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International immigrants’ health is receiving increasing attention, reflecting the need for health systems to adapt to diverse migrant populations. To better inform health policies suited for the needs of international immigrants living in China, empirical evidence on the health service utilization of these international immigrants living in China is urgently needed. Our study included 5459 international immigrants including inpatients and outpatients, who were treated over a 4-year period (2015–2018) in one of the most frequented hospitals by international immigrants in Yiwu, Zhejiang province. Data (e.g., demographic information, outpatient costs, inpatient costs, length of stay, and the average number of visits per patient) were extracted from the Health Information System at the hospital. Descriptive analysis was performed to analyze the basic characteristics of international immigrants living in China (e.g., medical costs, length of stay and the average number of visits per patient) during the study period. Multiple regression analysis was conducted to assess the factors that influence the health service utilization of international immigrants. International immigrants tended to use outpatient services (accounting for 97.22% of the whole sample) compared with inpatient services (only 2.78% of the whole sample). Most international immigrants visited the hospital because of orthopedics, otolaryngological diseases, pediatric-related diseases and skin-related diseases, followed by maternity and general surgery. The average number of visits to the outpatient department per patient was 2.1 in 2015 to 2.5 in 2018, and the length of stay increased from 3.45 days to 5.81 days during last four years. The outpatient costs increased from RMB 800.43(112.22 US$) to RMB 1756.98(246.33 US$), and inpatient costs rose from RMB 10,958.89(1536.44US$) to RMB 20,912.55(2931.94US$) during 2015–2018. The average number of visits and outpatient costs of international immigrants were both lower than those of local Chinese people (P < 0.05). However, there was no statistic difference in inpatient costs and LOS between international immigrants and Chinese. Having health insurance in China was significantly related with higher medical costs. Our results indicate that international immigrants living in China make greater use of outpatient services rather than hospitalization health services. Health services utilization is increasing in the last four years, but it was lower than that of local Chinese people especially outpatient service utilization. Moreover, more attention should be garnered toward specific health issues experienced by international immigrants, such as orthopedic health, maternal and child health, occupational diseases or accidents, and infectious diseases with skin-related symptoms. The policy implications from the results of this study are as follows. First, in order to improve international immigrants’ health and access to health services in China, the government needs to pay more attention to incorporating international immigrants’ health services to the current health system. Second, health policy is an important determining factor of access to health care, as policy can influence aspects of health services delivery such as the availability of resources, organization, and financing. Therefore, specific framework for the content of health policies focused on international immigrant populations should be developed.

Background With the effective prevention and control of COVID ‐ 19 in China, the number of cured cases increased significantly. Further monitoring of the disease prognosis and effective control of the "relapse" of the epidemic become the next focus of work. To analyse the clinical prognosis of discharged COVID‐19 patients by monitoring their SAR‐CoV‐2 nucleic acid status, which may provide evidence to establish discharge standards and follow‐up management for COVID‐19 patients. Methods We included 13 discharged COVID‐19 patients who were quarantined for 4‐week at home. The patient's daily clinical signs were recorded and sputum and faecal specimens were regularly sent for the detection of SARS‐CoV‐2 nucleic acid. Results The time between initial symptoms and meeting discharge criteria was 18 – 44 days with an average of 25 ± 6 days. The faecal samples of two patients still tested positive after meeting discharge criteria and the sputum samples of four patients returned positive 5 – 14 days after discharge. The rate of a recurring positive test result in samples from the respiratory system was 31%(4/13). Conclusion Under the present discharge criteria, the high presence of SARS‐CoV‐2 nucleic acid in faecal and respiratory samples of discharged COVID‐19 patients indicate potential infectivity. Therefore, we suggest that faecal virus nucleic acid should be tested as a routine monitoring index for COVID‐19 and a negative result be added to the criteria. Simultaneously, we should strengthen the regular follow‐up of discharged patients with continuous monitoring of the recurrence of viral nucleic acid. This article is protected by copyright. All rights reserved.

BackgroundWith the influence of factors such as ovarian surgery, high-dose radiotherapy and chemotherapy, environmental degradation, and bad living habits, the occurrence of premature ovarian insufficiency(POI) is getting younger and younger, and many young women's ovaries have entered the aging stage earlier. While many studies have investigated the patients with POI, which is still a challenge in reproductive medicine as the treatments available now are not ideal. POI patients have varying amounts of residual dormant follicles in the ovaries. Therefore, it is critical to further our understanding of primordial follicle activation in order to treat.This study aimed to investigate the activation of residual follicles in POI patients with injection of HCG, whether they could obtain embryos and become pregnant.Methods Four patients with POI were pretreated with dehydroepiandrosterone, Coenzyme Q10, estrogen and medroxyprogesterone. The prescribed amounts of estrogen and medroxyprogesterone were adjusted to maintain the level of FSH at ˂15 mIU/ml and the level of LH˂10 mIU/ml. When the treatments failed to induce the appearance of follicles after 3 months, the patients received treatment with 10000 IU of HCG. Results The residual dormant follicles in POI patients can be activated using our approach to obtain embryos and conceive by injection of HCG. ConclusionsPOI patients may conceive their own genetic children by activating dormant follicles in vivo. These findings may represent a new simple and feasible solution for the treatment of patients with POI to conceive their own genetic children.

Coronavirus disease 2019 (COVID‐19) poses a serious threat to human health and lives. The virus is still spreading throughout the world, and the cumulative number of confirmed cases is increasing. After patients with COVID‐19 are treated and discharged, some have repeated clinical symptoms and become positive for nucleic acid tests a second time. Through analysis and review of the existing literature, the proportion of repositive patients in the discharged patient population and their clinical characteristics were systematically described for the first time. Furthermore, an in‐depth analysis of the causes of repositive nucleic acid tests and the potential transmission of the disease provides the basis for the management and protection of discharged patients with COVID‐19.

OBJECTIVE: To investigate the clinical outcome of patients with moderate type of coronavirus disease 2019 (COVID-19) after discharge by retesting viral nucleic acid. METHODS: Seven patients with moderate COVID-19 met the discharge criteria enacted by National Health Commission were quarantined in hospital for 7 days, then continuously quarantined at home for 4 weeks after discharged. During the quarantined period, the symptoms and signs were documented, and sputum or nasal swab and feces samples were collected to test SARS-CoV-2 nucleic acid by RT-PCR method. RESULTS: There was no symptoms and signs during the quarantine period in all 7 patients. However, respiratory swabs from 3 patients were confirmed positive of SARS-CoV-2 nucleic acid at 5 to 7 days after they met the discharge criteria. CONCLUSION: There is a relatively high incidence of positive viral nucleic acid in patients met the discharge criteria, and it is suggested that patients met the current discharge criteria should be quarantined in hospital for another 7 days and the follow-up viral testing is necessary.

In China, mothers with confirmed or suspected COVID-19 pneumonia are recommended to stop breastfeeding. However, the evidence to support this guidance is lacking. This report analyzes the case of a mother who persisted breastfeeding her baby when both were diagnosed with confirmed COVID-19 pneumonia. SARS-CoV-2 nucleic acid was not detected in the breast milk, and antibodies against SARS-CoV-2 were present in detected in the mother's serum and milk. There was no evidence of mother-to-child transmission of the virus through breastfeeding. This case report demonstrates that breastfeeding may even be useful for improving the recovery of the infant without exacerbating disease severity.

Background In China, mothers with confirmed or suspected COVID-19 pneumonia are recommended to stop breastfeeding. However, the evidence to support this guidance is lacking. There have been relatively few cases reported about direct breastfeeding an infant by a mother with SARS-CoV-2 pneumonia. Therefore, it is necessary to assess the safety of breastfeeding and the possible protective effects of breast milk on infants. Case presentation This report analyzes the case of a mother who continued breastfeeding her 13 month-old child when both were diagnosed with confirmed COVID-19 pneumonia. We describe the clinical presentation, diagnosis, treatment, and outcome. The presence of SARS-CoV-2 nucleic acid was determined in maternal serum, breast milk, nasopharyngeal (NP) swabs and feces, and in infant serum, NP swabs and feces. IgM and IgG antibodies against SARS-CoV-2 were assessed in maternal serum and breast milk and in infant serum. SARS-CoV-2 nucleic acid was not detected in the breast milk, and antibodies against SARS-CoV-2 were detected in the mother’s serum and milk. Conclusions The present case further confirms that the possibility of mother-to-child transmission about SARS-CoV-2 via breast milk alone was very small, and breast milk is safe for direct feeding of infants.

Reduced graphene oxide (RGO)/Fe nanocomposites were synthesized by a facile one-step reduction reaction, using reduced graphene oxide and FeSO4·7H2O as raw materials. These RGO/Fe nanocomposites combine Fe nanoparticles with graphene in various thicknesses. The results show that the residual defects and groups in chemically reduced graphene oxide brought about defect polarization relaxation and groups’ electronic dipole relaxation, which both make the electromagnetic absorbing performance of RGO/Fe nanocomposites better than that of pure Fe nanoparticles. Most importantly, this paper reveals that graphene with different thicknesses has a great influence on the microwave-absorbing properties of the composites. There was serious agglomeration in RGO/Fe nanocomposites synthesized by thin graphene, while the graphene of a certain thickness could support the nanoparticles on its surface, thereby reducing the effect of agglomeration on the composite material and giving full play to dielectric loss properties of...

Cervical cancer is one of the leading causes of cancer death in women worldwide. While molecular mechanisms of initiation and cervical carcinogenesis are not well studied. Our data showed that the expression of Methyltransferase-like 3 (METTL3) was upregulated in cervical tumor tissues as compared with normal tissues. Its expression was associated with poor prognosis of cervical cancer. Knockdown of METTL3 can suppress the proliferation of cervical cancer cells. The expression of METTL3 was significantly correlated with the expression of RAB2B, one member of RAS oncogene family. Over expression of RAB2B can significantly attenuate sh-METTL3-suppressed cell proliferation. Mechanistically, METTL3 can increase the mRNA stability of RAB2B via an IGF2BP3-dependent manner. Collectively, METTL3 can trigger growth of cervical cancer cells via upregulation of RAB2B. It indicated that METTL3 might be a potential target for cervical cancer therapy.

Ferrite materials have good frequency characteristics. Their relative permeability is large and relative permittivity is small. These make it suitable for matching layer and have a good application prospect in broadening the absorption bandwidth. In this paper, ferrite was prepared by a simple chemical precipitation-dehydration method, and the ferrite Fe3O4 particles with 40% mass fraction were mixed with paraffin to form a ring test sample. The experimental results show that the as-prepared sample at higher temperatures has more stable nucleation and fewer defects, so it has more significant electromagnetic wave absorption performance. The minimum reflection loss is about - 44 dB, and the electromagnetic absorption band with the reflection loss RL less than - 10 dB is located at 12.5-14.1 GHz (3 mm) and 6.5-8.1 GHz (5 mm), respectively.

Reduced graphene oxide (RGO) was successfully prepared by reducing graphene oxide (GO) by zinc powder in this paper. Then the reduced graphene oxide (RGO) was combined with Fe and Ni nanoparticles to form RGO/Fe and RGO/Ni composite absorbing materials. The morphology, chemical composition, magnetic properties and electromagnetic parameters of RGO/Fe and RGO/Ni were characterized by means of scanning electron microscopy(SEM), X-ray diffraction(XRD), vibrating sample magnetometry (VSM) and vector network analysis (VNA) to study absorbing mechanism of the as-prepared RGO/magnetic-metal composites, including the effect of magnetic particles Fe and Ni on the absorbing properties. The results showed that in the frequency range of 2-18 GHz, the effective absorption band of RGO/Fe was wider than that of RGO/Ni, with larger reflection loss.

Dendritic-like Co particles consisting of leaf-shaped nano-units were successfully synthesized by chemical reduction method. The absorbing particles have abundant multi-stage branches. Since the crystal structure, size and special morphology have an important influence on the microwave absorption performance, the X-ray diffractometer, scanning electron microscope, vibration sample magnetic measurement and vector network analysis are used to characterize the dendritic Co. Absorbing mechanism was analyzed systematically. The nano-sized, multi-stage branches, porous structures and rough surfaces of the prepared particles all contribute to the penetration, scattering and attenuation of EM waves. Hence the composite, in the test band, especially in the S-band (2-4 GHz), presents excellent microwave absorption properties.

Increasing number of enterprises are mining Big Data for decision support, but they found Big Data not quite as usable as their own well organized databases. Useful information is hidden within Big Data, and could only be found by search, according to keywords, queries or other kinds of requirement express patterns. It is found that during decision making process, user information requirement highly depends on the decision task, that on processing tasks of a same type, requirements have similar content and scope. Based on this principle, a method is proposed to automatically generate information requirement against Big Data, by making use of a new kind of domain knowledge—the latent mapping relations among decision task types and information requirement models. It is proved by tests that, the method can improve efficiency of decision support information collection from Big Data.

Real-time decision-making requires efficient information support that dynamically provides information useful to decision makers. Traditional fixed information service mode is challenged by Big Data environment, while search-based methods do not guarantee efficiency. To solve the problem, a method is proposed to improve machine activeness on information collection, allowing user to be focused on decision-making, so as to improve the efficiency of the whole decision-making system. During human decision-making process, machine keeps aware of the decision task context, dynamically recognizes user information requirement, automatically activates search process, based on domain knowledge previously built reflecting the latent relations between decision task types and the information required. It is proved by experiments that the method can effectively save user time cost on information requirement expressing and improve task relevance of collected information.

Big Data on Internet contains information valuable for enterprise decision making, but also challenges their traditional customized information service mode. Keyword-based search supplies as a complementary mechanism to discover the required information from Big Data, while its passive service mode and low precision brings down the efficiency of decision making. To solve the problem, a method is proposed by keeping aware of the decision making context, dynamically recognizing information requirement, automatically activating search process, based on domain knowledge previously built reflecting the latent relations between decision task types and the information required. From user view, decision making is not intercepted, and information focused on his current decision task is actively discovered, sent and displayed as support, so as to improve the efficiency.