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6 results on '"Yoshio IZUNO"'

1. Cytomegalovirus Vasculitis Accompanied by an Exuberant Fibroblastic Reaction in the Intestine of an AIDS Patient

Author

Susumu Ikehara, Masayuki Shintaku, Yoshio Izuno, Noboru Inoue, Yoshihiro Ueda, and Masamichi Sasaki

Subjects
Adult, Male, Vasculitis, Pathology, medicine.medical_specialty, Congenital cytomegalovirus infection, Cytomegalovirus, Ileum, Biology, Inclusion Bodies, Viral, Pathology and Forensic Medicine, Lesion, Jejunum, Antigen, medicine, Mucosal Ulcer, Humans, Intestinal Mucosa, Sarcoma, Kaposi, Acquired Immunodeficiency Syndrome, General Medicine, Fibroblasts, medicine.disease, Intestinal Diseases, medicine.anatomical_structure, Cytomegalovirus Infections, Immunology, medicine.symptom, Immunostaining
Abstract

A case of cytomegalovirus (CMV) vasculitis in the intestine of a patient with acquired immune deficiency syndrome (AIDS) is reported. The distal jejunum and ileum had multiple well-demarcated mucosal ulcers and microscopic examination revealed an unusual, exuberant fibroblastic proliferation in the ulcer base. Amidst these fibroblasts, there were several small blood vessels of which the endothelial cells contained cytomegalic inclusion bodies. The lesion showed a Kaposi's sarcoma-like appearance, but spindle cells were negative in immunostaining for factor VIII-related antigen or Ulex europaeus agglutinin-1. Although the CMV infection was observed in almost all organs, the exuberant fibroblastic proliferation seen in the intestine was not found in other organs. This lesion might represent a peculiar reaction of the immunologically compromised host to the CMV in the intestinal blood vessels.

Published
1991

2. Immunohistochemical demonstration of epidermal growth factor in lactating mammary glands of sialoadenectomized mice

Author

Toshihiko Inui, Yoshio Izuno, Sotokichi Morii, Naoki Fujita, Airo Tsubura, and Hideto Senzaki

Subjects
medicine.medical_specialty, Histology, Pituitary Isograft, Physiology, Ratón, Mammary gland, Cell Biology, Biology, Biochemistry, Pathology and Forensic Medicine, Staining, Alveolar cells, medicine.anatomical_structure, Endocrinology, Epidermal growth factor, Internal medicine, Lactation, medicine, Immunohistochemistry
Abstract

Epidermal growth factor (EGF) was demonstrated immunohistochemically in the mammary glands of adult female SHN mice. Immunolocalization was found in all alveolar cells and some luminal contents of the lactating mammary glands, and it became intense during the lactation period. Weak staining was detected in the mammary gland in late pregnancy or in the hypersecretory mammary gland induced by pituitary isograft to the mammary fat pad. EGF staining was found in both intact and sialoadenectomized (sx) mice, and it was more intense in the intact mice than the sx ones, the offsprings mortality of the latter being greater in the first week of lactation. Still, staining in the sx group achieved an intensity comparable to that of the intact group in late lactation. At 7 days after parturition, staining in alveolar cells did not increase in the mother, from which all pups were withdrawn at Day 1 of lactation, though staining was intense in congesting milk. Therefore, the mammary gland itself may produce EGF by a secretory function, especially in lactation stage.

Published
1991

3. GENERAL SESSION

Author

Hisashi MATSUSHIMA, Kimio FUJITA, Nobuo MORIYAMA, Atsushi TAJIMA, Yoshio ASO, Morimasa Matsuta, Mayumi Matsuta, Heinz-Ulrich Weier, Daniel Pinkel, Yasmin Mehraein, Joe Gray, Vinci Mizuhira, Hiroshi Hasegawa, Mitsuru Notoya, Keiichi MORIGUCHI, Kei-Ichi HIRAI, Takashi MORITA, Nobuteru USUDA, Toru HANAI, Yongli KONG, Testuji NAGATA, M. MURAKOSHI, R. INADA, M. TAGAWA, M. SHOJI, M. SUZUKI, K. WATANABE, Noriyoshi NAGAMOTO, Katsumasa TAKAGI, Ken-ichi IYAMA, Mitsuhiko KITAOKA, Gentarou Usuku, Yasushi NAGASE, Yoshio HOSAKA, Eiji HIGASHIHARA, Toshiko NAGASHIMA, Hitoshi TANABE, Sachiko FUJII, Yuko GOTOHDA, Yasunori FUJIOKA, Kazuo NAGASHIMA, Yoshinao NISHIDA, Toyoshi FUJIMOTO, Kazuo OGAWA, Hiroshi NISHIMOTO, Gotaro YAMADA, Motowo MIZUNO, Hisashi ENDOH, Takao TSUJI, N. Nishimura, H. Nishimura, M. Karasawa, T. Kuroki, J. Suzuki, C. Tohyama, Mitsuru NOTOYA, Vinci MIZUHIRA, Hiroshi HASEGAWA, Fujio NUMANO, Toyohiro TSUKUDA, Tomoe KUROIWA, Akio SUZUKI, Jun AMANO, Y. Tokuda, M. Kubota, T. Tajima, R.Y. Osamura, Masami OGUNI, Hiroshi MATSUI, Haruko TAMURA, Haruo SHINOHARA, Osamu TANAKA, Keiji Oguro, Masahiko Nakagura, Toshio Masuzawa, K. OHTA, T. MINAGAWA, T. SUWA, N. MORIYAMA, Y. ASO, Haruo Ohtani, Hiroshi Nagura, Reiko Sasada, Yoshio Kozai, Yoshihisa Ohtawara, Kazuo Suzuki, Atsushi Tajima, Kazuki Kawabe, Yoshio Aso, Hiyoshi OKADA, Airo TSUBURA, Sotokichi MORII, Yuji NAKA, Yosuke KOMATSU, QIAN Liang, Masaru AOYAGI, Kimiyoshi HIRAKAWA, Yoshihiro AKIMOTO, Hiroshi HIRANO, Naoaki SAITO, Kaoru FUKUDA, Naoko FUJISAWA, Chikako TANAKA, Kazuyoshi SAKAI, Nobuyuki KARASAWA, Tetsuya FUJII, Keiki YAMADA, Isamu TAKAGI, Ikuko NAGATSU, Hideto SENZAKI, Testsji SHOJI, Yoshio IZUNO, Hisato SHIDA, Kazuto Shigematsu, Akira Nakatani, Masami Miwa, Kioko Kawai, Nobuaki SHIKATA, Iezo NAKAO, Naoki FUJITA, Rieko NISHIMURA, Tadahiro SHIMIZU, Takeshi YAMANDA, Akira SUGENOYA, Tetsuji NAGATA, Futoshi IIDA, Hiroyuki SUGIHARA, Kanade KATSURA, Tetsuro TAKAMATSU, Setsuya FUJITA, Yawara SUMI, Masayuki HARA, Takeshi MURAKI, Takuro SUZUKI, Etsuko SUZAKI, and Katsuko KATAOKA

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1991

4. Influence of strain and sex on the local development of mammary tumors induced by direct application of DMBA powder to rat mammary glands

Author

Naotaka Kusunose, Airo Tsubura, Sotokichi Morii, Yoshio Izuno, and Tetsuji Shoji

Subjects
Male, medicine.medical_specialty, 9,10-Dimethyl-1,2-benzanthracene, Administration, Topical, Ovariectomy, Local Development, Mammary gland, DMBA, Adenocarcinoma, medicine.disease_cause, Pathology and Forensic Medicine, Mammary Glands, Animal, Internal medicine, Medicine, Animals, Short latency, Carcinogen, Sex Characteristics, Strain (chemistry), business.industry, Mammary Neoplasms, Experimental, Rats, Inbred Strains, General Medicine, Rats, Disease Models, Animal, Endocrinology, medicine.anatomical_structure, Ovariectomized rat, Female, business, Carcinogenesis, Orchiectomy
Abstract

In order to determine the influence of strain and sex on local carcinogenesis in rat mammary tissue, 1 mg of 7, 12 dimethylbenz(a)anthracene (DMBA) was dusted directly onto the exposed mammary gland of 30-day-old Long-Evans (L-E) rats and Sprague-Dawley (S-D) rats. The experiment was terminated 28 weeks after application of the carcinogen. Tumors measuring between 1 and 2 cm in diameter were harvested from female L-E rats with high frequency (85%) and long latency (mean: 23.7 weeks after DMBA dusting), and from female S-D rats with extremely high frequency (98%) and short latency (16.7 weeks). Male rats of both strains were almost identically much less susceptible to DMBA (L-E; 55%, 25.0 weeks, S-D; 53%, 23.9 weeks). Ovariectomized S-D (47%, 24.9 weeks) and orchiectomized S-D (30%, 24.8 weeks) rats, which were gonadectomized at 30 days of age, respectively, were also much less susceptible. A variety of histologies, mostly malignant epithelial, mesenchymal or mixed tumors, were noted in each group. The carcinomatous response in the mammary tissue was much higher in female S-D (96%) than in female L-E (50%) rats, and very low in male and gonadectomized rats (10-20%). In contrast, the sar-comatous response in the mammary tissue was moderate in female and male L-E and male S-D (43-50%) rats, and low in the other groups (15-29%). Acta Pathol Jpn 40: 9–13, 1990.

Published
1990

5. GENERAL SESSION

Author

Toshiko NAGASHIMA, Hitoshi TANABE, Kazuo NAGASHIMA, Makoto NAGATA, Michiaki HIROE, Motoyoshi TSUJINO, Motonari HASUMI, Kiyomi NIKI, Toshiro NISHIKAWA, Toshinobu HORIE, Minoru SHIBUYA, Saichi HOSODA, Yukio HIRATA, Fumiaki MARUMO, Morie SEKIGUCHI, Tetsuji NAGATA, Nobuteru USUDA, Hongjun MA, Yoshiko Nakae, J Stoward, Mitsuru NAKAJIMA, Nobuaki ITO, Katsuji NISHI, Yoshiro OKAMURA, Tadaomi HIROTA, Atsushi Nakamura, Yutaka Futaesaku, Kennichi Kakudo, Keiichi Watanabe, Susumu NAKASONE, Takeyuki OHSHITA, Yasufumi UTSUMI, Teruo IWAMASA, Noriko NISHIMURA, Hisao NISHIMURA, Minako KASUYA, Shizuko KOBAYASHI, Chiharu TOHYAMA, Sakon NORIKI, Yoshiaki IMAMURA, Takuo IKEDA, Norio MIYOSHI, Kazuo NAKANISHI, Masaru FUKUDA, Masami Oguni, Haruo SHINOHARA, Osamu TANAKA, Keiji OGURO, Toshio MASUZAWA, Akiko SETO-OHSHIMA, Hitoshi OKAMURA, Marc ABITBOL, Jean-Francois JULIEN, Pierre BOBILLIER, Leif WIKLUND, Jaques MALLET, Kunio KITAHAMA, Yoshitake MATSUMOTO, Yukio ICHITANI, Yasuhiko IBATA, T. OLEA, T. NAGATA, Hiroyoshi OTA, Keiko ISHII, Tsutomu KATSUYAMA, Yoshinori OTSUKI, Suniko MAGARI, Hiramichi KUBO, Yuko ITO, Ying Jie Piao, Men Hu, Zheng Jin, Noriyuki SAHARA, Kazuo SUZUKI, Naoaki SAITO, Akiko KOSE, Atsuko ITO, Midori HIRATA, Takeshi TSUJINO, Chika YOSHIHARA, Chikako TANAKA, Yasutaka SAKAI, Atsuhiko HATTORI, Kayoko YAMASHITA, Takuro SUZUKI, Noriko SAKAIDA, Hideto SENZAKI, Nobuaki SHIKATA, Sotokichi MORII, Hiroyuki SAKUMA, Takashi FUKUDA, Kazuhide HIGUCHI, Tetsuo ARAKAWA, Kenzo KOBAYASHI, Yasuo SARUHASHI, Mineko FUJIMIYA, Hiroshi KIMURA, Sinsuke HUKUDA, Toshihiro MAEDA, Junzo SASAKI, Sadahiro WATANABE, Nagayasu OTSUKA, T. SAWADA, T. YAMAMOTO, T. YANAGISAWA, S. TAKUMA, H. HASEGAWA, K. WATANABE, H. SEGUCHI, T. KOBAYASHI, X. ZHANG, T. OKADA, Yoshio IZUNO, Airo TSUBURA, Hisato SHIDA, Kazuto SHIGEMATSU, Takihiro KAMIO, Kioko KAWAI, Iezo NAKAO, Noboru SHINDO, Seiichi SHIBATA, Hiroyuki SHINOHARA, Yoshiaki TAKAI, Yukio OKADA, Masahiko MORI, H. Sugihara, K. Katsura, S. Fujita, Yawara SUMI, Masashi OKANO, Fumio Suzuki, Jyoji Handa, Hidenori SUZUKI, Tomoko TANAKA, Kenjiro TANOUE, Hiroh YAMAZAKI, Koichi SUZUKI, Hirotaka MATSUMOTO, Makio KOBAYASHI, Akira KAWAOI, Kohtaro ASAYAMA, Shin-ichi MORIYAMA, Atsushi TAIRA, Kumiko KIMURA, Mitsuhiro KUDOH, Zyunzo MURATA, and Goro ASANO

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1989

6. GENERAL SESSION

Author

Kazuya Abbey, Hayato Kawakami, Takeo Kobayashi, Hiroshi Hirano, Hiromichi ABE, Yasunobu TOMIDA, Junzo OCHI, Morimi SHIMADA, Kazuharu IENAGA, Hiroshi KIMURA, Junko Akiyama, Koh Kawagoe, Takashi Kawana, Masaya Araki, Kouichiro Umemoto, Nobukazu ARAKI, Masao LEE, Yoichiro TAKASHIMA, Kazuo OGAWA, Tsutomu Araki, Akira Yamamoto, Youko Asaka, Jun Watanabe, Kazuo Kanai, Shinsuke Kanamura, T. DAIMON, K. KAWAI, K. UCHIDA, Naoto Doi, Nobuo Moriyama, Eiji Higashihara, Isao Murahashi, Yoshio Aso, Osamu FUJIMORI, Azuma TSUKISE, Kazuyori YAMADA, Akimune FUKUSHIMA, Toshihiko IZUTSU, Morimasa MATSUDA, Teruo KAGABU, Iwao NISHIYA, Sadayuki FUNATSUMARU, Nobuhisa YONEMITSU, Hajime SUGIHARA, Yasushi Furuta, Toshiya Shinohara, Kimiaki Sano, Mizuho Meguro, Kazuo Nagashima, HAN Minghu, PIAO Yingjie, Makoto HARA, Yoshinobu HOSHINO, Nobuo MORIYAMA, Masayuki HARA, Kayoko YAMASHITA, Yumi ISHIGE, Takuro SUZUKI, Hideaki HASEGAWA, Hideo TSUKAMOTO, Keiichi WATANABE, Hiroshi HIKITA, Keizo KAGAWA, Takeshi DEGUCHI, Takayuki TAKEUCHI, Hisashi TADA, Kazuo SAKABE, Masayuki MIZUMO, Masafumi MATSUMOTO, Takeshi OKANOUE, Kei KASHIMA, Tsukasa ASHIHARA, Tomoko HIRABAYASHI, Kazunori ISHIMURA, Hideaki TSURI, Hisao FUJITA, Makoto HIRAKAWA, Mitsuhiro KAWATA, Yutaka SANO, Yoshiaki HIRAYAMA, Tsugio AMEMIYA, Tajimi HIROHATA, Tetsuzo KUMAMOTO, Yohei HOSOKAWA, Kazushi ISETANI, Kazuhiko TOKITA, Shoji MITSUFUJI, Toshio TANI, Kyohei MARUYAMA, Tadashi KODAMA, Yasunari TSUCHIHASHI, H. Ichimal, T. Makita, Yukio ICHTANI, Sadatsugu MURAKAMI, Hitoshi OKAMURA, Ikuko NAGATSU, Noboru YANAIHARA, Yasuhiko IBATA, Hiroaki IGARASHI, Kenichirou INOMATA, Kaori IHIDA, Shinichiro TSUYAMA, Fusayoshi MURATA, Takuo IKEDA, Sakon NORIKI, Norio MIYOSHI, Hisataka KATO, Yoshiaki IMAMURA, Kazuo NAKANISHI, Kazuo MIYAZAWA, Toru HIROSE, Shirou KIMURA, Masaru FUKUDA, Kikuko Imamoto, Hiroyuki SUGIHARA, Toshihiko INUI, Yuji NAKA, Tetsuji SHOJI, Yoshio IZUNO, Airo TSUBURA, Sotokichi MORII, Keiko ISHIII, Takayuki HONDA, Tsutomu KATSUYAMA, Atsuko ITO, Masamichi ITO, Nobuaki ITO, Katsuji NISHI, Mitsuru NAKAJIMA, Yoshiro OKAMURA, Tadaomi HIROTA, Masaki IWAI, Motomu KASHIWADANI, Megumi Iwano, E-iti Yokomura, Hirohiko IWATSUKI, Kazushige UEDA, Masayuki MIZUNO, and Yoko KAMEDA

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1989

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