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16 results on '"Yu, Jiying"'

11. Efficient cocktail chemotherapy by co-delivery of a hydrogen sulfide-releasing aspirin prodrug and paclitaxel via single nanoparticles

Author

Cai, Lulu, primary, He, Lin, additional, Wang, Yan, additional, Zhong, Jian, additional, Zhao, Chengjian, additional, Zeng, Shi, additional, Yu, Jiying, additional, Bian, Yuan, additional, Wei, Yuquan, additional, Cai, Wei, additional, Long, Enwu, additional, Jiao, Pengcheng, additional, Yan, Junfeng, additional, and Xu, Quan, additional

Published
2017
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15. [Determination of artemisinin in rat plasma with HPLC-mS and its application].

Author

Fu C, Yu J, Zou J, He L, Dong Y, and Huang Y

Subjects
Animals, Rats, Artemisinins pharmacokinetics, Chromatography, High Pressure Liquid, Mass Spectrometry
Abstract

Objective: To develop a method for determining artemisinin in rat plasma in vivo., Method: HPLC-MS was adopted. Estazolam was selected as an internal standard (I.S.). The sample and I.S. were extracted using methyl tertbutyl ether and measured at m/z of 305 and 296, respectively., Result: Within the linear range of 5-500 microg x L(-1), the ratio of artemisinin's peak area and I.S. peak area and the concentration showed good linearity, thus the minimum concentration was set to be 5 mictrog x L(-1)., Conclusion: The methodology proved that the method is so suitable for determining the drug concentration in rat blood that it can be used for studying pharmacokinetics in animals.

Published
2012

16. [Determination of isosorbide-5-nitrate in human plasma by reversed-phase high performance liquid chromatography].

Author

He L, Yu J, Wu Z, and Sun S

Subjects
Humans, Isosorbide Dinitrate blood, Reproducibility of Results, Chromatography, High Pressure Liquid methods, Isosorbide Dinitrate analogs & derivatives
Abstract

The method was established to determine the level of isosorbide-5-nitrate in human plasma by reversed-phase high performance liquid chromatography (RP-HPLC). The sample preparation was carried by alkalizing the plasma sample followed by extraction with dichloromethane. The HPLC analysis was performed under the conditions as follows: a mixture of an aqueous buffer (pH adjusted to 7.8 by 0. 03 mol/L ammonia water) and acetonitrile (80: 20, v/v) as mobile phase, paracetamol as the internal standard, and the detection at 230 nm. The linear range was 20 - 1 000 microg/L using the ratio of peak areas; the detection limit was 12 microg/L; the average recovery was (97.11 +/- 2.45)% - (104.34 +/- 2.17)%, the intra-day relative standard deviations (RSDs) were less than 2.52%, and inter-day RSDs were less than 5.21%.

Published
2005

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