1. The association between environmental factors and the development of Crohn's disease with focusing on passive smoking: A multicenter case-control study in Japan
- Author
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Kondo, Kyoko, Ohfuji, Satoko, Watanabe, Kenji, Yamagami, Hirokazu, Fukushima, Wakaba, Ito, Kazuya, Suzuki, Yasuo, Hirota, Yoshio, Motoya Satoshi, Sakuraba Hirotake, Ishiguro Yo, Sasaki Iwao, Suzuki Kenji, Fukuda Katsuyuki, Saruta Masayuki, Shinozaki Masaru, Shimizu Toshiaki, You Aoyagi, Nagahori Masakazu, Watanabe Mamoru, Kanai Takanori, Iizuka Bunei, Watanabe Toshiaki, Kobayashi Kiyonori, Kunisaki Reiko, Sugita Akira, Ishige Takashi, Miura Soichiro, Hokari Ryota, Hanai Hiroyuki, Goto Hidemi, Ando Takafumi, Tanida Satoshi, Joh Takashi, Mizoshita Tsutomu, Sasaki Makoto, Kitamura Kazuya, Umegae Satoru, Fujiyama Yoshihide, Ando Akira, Shimizu Seiji, Yoshioka Kazuhiko, Kitano Atsuo, Aomatsu Kazuki, Naito Yuji, Yoshida Masaru, Ooi Makoto, Matsumoto Takayuki, Fukunaga Ken, Iimuro Masaki, Ikeuchi Hiroki, Ishihara, Shunji, Tanaka Shinji, Ueno Yoshitaka, Matsui Toshiyuki, Yano Yutaka, Yamasaki Hiroshi, Mitsuyama Keichi, Yamamoto Shojiro, Tsubouchi Hirohito, Sugimura Kazuhito, and Tenjin Takanori
- Subjects
Male ,Passive smoking ,Social Sciences ,Crohn's Disease ,medicine.disease_cause ,Logistic regression ,Habits ,0302 clinical medicine ,Crohn Disease ,Japan ,Smoking Habits ,Medicine and Health Sciences ,Psychology ,Family history ,Young adult ,Crohn's disease ,Multidisciplinary ,Alcohol Consumption ,Research Design ,030220 oncology & carcinogenesis ,Medicine ,030211 gastroenterology & hepatology ,Female ,Anatomy ,Research Article ,Adult ,medicine.medical_specialty ,Science ,Immunology ,Gastroenterology and Hepatology ,Environment ,Research and Analysis Methods ,Autoimmune Diseases ,03 medical and health sciences ,Young Adult ,Diagnostic Medicine ,Internal medicine ,medicine ,Humans ,Nutrition ,Behavior ,business.industry ,Inflammatory Bowel Disease ,Case-control study ,Biology and Life Sciences ,Odds ratio ,medicine.disease ,Appendicitis ,Confidence interval ,Diet ,Large Intestine ,Gastrointestinal Tract ,Case-Control Studies ,Tobacco Smoke Pollution ,Clinical Immunology ,Clinical Medicine ,business ,Digestive System - Abstract
BackgroundThe number of patients with Crohn's disease (CD) in Japan has recently been increasing. We examined the association between environmental factors and the development of CD in Japanese focusing on passive smoking.MethodsWe conducted a multicenter case-control study and compared the environmental factors of 93 cases who were newly diagnosed with CD to the environmental factors of 132 controls (hospital-, age-, and sex-matched patients with other diseases). The odds ratio (OR) of each factor for the development of CD and the 95% confidence interval (CI) were calculated using a logistic regression model. The association between the details of passive smoking history and the development of CD was examined for those who had an active smoking history "no". Odds ratios of number of passively smoked cigarettes (per day), time of passive smoking (per day) and period of passive smoking (year) were calculated using "passive smoking 'No'" as a reference.ResultsHistory of appendicitis, family history of inflammatory bowel disease, and active smoking history were not significantly associated with the development of CD. Drinking history showed a decreased OR for the development of CD (0.39, 0.19-0.77). "Passive smoking Yes" showed significantly increased OR (2.49, 1.09-5.73). Regarding the association between passive smoking and the development of CD, the OR increased as the number of cigarettes per day, smoking time per day, and smoking duration increased, and there was a dose-response relationship (trend P = 0.024, 0.032, 0.038).ConclusionsThe association between environmental factors and the development of CD among Japanese was examined by case-control study. It was suggested that the passive smoking history may be associated to the development of CD.
- Published
- 2019