Search

Your search keyword '"Yoshiura, Yukiko"' showing total 32 results
Start Over Author "Yoshiura, Yukiko"
32 results on '"Yoshiura, Yukiko"'

11. Additional file 1: of Usefulness of myeloperoxidase as a biomarker for the ranking of pulmonary toxicity of nanomaterials

Author

Tomonaga, Taisuke, Izumi, Hiroto, Yoshiura, Yukiko, Myojo, Toshihiko, Oyabu, Takako, Byeong-Woo Lee, Takami Okada, Marui, Takashi, Wang, Ke-Yong, Kubo, Masaru, Shimada, Manabu, Noguchi, Shingo, Chinatsu Nishida, Yatera, Kazuhiro, and Morimoto, Yasuo

Subjects
animal diseases
Abstract

Figure S1-S2. Relationship between MPO and inflammatory markers after intratracheal instillation or inhalation exposure. Figure S1: Relationship between MPO and inflammatory markers: (a) neutrophils, (b) percent of neutrophils in total cells, (c) total cell, (d) CINC-1, (e) HO-1 and (f) LDH versus MPO concentration in BALF after intratracheal instillation of inhaled chemicals. Values of ρ are Spearman’s rank correlation coefficient for each of the data. Figure S2. Relationship between MPO and inflammatory markers: (a) neutrophils, (b) percent of neutrophils in total cells, )c) total cell, (d) CINC-1, (e) HO-1 and (f) LDH versus MPO concentration in BALF after inhalation exposure. Values of ρ are Spearman’s rank correlation coefficient for each of the data. (DOCX 141 kb)

Published
2018
Full Text
View/download PDF

14. Biopersistence of NiO and TiO2 Nanoparticles Following Intratracheal Instillation and Inhalation

Author

Oyabu, Takako, primary, Myojo, Toshihiko, additional, Lee, Byeong-Woo, additional, Okada, Takami, additional, Izumi, Hiroto, additional, Yoshiura, Yukiko, additional, Tomonaga, Taisuke, additional, Li, Yun-Shan, additional, Kawai, Kazuaki, additional, Shimada, Manabu, additional, Kubo, Masaru, additional, Yamamoto, Kazuhiro, additional, Kawaguchi, Kenji, additional, Sasaki, Takeshi, additional, and Morimoto, Yasuo, additional

Published
2017
Full Text
View/download PDF

15. Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles

Author

Morimoto, Yasuo, Izumi, Hiroto, Yoshiura, Yukiko, Tomonaga, Taisuke, Byeong-Woo Lee, Takami Okada, Oyabu, Takako, Myojo, Toshihiko, Kawai, Kazuaki, Yatera, Kazuhiro, Shimada, Manabu, Kubo, Masaru, Yamamoto, Kazuhiro, Kitajima, Shinichi, Etsushi Kuroda, Horie, Masanori, Kawaguchi, Kenji, and Sasaki, Takeshi

Abstract

In order to examine whether intratracheal instillation studies can be useful for determining the harmful effect of nanoparticles, we performed inhalation and intratracheal instillation studies using samples of the same nanoparticles. Nickel oxide nanoparticles (NiO) and titanium dioxide nanoparticles (TiO2) were used as chemicals with high and low toxicities, respectively. In the intratracheal instillation study, rats were exposed to 0.2 or 1 mg of NiO or TiO2. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed from 3 days to 6 months following the single intratracheal instillation. In the inhalation study, rats were exposed to inhaled NiO or TiO2 (1.65, 1.84 mg/m3, respectively) for 4 weeks. The same endpoints were examined from 3 days to 3 months after the end of exposure. Inhalation of NiO induced an increase in the number of neutrophils in BALF and concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-2 and heme oxygenase (HO)-1. Intratracheal instillation of NiO induced persistent inflammation and upregulation of these cytokines was observed in the rats. However, inhalation of TiO2 did not induce pulmonary inflammation, and intratracheal instillation of TiO2 transiently induced an increase in the number of neutrophils in BALF and the concentrations of CINC-1, CINC-2 and HO-1. Taken together, a difference in pulmonary inflammation was observed between the high and low toxicity nanomaterials in the intratracheal instillation studies, as in the inhalation studies, suggesting that intratracheal instillation studies may be useful for ranking the harmful effects of nanoparticles.

Published
2016
Full Text
View/download PDF

20. Evaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation

Author

Morimoto, Yasuo, primary, Izumi, Hiroto, additional, Yoshiura, Yukiko, additional, Tomonaga, Taisuke, additional, Oyabu, Takako, additional, Myojo, Toshihiko, additional, Kawai, Kazuaki, additional, Yatera, Kazuhiro, additional, Shimada, Manabu, additional, Kubo, Masaru, additional, Yamamoto, Kazuhiro, additional, Kitajima, Shinichi, additional, Kuroda, Etsushi, additional, Kawaguchi, Kenji, additional, and Sasaki, Takeshi, additional

Published
2016
Full Text
View/download PDF

22. Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

Author

Horie, Masanori, primary, Yoshiura, Yukiko, additional, Izumi, Hiroto, additional, Oyabu, Takako, additional, Tomonaga, Taisuke, additional, Okada, Takami, additional, Lee, Byeong-Woo, additional, Myojo, Toshihiko, additional, Kubo, Masaru, additional, Shimada, Manabu, additional, and Morimoto, Yasuo, additional

Published
2016
Full Text
View/download PDF

23. Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles

Author

Morimoto, Yasuo, primary, Izumi, Hiroto, additional, Yoshiura, Yukiko, additional, Tomonaga, Taisuke, additional, Lee, Byeong-Woo, additional, Okada, Takami, additional, Oyabu, Takako, additional, Myojo, Toshihiko, additional, Kawai, Kazuaki, additional, Yatera, Kazuhiro, additional, Shimada, Manabu, additional, Kubo, Masaru, additional, Yamamoto, Kazuhiro, additional, Kitajima, Shinichi, additional, Kuroda, Etsushi, additional, Horie, Masanori, additional, Kawaguchi, Kenji, additional, and Sasaki, Takeshi, additional

Published
2015
Full Text
View/download PDF

24. Comparison between whole-body inhalation and nose-only inhalation on the deposition and health effects of nanoparticles

Author

Oyabu, Takako, primary, Morimoto, Yasuo, additional, Izumi, Hiroto, additional, Yoshiura, Yukiko, additional, Tomonaga, Taisuke, additional, Lee, Byeong-Woo, additional, Okada, Takami, additional, Myojo, Toshihiko, additional, Shimada, Manabu, additional, Kubo, Masaru, additional, Yamamoto, Kazuhiro, additional, Kawaguchi, Kenji, additional, and Sasaki, Takeshi, additional

Published
2015
Full Text
View/download PDF

27. Gene expression profile of pulmonary inflammation in rat lung induced by nickel oxide nanoparticles following intratracheal instillation

Author

Izumi, Hiroto, primary, Yoshiura, Yukiko, additional, Tomonaga, Taisuke, additional, Lee, Byeong-Woo, additional, Okada, Takami, additional, Oyabu, Takako, additional, Myojo, Toshihiko, additional, Shimada, Manabu, additional, Kubo, Masaru, additional, Yamamoto, Kazuhiro, additional, Kitajima, Shinichi, additional, and Morimoto, Yasuo, additional

Published
2015
Full Text
View/download PDF

29. Comparison between whole-body inhalation and nose-only inhalation on the deposition and health effects of nanoparticles.

Author

Oyabu, Takako, Morimoto, Yasuo, Izumi, Hiroto, Yoshiura, Yukiko, Tomonaga, Taisuke, Lee, Byeong-Woo, Okada, Takami, Myojo, Toshihiko, Shimada, Manabu, Kubo, Masaru, Yamamoto, Kazuhiro, Kawaguchi, Kenji, and Sasaki, Takeshi

Abstract

Objectives: We performed the two inhalation exposures, whole-body inhalation and nose-only inhalation, to investigate the pulmonary deposition and health effects of the two inhalation methods. Methods: In both methods, we exposed rats to the same TiO nanoparticles at almost the same exposure concentration for 6 h and compared the deposited amounts of nanoparticles and histopathological changes in the lungs. Rats were exposed to rutile-type TiO nanoparticles generated by the spray-dry method for 6 h. The exposure concentration in the whole-body chamber was 4.10 ± 1.07 mg/m, and that in nose-only chamber was 4.01 ± 1.11 mg/m. The particle sizes were 230 and 180 nm, respectively. A control group was exposed to fresh air. Results: The amounts of TiO deposited in the lungs as measured by ICP-AES after acid digestion just after the exposure were: 42.6 ± 3.5 μg in the whole-body exposure and 46.0 ± 7.7 μg in the nose-only exposure groups. The histopathological evaluation was the same in both exposure groups: no infiltration of inflammatory cells in the alveolar space and interstitium, and no fibrosis. Conclusion: The two inhalation methods using the same material under the same exposure conditions resulted in the same particle deposition and histopathology in the lung. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

32. Comparison of pulmonary inflammatory responses following intratracheal instillation and inhalation of nanoparticles.

Author

Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Lee BW, Okada T, Oyabu T, Myojo T, Kawai K, Yatera K, Shimada M, Kubo M, Yamamoto K, Kitajima S, Kuroda E, Horie M, Kawaguchi K, and Sasaki T

Subjects
Administration, Inhalation, Animals, Bronchoalveolar Lavage Fluid cytology, Cytokines immunology, Instillation, Drug, Lung immunology, Male, Neutrophils drug effects, Rats, Rats, Wistar, Lung drug effects, Nanoparticles administration & dosage, Nanoparticles toxicity, Nickel administration & dosage, Nickel toxicity, Pneumonia chemically induced, Titanium administration & dosage, Titanium toxicity
Abstract

In order to examine whether intratracheal instillation studies can be useful for determining the harmful effect of nanoparticles, we performed inhalation and intratracheal instillation studies using samples of the same nanoparticles. Nickel oxide nanoparticles (NiO) and titanium dioxide nanoparticles (TiO2) were used as chemicals with high and low toxicities, respectively. In the intratracheal instillation study, rats were exposed to 0.2 or 1 mg of NiO or TiO2. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed from 3 days to 6 months following the single intratracheal instillation. In the inhalation study, rats were exposed to inhaled NiO or TiO2 (1.65, 1.84 mg/m(3), respectively) for 4 weeks. The same endpoints were examined from 3 days to 3 months after the end of exposure. Inhalation of NiO induced an increase in the number of neutrophils in BALF and concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-2 and heme oxygenase (HO)-1. Intratracheal instillation of NiO induced persistent inflammation and upregulation of these cytokines was observed in the rats. However, inhalation of TiO2 did not induce pulmonary inflammation, and intratracheal instillation of TiO2 transiently induced an increase in the number of neutrophils in BALF and the concentrations of CINC-1, CINC-2 and HO-1. Taken together, a difference in pulmonary inflammation was observed between the high and low toxicity nanomaterials in the intratracheal instillation studies, as in the inhalation studies, suggesting that intratracheal instillation studies may be useful for ranking the harmful effects of nanoparticles.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results