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178 results on '"Yoshioka, Kyoko"'

5. Lower effectiveness of intravenous steroid treatment for moderate‐to‐severe ulcerative colitis in hospitalised patients with older onset: a multicentre cohort study.

Author

Okabayashi, Shinji, Yamazaki, Hajime, Tominaga, Keiichi, Miura, Miki, Sagami, Shintaro, Matsuoka, Katsuyoshi, Yamaguchi, Yoshiharu, Noake, Toshihiro, Ozeki, Keiji, Miyazaki, Ryosuke, Kamano, Toshiaki, Fukuda, Tomohiro, Yoshioka, Kyoko, Ando, Katsuyoshi, Fukuzawa, Masakatsu, Andoh, Akira, Yamamoto, Yosuke, Hibi, Toshifumi, and Kobayashi, Taku

Subjects
ULCERATIVE colitis, COHORT analysis, DISEASE remission, VENOUS thrombosis, POISSON regression, OLDER patients, INFLAMMATORY bowel diseases, PERIPHERALLY inserted central catheters
Abstract

Summary: Background: The increasing incidence of older‐onset ulcerative colitis (UC), which has a higher risk of surgery, is a global health issue. However, data regarding intravenous steroid treatment, one of the important treatment options to avoid surgery, for older‐onset UC is lacking. Aims: To evaluate the association between onset age and effectiveness of intravenous steroids in UC. Methods: This retrospective multicentre (27 facilities) cohort study included moderate‐to‐severe hospitalised UC patients who underwent their first intravenous steroids between April 2014 and July 2019. The primary outcome was clinical remission at day 30, using two‐item patient‐reported outcome scoring. The key secondary outcomes were risks of surgery and adverse events (death, infection and venous thrombosis) within 90 days. A modified Poisson regression model was used for analysis. Results: Overall, 467 UC patients (384 younger‐onset and 83 older‐onset) were enrolled. Clinical remission at day 30 was observed in 252 (65.6%) among younger‐onset patients and 43 (51.8%) among older‐onset patients (adjusted risk difference, −21.7% [95% CI, −36.1% to −7.2%]; adjusted risk ratio [ARR], 0.74 [95% CI, 0.59 to 0.93]). The risks of surgery and adverse events were higher in older‐onset UC (20.5% vs. 3.1%; ARR, 8.92 [95% CI, 4.13 to 19.27], 25.3% vs. 9.1%; ARR, 2.19 [95% CI, 1.22 to 3.92], respectively). Four deaths occurred, all involving older‐onset UC. The risks of infection and venous thrombosis were also higher in older‐onset UC (18.1% vs. 8.6%, 7.2% vs. 0.5%, respectively). Conclusions: Older‐onset was associated with a lower effectiveness of intravenous steroids with higher risks of surgery and adverse events in UC. [ABSTRACT FROM AUTHOR]

Published
2022
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8. One-step detection of galectins on hybrid monolayer surface with protruding lactoside

Author

Yoshioka, Kyoko, Sato, Yukari, Murakami, Teiichi, Tanaka, Mutsuo, and Niwa, Osamu

Subjects
Lectins -- Chemical properties, Lectins -- Identification and classification, Tumors -- Chemical properties, Tumors -- Composition, Chemistry, Analytic -- Quantitative, Chemistry, Analytic -- Methods, Chemistry, Analytic -- Technology application, Technology application, Chemistry
Abstract

Galectins, or [beta]-galactoside binding iectins, are detected deep in tumor tissue and are recognized as diagnostic and prognostic markers of cancer and other serious diseases. There is a need to develop a faster, easier, and simpler method for detecting galectins. We have succeeded in forming a mixed self-assembled monolayer (SAM) interface consisting of fl-galactoside terminated alkanethiol (lactoside protuberant dodecanethiol) and tri(ethylene glycol) (TEG) terminated short alkanethiol, which proved to be a superior protein resistant material, to enable us to develop a label-free, one-step, and highly sensitive system for detecting the expected biomarker, galectin. We successfully detected nanomolar level (~ 1 nM) galectin-4 and -8 on a 4% lactoside protrusive surface, even though the affinity between the galectins and lactoside was very weak (KD = 1 x [10.sup.-3] ~1 x [10.sup.-6]).The combination of the suppression of background noise by filling with TEG terminated short alkanethiol and control of the ligand ratio in the interface contributed to the highly sensitive detection of galectin. We also detected galectin-4 at subten nanomolar levels even in a solution containing much higher concentrations of serum proteins (1800 times larger than the galectin concentration) without using molecule labeling or an immunological method. 10.1021/ac9022346

Published
2010

15. Flagellar filament structure and cell motility of Salmonella typhimurium mutants lacking part of the outer domain of flagellin

Author

Yoshioka, Kyoko, Aizawa, Shin-ichi, and Yamaguchi, Shigeru

Subjects
Salmonella typhimurium -- Research, Bacteria -- Motility, Biological sciences
Abstract

Experimental studies enable the isolation of spontaneous mutants of Salmonella typhimurium exhibiting ability to swim in the presence of antifilament antibodies. Analysis of the domains structures of flagellins associated with two mutants by trypsin digestion reveals that the two flagellins exhibit deletions at Ala-204 to Lys-292 and Thr-183 to Lys-279, respectively. Outer domains of flagellin have these deleted portions, and side by side aggregation of these mutant filaments leads to motility disorder.

Published
1995

22. 学校における大学院生による学校不適応児の援助に関する研究 : 学習指導補助員制度の効果と限界

Author

Kobayashi, Masayuki, Ookuma, Masashi, Ogawara, Mami, Kanazawa, Takiko, Takeuti, Yoshiko, Nakagawa, Yukako, Makino, Nanae, Yoshioka, Kyoko, Kobayashi, Masayuki(Tokyo Gakugei University, Integrated Research Center for Educational Practice), Ookuma, Masashi(Koganei City Educational Committee), Ogawara, Mami(Tokyo Gakugei University, Graduate School), Kanazawa, Takiko(Tokyo Gakugei University, Takeuti, Yoshiko(Tokyo Gakugei University, Nakagawa, Yukako(Tokyo Gakugei University, Makino, Nanae(Tokyo Gakugei University, and Yoshioka, Kyoko(Tokyo Gakugei University

Published
1999

37. Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

Author

Hara, Yoshikazu, primary, Wakino, Shu, additional, Tanabe, Yoshiyuki, additional, Saito, Maki, additional, Tokuyama, Hirobumi, additional, Washida, Naoki, additional, Tatematsu, Satoru, additional, Yoshioka, Kyoko, additional, Homma, Koichiro, additional, Hasegawa, Kazuhiro, additional, Minakuchi, Hitoshi, additional, Fujimura, Keiko, additional, Hosoya, Koji, additional, Hayashi, Koichi, additional, Nakayama, Koichi, additional, and Itoh, Hiroshi, additional

Published
2011
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40. Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

Author

Hasegawa, Kazuhiro, primary, Wakino, Shu, additional, Yoshioka, Kyoko, additional, Tatematsu, Satoru, additional, Hara, Yoshikazu, additional, Minakuchi, Hitoshi, additional, Sueyasu, Keiko, additional, Washida, Naoki, additional, Tokuyama, Hirobumi, additional, Tzukerman, Maty, additional, Skorecki, Karl, additional, Hayashi, Koichi, additional, and Itoh, Hiroshi, additional

Published
2010
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41. Abstract 5080: Role of Mineralocorticoid Receptor/Rho/Rho-kinase Pathway in Obesity-Related Renal Injury

Author

Tokuyama, Hirobumi, primary, Wakino, Shu, additional, Tatematsu, Satoru, additional, Yoshioka, Kyoko, additional, Hasegawa, Kazuhiro, additional, Hara, Yoshikazu, additional, Minakuchi, Hitoshi, additional, Sueyasu, Keiko, additional, Homma, Koichiro, additional, Washida, Naoki, additional, Hayashi, Koichi, additional, and Itoh, Hiroshi, additional

Published
2009
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