Drapier, D., Froelich, P., Garroum, N., Guellati-Khelifa, S., Guyomard, J., Hervieux, P.-A., Hilico, L., Indelicato, P., Jonsell, S., Karr, J.-P., Kim, B., Kim, S., Kim, E.-S., Ko, Y. J., Kosinski, T., Kuroda, N., Latacz, B. M., Lee, B., Lee, H., Lee, J., Lim, E., Liszkay, L., Lunney, D., Manfredi, G., Mansoulié, B., Matusiak, M., Nesvizhevsky, V., Nez, F., Niang, S., Ohayon, B., Park, K., Paul, N., Pérez, P., Regenfus, C., Reynaud, S., Roumegou, C., Roussé, J.-Y., Sacquin, Y., Sadowski, G., Sarkisyan, J., Sato, M., Schmidt-Kaler, F., Staszczak, M., Szymczyk, K., Tanaka, T. A., Tuchming, B., Vallage, B., Voronin, A., van der Werf, D. P., Welker, A., Won, D., Wronka, S., Yamazaki, Y., Yoo, K.-H., and Yzombard, P.

Published
2024
Full Text
View/download PDF

3. Positron accumulation in the GBAR experiment

Author

Blumer, P., Charlton, M., Chung, M., Clade, P., Comini, P., Crivelli, P., Dalkarov, O., Debu, P., Dodd, L., Douillet, A., Guellati, S., Hervieux, P. -A, Hilico, L., Indelicato, P., Janka, G., Jonsell, S., Karr, J. -P., Kim, B. H., Kim, E. S., Kim, S. K., Ko, Y., Kosinski, T., Kuroda, N., Latacz, B. M., Lee, B., Lee, H., Lee, J., Leitee, A. M. M., Leveque, K., Lim, E., Liszkay, L., Lotrus, P., Lunney, D., Manfredi, G., Mansoulie, B., Matusiak, M., Mornacchi, G., Nesvizhevsky, V., Nez, F., Niang, S., Nishi, R., Ohayon, B., Park, K., Paul, N., Perez, P., Procureur, S., Radics, B., Regenfus, C., Reymond, J. -M., Reynaud, S., Rousse, J. -Y., Rousselle, O., Rubbia, A., Rzadkiewicl, J., Sacquin, Y., Schmidt-Kaler, F., Staszczak, M., Szymczyk, K., Tanaka, T., Tuchming, B., Vallage, B., Voronin, A., van der Werf, D. P., Wolf, S., Won, D., Wronka, S., Yamazaki, Y., Yoo, K. H., Yzombard, P., and Baker, C. J.

Subjects
Physics - Plasma Physics
Abstract

We present a description of the GBAR positron (e+) trapping apparatus, which consists of a three stage Buffer Gas Trap (BGT) followed by a High Field Penning Trap (HFT), and discuss its performance. The overall goal of the GBAR experiment is to measure the acceleration of the neutral antihydrogen (H) atom in the terrestrial gravitational field by neutralising a positive antihydrogen ion (H+), which has been cooled to a low temperature, and observing the subsequent H annihilation following free fall. To produce one H+ ion, about 10^10 positrons, efficiently converted into positronium (Ps), together with about 10^7 antiprotons (p), are required. The positrons, produced from an electron linac-based system, are accumulated first in the BGT whereafter they are stacked in the ultra-high vacuum HFT, where we have been able to trap 1.4(2) x 10^9 positrons in 1100 seconds.

Published
2022
Full Text
View/download PDF

4. Positron production using a 9 MeV electron linac for the GBAR experiment

Author

Charlton, M., Choi, J. J., Chung, M., Clade, P., Comini, P., Crepin, P-P., Crivelli, P., Dalkarov, O., Debu, P., Dodd, L., Douillet, A., Guellati-Khelifa, S., Hervieux, P-A., Hilico, L., Husson, A., Indelicato, P., Janka, G., Jonsell, S., Karr, J-P., Kim, B. H., Kim, E-S., Kim, S. K., Ko, Y., Kosinski, T., Kuroda, N., Latacz, B., Lee, H., Lee, J., Leite, A. M. M., Leveque, K., Lim, E., Liszkay, L., Lotrus, P., Louvradoux, T., Lunney, D., Manfredi, G., Mansoulie, B., Matusiak, M., Mornacchi, G., Nesvizhevsky, V. V., Nez, F., Niang, S., Nishi, R., Nourbaksh, S., Park, K. H., Paul, N., Perez, P., Procureur, S., Radics, B., Regenfus, C., Rey, J-M., Reymond, J-M., Reynaud, S., Rousse, J-Y., Rousselle, O., Rubbia, A., Rzadkiewicz, J., Sacquin, Y., Schmidt-Kaler, F., Staszczak, M., Tuchming, B., Vallage, B., Voronin, A., Welker, A., van der Werf, D. P., Wolf, S., Won, D., Wronka, S., Yamazaki, Y., and Yoo, K-H.

Subjects
Physics - Instrumentation and Detectors
Abstract

For the GBAR (Gravitational Behaviour of Antihydrogen at Rest) experiment at CERN's Antiproton Decelerator (AD) facility we have constructed a source of slow positrons, which uses a low-energy electron linear accelerator (linac). The driver linac produces electrons of 9 MeV kinetic energy that create positrons from bremsstrahlung-induced pair production. Staying below 10 MeV ensures no persistent radioactive activation in the target zone and that the radiation level outside the biological shield is safe for public access. An annealed tungsten-mesh assembly placed directly behind the target acts as a positron moderator. The system produces $5\times10^7$ slow positrons per second, a performance demonstrating that a low-energy electron linac is a superior choice over positron-emitting radioactive sources for high positron flux., Comment: published in NIM A. 33 pages 9 figures

Published
2020
Full Text
View/download PDF

5. Publisher Erratum: Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud

Author

Adrich, P., Blumer, P., Caratsch, G., Chung, M., Cladé, P., Comini, P., Crivelli, P., Dalkarov, O., Debu, P., Douillet, A., Drapier, D., Froelich, P., Garroum, N., Guellati-Khelifa, S., Guyomard, J., Hervieux, P.-A., Hilico, L., Indelicato, P., Jonsell, S., Karr, J.-P., Kim, B., Kim, S., Kim, E.-S., Ko, Y. J., Kosinski, T., Kuroda, N., Latacz, B. M., Lee, B., Lee, H., Lee, J., Lim, E., Liszkay, L., Lunney, D., Manfredi, G., Mansoulié, B., Matusiak, M., Nesvizhevsky, V., Nez, F., Niang, S., Ohayon, B., Park, K., Paul, N., Pérez, P., Regenfus, C., Reynaud, S., Roumegou, C., Roussé, J.-Y., Sacquin, Y., Sadowski, G., Sarkisyan, J., Sato, M., Schmidt-Kaler, F., Staszczak, M., Szymczyk, K., Tanaka, T. A., Tuchming, B., Vallage, B., Voronin, A., van der Werf, D. P., Welker, A., Won, D., Wronka, S., Yamazaki, Y., Yoo, K.-H., and Yzombard, P.

Published
2023
Full Text
View/download PDF

6. A pulsed high-voltage decelerator system to deliver low-energy antiprotons

Author

Husson, A., Kim, B.H., Welker, A., Charlton, M., Choi, J.J., Chung, M., Cladé, P., Comini, P., Crépin, P.-P., Crivelli, P., Dalkarov, O., Debu, P., Dodd, L., Douillet, A., Guellati-Khélifa, S., Garroum, N., Hervieux, P.-A., Hilico, L., Indelicato, P., Janka, G., Jonsell, S., Karr, J.-P., Kim, E.-S., Kim, S.K., Ko, Y., Kosinski, T., Kuroda, N., Latacz, B., Lee, H., Lee, J., Leite, A.M.M., Lévêque, K., Lim, E., Liszkay, L., Lotrus, P., Lunney, D., Manfredi, G., Mansoulié, B., Matusiak, M., Mornacchi, G., Nesvizhevsky, V.V., Nez, F., Niang, S., Nishi, R., Nourbaksh, S., Park, K.H., Paul, N., Pérez, P., Procureur, S., Radics, B., Regenfus, C., Reymond, J.-M., Reynaud, S., Roussé, J.-Y., Rousselle, O., Rubbia, A., Rzadkiewicz, J., Sacquin, Y., Schmidt-Kaler, F., Staszczak, M., Tuchming, B., Vallage, B., Voronin, A., van der Werf, D.P., Wolf, S., Won, D., Wronka, S., Yamazaki, Y., and Yoo, K.-H.

Published
2021
Full Text
View/download PDF

7. Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud

Author

Adrich, P., primary, Blumer, P., additional, Caratsch, G., additional, Chung, M., additional, Cladé, P., additional, Comini, P., additional, Crivelli, P., additional, Dalkarov, O., additional, Debu, P., additional, Douillet, A., additional, Drapier, D., additional, Froelich, P., additional, Garroum, N., additional, Guellati-Khelifa, S., additional, Guyomard, J., additional, Hervieux, P.-A., additional, Hilico, L., additional, Indelicato, P., additional, Jonsell, S., additional, Karr, J.-P., additional, Kim, B., additional, Kim, S., additional, Kim, E.-S., additional, Ko, Y. J., additional, Kosinski, T., additional, Kuroda, N., additional, Latacz, B. M., additional, Lee, B., additional, Lee, H., additional, Lee, J., additional, Lim, E., additional, Liszkay, L., additional, Lunney, D., additional, Manfredi, G., additional, Mansoulié, B., additional, Matusiak, M., additional, Nesvizhevsky, V., additional, Nez, F., additional, Niang, S., additional, Ohayon, B., additional, Park, K., additional, Paul, N., additional, Pérez, P., additional, Regenfus, C., additional, Reynaud, S., additional, Roumegou, C., additional, Roussé, J.-Y., additional, Sacquin, Y., additional, Sadowski, G., additional, Sarkisyan, J., additional, Sato, M., additional, Schmidt-Kaler, F., additional, Staszczak, M., additional, Szymczyk, K., additional, Tanaka, T. A., additional, Tuchming, B., additional, Vallage, B., additional, Voronin, A., additional, van der Werf, D. P., additional, Welker, A., additional, Won, D., additional, Wronka, S., additional, Yamazaki, Y., additional, Yoo, K.-H., additional, and Yzombard, P., additional

Published
2023
Full Text
View/download PDF

8. Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud

Author

Adrich, P, Blumer, P, Caratsch, G, Chung, M, Cladé, P, Comini, P, Crivelli, P, Dalkarov, O, Debu, P, Douillet, A, Drapier, D, Froelich, P, Garroum, N, Guellati-Khelifa, S, Guyomard, J, Hervieux, P-A, Hilico, L, Indelicato, P, Jonsell, S, Karr, J-P, Kim, B, Kim, S, Kim, E-S, Ko, Y.J, Kosinski, T, Kuroda, N, Latacz, B.M, Lee, B, Lee, H, Lee, J, Lim, E, Liszkay, L, Lunney, D, Manfredi, G, Mansoulié, B, Matusiak, M, Nesvizhevsky, V, Nez, F, Niang, S, Ohayon, B, Park, K, Paul, N, Pérez, P, Regenfus, C, Reynaud, S, Roumegou, C, Roussé, J-Y, Sacquin, Y, Sadowski, G, Sarkisyan, J, Sato, M, Schmidt-Kaler, F, Staszczak, M, Szymczyk, K, Tanaka, T.A, Tuchming, B, Vallage, B, Voronin, A, van der Werf, D.P, Won, D, Wronka, S, Yamazaki, Y, Yoo, K-H, Yzombard, P, Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université d'Évry-Val-d'Essonne (UEVE), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Institut Laue-Langevin (ILL)

Subjects
antihydrogen, production, CERN Lab, Physics - Instrumentation and Detectors, background, anti-p, beam, positron, beam, atom, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), antihydrogen, beam, charge exchange, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), positronium, target, electron, linear accelerator, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], cloud, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

International audience; We report on the first production of an antihydrogen beam by charge exchange of 6.1 keV antiprotons with a cloud of positronium in the GBAR experiment at CERN. The antiproton beam was delivered by the AD/ELENA facility. The positronium target was produced from a positron beam itself obtained from an electron linear accelerator. We observe an excess over background indicating antihydrogen production with a significance of 3-4 standard deviations.

Published
2023

11. AD-7/GBAR status report for the 2023 CERN SPSC

Author

Lunney, D, Roumegou, C, Blumer, P, Caratsch, G, Crivelli, P, Ohayon, B, Regenfus, C, Sarkisyan, J, Nesvizhevsky, V, Sacquin, Y, Vallage, B, Liszkay, L, Debu, P, Comini, P, Roussé, J-Y, Tuchming, B, Mansoulié, B, Niang, S, Pérez, P, Sadowski, G, Schmidt-Kaler, F, Indelicato, P, Drapier, D, Guellati, S, Hilico, L, Cladé, P, Douillet, A, Karr, J-P, Nez, F, Yzombard, P, Paul, N, Reynaud, S, van der Werf, DP, Jonsell, S, Froelich, P, Kim, B, Kim, S, Lee, B, Lee, H, Park, K, Won, D, Lee, J, Ko, Y, Kim, E-S, Lim, E, Chung, M, Yoo, K-H, Hervieux, P-A, Manfredi, G, Yamazaki, Y, Kuroda, N, Tanaka, T, Sato, M, Kosinski, T, Matusiak, M, Staszczak, M, Wronka, S, Adrich, P, and Szymczyk, K

Subjects
Detectors and Experimental Techniques
Abstract

We report on the activities performed during 2022 and the plans for 2023 for the GBAR experiment.

Published
2023

19. P975: INTERIM ANALYSIS OF PHASE II STUDY OF DARATUMUMAB IN COMBINATION WITH BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH MULTIPLE MYELOMA WHO RECEIVED 1 PRIOR LINE OF THERAPY (KMM1906)

Author

Yoo, K. H., primary, Gang, G. W., additional, Yi, J. H., additional, Kim, M. K., additional, Kim, H. J., additional, Kim, S.-H., additional, Park, J. S., additional, Lee, J.-J., additional, Min, C.-K., additional, Lee, J. H., additional, Cho, D., additional, and Kim, K., additional

Published
2022
Full Text
View/download PDF

46. Positron production using a 9 MeV electron linac for the GBAR experiment

Author

Charlton, M., Choi, J. J., Chung, M., Cladé, P., Comini, P., Crépin, P.-P., Crivelli, P., Dalkarov, O., Debu, P., Dodd, L., Douillet, A., Guellati-Khélifa, S., Hervieux, P.-A., Hilico, L., Husson, A., Indelicato, P., Janka, G., Jonsell, Svante, Karr, J.-P., Kim, B. H., Kim, E.-S., Kim, S. K., Ko, Y., Kosinski, T., Kuroda, N., Latacz, B., Lee, H., Lee, J., Leite, A. M. M., Lévêque, K., Lim, E., Liszkay, L., Lotrus, P., Louvradoux, T., Lunney, D., Manfredi, G., Mansoulié, B., Matusiak, M., Mornacchi, G., Nesvizhevsky, V. V., Nez, F., Niang, S., Nishi, R., Nourbaksh, S., Park, K. H., Paul, N., Pérez, P., Procureur, S., Radics, B., Regenfus, C., Rey, J.-M., Reymond, J.-M., Reynaud, S., Roussé, J.-Y., Rousselle, O., Rubbia, A., Rzadkiewicz, J., Sacquin, Y., Schmidt-Kaler, F., Staszczak, M., Tuchming, B., Vallage, B., Voronin, A., Welker, A., van der Werf, D. P., Wolf, S., Won, D., Wronka, S., Yamazaki, Y., Yoo, K.-H., Charlton, M., Choi, J. J., Chung, M., Cladé, P., Comini, P., Crépin, P.-P., Crivelli, P., Dalkarov, O., Debu, P., Dodd, L., Douillet, A., Guellati-Khélifa, S., Hervieux, P.-A., Hilico, L., Husson, A., Indelicato, P., Janka, G., Jonsell, Svante, Karr, J.-P., Kim, B. H., Kim, E.-S., Kim, S. K., Ko, Y., Kosinski, T., Kuroda, N., Latacz, B., Lee, H., Lee, J., Leite, A. M. M., Lévêque, K., Lim, E., Liszkay, L., Lotrus, P., Louvradoux, T., Lunney, D., Manfredi, G., Mansoulié, B., Matusiak, M., Mornacchi, G., Nesvizhevsky, V. V., Nez, F., Niang, S., Nishi, R., Nourbaksh, S., Park, K. H., Paul, N., Pérez, P., Procureur, S., Radics, B., Regenfus, C., Rey, J.-M., Reymond, J.-M., Reynaud, S., Roussé, J.-Y., Rousselle, O., Rubbia, A., Rzadkiewicz, J., Sacquin, Y., Schmidt-Kaler, F., Staszczak, M., Tuchming, B., Vallage, B., Voronin, A., Welker, A., van der Werf, D. P., Wolf, S., Won, D., Wronka, S., Yamazaki, Y., and Yoo, K.-H.

Abstract

For the GBAR (Gravitational Behaviour of Antihydrogen at Rest) experiment at CERN's Antiproton Decelerator (AD) facility we have constructed a source of slow positrons, which uses a low-energy electron linear accelerator (linac). The driver linac produces electrons of 9 MeV kinetic energy that create positrons from bremsstrahlung-induced pair production. Staying below 10 MeV ensures no persistent radioactive activation in the target zone and that the radiation level outside the biological shield is safe for public access. An annealed tungsten-mesh assembly placed directly behind the target acts as a positron moderator. The system produces 5 x 10(7) slow positrons per second, a performance demonstrating that a low-energy electron linac is a superior choice over positron-emitting radioactive sources for high positron flux.

Published
2021
Full Text
View/download PDF

47. A phase 2 study of nilotinib in pediatric patients with CML: Long-term update on growth retardation and safety

Author

Hijiya, N, Maschan, A, Rizzari, C, Shimada, H, Dufour, C, Goto, H, Kang, H, Guinipero, T, Karakas, Z, Bautista, F, Ducassou, S, Yoo, K, Zwaan, C, Millot, F, Patterson, B, Samis, J, Aimone, P, Allepuz, A, Titorenko, K, Sosothikul, D, Hijiya N., Maschan A., Rizzari C., Shimada H., Dufour C., Goto H., Kang H. J., Guinipero T., Karakas Z., Bautista F., Ducassou S., Yoo K. H., Zwaan C. M., Millot F., Patterson B., Samis J., Aimone P., Allepuz A., Titorenko K., Sosothikul D., Hijiya, N, Maschan, A, Rizzari, C, Shimada, H, Dufour, C, Goto, H, Kang, H, Guinipero, T, Karakas, Z, Bautista, F, Ducassou, S, Yoo, K, Zwaan, C, Millot, F, Patterson, B, Samis, J, Aimone, P, Allepuz, A, Titorenko, K, Sosothikul, D, Hijiya N., Maschan A., Rizzari C., Shimada H., Dufour C., Goto H., Kang H. J., Guinipero T., Karakas Z., Bautista F., Ducassou S., Yoo K. H., Zwaan C. M., Millot F., Patterson B., Samis J., Aimone P., Allepuz A., Titorenko K., and Sosothikul D.

Abstract

The phase 2, open-label study (DIALOG) of nilotinib in pediatric patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) met its coprimary end points, showing sustained nilotinib efficacy in patients with newly diagnosed (ND) or imatinib/dasatinib resistant/intolerant (R/I) CML. This update assessed growth and safety profiles in patients who had completed ≥48, 28-day treatment cycles of nilotinib 230 mg/m2 twice daily, or previously discontinued the study. Height was assessed regularly and reported using standard deviation scores (SDSs) based on World Health Organization growth charts. All data were summarized descriptively (cutoff, 6 March 2019). Overall, 33 patients in the R/I cohort and 25 patients in the ND cohort received nilotinib. Each cohort showed a negative slope in height SDS over the course of the study, indicating attenuated growth rates during nilotinib treatment: overall median change from baseline in height SDS after 48 cycles was 20.54 SDS (range, 2 1.6 to 0.4) and 20.91 SDS (21.4 to 20.1) in R/I and ND cohorts, respectively. Patients in the R/I cohort were shorter at baseline than those in the ND cohort, and remained so throughout the study. The most common all-cause adverse events were increased blood bilirubin (53.4%), headache (46.6%), pyrexia (37.9%), and increased alanine transferase (36.2%). Apart from the impact on growth, the safety profile of nilotinib was generally consistent with previous reports. This study was registered on www.clinicaltrials.gov at #NCT01844765.

Published
2021

48. A randomized phase II trial of CHOP versus ICED and autologous stem cell transplantation in newly diagnosed T‐cell lymphoma.

Author

Yoo, K. H., Kim, S. J., Jo, J., Yoon, D. H., Yang, D., Yoon, S. E., Lee, G., Park, Y., Kang, K., Lee, H., Oh, S. Y., Shin, H., Kang, H. J., Lee, W. S., Choi, Y. S., Jeong, S. H., Kim, M. K., Yi, J. H., Lim, S., and Yhim, H.

Subjects
T-cell lymphoma, STEM cell transplantation, ANAPLASTIC large-cell lymphoma, DIAGNOSIS
Abstract

Patients with ALK-positive ALCL, extranodal NK/T-cell lymphoma, and mycosis fungoides/sezary syndrome were not included in the study. CHOP was favored over ICED in AITL patients, whereas ICED was favored over CHOP in EATL/HSTL patients. B Purpose: b Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas, and their prognoses are still poor because of frequent relapses and the absence of optimal standard therapy. [Extracted from the article]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results