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16 results on '"You, Zhiqing"'

2. Comprehensive evaluation of plasma microbial cell-free DNA sequencing for predicting bloodstream and local infections in clinical practice: a multicenter retrospective study

Author

Pang, Feng, primary, Xu, Wenbin, additional, Zhao, Hui, additional, Chen, Shuai, additional, Tian, Yaxian, additional, Fu, Juanjuan, additional, You, Zhiqing, additional, Song, Pingping, additional, Xian, Qingjie, additional, Zhao, Qigang, additional, Wang, Chengtan, additional, and Jia, Xiuqin, additional

Published
2024
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12. In-depth research on direct torque control of permanent magnet synchronous motor

Author

Muhammed Fazlur Rahman, Lixin Tang, Gu Yikang, Tian Cun, You Zhiqing, and Hu Yuwen

Subjects
Stall torque, Vector control, Direct torque control, Torque motor, Computer Science::Systems and Control, Control theory, Computer science, Condensed Matter::Superconductivity, Control engineering, Permanent magnet synchronous generator, Torque ripple, Synchronous motor, Induction motor
Abstract

The direct torque control theory has achieved great success in the control of induction motor. However, in the DTC drive system of permanent magnet synchronous machine (PMSM) proposed a few years ago, there are many basic theoretical problems that must be clarified. This paper describes an investigation about the effect of the zero voltage space vectors in the DTC system of PMSM and points out that if using the zero voltage space vectors rationally, not only the DTC system can be driven successfully but torque ripple is reduced and performance of the system is improved. This paper also studies the sensorless technique in the DTC system of PMSM and configures the DTC system of PMSM with sensorless technique including zero voltage space vectors. Numerical simulations and experimental tests have proved the theory correct. In the sensorless condition, the DTC system of PMSM is wide-ranged speed adjusting, and the ratio of speed adjustment is 1:100.

Published
2003

14. Diagnosis of Ureaplasma parvummeningitis by mNGS in an extremely low birth weight infant with multi-system lesions

Author

Duan, Jing, Zhang, Chuncheng, Wang, Jun, Fu, Juanjuan, Song, Pingping, Pang, Feng, Zhao, Qigang, and You, Zhiqing

Abstract

Ureaplasma parvumencephalitis is a rare disease with high mortality in the neonates. While the manifestations are atypical and identification of U. parvumis difficult, diagnosis would always be delayed. Metagenomic next-generation sequencing (mNGS) is a pre-hypothesis free technique which could theoretically detect all the microbes in a sample. Herein we report a case of U. parvummeningitis identified by mNGS in an extremely low birth weight neonate complicated with multi-system lesions. The patient was treated with erythromycin and ciprofloxacin, symptoms were relieved in the following days and the patient was transferred to treat complications after three weeks' therapy.

Published
2022
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16. Characterization of miR-218/322-Stxbp1 pathway in the process of insulin secretion.

Author

Lang H, Ai Z, You Z, Wan Y, Guo W, Xiao J, and Jin X

Subjects
3' Untranslated Regions, Animals, Base Sequence, Binding Sites, Cell Line, Gene Expression, Glucose physiology, Insulin metabolism, Insulin Secretion, Islets of Langerhans cytology, Islets of Langerhans metabolism, Male, Mice, Inbred C57BL, RNA Interference, MicroRNAs genetics, Munc18 Proteins physiology
Abstract

MicroRNAs (miRNAs) have been implicated in a variety of physiological processes, however, the function of miRNAs in insulin secretion and type 2 diabetes is still unclear. Stxbp1 plays an essential role in exocytosis, and is crucial for insulin secretion. In this study, we focused on the molecular mechanism of Stxbp1 in insulin secretion by identifying its upstream regulators: miR-218 and miR-322. The expression of Stxbp1 was significantly increased in isolated mouse islets exposed to high levels of glucose within 1 h; while two of its predicted upstream miRNAs were found to be downregulated. Further study found that miR-218 and miR-322 directly interact with Stxbp1 by targeting the 3'UTR of its mRNA. MIN6 cells overexpressing the two miRNAs showed a sharp decline in insulin secretion and a decreased sensitivity to glucose; while the inhibition of the two miRNAs promoted insulin secretion. However, islets treated with prolonged high levels of glucose, which is known as glucolipotoxicity, displayed relatively high expression of miR-218 and miR-322, and a reduced level of expression of Stxbp1 accompanied by the blocking of insulin secretion. In summary, this study identified a pathway consisting of miR-218/322 and Stxbp1 in insulin secretion, contributing to a network of β-cell function involving miRNA., (© 2015 Society for Endocrinology.)

Published
2015
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