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In this paper, capacitor current sensorless control by using an observer is applied in a seamless transfer single-phase inverter. The proposed control system is a multiloop control system. The control loop is composed of a capacitor voltage outer control loop and capacitor current inner control loop for stand-alone mode. For on-grid mode, the grid current outer loop controller is combined with the stand-alone control structure to form a simple controller structure for mode switching. The capacitor current feedback signal is calculated using the observer in the discrete-time domain and thus sensors are not required. Use of the proposed observer for the inverter with capacitor current control has many advantages, such as sensorless capacitor current calculation, one-sample-ahead data prediction for sampling delay compensation, and an average capacitor current without ripple components. Verification of the theoretical analysis is presented through simulation and experiment. A 5-kW single-phase inverter prototype combined with a Li-ion battery is set up with a digital controller using a TI TMS320F28377D microcontroller unit to confirm the feasibility of the system.

A novel interferometric method is presented for the measurement of the absolute energy of electron beams. In the year 2016, a pioneering experiment was performed using a 195 MeV beam of the Mainz Microtron (MAMI). The experimental setup consisted of two collinear magnetic undulators as sources of coherent optical synchrotron light and a high-resolving grating monochromator. Beam energy measurements required the variation of the relative undulator distance in the decimeter range and the analysis of the intensity oscillation length in the interference spectrum. A statistical precision of 1 keV was achieved in 1 h of data taking, while systematic uncertainties of 700 keV were present in the experiment. These developments aim for a relative precision of 1 0 − 5 in the absolute momentum calibrations of spectrometers and high-precision hypernuclear experiments. Other electron accelerators with beam energies in this regime such as the Mainz Energy Recovering Superconducting Accelerator (MESA) might benefit from this new method.

The main purpose of this paper is to develop a DC voltage controller with AC power ripple compensation for single phase ACDC converter, which is served as the front-end converter for an energy storage system. Due to the single phase ACDC converter circuit topology, the AC and DC side both exist power ripple with doubled grid frequency. In conventional controller, DC voltage is controlled to be a constant value, thus the ripple current flowing into DC capacitor increases and the control of input current is also affected. A DC voltage controller with AC power ripple compensation for single phase ACDC converter is implemented to control DC voltage with voltage ripple compensation. Therefore the power of AC and DC side will be balanced. The voltage ripple is calculated by AC input power with a fully digital controller. By controlling the DC voltage with voltage ripple obtained from AC power, the ripple current flowing into DC capacitor will decrease. The test plant of this paper is a 3kW single phase ACDC converter with fully digitalized control. The experiment results are introduced to verify the control method.

We have recently developed aged cortical neuron cultures from autopsied human brains with Alzheimer's disease (AD). During the culturing process, we found that glutamatergic cortical neurons from the AD brain lacked a response to glial cell line-derived neurotrophic factor (GDNF), including no axonal regrowth, and were starting to undergo apoptosis. Here we showed that, in cortical neurons from age- and gender-matched cognitively normal control (NC) subjects (NC neurons), GDNF enhanced the expression of GDNF family receptor subtype α1 (GFRα1), but not the other three subtypes (GFRα2, GFRα3, and GFRα4), whereas GDNF failed to induce GFRα1 expression in cortical neurons from the AD brain (AD neurons). The exogenous introduction of GFRα1, but not of its binding partner α1-neural cell adhesion molecule, or RET into AD neurons restored the effect of GDNF on neuronal survival. Moreover, between NC and AD neurons, the AMPA receptor blocker CNQX and the NMDA receptor blocker AP-5 had opposite effects on the GFRα1 expression induced by GDNF. In NC neurons, the presence of glutamate receptors was necessary for GDNF-linked GFRα1 expression, while in AD neurons the absence of glutamate receptors was required for GFRα1 expression by GDNF stimulation. These results suggest that, in AD neurons, specific impairments of GFRα1, which may be linked to glutamatergic neurotransmission, shed light on developing potential therapeutic strategies for AD by upregulation of GFRα1 expression.

Inhibition of the β-secretase, BACE1, which cleaves amyloid precursor protein (APP) to produce β-amyloid protein (Aβ), is thought to be a feasible therapeutic strategy for Alzheimer's disease. Reticulon (RTN) proteins such as RTN3 have been identified as membrane proteins that interact with BACE1 and inhibit its Aβ-generating activity. In this study, we investigated whether RTN3 can regulate Aβ production in vivo, using transgenic (Tg) mice expressing APP with Swedish and London mutations (APP Tg mice) and those expressing RTN3; the latter mice showed ~1.4-fold higher expression levels of RTN3 protein in the cerebral cortex than non-Tg controls. We analyzed the brains of single APP Tg and double APP/RTN3 Tg mice at the age of approximately 15 months. The levels of secreted APP-β, a direct BACE1 cleavage product of APP, in Tris-soluble fraction were considerably reduced in the hippocampus and cerebral cortex of APP/RTN3 Tg mice relative to those in APP Tg mice. Immunohistochemical analyses demonstrated that Aβ burden and plaques were significantly (by approximately 50%) decreased in both the hippocampus and cerebral cortex of double Tg mice compared to APP Tg mice. Furthermore, the levels of guanidine-soluble Aβ40 and Aβ42 in these brain regions of APP/RTN3 Tg mice were relatively lower than those in APP Tg mice. These findings indicate that even a small increase in RTN3 expression exerts suppressive effects on amyloidogenic processing of APP and Aβ accumulation through modulation of BACE1 activity in vivo, and suggest that induction of RTN3 might be an effective therapeutic strategy against Alzheimer's disease.

A patient with xerostomia and xerophthalmia due to Sjogren's syndrome presented with acute motor-dominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barre syndrome and multiple mononeuropathy via Sjogren's syndrome. We speculate that Guillain-Barre syndrome occurred in the patient and Guillain-Barre syndrome itself activated multiple mononeuropathy via Sjogren's syndrome.

Inflammatory mechanisms are implicated in the pathology of Alzheimer's disease (AD). However, it is unclear whether inflammatory alterations are a cause or consequence of neurodegeneration leading to dementia. Clarifying this issue would provide valuable insight into the early diagnosis and therapeutic management of AD. To address this, we compared the mRNA expression profiles of cytokines in the brains of AD patients with "non-demented individuals with AD pathology" and non-demented healthy control (ND) individuals. "Non-demented individuals with AD pathology" are referred to as high pathology control (HPC) individuals that are considered an intermediate subset between AD and ND. HPC represents a transition between normal aging and early stage of AD, and therefore, is useful for determining whether neuroinflammation is a cause or consequence of AD pathology. We observed that immunological conditions that produce cytokines in the HPC brain were more representative of ND than AD. To validate these result, we investigated the expression of inflammatory mediators at the protein level in postmortem brain tissues. We examined the protein expression of tumor necrosis factor (TNF)α and its receptors (TNFRs) in the brains of AD, HPC, and ND individuals. We found differences in soluble TNFα and TNFRs expression between AD and ND groups and between AD and HPC groups. Expression in the temporal cortex was lower in the AD brains than HPC and ND. Our findings indicate that alterations in immunological conditions involving TNFR-mediated signaling are not the primary events initiating AD pathology, such as amyloid plaques and tangle formation. These may be early events occurring along with synaptic and neuronal changes or later events caused by these changes. In this review, we emphasize that elucidating the temporal expression of TNFα signaling molecules during AD is important to understand the selective tuning of these pathways required to develop effective therapeutic strategies for AD.

A transient three-dimensional computational fluid dynamics model was developed to investigate the cooling performance of a partially loaded cold store in cooling process. The model accounted for turbulence by means of the standard k-e model with standard wall profiles. The model was validated successfully in cooling experiments with a mean error of 0.36 m/s and 1.4C for the air velocity in a refrigerated room and the temperature of the product, respectively. Based on the model, we studied the effect of different loading patterns of corrugated fiberboard containers filled with products in a cold store on cooling effectiveness. As a result, flat loading with air gaps was the optimal configuration to achieve high uniformity of temperature and rapid cooling. The findings of this study can help to elucidate and improve the cooling performance of refrigerated rooms for storing agricultural products. PRACTICAL APPLICATIONS The developed model is used to assess the cooling performance of partially loaded store. In this study, we have investigated how to stack the product in cold store to achieve uniform and rapid cooling. In order to extend the shelf life of fresh produce, it is very important to investigate the effect of loaded pattern on the cooling performance. The developed cooling model with 48 loaded corrugated fiberboard containers was based on one container cooling model. The approach presented in this paper can be used to design the loading pattern of agricultural products in a cold store.

We and others have previously shown that reactive microglia express the major histocompatibility complex (MHC) class I and class II antigens in the hippocampus of patients suffering from epilepsy. Although the MHC glycoproteins serve as restriction elements for T lymphocytes, there is little information available regarding T lymphocytes in hippocampal sclerosis. In the present study, we investigated T lymphocyte infiltration in human hippocampi in four cases of epilepsy with hippocampal sclerosis, as well as in four control cases without neurological disease. No CD8- or CD4-positive T lymphocytes were seen in hippocampi from the control cases. In contrast, CD8- and CD4-positive T lymphocytes had infiltrated into the hippocampi of patients with hippocampal sclerosis. In addition, expression of intercellular adhesion molecule-1 was diffusely upregulated in the hippocampi with hippocampal sclerosis. These results indicate that T lymphocyte infiltration is involved in the pathology of hippocampal sclerosis.

AIMS Reticulon 3 (RTN3), a member of the reticulon family of proteins, interacts with the beta-secretase, beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1), and inhibits its activity to produce beta-amyloid protein. The aim of the present study was to clarify the biological role of RTN3 in the brain and its potential involvement in the neuropathology of Alzheimer's disease (AD). METHODS We performed immunohistochemical and biochemical analyses using a specific antibody against RTN3 to investigate the expression and subcellular localization of RTN3 in control and AD brain tissue samples. RESULTS Western blot analysis revealed no significant differences in the RTN3 levels between control and AD brains. Immunohistochemical staining showed that RTN3 immunoreactivity was predominantly localized in pyramidal neurones of the cerebral cortex. The patterns of RTN3 immunostaining were similar in control and AD cerebral cortices, and senile plaques were generally negative for RTN3. Biochemical subcellular fractionation disclosed that RTN3 colocalized with BACE1 in various fractions, including the endoplasmic reticulum and the Golgi apparatus. Double-immunofluorescence staining additionally indicated that RTN3 was localized in both endoplasmic reticulum and Golgi compartments in neurones. CONCLUSIONS These results show that RTN3 is primarily expressed in pyramidal neurones of the human cerebral cortex and that no clear difference of RTN3 immunoreactivity is observable between control and AD brains. Our data also suggest that there is considerable colocalization of RTN3 with BACE1 at a subcellular level.

We and others have previously reported that lactotransferrin (LF), acting both as an iron-binding protein and inflammatory modulator, is greatly up-regulated in the brain of patients with Alzheimer’s disease (AD). However, it remains unknown which type of cells express LF in the brain of AD. In this study, therefore, we investigated the expression and localization of LF messenger RNA (mRNA) in the cerebral cortex of AD and control cases using real-time polymerase chain reaction (PCR) and in situ hybridization histochemistry. Real-time PCR demonstrated that LF mRNA expression in the cortex of AD cases was significantly greater than that in control cases. LF mRNA-positive granules were observed in the cortex by in situ hybridization histochemistry, and the number of positive granules was increased in AD cases compared to controls. The double staining technique of LF mRNA in situ hybridization and D-related human leukocyte antigen (HLA-DR) immunohistochemistry revealed that positive granules were localized in a subpopulation of HLA-DR-positive reactive microglia. In addition, LF mRNA-positive granules were observed in some cells that were negative for HLA-DR. These cells were also negative for CD4 and CD8 but positive for leukocyte common antigen (CD45RB), suggesting they were monocytes/macrophages. These results indicate that reactive microglia in the cerebral cortex and monocytes/macrophages infiltrating from the circulation might be responsible for synthesizing LF in AD brain.

Tightly coupled lines are widely used for wide band directional couplers, filters and baluns(1)(2). Though the phase velocity of TEM modes constructed in the uniform medium takes the equal values, the coupled line made on the surface of the dielectric substrate, however, are often used to make it easy. Sometimes, the technologies are used for the band pass filter and others. In this case, the phase velocity of eigen modes such as an even mode and odd mode take the different values, and the performance of the circuits using the coupled line are quite deteriorated. This paper, therefore, proposes the technology to give the delay function for either mode such as the even mode for the symmetrical coupled line to make same values of both eigen modes. Especially, the directional coupler of two microstrip lines coupled through the aperture with step impedance of the even mode are shown with the design theory and the experimental results comparing without step impedance.

A 60-year-old man developed levodopa-resistant pure akinesia. The patient gradually became more akinetic without accompanying gaze palsies, nuchal dystonia, or other parkinsonian features such as rigidity or tremor. At the age of 71, he died of bronchopneumonia. Neuropathologically, bilateral marked neuronal loss and gliosis were restrictedly observed in the globus pallidus, substantia nigra and corpus luysii, whereas mild gliosis without neuronal loss was found in the brain stem. With Gallyas-Braak silver stain, numerous argyrophilic fibrous structures partly surrounding glial nuclei were observed in the three major affected regions. With Bodian stain, however, they were rarely recognized. The structures were partly positive for tau protein. Rare neurofibrillary tangles were found in the three areas and brain stem. They were relatively more numerous but still sparse in the hippocampus and the parahippocampus. The present case was diagnosed as having pallidonigro-luysian atrophy based on two characteristic findings: (i) the distribution of lesions showing neuronal loss with gliosis; and (ii) significant presence of tau-positive argyrophilic fibrous structures related to glia but with the absence of neurofibrillary tangles in the major affected regions and the brain stem. As our present case uniquely showed pure akinesia for the whole clinical course, it is noteworthy to report it here with a full neuropathological evaluation. In addition, a moderate number of diffuse plaques positive for beta-amyloid were distributed in the thalamus.

In this paper, a two-switch high-frequency flyback transformer-type zero voltage soft-switching PWM DC-DC converter using IGBTs is proposed. Effective applications for this power converter can be found in auxiliary power supplies of rolling stock transportation and electric vehicles. This power converter is basically composed of two active power switches and a flyback high-frequency transformer. In addition to these, two passive lossless snubbers with power regeneration loops for energy recovery, consisting of a three-winding auxiliary high-frequency transformer, auxiliary capacitors and diodes are introduced to achieve zero voltage soft switching from light to full load conditions. Furthermore, this power converter has some advantages such as low cost circuit configuration, simple control scheme, and high efficiency. Its operating principle is described and to determine circuit parameters, some practical design considerations are discussed. The effectiveness of the proposed power converter is evaluated and compared with the hard switching PWM DC-DC converter from an experimental point of view, and the comparative electromagnetic conduction and radiation noise characteristics of both DC-DC power converter circuits are also depicted. © 2005 Wiley Periodicals, Inc. Electr Eng Jpn, 152(3): 74–81, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20081

We investigated the cellular and subcellular localization of IGF-II receptors in the adult mouse central nervous system (CNS). The IGF-II receptor and the cation-independent (CI) mannose-6-phosphate (M6P) receptor are identical. Immunohistochemistry demonstrated that IGF-II/CI-M6P receptor immunoreactivity was mostly restricted to middle- to large-sized neurons throughout the CNS. A small number of glial cells were weakly to moderately labeled. IGF-II/CI-M6P receptor immunoreactivity was largely recognized within endosome-lysosomal structures in the neurons by immuno-electron microscopy (EM) of the CNS tissues. More intense labeling was observed in larger neurons that included more abundant endosome-lysosomal structures, indicating that IGF-II/CI-M6P receptor immunoreactivity reflects the endosome-lysosomal activity specifically present in neurons. These results are consistent with the general assumption that IGF-II/CI-M6P receptors are involved in sorting lysosomal enzymes within cells. IGF-II/CI-M6P receptors also endocytose secreted IGF-II and M6P-containing glycoproteins as scavenger receptors. Furthermore, it has been reported that they are involved in the development of transmembrane IGF-II signals. Therefore, we next tried to determine if they are expressed on the cell surface of primary cultured cortical neurons. By immunofluorescence and immuno-EM, particularly by immuno-scanning EM, expression of IGF-II/CI-M6P receptors was demonstrated in the neuronal cell surface in response to IGF-II treatment.

An effective system control method is presented for applying a three-phase current-source PWM converter with a deadbeat controller to active power filters (APFs). In the shunt-type configuration, the APF is controlled such that the current drawn by the APF from the utility is equal to the current harmonics and reactive current required for the load. To attain the time-optimal response of the APF supply current, a two-dimensional deadbeat control scheme is applied to APF current control. Furthermore, in order to cancel both the delay in the two-dimensional deadbeat control scheme and the delay in DSP control strategy, an Adaptive Line Enhancer (ALE) is introduced in order to predict the desired value three sampling periods ahead. ALE has another function of bringing robustness to the deadbeat control system. Due to the ALE, settling time is made short in a transient state. On the other hand, total harmonic distortion (THD) of source currents can be minimized compared to the case where ideal identification of the controlled system can be made. The experimental results obtained from the DSP-based APF are also reported. The compensating ability of this APF is very high in accuracy and responsiveness although the modulation frequency is rather low. © 2004 Wiley Periodicals, Inc. Electr Eng Jpn, 150(1): 50–61, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20014

The purpose of this paper is to improve power conversion efficiency of a three-phase voltage source type soft-switching inverter with a single auxiliary resonant DC link (ARDCL) snubber. First, the operating principle of an ARDCL snubber discussed here is described. Second, this paper proposes an effective pulse pattern generation method of the zero voltage space vector of the three-phase soft-switching inverter using IGBTs or power modules that can reduce power losses in the ARDCL snubber treated here. In particular, a zero voltage holding interval in the DC rail busline of this three-phase soft-switching inverter is to be regulated according to the generation method of the zero voltage space vector. Third, the maximum modulation depth Mmax under the condition of correction of the instantaneous voltage space vector can be improved by using a new zero voltage space vector generation method. Finally, the feasible experimental results of this inverter are obtained confirming the operating characteristics such as power conversion actual efficiency, as well as conventional efficiency THD and RMS value of the balanced three-phase output voltage for an experimentally built three-phase voltage source type soft-switching pulse modulated inverter using the latest IGBT modules and evaluated from the standpoint of practical applications in industry UPS and new energy systems. © 2003 Wiley Periodicals, Inc. Electr Eng Jpn, 146(1): 89–99, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.10234

An effective system control method is presented for applying a three-phase current-source PWM converter with a deadbeat controller to active power filters (APFs). In the shunt-type configuration, the APF is controlled such that the current drawn by the APF from the utility is equal to the current harmonics and reactive current required for the load. To attain the time-optimal response of the APF supply current, a two-dimensional deadbeat control scheme is applied to APF current control. Further more, in order to cancel both the delay in the two-dimensional deadbeat control scheme and the delay in DSP control strategy, an adaptive Line Enhancer (ALE) is introduced in order to predict the desired value of three sampling periods ahead. ALE has another function of bringing the robustness to the deadbeat control system. Due to the ALE, settling time is made short in a transient state. On the other hand, total harmonic distortion (THD) of source currents can be reduced as much as possible compared to the case that ideal identification of controlled system could be made. The experimental results obtained from the DSP-based APF are also reported. The compensating ability of this APF is very high in accuracy and responsiveness although the modulation frequency is rather low.

Tumor necrosis factor receptor-I (TNFRI) and TNFRII are two TNFR subtypes in the immune system, but their roles in the brain remain unclear. Here we present a novel interaction between TNFR subtypes and TNF-alpha in the brain. Our studies on target-depleted TNFR in mice show that TNF-alpha has little effect on hippocampal neurons in which TNFRI, containing an "intracellular death domain," is absent (TNFRI -/-), whereas neurons from TNFRII knock-out mice are vulnerable to TNF-alpha even at low doses. Moreover, little nuclear factor-kappaB (NF-kappaB) translocation is induced by TNF-alpha in neurons of TNFRI -/-, whereas NF-kappaB subunit p65 is still translocated from the cytoplasm into the nucleus in neurons from wild-type and TNFRII -/- mice. Furthermore, p38 mitogen-activated protein (MAP) kinase activity is upregulated in neurons from both wild-type and TNFRI -/-, but no alteration of p38 MAP kinase was found in neurons from TNFRII. Results from overexpression of TNF receptors further support the above findings. NT2 neuronal-like cells transiently transfected with TNFRI are very sensitive to TNF-alpha, whereas TNF-alpha is not toxic and even seems to be trophic to the cells with TNFRII overexpression. Last, our radioligand-binding experiments demonstrate that TNF-alpha binds TNFRI with high affinity (K(d) of 0.6 nm), whereas TNFRII shows lower binding affinity (K(d) of 1.14 nm) to TNF-alpha in NT2 transfected cells. Together, these studies reveal novel neuronal responses of TNF-alpha in mediating consequences of TNF receptor activation differently. Subsequent neuronal death or survival may ultimately depend on a particular subtype of TNF receptor that is predominately expressed in neurons of the brain during neural development or with neurological diseases.

We investigated the effects of inhibitors of cAMP-specific phosphodiesterase type IV (PDE IV) on cultured rat microglial cells. Microglial cells expressed mRNA encoding PDE IV. Rolipram and RO-20-1724, specific inhibitors of PDE IV, elevated the intracellular cAMP level much higher than the other types of PDE inhibitors. cAMP in astrocytes but not in cerebrocortical neurons was similarly increased in response to treatment with PDE IV inhibitors examined. The PDE IV inhibitors, a beta-adrenergic agonist isoproterenol and an adenylyl cyclase stimulant forskolin suppressed the proliferation of microglial cells as revealed by PCNA-immunocytochemical staining. The PDE IV inhibitors suppressed release of TNF alpha and nitric oxide (NO) from lipopolysaccharide-activated microglial cells in pure culture, while they did not affect NO release from microglial cells in neuron-microglia coculture. The PDE IV inhibitors also suppressed superoxide anion production by phorbol ester-treated microglial cells. Isoproterenol and forskolin similarly suppressed the macrophage-like functions of activated microglial cells. However, the PDE IV inhibitors displayed novel effects distinct from those of isoproterenol, forskolin and 8Br-cAMP, regarding expression of mRNAs encoding PDE IV, metallothionein-1 and hemeoxigenase-1. The present data showed that the PDE IV inhibitors can be available to control microglial function and that their effects on glial cells should be taken into account when PDE IV inhibitors are used for treatment of brain diseases, such as multiple sclerosis.

In this paper a dynamic circuit system model of active three-phase current-source PWM converter for Power Factor Correction is described on the basis of instantaneous space vector modulation scheme. The formulation of the discretized system and control algorithm to achieve the deadbeat responses of state variables in the utility AC power side low pass filter of this converter are evaluated and discussed from an experimental point of view. The system response of this converter is much faster and transient oscillations of both source current and capacitor voltage are suppressed effectively, though the state variable in the state feedback is only the current obtained from the precise current sensor interface circuit.

This paper presents a novel prototype of a voltage-source load resonant inverter using insulated gate bipolar transistors for driving a silent-discharge-type ozone-generation tube. Ozone-generation technology has a history of more than 100 years and ozonization has been recognized as one of the best methods for water treatment, desinfection, industrial wastes utilization, and so on. However, some technological difficulties related to efficient ozone production and high cost of the ozone-generating equipment have been significant problems restricting ozone usage in the industrial plants. Introduced in this paper is a pulse-density-modulated high-frequency inverter for a silent-discharge-type ozonizer, which is developed with the aim to improve power conversion and control characteristics of the ozone generation by using advances in power electronic technology. The developed system implements the feedforward control-based pulse-density-modulation control scheme with pulsewidth-modulation feedback control strategy to compensate temperature and other environmental influences on ozone gas output.

The purpose of this paper is to improve power conversion efficiency of three-phase voltage-source type soft-switching inverter with a single auxiliary resonant DC link (ARDCL) snubber. In the first place, the operating principle of an ARDCL snubber discussed here is described. In the second place, this paper proposes an effective generation scheme of zero voltage space vector of three-phase soft-switching inverter using IGBTs that can reduce power losses in the ARDCL snubber treated here. In particular, a zero voltage holding interval in the DC busline of this soft switching inverter is to be regulated due to, the generation scheme of zero voltage space vector. In the third place, the maximum modulation depth Mmax under the condition of compensation of space voltage space vector can be improved by using a new zero voltage space vector generation scheme. Finally, the feasible experimental results to confirm the operating characteristics such as power conversion efficiency, THD and RMS value of output voltage for three-phase voltage-source type soft-switching inverter using IGBTs is concretely implemented and evaluated from a practical point of view.

Alpha1-chimaerin is a GTPase-activating protein (GAP) for Rac1, a member of the Rho small GTPase family, whose action leads to the inactivation of Rac1. Rac1 activity is upregulated in Alzheimer's disease, but little is known about the role of α1-chimaerin. In this study, we investigated the expression and localization of α1-chimaerin mRNA in postmortem human brains from patients with Alzheimer's disease and control subjects. In situ hybridization studies demonstrated that α1-chimaerin was expressed by neurons in the neo-cortex of the temporal lobe and the hippocampus of both controls and Alzheimer's disease cases, with the signal intensity dramatically decreased in patients with Alzheimer's disease. Real-time PCR analysis confirmed a significant reduction of α1-chimaerin mRNA expression in the temporal cortex of Alzheimer's disease cases. In contrast, α2-chimaerin mRNA levels showed no significant difference between the groups. The present study showed reduced α1-chimaerin expression in the brain of Alzheimer's disease cases, suggesting a role in the upregulation of Rac1 activity during the disease process.

In this paper, a novel prototype of pulse density modulated voltage source high-frequency resonant inverter using IGBT modules is presented for driving a silent discharge (SD) type ozone generating tube. An optimum design procedure of the series resonant inductor, which compensates the capacitance of the ozone generating tube, is described. The effective power regulation scheme, which is based on PDM (Pulse Density Modulation) and PWM (Pulse Width Modulation) hybrid control strategy implemented on DSP, and characteristics of this ozone generating tube load are illustrated. The effectiveness of this high-frequency inverter type ozonizer is proved in experiment, together with the simulation results.