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The purpose of this study was to make it a study material to prevent inadequate incidents in correspondence of Yogo teachers to mental health problems. We analyzed the cause of incidents experienced by Yogo teachers actually, and clarified factors that occurred due to the problems of Yogo teachers' response. Factors of incidents of mental health problems are [inappropriate response], [belief], [mistake in consideration], [insufficient pursuit], [observation, inquiry, lack of palpation], [insufficient situation grasping], [inadequacy of school system], [misidentification of priority] 8 items were found. As a concrete measure for these problems / cause factors, "A: to study about contemporary health problems", "B: to study about interviews, palpation, observation", "C: don’t correspondence only of main symptoms", "D: Accurately collect information", "E: Looking back to allow judgment to be corrected", "F: Comprehensively looking at", "G: collaboration among teachers from everyday and construction of support system", "H: don’t leave suspicions and doubts, pursue", "I: retrospective and study on Yogo diagnosis and response", "J: don’t mistake to judge the urgency of job content and its response". From these facts, it was suggested that the mental condition of the Yogo teacher himself / herself was related to the occurrence factor of the incorrect incident report of the mental health problem, and the incident report happened. In order to identify necessary abilities and acquire the ability to cope with changes in the health problems of children, it is expected that attitudes that the Yogo teacher themselves widen their perspectives and constantly learn.

金沢大学医薬保健研究域医学系, Stromal cells in adipose tissue are useful for repair/regenerative therapy as they harbor a substantial number of mesenchymal stem cells; therefore, freshly isolated autologous uncultured adipose tissue derived stromal cells (u-ADSCs) are useful for regenerative therapy, and obviate the need for mesenchymal stem cells. We evaluated the therapeutic effect of murine u-ADSCs and sorted subsets of u-ADSCs in a concanavalin A (ConA) induced murine model of hepatitis, as well as their characteristics. We found that 10–20% of u-ADSCs expressed the CD45 leukocyte-related antigen. CD68, which is a marker of macrophages (MΦs), was expressed by 50% of CD45+ u-ADSCs. About 90% of CD68+CD45+ cells expressed CD206 antigen, which is a marker of inhibitory M2-type MΦs. Genes related to M2-type MUs were especially more highly expressed by CD45+CD206+ u-ADSCs than by CD45− u-ADSCs. CD45+ u-ADSCs inhibited the expression of cytokines/chemokines and suppressed the proliferation of splenocytes stimulated with ConA. We observed that not only whole u-ADSCs, but also the CD45+ subset of u-ADSCs ameliorated the ConA-induced hepatitis in mice. In conclusion, we show that freshly isolated murine u-ADSCs were effective against acute hepatitis, and CD45+ u-ADSCs acting phenotypically and functionally like M2-type MΦs, contributed to the repair of liver tissue undergoing inflammation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Embargo Period 12 months