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3. Contribution of traditional Japanese Kampo medicines, kakkonto with shosaikotokakikyosekko, in treating patients with mild-to-moderate coronavirus disease 2019: Further analysis of a multicenter, randomized controlled trial

Author

Takayama, Shin, Namiki, Takao, Arita, Ryutaro, Ono, Rie, Kikuchi, Akiko, Ohsawa, Minoru, Saito, Natsumi, Suzuki, Satoko, Nakae, Hajime, Kobayashi, Seiichi, Yoshino, Tetsuhiro, Ishigami, Tomoaki, Tanaka, Koichiro, Takagi, Airi, Yamaguchi, Takuhiro, Ishii, Tadashi, Hisanaga, Akito, Mitani, Kazuo, and Ito, Takashi

Published
2023
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7. Conference report: Fifth annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine.

Author

Yoshino, Tetsuhiro, Tanide, Sayaka, Hamai, Miho, Nishiura, Riko, Hatae, Akinobu, Nose, Itsuki, Oda, Yoshimi, Fukada, Yusuke, Yang, Ximeng, Ando, Hirokazu, Ogawa, Keiko, Murakami, Kazuhito, and Nakashima, Souichi

Subjects
*MEDICAL sciences, *TRADITIONAL medicine, *CLOCK genes, *MEDICAL societies, JAPANESE herbal medicine
Abstract

Seven young researchers presented their studies in the field of traditional Japanese herbal medicine (Wakan‐yaku) at the Fifth Annual Young Researcher Forum held the day before the 2024 annual meeting of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine. Ms Tanide presented on the changes in flavonoid and synephrine content in chimpi based on the storage period. Ms Hamai discussed natural compounds that contribute to improving bortezomib resistance in myeloma cells and their mechanisms of action. Ms Nishiura presented the production of a monoclonal antibody against geniposide and its application in indirect competitive enzyme‐linked immunosorbent assay. Mr Hatae presented about the effects of ninjin'yoeito on cisplatin‐induced anorexia and the variations in intestinal clock genes. Ms Nose explored the analgesic effects of bushi‐containing Kampo formulas, with a focus on goshajinkigan's improvement of cold allodynia. Dr Oda discussed the antifungal activity of henna leaves against Malassezia. Lastly, Mr Fukuda presented how cultivation environments affect the quality of Schizonepeta spikes, including their morphology and component content. The event, conducted both in person and online, attracted a total of 54 participants. Looking ahead, we aim to further develop and continue hosting this forum in 2025 and beyond, fostering the advancement of research in this field. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Machine learning model for predicting the cold–heat pattern in Kampo medicine: a multicenter prospective observational study.

Author

Maeda-Minami, Ayako, Yoshino, Tetsuhiro, Katayama, Kotoe, Horiba, Yuko, Hikiami, Hiroaki, Shimada, Yutaka, Namiki, Takao, Tahara, Eiichi, Minamizawa, Kiyoshi, Muramatsu, Shin-Ichi, Yamaguchi, Rui, Imoto, Seiya, Miyano, Satoru, Mima, Hideki, Uneda, Kazushi, Nogami, Tatsuya, Fukunaga, Koichi, and Watanabe, Kenji

Subjects
MACHINE learning, JAPANESE herbal medicine, BODY mass index, NOSOLOGY, PREDICTION models
Abstract

Objective: The purpose of this study was to predict the four cold–heat patterns in patients who have the subjective symptoms of the cold–heat pattern described in the International Classification of Diseases Traditional Medicine Conditions – Module 1 by applying a machine learning algorithm. Methods: Subjects were first-visit Kampo outpatients at six institutions who agreed to participate in this multicenter prospective observational study. The cold pattern model and the heat pattern model were created separately with 148 symptoms, body mass index, blood pressure (systolic and diastolic), age, and sex. Along with a single cold or heat pattern, the tangled heat/cold pattern is defined as being predicted by both cold and heat patterns, while the moderate (heat/cold) pattern is defined as being predicted by neither the cold pattern nor the heat pattern. Results: We included 622 participants (mean age ±standard deviation, 54.4 ± 16.9; with female 501). The accuracy, macro-recall, precision, and F1-score of a combination of the two prediction models were 96.7%, 93.2%, 85.6%, and 88.5% respectively. The important items were compatible with the definitions of the cold–heat pattern. Conclusion: We developed a prediction model on cold–heat patterns with data from patients whose subjective cold/heat-related symptoms matched the cold–heat pattern diagnosis by the physician. [ABSTRACT FROM AUTHOR]

Published
2024
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14. A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study)

Author

Namiki, Takao, Takayama, Shin, Arita, Ryutaro, Ishii, Tadashi, Kainuma, Mosaburo, Makino, Toshiaki, Mimura, Masaru, Yoshino, Tetsuhiro, Nogami, Tatsuya, Arai, Makoto, Sato, Juichi, Tanaka, Koichiro, Nakae, Hajime, Igari, Hidetoshi, Ozawa, Yoshihito, Shiko, Yuki, Kawasaki, Yohei, Nezu, Masahiko, and Ito, Takashi

Published
2021
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15. Current situation and future issues with Kampo medicine: A survey of Japanese physicians.

Author

Uneda, Kazushi, Yoshino, Tetsuhiro, Ito, Hidenori, Imoto, Seiya, and Nogami, Tatsuya

Subjects
*ASIAN medicine, *MEDICAL education, *APPETITE loss, *MEDICAL software, *MEDICALLY unexplained symptoms, JAPANESE herbal medicine
Abstract

Aim: We aimed to elucidate the present clinical situation, future challenges, and potential need for diagnostic support software in Kampo medicine. Methods: We conducted an online survey (comprising 28 questions) of Japanese physicians from the 23 to 24 January 2024 via MedPeer. The participants' responses were stratified according to their age distribution. Results: We evaluated data for 652 respondents. The most common respondent age groups were those in their 30s and 40s. The most common specialty of respondents was internal medicine (43.7%). Only 33.7% of respondents had received education on Kampo medicine at university. Most respondents (90.0%) were not licensed as certified physicians or members of the Japan Society for Oriental Medicine. Most respondents (86.7%) currently prescribed Kampo formulas (current users); only 3.8% had no experience in prescribing Kampo formulas. The conditions for which Kampo formulas were frequently prescribed were muscle cramps, constipation, medically unexplained symptoms/menopausal syndrome, appetite loss/malnutrition, and fatigue. However, 48.3% of current users did not use traditional Kampo patterns (sho). The most frequent issues reported by respondents were the lack of scientific evidence and standardization of diagnostic methods in Kampo medicine. Respondents indicated the need for postgraduate education and implementation of diagnostic support software for using Kampo patterns by non‐specialists in Kampo medicine. Conclusion: There was a discrepancy between the high frequency of Kampo formula prescriptions and the low use of traditional Kampo patterns in Japan. Diagnostic support software is likely to become a useful method of improving appropriate Kampo formula prescriptions by non‐specialists. [ABSTRACT FROM AUTHOR]

Published
2024
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19. A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-to-moderate COVID-19 patients for symptomatic relief and prevention of severe stage: a structured summary of a study protocol for a randomized controlled trial

Author

Takayama, Shin, Namiki, Takao, Ito, Takashi, Arita, Ryutaro, Nakae, Hajime, Kobayashi, Seiichi, Yoshino, Tetsuhiro, Ishigami, Tomoaki, Tanaka, Koichiro, Kainuma, Mosaburo, Nochioka, Kotaro, Takagi, Airi, Mimura, Masaru, Yamaguchi, Takuhiro, and Ishii, Tadashi

Published
2020
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22. Discrepancies of frequent symptoms in licorice‐induced pseudoaldosteronism: A comparison of a systematic case review and the Ministry of Health, Labour and Welfare's manual.

Author

Hattori, Yuna, Asano, Yoichi, and Yoshino, Tetsuhiro

Subjects
JAPANESE herbal medicine, PATIENTS' families, TRADITIONAL medicine, GLYCYRRHIZA, SYMPTOMS, SPASTICITY
Abstract

Background: Licorice‐induced pseudoaldosteronism has been identified as a side effect of excessive licorice consumption. This condition is often characterized by hypertension, hypokalemia, and hyporeninemic hypoaldosteronism. If left untreated, this condition can lead to severe complications, such as arrhythmia and rhabdomyolysis, which can be life‐threatening. Thus, it is critical to recognize the early symptoms of pseudoaldosteronism to facilitate prompt intervention and effective management. Here, we investigated the frequency of various accompanying symptoms by systematically reviewing case reports of licorice‐induced pseudoaldosteronism not covered in similar studies and comparing findings with the manual on pseudoaldosteronism published by the Ministry of Health, Labour and Welfare (MHLW). Methods: A comprehensive search was conducted using MEDLINE/PubMed to gather relevant human studies published between 1960 and July 2023 and written in English; data focusing on accompanying symptoms were summarized. Results: Thirty‐seven pertinent articles, encompassing 48 case reports (26 females and 1 unreported sex, mean age 64.6 ± 14.6), were identified and scrutinized. The analysis revealed that hypertension was the most prevalent followed by weakness and edema. None of the researched cases reported instances of spasticity or rigidity. Discussion: The study findings identified hypertension and weakness followed by edema as the predominant symptoms associated with pseudoaldosteronism which is in agreement with the MHLW manual. However, we doubt that spasticity, rigidity, and possibly numbness could be noticed by patients and their families as common initial symptoms outlined in the manual. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Conventional and Kampo Medicine Treatment for Mild-to-moderate COVID-19: A Multicenter, Retrospective, Observational Study by the Integrative Management in Japan for Epidemic Disease (IMJEDI Study-observation)

Author

Takayama, Shin, primary, Yoshino, Tetsuhiro, additional, Koizumi, Sayaka, additional, Irie, Yasuhito, additional, Suzuki, Tomoko, additional, Fujii, Susumu, additional, Katori, Rie, additional, Kainuma, Mosaburo, additional, Kobayashi, Seiichi, additional, Nogami, Tatsuya, additional, Yokota, Kenichi, additional, Yamazaki, Mayuko, additional, Minakawa, Satoko, additional, Chiba, Shigeki, additional, Suda, Norio, additional, Nakada, Yoshinobu, additional, Ishige, Tatsuya, additional, Maehara, Hirofumi, additional, Tanaka, Yutaka, additional, Nagase, Mahiko, additional, Kashio, Akihiko, additional, Komatsu, Kazuhisa, additional, Nojiri, Makoto, additional, Shimooki, Osamu, additional, Nakamoto, Kayo, additional, Arita, Ryutaro, additional, Ono, Rie, additional, Saito, Natsumi, additional, Kikuchi, Akiko, additional, Ohsawa, Minoru, additional, Nakae, Hajime, additional, Mitsuma, Tadamichi, additional, Mimura, Masaru, additional, Ishii, Tadashi, additional, Nochioka, Kotaro, additional, Chiu, Shih-Wei, additional, Yamaguchi, Takuhiro, additional, Namiki, Takao, additional, Hisanaga, Akito, additional, Mitani, Kazuo, additional, and Ito, Takashi, additional

Published
2023
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26. Corrigendum: Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker

Author

Ishiuchi, Kan’ichiro, primary, Morinaga, Osamu, additional, Yoshino, Tetsuhiro, additional, Mitamura, Miaki, additional, Hirasawa, Asuka, additional, Maki, Yasuhito, additional, Tashita, Yuuna, additional, Kondo, Tsubasa, additional, Ogawa, Kakuyou, additional, Lian, Fangyi, additional, Ogawa-Ochiai, Keiko, additional, Minamizawa, Kiyoshi, additional, Namiki, Takao, additional, Mimura, Masaru, additional, Watanabe, Kenji, additional, and Makino, Toshiaki, additional

Published
2022
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27. Multicenter, randomized controlled trial of traditional Japanese medicine, kakkonto with shosaikotokakikyosekko, for mild and moderate coronavirus disease patients

Author

Takayama, Shin, primary, Namiki, Takao, additional, Arita, Ryutaro, additional, Ono, Rie, additional, Kikuchi, Akiko, additional, Ohsawa, Minoru, additional, Saito, Natsumi, additional, Suzuki, Satoko, additional, Nakae, Hajime, additional, Kobayashi, Seiichi, additional, Yoshino, Tetsuhiro, additional, Ishigami, Tomoaki, additional, Tanaka, Koichiro, additional, Nochioka, Kotaro, additional, Takagi, Airi, additional, Mimura, Masaru, additional, Yamaguchi, Takuhiro, additional, Ishii, Tadashi, additional, Hisanaga, Akito, additional, Mitani, Kazuo, additional, and Ito, Takashi, additional

Published
2022
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36. Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker

Author

Ishiuchi, Kan'ichiro, primary, Morinaga, Osamu, additional, Yoshino, Tetsuhiro, additional, Mitamura, Miaki, additional, Hirasawa, Asuka, additional, Maki, Yasuhito, additional, Tashita, Yuuna, additional, Kondo, Tsubasa, additional, Ogawa, Kakuyou, additional, Lian, Fangyi, additional, Ogawa-Ochiai, Keiko, additional, Minamizawa, Kiyoshi, additional, Namiki, Takao, additional, Mimura, Masaru, additional, Watanabe, Kenji, additional, and Makino, Toshiaki, additional

Published
2021
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39. Conventional and Kampo medicine in the treatment of mild to moderate COVID‐19: A multicenter, retrospective observational study protocol by the Integrative Management in Japan for Epidemic Disease ( IMJEDI study‐Observation )

Author

Takayama, Shin, primary, Kashima, Masayuki, additional, Namiki, Takao, additional, Ito, Takashi, additional, Ono, Rie, additional, Arita, Ryutaro, additional, Saito, Natsumi, additional, Nakae, Hajime, additional, Irie, Yasuhito, additional, Kobayashi, Seiichi, additional, Yoshino, Tetsuhiro, additional, Ishigami, Tomoaki, additional, Tanaka, Koichiro, additional, Nogami, Tatsuya, additional, Minakawa, Satoko, additional, Nagase, Mahiko, additional, Kashio, Akihiko, additional, Ishige, Tatsuya, additional, Maehara, Hirofumi, additional, Saito, Toshiaki, additional, Sempuku, Sadahiro, additional, Yamazaki, Mayuko, additional, Tahara, Eiichi, additional, Suda, Norio, additional, Nakamoto, Kayo, additional, Mitsuma, Tadamichi, additional, Sato, Hiroko, additional, Shimooki, Osamu, additional, Nakada, Yoshinobu, additional, Abe, Shuichi, additional, Masuda, Takuya, additional, Kai, Hiroki, additional, Yokota, Kenichi, additional, Chiba, Shigeki, additional, Saitoh, Fumihiro, additional, Tanaka, Yutaka, additional, Koizumi, Sayaka, additional, Fujii, Susumu, additional, Katori, Rie, additional, Kainuma, Mosaburo, additional, Nochioka, Kotaro, additional, Chiu, Shih‐Wei, additional, Kikuchi, Akiko, additional, Suzuki, Tomoko, additional, Mimura, Masaru, additional, Yamaguchi, Takuhiro, additional, and Ishii, Tadashi, additional

Published
2020
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42. Additional file 1 of A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-to-moderate COVID-19 patients for symptomatic relief and prevention of severe stage: a structured summary of a study protocol for a randomized controlled trial

Author

Takayama, Shin, Namiki, Takao, Ito, Takashi, Arita, Ryutaro, Nakae, Hajime, Kobayashi, Seiichi, Yoshino, Tetsuhiro, Ishigami, Tomoaki, Tanaka, Koichiro, Mosaburo Kainuma, Nochioka, Kotaro, Takagi, Airi, Mimura, Masaru, Takuhiro Yamaguchi, and Ishii, Tadashi

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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48. Prediction Model for Deficiency-Excess Patterns, Including Medium Pattern

Author

MAEDA-MINAMI, Ayako, primary, YOSHINO, Tetsuhiro, additional, KATAYAMA, Kotoe, additional, HORIBA, Yuko, additional, HIKIAMI, Hiroaki, additional, SHIMADA, Yutaka, additional, NAMIKI, Takao, additional, TAHARA, Eiichi, additional, MINAMIZAWA, Kiyoshi, additional, MURAMATSU, Shinichi, additional, YAMAGUCHI, Rui, additional, IMOTO, Seiya, additional, MIYANO, Satoru, additional, MIMA, Hideki, additional, MIMURA, Masaru, additional, NAKAMURA, Tomonori, additional, and WATANABE, Kenji, additional

Published
2020
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