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25 results on '"Yu, Huanghe"'

4. Optimal Extraction of Xuetongsu and its Mechanisms in Inhibiting RA Synovial Hyperplasia: Intervention in Migration and Apoptosis of Synovial Cells

Author

Deng, Yasi, primary, Zheng, Hao, additional, Liu, Shiqi, additional, Deng, Ying, additional, Chen, Yuxin, additional, Liang, Ling, additional, Wang, Mengyun, additional, Xie, Qingling, additional, Yang, Yupei, additional, Li, Bin, additional, Huang, Juan, additional, Yuan, Hanwen, additional, Wang, Wei, additional, and Yu, Huanghe, additional

Published
2024
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13. Xuetongsu as a Novel Regulator of Inflammation and Apoptosis Related Pathways for Treating Rheumatoid Arthritis

Author

Yu, Huanghe, primary, Li, Bin, additional, Zheng, Hao, additional, Deng, Yasi, additional, Wang, Mengyun, additional, Su, Wei, additional, Sheng, Wenbing, additional, Liu, Jin-zhi, additional, Yang, Yupei, additional, Peng, Caiyun, additional, Ning, Luyun, additional, Liu, Bin, additional, Cai, Xiong, additional, and Wang, Wei, additional

Published
2023
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14. Biomimetic Hybrid Membrane-Coated Xuetongsu Assisted with Laser Irradiation for Efficient Rheumatoid Arthritis Therapy

Author

Yu, Huanghe, primary, Fan, Jialong, additional, Shehla, Nuzhat, additional, Qiu, Yixing, additional, Lin, Ye, additional, Wang, Zhou, additional, Cao, Liang, additional, Li, Bin, additional, Daniyal, Muhammad, additional, Qin, Yan, additional, Peng, Caiyun, additional, Cai, Xiong, additional, Liu, Bin, additional, and Wang, Wei, additional

Published
2021
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20. Endogenous Cys-Assisted GSH@AgNCs-rGO Nanoprobe for Real-Time Monitoring of Dynamic Change in GSH Levels Regulated by Natural Drug

Author

Qin, Yan, primary, Fan, Jialong, additional, Yang, Wei, additional, Shen, Bingbing, additional, Yang, Yupei, additional, Zhou, Qi, additional, Chen, Wenming, additional, Daniyal, Muhammad, additional, Xiao, Feng, additional, Sheng, Wen-Bing, additional, Yu, Huanghe, additional, Zhou, Jiantao, additional, Wang, Wei, additional, Tong, Chunyi, additional, and Liu, Bin, additional

Published
2019
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21. New Lignans from roots of Kadsura coccinea

Author

Yang, Yupei, primary, Liu, Yongbei, additional, Daniyal, Muhammad, additional, Yu, Huanghe, additional, Xie, Qingling, additional, Li, Bin, additional, Jian, Yuqing, additional, Man, Rongyong, additional, Wang, Sanhu, additional, Zhou, Xiaoling, additional, Liu, Bin, additional, and Wang, Wei, additional

Published
2019
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22. Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu

Author

Cao, Mengru, primary, Yuan, Hanwen, additional, Daniyal, Muhammad, additional, Yu, Huanghe, additional, Xie, Qingling, additional, Liu, Yingkai, additional, Li, Bin, additional, Jian, Yuqing, additional, Peng, Caiyun, additional, Tan, Dianbo, additional, Peng, Yanmei, additional, Choudhary, M. Iqbal, additional, Rahman, Atta-ur, additional, and Wang, Wei, additional

Published
2019
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24. Endogenous Cys-Assisted GSH@AgNCs-rGO Nanoprobe for Real-Time Monitoring of Dynamic Change in GSH Levels Regulated by Natural Drug

Author

Qin, Yan, Fan, Jialong, Yang, Wei, Shen, Bingbing, Yang, Yupei, Zhou, Qi, Chen, Wenming, Daniyal, Muhammad, Xiao, Feng, Sheng, Wen-Bing, Yu, Huanghe, Zhou, Jiantao, Wang, Wei, Tong, Chunyi, and Liu, Bin

Abstract

Glutathione (GSH) levels are closely related to the homeostasis of redox state which directly affects human disease occurrence by regulating cell apoptosis. Hence, real-time monitoring of dynamic changes in intracellular GSH levels is urgently needed for disease early diagnosis and evaluation of therapy efficiency. In this study, an endogenous cysteine (Cys)-assisted detection system based on GSH@AgNCs and reduced graphene oxide (rGO) with high sensitivity and specificity was developed for GSH detection. Compared with GSH, GSH@AgNCs with weaker affinity and bonding force was quite easier to extrude from the rGO surface when competing against GSH, leading to the obvious change in fluorescence signal. This phenomenon was termed as “a crowding out effect”. Furthermore, the presence of Cys can improve GSH assay sensitivity by enhancing the quenching efficiency of rGO on the GSH@AgNCs. In vitro assay indicated that the efficiency of fluorescence recovery was positively related with GSH concentration in the range from 0 to 10 mM. In addition, the method was employed for real-time monitoring of the dynamic changes in GSH levels regulated by natural drugs. The imaging results showed that the natural compound 3(C3) can downregulate GSH levels in HepG2 cells, which was accompanied by reactive oxygen species (ROS) release and apoptosis induction. Finally, the method was used to monitor the change of GSH levels in serum samples with chronic hepatitis B (CHB) infection. The results demonstrated that the occurrence and development of CHB may be positively correlated with GSH levels to some extent. Overall, the above results demonstrate the potential application of this new nanosystem in anticancer natural drug screening and clinical assay regarding GSH levels.

Published
2020
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25. Advancement of Natural Compounds as Anti-rheumatoid Arthritis Agents: A Focus on Their Mechanism of Actions.

Author

Yu H, Qiu Y, Tasneem S, Daniyal M, Li B, Cai X, Atta-Ur Rahman, and Wang W

Subjects
Humans, Arthritis, Rheumatoid drug therapy, Biological Products pharmacology, Biological Products therapeutic use
Abstract

Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by infiltration of inflammatory cells, synovial hyperplasia, pannus formation and bone destruction. RA is associated with high incidence of disability worldwide. Although several anti-RA agents are available in the market, clinical use of these drugs is limited due to their severe side effects. Several studies are currently exploring new anti-rheumatic drugs which are more effective and have fewer side effects. Notably, natural products with anti-RA effect have been identified and studies have reported the underlying molecular mechanisms of action of the novel and known compounds. This review explored naturally occurring known and novel compounds that have anti-RA activity. Further, the compounds are classified based on their molecular mechanisms of action as anti-RA agents. In addition, the safety of compounds from natural sources is compared with that of conventional drugs. In addition, clinical trials for anti-RA compounds isolated from natural plant sources were summarized in this manuscript., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2021
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