Search

Your search keyword '"Yoshihara, Masato"' showing total 442 results
Start Over Author "Yoshihara, Masato"
442 results on '"Yoshihara, Masato"'

11. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins

Author

Mogi, Kazumasa, Koya, Yoshihiro, Yoshihara, Masato, Sugiyama, Mai, Miki, Rika, Miyamoto, Emiri, Fujimoto, Hiroki, Kitami, Kazuhisa, Iyoshi, Shohei, Tano, Sho, Uno, Kaname, Tamauchi, Satoshi, Yokoi, Akira, Shimizu, Yusuke, Ikeda, Yoshiki, Yoshikawa, Nobuhisa, Niimi, Kaoru, Yamakita, Yoshihiko, Tomita, Hiroyuki, Shibata, Kiyosumi, Nawa, Akihiro, Tomoda, Yutaka, and Kajiyama, Hiroaki

Published
2023
Full Text
View/download PDF

18. Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis

Author

Kitami, Kazuhisa, Yoshihara, Masato, Tamauchi, Satoshi, Sugiyama, Mai, Koya, Yoshihiro, Yamakita, Yoshihiko, Fujimoto, Hiroki, Iyoshi, Shohei, Uno, Kaname, Mogi, Kazumasa, Ikeda, Yoshiki, Yokoi, Akira, Yoshikawa, Nobuhisa, Nishino, Kimihiro, Niimi, Kaoru, Nawa, Akihiro, Enomoto, Atsushi, and Kajiyama, Hiroaki

Published
2022
Full Text
View/download PDF

19. Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery.

Author

Mogi, Kazumasa, Yoshihara, Masato, Emoto, Ryo, Miyamoto, Emiri, Fujimoto, Hiroki, Uno, Kaname, Tano, Sho, Iyoshi, Shohei, Kitami, Kazuhisa, Yoshikawa, Nobuhisa, Matsui, Shigeyuki, and Kajiyama, Hiroaki

Subjects
*OVARIAN epithelial cancer, *LOGISTIC regression analysis, *SURGICAL excision, *OVARIAN tumors, *SURVIVAL analysis (Biometry), TUMOR surgery
Abstract

Objective: Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term oncologic outcomes in OvCa patients who underwent complete tumor resection using a large-scale patient cohort form multiple institutions under a central pathological review system. Methods: A regional multi-institutional study was conducted from 1986 to 2019. Of the 4,898 patients with ovarian tumors enrolled, 1,175 patients who underwent complete tumor resection were classified into three classes based on clinically important prognostic factors: stage, cytology, ascites volume. For each class category, the effect of histology types on recurrence-free survival, the site of recurrence, and post-recurrence survival was evaluated. Results: Recurrence-free survival varied significantly across different histologies (P < 0.001). The risk of recurrence was higher in serous carcinoma compare to other histologies (P < 0.001). The site of tumor recurrence varied by the histology type. Multinominal logistic regression analysis revealed that mucinous histology had a significantly higher likelihood of developing recurrent tumors at distant sites from the peritoneum compared to other histologies (P = 0.002). Conversely, serous histology was associated with better post-recurrence survival (Log-rank P < 0.001). Conclusions: Long-term oncologic outcomes significantly differ by histology type in OvCa patients who have undergone complete tumor resection at the initial surgery. A careful evaluation of the clinical background is necessary for these patients, and further clinical research into individualized treatment approaches is essential. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

28. Factors affecting the long‐term prognosis of patients in the AYA generation with epithelial ovarian cancer: A multicenter propensity score matching analysis.

Author

Miyamoto, Emiri, Yoshihara, Masato, Iyoshi, Shohei, Mogi, Kazumasa, Uno, Kaname, Fujimoto, Hiroki, Kitami, Kazuhisa, Yoshikawa, Nobuhisa, and Kajiyama, Hiroaki

Subjects
*OVERALL survival, *PROPENSITY score matching, *YOUNG adults, *PROGNOSIS, *REGRESSION analysis
Abstract

Objective: Ovarian carcinoma (OvCa) is more common in the elderly, but also affects the adolescent and young adult (AYA) generation, which refers to those aged 15–39 years. Although the characteristics of OvCa may differ between AYAs and non‐AYAs, limited information is currently available on differences in prognostic factors. Therefore, we herein investigated prognostic factors for and the prognosis of OvCa in AYAs. We also examined the prognostic impact of fertility‐sparing surgery in a subgroup analysis. Methods: We retrospectively collected data on 4897 patients with OvCa from the databases of multiple institutions and ultimately included 1161 patients with epithelial ovarian cancer (EOC). We performed a survival analysis to compare AYAs and non‐AYAs with backgrounds that conformed to those of AYAs using the propensity score (PS) matching method. A Cox regression analysis was also conducted to evaluate each predictor of recurrence‐free survival (RFS) and overall survival (OS) in the original population. As a subgroup analysis, a multivariate analysis stratified by the AYA and non‐AYA generations was performed. Results: In total, 119 AYA patients were included in this study. After PS adjustments, no significant differences were observed in RFS or OS between AYAs and non‐AYAs. Prognostic factors differed between AYAs and non‐AYAs, particularly in histology and cytology. A multivariate analysis stratified by the AYA and non‐AYA generations described that uterine‐preserving surgery (UPS) did not have a significant impact on the prognosis of AYAs or non‐AYAs. In cases with recurrence, no significant differences were observed in RFS and recurrent sites in the two groups. Conclusion: Characteristic prognostic factors for EOC in AYAs were identified. The present results indicate the limited prognostic impact of UPS for EOC in AYAs. Synopsis: There were no significant differences in prognosis between AYAs and non‐AYAs. AYAs had specific prognostic factors and uterine‐preserving surgery was not a significant prognostic factor. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Update on the oncologic and obstetric outcomes of medroxyprogesterone acetate treatment for atypical endometrial hyperplasia and endometrial cancer.

Author

Tamauchi, Satoshi, Nakagawa, Atsushi, Yoshida, Kosuke, Yoshihara, Masato, Yokoi, Akira, Yoshikawa, Nobuhisa, Niimi, Kaoru, and Kajiyama, Hiroaki

Subjects
ENDOMETRIAL diseases, HYPERPLASIA, CANCER relapse, MEDROXYPROGESTERONE, PATIENT safety, ACADEMIC medical centers, QUESTIONNAIRES, PATHOLOGIC complete response, RETROSPECTIVE studies, DESCRIPTIVE statistics, ORAL drug administration, CANCER patients, TREATMENT duration, ENDOMETRIAL tumors, DOSE-effect relationship in pharmacology, DRUG efficacy, MEDICAL records, ACQUISITION of data, DISEASE relapse, FERTILITY preservation, EVALUATION
Abstract

Aims: To evaluate the safety and effectiveness of high‐dose oral medroxyprogesterone acetate (MPA) therapy as a fertility‐sparing treatment for patients diagnosed with atypical endometrial hyperplasia (AEH) and endometrioid carcinoma G1 without myometrial invasion (G1EC). Particular attention was given to the extended administration and readministration of MPA for patients with persistent disease following initial treatment and those with recurrence. Methods: We conducted a retrospective analysis of data from 79 patients who underwent daily oral MPA treatment between 2005 and 2024 at Nagoya University Hospital. Patient characteristics, treatment outcomes, factors contributing to recurrence, and post‐MPA therapy pregnancies were examined. Results: MPA therapy achieved a remarkable complete response (CR) rate of 91.1%. The median time to achieve CR was 26.0 and 40.0 weeks for AEH and G1EC patients, respectively. Importantly, 27 patients (39.7%) attained CR after more than 6 months of treatment, including 8 patients (11.8%) who achieved CR after more than a year of treatment. The recurrence rates were 52.9% for AEH and 64.7% for G1EC. Twenty eight patients resumed MPA treatment, and 23 achieved second CR. Notably, recurrence was not associated with clinical factors such as age, body mass index, or post‐CR pregnancy. Among patients who attempted pregnancy after achieving CR, 22 live births were successfully achieved. Conclusions: High‐dose oral MPA therapy demonstrated both safety and efficacy for preserving fertility in patients with AEH and G1EC, resulting in a high CR rate. MPA extension and readministration proved to be beneficial strategies for managing patients with recurrence and persistent disease following initial treatment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

41. Endometriosis and cancer

Author

Kajiyama, Hiroaki, Suzuki, Shiro, Yoshihara, Masato, Tamauchi, Satoshi, Yoshikawa, Nobuhisa, Niimi, Kaoru, Shibata, Kiyosumi, and Kikkawa, Fumitaka

Published
2019
Full Text
View/download PDF

44. An update of oncologic and obstetric outcomes of radical trachelectomy for early‐stage cervical cancer: The need for further minimally invasive treatment

Author

Tamauchi, Satoshi, primary, Iyoshi, Shohei, additional, Yoshihara, Masato, additional, Yoshida, Kosuke, additional, Ikeda, Yoshiki, additional, Shimizu, Yusuke, additional, Yokoi, Akira, additional, Niimi, Kaoru, additional, Yoshikawa, Nobuhisa, additional, and Kajiyama, Hiroaki, additional

Published
2023
Full Text
View/download PDF

45. EP287/#748 The prognostic impact of limited-staging surgery in patients with stage ia epithelial ovarian cancer: a multi-center study with a propensity score-adjusted analysis

Author

Miyamoto, Emiri, primary, Suzuki, Hironori, additional, Yoshihara, Masato, additional, Iyoshi, Shohei, additional, Mogi, Kazumasa, additional, Uno, Kaname, additional, Fujimoto, Hiroki, additional, Kitami, Kazuhisa, additional, Tano, Sho, additional, and Kajiyama, Hiroaki, additional

Published
2023
Full Text
View/download PDF

47. Small Extracellular Vesicles from adipose-derived stem cells suppress cell proliferation by delivering the let-7 family of microRNAs in ovarian cancer

Author

Suzuki, Hironori, primary, Yokoi, Akira, additional, Uno, Kaname, additional, Yoshida, Kosuke, additional, Kitagawa, Masami, additional, Asano-Inami, Eri, additional, Matsuo, Seiko, additional, Nagao, Yukari, additional, Suzuki, Kazuhiro, additional, Nakamura, Kae, additional, Yoshihara, Masato, additional, Tamauchi, Satoshi, additional, Shimizu, Yusuke, additional, Ikeda, Yoshiki, additional, Yoshikawa, Nobuhisa, additional, Kajiyama, Hiroaki, additional, and Yamamoto, Yusuke, additional

Published
2023
Full Text
View/download PDF

48. The prognostic significance of DDIT4 in endometrial cancer

Author

Yoshikawa, Nobuhisa, primary, Yoshida, Kosuke, additional, Liu, Wenting, additional, Matsukawa, Tetsuya, additional, Hattori, Satomi, additional, Yoshihara, Masato, additional, Tamauchi, Satoshi, additional, Ikeda, Yoshiki, additional, Yokoi, Akira, additional, Shimizu, Yusuke, additional, Niimi, Kaoru, additional, and Kajiyama, Hiroaki, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results