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Abstract Background Isolated testicular tuberculosis (TB) is extremely uncommon. It has non-specific presentation; thus, diagnosis is challenging and is often discovered on pathology examination after orchiectomy. Case presentation We report herein the case of a 73-year-old male, with no significant medical or family history, who presented with left scrotal swelling, physical examination revealed a left testicular firm mass measuring 3 cm and ultrasound was suggestive of testicular tumor. Left inguinal orchiectomy was performed and the pathologic examination revealed testicular TB. The presentation was typically mimicking a testicular cancer with no evocative evidence of TB; this can lead to a dilemma and highlights the need to consider TB in differential diagnosis of testicular tumor, especially in areas endemic for the disease. Conclusions The aim of our presentation is to argue if orchiectomy was avoidable. It also illustrates the probable hematogenous or lymphatic spread of Mtb to the testicle.

Abstract Background Isolated genital elephantiasis outside filariasis endemic tropical and subtropical regions is rare and presents a diagnostic and therapeutic challenge. Serologic and radiographic investigation must be undertaken to exclude reversible causes of genital elephantiasis. Case presentation Authors report herein the case of a 58-year-old patient with chronic penile and scrotal elephantiasis. He had a history of untreated urethritis and an endoscopic urethrotomy for urethra stricture three years ago. Serological test for chlamydiosis was positive. Retrograde urethrocystography demonstrated a bulbar urethra stricture. The patient spectacularly and completely improved after endoscopic urethrotomy and long-term doxycycline. Conclusions Early treatment of sexual transmitted infections such as chlamydiosis is important to prevent the evolution of penoscrotal elephantiasis and to avoid surgical procedures.

Objective: To define the role of Toll-like receptors (TLR-2, TLR-4) and triggering receptor expressed on myeloid cells-1 (TREM-1) in pregnant human myometrium., Study Design: Expression of TLR-2 and -4 mRNA and protein and TREM-1 mRNA was quantified in human myometrial samples. Subsequently, we investigated the effect of medroxyprogesterone acetate (MPA) as a functional inhibitor of the TLR agonist lipopolysaccharide (LPS)., Results: Messenger RNA expression of TLR-2 and -4 was significantly higher in myometrium at term compared with preterm (P = .009 and .016, respectively). Toll-like receptor-2 protein expression was significantly higher during labor (P = .002) compared with nonlaboring samples. Triggering receptor expressed on myeloid cells-1 mRNA expression was increased in both myometrium and cervix after labor at term (P < .05). Medroxyprogesterone acetate significantly suppressed LPS-induced production of interleukin 1b (IL-1b), IL-6, and IL-8 in vitro (P < .05)., Conclusion: Toll-like receptors 2and 4 and TREM-1 are expressed in human myometrium and may play a role in the mechanism of labor at term, and their functional effects are inhibited by MPA.

Statement of Problem: Though computer-based systems for recording three-dimensional jaw motion and muscle activity during mastication are common, few computer programs are available to analyze the resultant data. Few studies have discussed the variability over time of the many parameters of the masticatory cycle now measurable by computer systems., Purpose: The purposes of this study were to (1) use a custom computer program, (MAS), for analysis of long-term repeated measurements of mandibular motion and muscle activity; (2) determine sex differences for mandibular movements and activity of the muscles involved during mastication; and (3) determine the variability over time and the statistical power of these methods., Materials and Methods: Masticatory cycles of 20 normal men and 17 normal women were examined during mastication of a constant bolus at a sampling rate of 500 fps. Measurements included duration of chewing cycle and its component phases, mandibular displacement in three dimensions, and electromyographic activity in the temporalis and masseter muscles. The MAS custom computer program was used for analysis. Two-way repeated measures analysis of variance was used to compare the men with the women over three trials at 0, 6, and 12 months. The variability over time associated with each measurement was also estimated., Results: Timing of the phases of the chewing cycle were most repeatable between trials, whereas lateral excursions and muscle force magnitudes were the least repeatable measures. Durations of total cycle, its slow-open and fast-close phases, were significantly longer for the female group, and their bursts of muscle activity tended to be longer. The amount of vertical mandibular excursion tended to be greater for men. There were no gender-related differences in the amplitude of muscle activity., Conclusions: This study demonstrated that men have significantly shorter chewing cycles with faster velocities than women. Men used significantly greater chewing force than women, although their electromyographic activity levels were equivalent. The masticatory measurements made by the MAS program had differing amounts of variation over time. Total duration of the chewing cycle and amount of opening varied the least, whereas amount of lateral excursion and jaw muscle electromyographic magnitudes exhibited the greatest variation.

Purpose: The purpose of this investigation was to study the long-term effects of orthognathic surgery on mastication in patients before and after four surgical procedures: mandibular advancement, maxillary intrusion, maxillary intrusion with mandibular advancement, and maxillary inferior repositioning., Materials and Methods: The components and timing of mandibular motion, electromyography (EMG), and estimated biting forces during mastication were studied in 61 patients who underwent orthognathic surgery for correction of four different deformities. The data were statistically compared with 38 control subjects using ANOVA., Results: Preoperatively, there were no significant differences in the duration of the chewing cycles and mandibular excursions among the groups, nor did surgery have any affect on these variables. Before surgery, estimated occlusal forces in the patient groups were smaller than controls. Although these appeared to increase after surgery, the increases did not exceed changes in our untreated controls., Conclusions: The results of this study suggest that, with the exception of EMG and occlusal forces, mastication in orthognathic surgery patients is not significantly different from controls either before or after surgery. EMG during mastication, although significantly lower than in controls before surgery, showed significant increases after surgery, but these increases did not bring estimated occlusal forces up to control levels.