1. Analysis for data-derived extrapolation factors for procymidone.
- Author
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Gadagbui BK, York RG, Dourson ML, McGinnis PM, and Cope RB
- Subjects
- Animals, Area Under Curve, Bridged Bicyclo Compounds administration & dosage, Data Interpretation, Statistical, Female, Humans, Male, Toxicokinetics, Bridged Bicyclo Compounds toxicity, Fetal Development drug effects, Fungicides, Industrial toxicity, Hypospadias chemically induced, Toxicity Tests statistics & numerical data
- Abstract
The derivation of Chemical Specific Adjustment Factors (CSAFs) (IPCS, 2005; U.S. EPA, 2014) depends on the choice of appropriate dose metric. EPA and IPCS guidance was applied to derive a CSAF for developmental toxicity for procymidone (PCM). Although kinetic data were not available in humans at any dose, sufficient toxicokinetic data are available in a surrogate species, primates, and from chimeric mice with both rat and human liver cells to offer insights. Alternative approaches were explored in the derivation of the CSAG based on review of the available kinetic data. The most likely dosimetric adjustment is the Cmax based on the character of the critical effect - reduced anogenital distance and increased incidence of hypospadias in male rats, which likely occurs during a small window of time during development of the rat fetus. Cmax is also the default dosimeter from U.S. EPA (1991). However, in this case, the use of Cmax is also likely more conservative than the use of area under the curve (AUC), which otherwise is the default recommendation of the IPCS (2005). Despite human data, estimated tentative CSAF value is 0.48 (range, 0.22 to 0.74). The use of any of these values would be supported by the available data., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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