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475 results on '"Yoshinaga, Shigetaka"'

3. Evaluating the usefulness of considering the size and morphological type of type B2 vessel area based on Japan Esophageal Society classification in estimating tumor invasion depth in superficial esophageal squamous cell carcinomas: study protocol for a prospective observational study (Japan BEES study)

Author

Yoshida, Masao, Mori, Keita, Urabe, Yuji, Hirasawa, Dai, Sasaki, Fumisato, Takeuchi, Manabu, Kadota, Tomohiro, Yoshio, Toshiyuki, Yoshinaga, Shigetaka, Kitamura, Yoko, Ohno, Kazuya, Ono, Yoichiro, Igarashi, Kimihiro, Takahashi, Hiroaki, and Ishihara, Ryu

Published
2024
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4. Exploratory investigation of virtual lesions in gastrointestinal endoscopy using a novel phase‐shift method for three‐dimensional shape measurement

Author

Sakamoto, Taku, primary, Oda, Ichiro, additional, Okamura, Takuma, additional, Cho, Hourin, additional, Toyoshima, Naoya, additional, Nonaka, Satoru, additional, Suzuki, Haruhisa, additional, Nakamura, Tatsuya, additional, Watanabe, Daichi, additional, Matsuo, Keigo, additional, Hanano, Kazunari, additional, Takeyama, Tetsuhide, additional, Yoshinaga, Shigetaka, additional, and Saito, Yutaka, additional

Published
2024
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6. Long-term outcomes after non-curative endoscopic resection for esophageal squamous cell carcinoma followed by additional chemoradiotherapy.

Author

Cho, Hourin, Abe, Seiichiro, Nonaka, Satoru, Suzuki, Haruhisa, Yoshinaga, Shigetaka, Okuma, Kae, Yamamoto, Shun, Daiko, Hiroyuki, Kato, Ken, Sekine, Shigeki, Boku, Narikazu, and Saito, Yutaka

Subjects
ENDOSCOPIC surgery, SQUAMOUS cell carcinoma, CHEMORADIOTHERAPY, DISEASE risk factors, LYMPHATIC metastasis, OVERALL survival, ESOPHAGEAL cancer, RECTAL cancer
Abstract

Endoscopic resection (ER) of esophageal squamous cell carcinoma (ESCC) is evaluated pathologically, and additional treatment is recommended for cases resulting in non-curative resection, defined as pMM with lymphovascular invasion (LVI), pSM, or positive vertical margin. This study aimed to assess long-term outcomes and risk factors for recurrence in patients with ESCC treated with non-curative ER followed by additional chemoradiotherapy (CRT). We retrospectively reviewed the clinical courses of patients who underwent non-curative ER followed by additional CRT for ESCCs between August 2007 and December 2017. Recurrence rates and risk factors for recurrence were analyzed. Among 97 patients with non-curative ER, 73 underwent additional CRT. With a median follow-up period of 71 months, recurrences were observed in 10 (14%) of 73 patients, with a median interval of 24.5 (1–59 months). The 3- and 5-year recurrence-free survival were 89 and 85%, respectively, and the 3- and 5-year overall survival rates were 96 and 91%, respectively. Multivariate analysis showed that lymphatic invasion was an independent risk factor for recurrence in patients with non-curative ESCC receiving additional CRT. Among the 10 patients with recurrence, 4, 3, 2, and 1 underwent surgery, chemotherapy, supportive care, and CRT, respectively. Notably, all four patients who underwent surgery survived, regardless of regional and/or distant lymph node metastasis. Lymphatic invasion is an independent risk factor for the recurrence of non-curative ESCCs. Careful follow-up is required for at least 5 years after ER with additional CRT. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Performance evaluation of a computer‐aided polyp detection system with artificial intelligence for colonoscopy.

Author

Chino, Akiko, Ide, Daisuke, Abe, Seiichiro, Yoshinaga, Shigetaka, Ichimasa, Katsuro, Kudo, Toyoki, Ninomiya, Yuki, Oka, Shiro, Tanaka, Shinji, and Igarashi, Masahiro

Subjects
COMPUTER-aided diagnosis, DEEP learning, ARTIFICIAL intelligence, COLONOSCOPY, INFORMATION networks, INFORMED consent (Medical law)
Abstract

Objectives: A computer‐aided detection (CAD) system was developed to support the detection of colorectal lesions by deep learning using video images of lesions and normal mucosa recorded during colonoscopy. The study's purpose was to evaluate the stand‐alone performance of this device under blinded conditions. Methods: This multicenter prospective observational study was conducted at four Japanese institutions. We used 326 videos of colonoscopies recorded with patient consent at institutions in which the Ethics Committees approved the study. The sensitivity of successful detection of the CAD system was calculated using the target lesions, which were detected by adjudicators from two facilities for each lesion appearance frame; inconsistencies were settled by consensus. Successful detection was defined as display of the detection flag on the lesion for more than 0.5 s within 3 s of appearance. Results: Of the 556 target lesions from 185 cases, detection success sensitivity was 97.5% (95% confidence interval [CI] 95.8–98.5%). The "successful detection sensitivity per colonoscopy" was 93% (95% CI 88.3–95.8%). For the frame‐based sensitivity, specificity, positive predictive value, and negative predictive value were 86.6% (95% CI 84.8–88.4%), 84.7% (95% CI 83.8–85.6%), 34.9% (95% CI 32.3–37.4%), and 98.2% (95% CI 97.8–98.5%), respectively. Trial registration: University Hospital Medical Information Network (UMIN000044622). [ABSTRACT FROM AUTHOR]

Published
2024
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14. A discrimination model by machine learning to avoid gastrectomy for early gastric cancer.

Author

Hayashi, Tsutomu, Takasawa, Ken, Yoshikawa, Takaki, Hashimoto, Taiki, Sekine, Shigeki, Wada, Takeyuki, Yamagata, Yukinori, Suzuki, Haruhisa, Abe, Seiichirou, Yoshinaga, Shigetaka, Saito, Yutaka, Kouno, Nobuji, and Hamamoto, Ryuji

Abstract

Aim: Gastrectomy is recommended for patients with early gastric cancer (EGC) because the possibility of lymph node metastasis (LNM) cannot be completely denied. The aim of this study was to develop a discrimination model to select patients who do not require surgery using machine learning. Methods: Data from 382 patients who received gastrectomy for gastric cancer and who were diagnosed with pT1b were extracted for developing a discrimination model. For the validation of this discrimination model, data from 140 consecutive patients who underwent endoscopic resection followed by gastrectomy, with a diagnosis of pT1b EGC, were extracted. We applied XGBoost to develop a discrimination model for clinical and pathological variables. The performance of the discrimination model was evaluated based on the number of cases classified as true negatives for LNM, with no false negatives for LNM allowed. Results: Lymph node metastasis was observed in 95 patients (25%) in the development cohort and 11 patients (8%) in the validation cohort. The discrimination model was developed to identify 27 (7%) patients with no indications for additional surgery due to the prediction of an LNM‐negative status with no false negatives. In the validation cohort, 13 (9%) patients were identified as having no indications for additional surgery and no patients with LNM were classified into this group. Conclusion: The discrimination model using XGBoost algorithms could select patients with no risk of LNM from patients with pT1b EGC. This discrimination model was considered promising for clinical decision‐making in relation to patients with EGC. [ABSTRACT FROM AUTHOR]

Published
2023
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18. ENDOSCOPIC FEATURES OF PRIMARY MALIGNANT MELANOMA OF THE ESOPHAGUS

Author

Kusaka, Hiroyasu, primary, Suzuki, Haruhisa, additional, Ego, Mai, additional, Toyoshima, Naoya, additional, Sekiguchi, Masau, additional, Takamaru, Hiroyuki, additional, Yamada, Masayoshi, additional, Abe, Seiichiro, additional, Nonaka, Satoru, additional, Yoshinaga, Shigetaka, additional, Daiko, Hiroyuki, additional, Kato, Ken, additional, Sekine, Shigeki, additional, and Saito, Yutaka, additional

Published
2023
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27. Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy

Author

Inoki, Kazuya, Abe, Seiichiro, Tanaka, Yusaku, Yamamoto, Koji, Hihara, Daisuke, Ichijima, Ryoji, Nakatani, Yukihiro, Chen, HsinYu, Takamaru, Hiroyuki, Sekiguchi, Masau, Yamada, Masayoshi, Sakamoto, Taku, Nonaka, Satoru, Suzuki, Haruhisa, Yoshinaga, Shigetaka, Oda, Ichiro, Matsuda, Takahisa, and Saito, Yutaka

Subjects
medicine.medical_specialty, Duodenum, Medicine (miscellaneous), RC799-869, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Lower gastrointestinal tract, Medicine, Radiology, Nuclear Medicine and imaging, Fluorescein, Confocal laser endomicroscopy, Lower Gastrointestinal Tract, medicine.diagnostic_test, business.industry, Stomach, Endoscopy, Diseases of the digestive system. Gastroenterology, Reduced dose, medicine.disease, RC31-1245, medicine.anatomical_structure, chemistry, Dysplasia, 030220 oncology & carcinogenesis, Original Article, 030211 gastroenterology & hepatology, business
Abstract

Background/aims Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE. Methods Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in the study. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination of the optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by three endoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were not deemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated. Results A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to 0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLE with IV fluorescein at 0.5 mg/kg. Conclusions In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both the upper and lower GI tract.

Published
2021

28. COLOR DIFFERENCE OF INTRAPROCEDURAL BLEEDING DURING ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) BETWEEN WHITE LIGHT IMAGING (WLI) AND RED DICHROMATIC IMAGING (RDI): POST HOC ANALYSIS OF A MULTI-CENTER, OPEN-LABEL, RANDOMIZED CONTROLLED TRIAL

Author

Ego, Mai, primary, Abe, Seiichiro, additional, Fujimoto, Ai, additional, Nonaka, Satoru, additional, Suzuki, Haruhisa, additional, Yoshinaga, Shigetaka, additional, Saito, Yutaka, additional, and Yahagi, Naohisa, additional

Published
2022
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31. Circularity Is a Potential Noninvasive Diagnostic Indicator to Differentiate Gastric Submucosal Tumors

Author

Koizumi, Eriko, primary, Goto, Osamu, additional, Yoshinaga, Shigetaka, additional, Yabuuchi, Yohei, additional, Yoshida, Masao, additional, Akimoto, Teppei, additional, Noda, Hiroto, additional, Onda, Takeshi, additional, Kirita, Kumiko, additional, Umeda, Takamitsu, additional, Higuchi, Kazutoshi, additional, Omori, Jun, additional, Kaise, Mitsuru, additional, and Iwakiri, Katsuhiko, additional

Published
2022
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35. Endoscopic ultrasound‐based application for determining the management of subepithelial lesions: Do androids dream of endoscopic ultrasound?

Author

Yoshinaga, Shigetaka

Subjects
*ENDOSCOPIC ultrasonography, *COMPUTER-aided diagnosis, *ENDOSCOPIC surgery, *NEEDLE biopsy, *GASTROINTESTINAL stromal tumors
Abstract

The article discusses the use of endoscopic ultrasound (EUS) for diagnosing subepithelial lesions (SELs) and determining the management of gastrointestinal cancer. EUS-guided fine needle aspiration (EUS-FNA) is commonly used to obtain tissue samples from SELs, but the diagnostic yield is lower compared to pancreatic solid tumors. The article also mentions the development of minimally invasive treatments for SELs, such as endoscopic resection (ER), but highlights the challenges associated with these treatments. The study presented in the article evaluates an application system called SELERP for determining the management of SELs, and while the diagnostic results are somewhat inferior to previous studies, the application shows promise for predicting diagnosis and ER-related outcomes. The article concludes by emphasizing the importance of human training in performing EUS and making treatment decisions, despite the advancements in computer-aided diagnosis. [Extracted from the article]

Published
2024
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45. ID: 3520683 CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH MAJOR RECURRENCE AFTER SALVAGE ENDOSCOPIC RESECTION FOR PATIENTS WITH LOCAL FAILURE AFTER DEFINITIVE CHOMORADIOTHERAPY FOR STAGE I ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Author

Ego, Mai, primary, Kadota, Tomohiro, additional, Yamashita, Hiroki, additional, Nakajo, Keiichiro, additional, Yoda, Yusuke, additional, Nonaka, Satoru, additional, Suzuki, Haruhisa, additional, Yoshinaga, Shigetaka, additional, Oda, Ichiro, additional, Abe, Seiichiro, additional, and Yano, Tomonori, additional

Published
2021
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47. Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan

Author

Katada, Chikatoshi, primary, Muto, Manabu, additional, Fujii, Satoshi, additional, Yokoyama, Tetsuji, additional, Yano, Tomonori, additional, Watanabe, Akihito, additional, Iizuka, Toshiro, additional, Yoshinaga, Shigetaka, additional, Tateya, Ichiro, additional, Mitani, Hiroki, additional, Shimizu, Yuichi, additional, Takahashi, Akiko, additional, Kamijo, Tomoyuki, additional, Hanaoka, Noboru, additional, Abe, Makoto, additional, Shiotani, Akihiro, additional, Kano, Koichi, additional, Asada, Yukinori, additional, Matsuhashi, Tamotsu, additional, Umeno, Hirohito, additional, Okami, Kenji, additional, Goda, Kenichi, additional, Hori, Shinichiro, additional, Ono, Yoichiro, additional, Terai, Shuji, additional, Nagami, Yasuaki, additional, Takemura, Kenichi, additional, Kawada, Kenro, additional, Ando, Mizuo, additional, Shimeno, Naoto, additional, Arai, Akihito, additional, Sakamoto, Yasutoshi, additional, Ichinoe, Masaaki, additional, Nemoto, Tetsuo, additional, Fujita, Masahiro, additional, Watanabe, Hidenobu, additional, Shimoda, Tadakazu, additional, Ochiai, Atsushi, additional, Kato, Takakuni, additional, and Hayashi, Ryuichi, additional

Published
2021
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49. Scheduled second-look endoscopy is not recommended after endoscopic submucosal dissection for gastric neoplasms (the SAFE trial): a multicentre prospective randomised controlled non-inferiority trial

Author

Mochizuki, Satoshi, Uedo, Noriya, Oda, Ichiro, Kaneko, Kazuhiro, Yamamoto, Yorimasa, Yamashina, Takeshi, Suzuki, Haruhisa, Kodashima, Shinya, Yano, Tomonori, Yamamichi, Nobutake, Goto, Osamu, Shimamoto, Takeshi, Fujishiro, Mitsuhiro, Koike, Kazuhiko, Shinozaki, Tomohiro, Yoshinaga, Shigetaka, Nonaka, Satoru, Abe, Seiichiro, Ohno, Yasuhiro, Odagaki, Tomoyuki, Yagishita, Atsushi, Yoda, Yusuke, Kato, Tomoji, Ono, Satoshi, Niimi, Keiko, Tsuji, Yosuke, Asada-Hirayama, Itsuko, Konno-Shimizu, Maki, Matsuda, Rie, Minatsuki, Chihiro, Sakaguchi, Yoshiki, Takahahi, Yu, Nakayama, Chiemi, and Yoshida, Kanako

Published
2015
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