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4. The Relation between the Duty Cycle and Anesthetic Effect in Lidocaine Iontophoresis Using Alternating Current

Author

Haruhisa Fukayama, Atsushi Nakajima, Ryo Wakita, Yu Haida, and Masahiro Umino

Subjects
medicine.medical_specialty, Iontophoresis, Lidocaine, business.industry, Anesthetic Effect, Surgery, Antecubital skin, Anesthesiology and Pain Medicine, Duty cycle, Anesthesia, Medicine, Nociception assay, business, medicine.drug
Abstract

We assessed the effect of the duty cycle on the anesthetic effect during lidocaine alternating current (AC) iontophoresis. A solution of 2% lidocaine was delivered to the medial antecubital skin for 20 minutes using AC iontophoresis with a duty cycle of 60%, 70%, or 80%. The von Frey test was then performed to evaluate the anesthetic effect. In the groups treated with a duty cycle of 80% or 70% the touch thresholds (TT) were significantly elevated from 0 minutes to 30 minutes and from 0 minutes to 20 minutes. TT were significantly elevated at 0 minutes in the group treated with a 60% duty cycle. The anesthetic effect was significantly enhanced in a duty cycle-dependent manner.

Published
2010

6. The relation between the duty cycle and anesthetic effect in lidocaine iontophoresis using alternating current

Author

Ryo, Wakita, Atsushi, Nakajima, Yu, Haida, Masahiro, Umino, and Haruhisa, Fukayama

Subjects
Adult, Male, Pain Threshold, Time Factors, Lidocaine, Iontophoresis, Administration, Cutaneous, Double-Blind Method, Electricity, Touch, Humans, Female, Anesthetics, Local, Pain Measurement
Abstract

We assessed the effect of the duty cycle on the anesthetic effect during lidocaine alternating current (AC) iontophoresis. A solution of 2% lidocaine was delivered to the medial antecubital skin for 20 minutes using AC iontophoresis with a duty cycle of 60%, 70%, or 80%. The von Frey test was then performed to evaluate the anesthetic effect. In the groups treated with a duty cycle of 80% or 70% the touch thresholds (TT) were significantly elevated from 0 minutes to 30 minutes and from 0 minutes to 20 minutes. TT were significantly elevated at 0 minutes in the group treated with a 60% duty cycle. The anesthetic effect was significantly enhanced in a duty cycle-dependent manner.

Published
2010

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