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155 results on '"Yoo, Soo Jin"'

5. Clinical application of a real-time polymerase chain reaction test for CYP2C19 genotyping based on genotype distribution in a healthy Korean population.

Author

Park, Kuenyoul and Yoo, Soo Jin

Subjects
*RISK assessment, *PREDICTIVE tests, *DRUG side effects, *GENOMICS, *REVERSE transcriptase polymerase chain reaction, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *GENES, *MEDICAL records, *ACQUISITION of data, *GENOTYPES, *ALLELES
Abstract

Objective With the recent reports of additional alleles of the CYP2C19 gene with decreased or no function, the clinical utility of real-time polymerase chain reaction (PCR)-based testing that detects only a small number of variant targets needs to be evaluated. Method We retrospectively reviewed 7-year data for real-time PCR test records from a single hospital and analyzed CYP2C19 genotypes from publicly available whole-genome or whole-exome data from a healthy Korean population. Results Of the 2327 test results in this hospital, the *1 allele was most common (60.5%), followed by *2 (28.0%), *3 (10.1%), and *17 (1.4%). Among 5305 healthy Korean individuals, the frequencies of the *2, *3, and *17 alleles were 28.6%, 9.9%, and 1.0%, respectively, which were not statistically different from those of the hospital data (P =.4439, P =.6025, and P =.1142, respectively). Interestingly, the total frequency of additional nonfunctional alleles (*4, *6, *22, and *24) that could not be detected using real-time PCR was only 0.1%, with a total allele count of 8. Conclusion Our study shows that the clinical utility of real-time PCR for CYP2C19 genotyping remains satisfactory. However, caution should be exercised because the test can miss patients with decreased CYP2C19 function. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Practical delta check limits for tumour markers in different clinical settings.

Author

Yu, Shinae, Shin, Kyung-Hwa, Shin, Sunghwan, Lee, Hyeyoung, Yoo, Soo Jin, Jun, Kyung Ran, Shin, Hangsik, and Kim, Sollip

Subjects
TUMOR markers, BIOMARKERS, PROSTATE-specific antigen, CARCINOEMBRYONIC antigen, UNIVERSITY hospitals
Abstract

Few studies have reported on delta checks for tumour markers, even though these markers are often evaluated serially. Therefore, this study aimed to establish a practical delta check limit in different clinical settings for five tumour markers: alpha-fetoprotein, cancer antigen 19-9, cancer antigen 125, carcinoembryonic antigen, and prostate-specific antigen. Pairs of patients' results (current and previous) for five tumour markers between 2020 and 2021 were retrospectively collected from three university hospitals. The data were classified into three subgroups, namely: health check-up recipient (subgroup H), outpatient (subgroup O), and inpatient (subgroup I) clinics. The check limits of delta percent change (DPC), absolute DPC (absDPC), and reference change value (RCV) for each test were determined using the development set (the first 18 months, n=179,929) and then validated and simulated by applying the validation set (the last 6 months, n=66,332). The check limits of DPC and absDPC for most tests varied significantly among the subgroups. Likewise, the proportions of samples requiring further evaluation, calculated by excluding samples with both current and previous results within the reference intervals, were 0.2–2.9% (lower limit of DPC), 0.2–2.7% (upper limit of DPC), 0.3–5.6% (absDPC), and 0.8–35.3% (RCV99.9%). Furthermore, high negative predictive values >0.99 were observed in all subgroups in the in silico simulation. Using real-world data, we found that DPC was the most appropriate delta-check method for tumour markers. Moreover, Delta-check limits for tumour markers should be applied based on clinical settings. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Effect of Characterized Green Tea Extraction Methods and Formulations on Enzymatic Starch Hydrolysis and Intestinal Glucose Transport

Author

Oh, Jeong-Ho, primary, Lee, Chan-Yang, additional, Kim, Jeong-Eun, additional, Kim, Woo-Hyun, additional, Seo, Ji-Won, additional, Lim, Tae-Gyu, additional, Lee, Su-Yong, additional, Chung, Jin-Oh, additional, Hong, Yong-Deog, additional, Kim, Wan-Gi, additional, Yoo, Soo-Jin, additional, Shin, Kwang-Soon, additional, and Shim, Soon-Mi, additional

Published
2021
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40. Outbreak of Swine-Origin Influenza A (H1N1); Experience of a Regional Center in Seoul during a Month, August-September 2009

Author

Yoo, Soo Jin, primary, Noh, Choong-Hee, additional, Yoo, Hyeon Mi, additional, Shin, Won Chang, additional, Choi, Soo Jeon, additional, Kim, Baek-Nam, additional, Kim, Chang Keun, additional, Chey, Myoung-Jae, additional, Kim, Kyunam, additional, Lee, Sang-Lae, additional, Kuak, Eun-Young, additional, and Shin, Bo-Moon, additional

Published
2010
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49. Low Frequency and Variability of FLT3 Mutations in Korean Patients with Acute Myeloid Leukemia

Author

Bang, Soo-Mee, primary, Ahn, Jeong Yeal, additional, Park, Jiyoon, additional, Park, Se Hoon, additional, Park, Jinny, additional, Cho, Eun Kyung, additional, Shin, Dong Bok, additional, Lee, Jae Hoon, additional, Yoo, Soo Jin, additional, Jeon, In Sang, additional, Kim, Yeo-Kyeoung, additional, Kim, Hyeoung Joon, additional, Kim, Hee-Nam, additional, Lee, Il-Kwon, additional, Kang, Hyoung Jin, additional, Shin, Hee Young, additional, and Ahn, Hyo Seop, additional

Published
2008
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