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The B-box (BBX) proteins are a class of zinc finger transcription factors and play critical roles in plant development and growth. However, they have not been systematically characterized in Chinese chestnut (Castanea mollissima), an important nut with rich nutrition and high economic value. Here, 18 BBX genes were identified in Chinese chestnut genome and divided into five groups through phylogenetic analysis, with members in the same group containing the same conserved domain organization. The collinearity analysis showed that dispersed duplication played a major role in the expansion of CmBBX gene family inferred to have evolved through purifying selection. Transcriptome analysis and qRT-PCR experiments suggested that CmBBX genes showed different expression patterns in different Chinese chestnut tissues, and revealed some CmBBXs may have potential functions in the development of Chinese chestnut buds, nuts, fertile/abortive ovules. Combined with the analysis of conserved domain, motif, cis-elements, expression level and protein three-dimensional structure, the lack of cis-acting elements related to meristem expression and gibberellin-responsiveness may lead to the no-expression of CmBBX9 in Chinese chestnut. The systematic analysis of Chinese chestnut BBX genes provides a basis for further understanding the characteristics and potential functions of BBX gene family. [ABSTRACT FROM AUTHOR]

In order to reflect the dynamic response of the rubber vibration isolation system more accurately in medium and low frequency ranges, the nonlinear Zener model is used to characterize the mechanical properties of viscoelastic materials like rubber. The approximate analytical solution of the system response is obtained by harmonic balance method, and its correctness is verified through numerical method and Universal Mechanism (UM) software simulation. The quantitative relationship between mass displacement and node displacement is calculated, and a new method to obtain hysteresis characteristics of rubber vibration isolation system based on approximate analytical solution of the model is presented. Under the influence of symmetry and hysteresis, the system possesses bifurcation, chaos, polymorphic coexistence and other complex nonlinear dynamical behaviors. Then, with the help of global bifurcation diagram, phase diagram, Poincaré map and cell mapping, the formation mechanism of polymorphic coexisting motion induced by pitchfork bifurcation, saddle-node bifurcation, period-doubling bifurcation and boundary crisis is comprehensively analyzed. Based on this, the formation mechanism of bursting oscillation is revealed. Finally, the influence of nonlinear stiffness on the transition law of the system periodic motion is analyzed, and the distribution law of the coexisting attractors and the variation of the attracting domain in various of polymorphic coexisting motions are presented. The research results of the complex dynamic behavior of the nonlinear Zener vibration isolation system in this paper can provide some theoretical guidance for the optimal design of the viscoelastic vibration isolation system. [ABSTRACT FROM AUTHOR]

Summary: Plants of the Elaeagnaceae family are widely used to treat various health disorders owing to their natural phytochemicals. Seabuckthorn (Hippophae rhamnoides L.) is an economically and ecologically important species within the family with richness of biologically and pharmacologically active substances. Here, we present a chromosome‐level genome assembly of seabuckthorn (http://hipp.shengxin.ren/), the first genome sequence of Elaeagnaceae, which has a total length of 849.04 Mb with scaffold N50 of 69.52 Mb and 30 864 annotated genes. Two sequential tetraploidizations with one occurring ~36‐41 million years ago (Mya) and the last ~24–27 Mya were inferred, resulting in expansion of genes related to ascorbate and aldarate metabolism, lipid biosynthesis, and fatty acid elongation. Comparative genomic analysis reconstructed the evolutionary trajectories of the seabuckthorn genome with the predicted ancestral genome of 14 proto‐chromosomes. Comparative transcriptomic and metabonomic analyses identified some key genes contributing to high content of polyunsaturated fatty acids and ascorbic acid (AsA). Additionally, we generated and analysed 55 whole‐genome sequences of diverse accessions, and identified 9.80 million genetic variants in the seabuckthorn germplasms. Intriguingly, genes in selective sweep regions identified through population genomic analysis appeared to contribute to the richness of AsA and fatty acid in seabuckthorn fruits, among which GalLDH, GMPase and ACC, TER were the potentially major‐effect causative genes controlling AsA and fatty acid content of the fruit, respectively. Our research offers novel insights into the molecular basis underlying phytochemical innovation of seabuckthorn, and provides valuable resources for exploring the evolution of the Elaeagnaceae family and molecular breeding. [ABSTRACT FROM AUTHOR]

The B-box proteins are a class of zinc finger transcription factors and play important roles in regulating plant growth, development, and stress response. However, their origin and expansion model in plants have been very vague. In this study, 208 B-box genes were identified in 18 plant species, and phylogenetic analyses divided them into five structure groups. Subsequently, the sequence analysis including theoretical isoelectric point, instability index, and aliphatic index showed the wide variation of B-box gene in different species. Our multispecies genome-wide analysis reveals that the structure groups III and IV in the plant BBX gene family have the earliest origin (Rhodophyta) and are extensively expanded in land plants, while the other three structure groups (I, II, and V) seem to originate at least in the last common ancestor of land plants. Furthermore, whole genome duplication (WGD) was the main driver (28 gene pairs, 65.12%) of the B-box gene family expansion, followed by segmental duplication, which tend to have more introns and are subject to more intense purification selections. We also analyzed the sequence differences between B-box domains to propose a new evolutionary model of B-box domain. These analyses provide new insights for understanding the origin and evolution of the B-box gene family. [ABSTRACT FROM AUTHOR]

The most popular approach to fabricating organic solar cells (OSCs) is solution processing a mixture of donor (D) and acceptor (A) materials into an active layer with a bulk heterojunction (BHJ) nanostructure. Herein, it is demonstrated that the interdigitated heterojunction (IHJ) is a more suitable nanostructure of the active layer for high‐performance OSCs whereas it is a long standing challenge to realize well‐defined IHJ structures. In this study, a facile and versatile sequential solution processing method is developed to produce an IHJ nanostructure with power conversion efficiency reaching 18.74% (18.10% for BHJ the counterpart) by fabricating a donor film with nanopores created by a wax additive, sequentially casting the acceptor on top of infiltrating the nanopores. Compared to the BHJ, the IHJ structure with an interpillar distance within the exciton diffusion length can afford a large bulk D/A interface for efficient exciton dissociation with a minimized charge recombination while free electrons and holes can transport to the respective electrodes through more straightforward pathways, thus enhance performance. Furthermore, the D or A phase in the IHJ device contacts with only one electrode, which can prevent shunting between the anode and cathode and facilitate the industrial mass production of OSCs. [ABSTRACT FROM AUTHOR]

Sequential doping of 1 mm3 sized cubes of regio-regular poly(3-hexylthiophene) (P3HT) with 2,3,5,6-tetrafluoro-tetracyanoquinodimethane is found to result in a doping gradient. The dopant ingresses into the solid material and after two weeks of sequential doping yields a 250 μm thick doped surface layer, while the interior of the cubes remains undoped. The doping gradient is mapped with energy dispersive x-ray spectroscopy (EDX), which is used to estimate a diffusion coefficient of 1 × 10−10 cm2 s−1 at room temperature. The cubes, prepared by pressing at 150 °C, feature alignment of polymer chains along the flow direction, which yields an electrical conductivity of 2.2 S cm−1 in the same direction. A 4-leg thermoelectric module was fabricated with slabs of pressed and doped P3HT, which generated a power of 0.22 μW for a temperature gradient of 10.2 °C generated by body heat. [ABSTRACT FROM AUTHOR]

Key message: Genome-wide identification of the sea buckthorn GRAS genes and their transcription profiles in different organizations. GRAS proteins comprise a large family of transcription factors that experienced extensive replication, and play important roles in many aspects of growth regulatory and environmental signals. Sea buckthorn is a unique and valuable plant which has tremendous value for medical researching, ecological protection, and providing daily necessities. We identified, characterized, and distinguished duplication models of GRAS transcription factors in sea buckthorn. A systematic whole-genome analysis was performed to identify and characterize the GRAS gene family of sea buckthorn, especially the comparative genome method was used to demonstrate its different duplication models. We identified 62 sea buckthorn GRAS (HrGRAS) genes and renamed based on their respective chromosome distribution. Fifty-nine HrGRASs were classified into nine subgroups and three HrGRASs did not belong to any of the subfamilies according to their phylogenetic features. HrGRAS genes tend to have a representative GRAS domain, few introns, and unevenly distributed on chromosomes. Segmental duplication was the main driver of the GRAS gene family expansion, followed by whole-genome duplication (WGD) and tandem duplication, according to the results of comparative genome analysis. GRAS genes involved in duplication experienced strong purifying selection pressure according to the Ka/Ks ratios. The expression profile derived from transcriptome data shows the expression patterns of HrGRAS gene in different tissues and the characterization of differentially expressed genes. This systematic analysis provided a foundation to understand the expansion and potential functions of GRAS genes with an aim of sea buckthorn crop improvement. [ABSTRACT FROM AUTHOR]

Organic solar cells (OSCs) have attracted wide research interests in the past decades. In recent years, our group mainly focused on the new photovoltaic materials design and device engineering technologies for highly efficient OSCs. This account mainly summarizes our recent studies on the structural design of wide bandgap (WBG) polymers and their morphology control as well as applications in OSCs. Additionally, we introduce our work on binary and ternary blend devices and tandem solar cells containing these materials. What is the most favorite and original chemistry developed in your research group? We focus on design and synthesis of high‐performance organic semiconductors for photovoltaic applications. Our interests are exploring the relationships between the conjugated molecular structures and their photovoltaic properties. How do you get into this specific field? Could you please share some experiences with our readers? When I was in Singapore and USA as a postdoctoral research fellow, I found that the energy crisis and environmental pollution were becoming more and more serious. I believed that organic solar cell (OSC) would be sprung up in the near future and I needed to do something about it. Therefore, I begun to follow with interest the OSCs in 2006 and got into this field in 2007. How do you supervise your students? I am in pursuit of development on self‐thinking abilities of my students. More specifically, encourage and guide the students to find the problems, analyze the problems and figure out some ways to resolve the problems. What is the most important personality for scientific research? Intelligence, diligence and perseverance. What is your favorite journal(s)? Those journals with high scientific nature and good timeliness. Also, the reported results shall be reliable and repeated easily. [ABSTRACT FROM AUTHOR]

Background: Opioid agonist therapy (OAT) has been shown to reduce mortality in patients with opioid use disorder (OUD), yet mortality in individuals receiving OAT remains higher than in an age- and gender-matched population. Objective: To identify baseline risk factors in patients who engaged in buprenorphine treatment that are associated with this elevated risk of death. Design: We performed a retrospective cohort study from January 1, 2007, to December 31, 2018, using a centralized clinical data registry within a multi-hospital health system in Boston, MA, USA. Participants: All adult patients who had ≥ 2 consecutive encounters with sublingual buprenorphine on the active medication list from January 1, 2007, to December 31, 2018. Main Measures: We abstracted several sociodemographic, clinical, and healthcare use characteristics from the clinical data registry. The primary outcome was all-cause mortality and the secondary outcome was opioid overdose-related mortality. We performed multivariable cox regression to identify baseline characteristics independently associated with these outcomes. Key Results: Of 5948 patients in the cohort, the majority were white (80.7%) and male (59.7%), with a mean age of 38.2 years. The all-cause mortality rate was 24.0 deaths per 1000 person-years. Baseline characteristics independently associated with an increased hazard of all-cause mortality included homelessness (adjusted hazard ratio [aHR] = 1.39; 95% confidence interval [CI] = 1.09, 1.78), an opioid on the active medication list (aHR = 1.28; 95% CI = 1.08, 1.52), and entry into the cohort during an inpatient hospitalization (aHR = 1.43; 95% CI = 1.18, 1.73). Homelessness was also associated with an increased hazard of opioid overdose-related mortality (aHR = 1.77; 95% CI = 1.25, 2.50). Conclusions: We identified several novel and potentially modifiable predictors of mortality among patients engaging in buprenorphine treatment who remain at an increased risk of death compared with the general population. Understanding these risk factors can assist healthcare providers in risk stratification and inform the design of targeted interventions to improve outcomes in a high-risk patient population. [ABSTRACT FROM AUTHOR]

Additives are extensively explored for improving PEDOT:PSS performances mainly through the removal of excess PSS and as a secondary dopant. In this work, amine‐containing additives are introduced to PEDOT:PSS solutions as processing additives where the interactions to the PSS are anticipated through electrostatic interactions. Such interactions affected solution property where the increased viscosity is found to significantly increase the out‐of‐plane conductivity of the PEDOT:PSS thin films. Organic solar cells adopting these additive‐assisted processed PEDOT:PSS layers as hole transporting layers (HTL) showed the improved device performances that resulted from the reduced series resistance provided by the PEDOT:PSS HTL. A top power conversion efficiency of 18.28% is achieved with para‐phenylenediamine (PPD) additive in the PEDOT:PSS HTL, which is 3.5% higher compared to devices with neat PEDOT:PSS thin film as the HTL. [ABSTRACT FROM AUTHOR]

Many existing methods for frame deletion detection attempt to detect abnormal periodical artifacts in video stream, however, due to a number of reasons, the periodical artifacts can not always be reliably detected. In this paper, we propose a new method for frame deletion detection. Rather than detecting abnormal periodical artifacts, we devise two features to measure the magnitude of variation in prediction residual and the number of intra macro blocks. Based on the devised features, we propose a fused index to capture abnormal abrupt changes in video streams. We create a dataset which consists of 6 subsets, and test the detection capability of our method in both video level and GOP (Group of Pictures) level. The experimental results show that the proposed method performs stably under various configurations. [ABSTRACT FROM AUTHOR]

Most of the existing image modification detection methods which are based on DCT coefficient analysis model the distribution of DCT coefficients as a mixture of a modified and an unchanged component. To separate the two components, two parameters, which are the primary quantization step, Q1, and the portion of the modified region, α, have to be estimated, and more accurate estimations of α and Q1 lead to better detection and localization results. Existing methods estimate α and Q1 in a completely blind manner, without considering the characteristics of the mixture model and the constraints to which α should conform. In this paper, we propose a more effective scheme for estimating α and Q1, based on the observations that, the curves on the surface of the likelihood function corresponding to the mixture model is largely smooth, and α can take values only in a discrete set. We conduct extensive experiments to evaluate the proposed method, and the experimental results confirm the efficacy of our method. [ABSTRACT FROM AUTHOR]

This paper reports a novel solid-mounted flexible film bulk acoustic resonator (FBAR) directly on polymer substrate with the merits of flexibility and no need for back etching process. (0002) oriented ZnO films deposited by sputtering, and aluminum and gold as the electrodes were used to fabricate the FBARs. Results show that the devices with aluminum electrodes have a resonant frequency at 1.2 GHz with an effective electromechanical coupling coefficient of ∼ 4.7%, a filter-like architecture improved the quality factor of FBAR from 19.6 to 164.2, and the devices remained working after bending at a large angle for hundreds of times. [ABSTRACT FROM PUBLISHER]

The rich phase behavior of 5,11-bis(triethylsilylethynyl)anthradithiophene(TES ADT) – one of the most promising, solution-processablesmall-molecular organic semiconductors – is analyzed, revealingthe highest performing polymorph among four solid-state phases, openingpathways toward the reliable fabrication of high-performance bottom-gate/bottom-contacttransistors. [ABSTRACT FROM AUTHOR]

Background: As guidelines and payers increasingly recommend use of patient decision aids (DAs), evidence about the comparative effectiveness of available DAs is critical for organizations interested in implementing them. The primary purpose of this study was to compare 2 DAs with regard to their ability to help patients become informed and receive their preferred treatment (that is, make an informed patient-centered decision), shared decision-making, surgical rates, and surgeon satisfaction.Methods: We performed a multisite factorial randomized trial enrolling patients with hip or knee osteoarthritis. Patients were randomly assigned to use a long, detailed DA (long DA) or short, interactive DA (short DA). Eight surgeons were randomly assigned to receive a patient preference report detailing the patient's goals and treatment preferences or to administer usual care.Results: We distributed 1,636 pre-visit surveys, 1,220 of which were returned (75% response rate), and 1,124 post-visit surveys, 967 of which were returned (86% response rate). The patients in the sample had a mean age (and standard deviation) of 65 ± 10 years, 57% were female, 89% were white non-Hispanic, and 67% had knee osteoarthritis. The majority (67.2%) made informed patient-centered decisions, and the rate did not vary significantly between the DA groups (p = 0.97) or between the surgeon groups (p = 0.23). Knowledge scores were higher for the short-DA group (mean difference = 9%; p < 0.001). More than half of the sample (60.5%) had surgery within 6 months after the visit, and rates did not differ significantly by DA or surgeon group. Overall, the surgeons were highly satisfied and reported that the majority (88.7%) of the visits were of normal duration or shorter.Conclusions: The DECIDE-OA study is, to our knowledge, the first randomized comparative effectiveness study of 2 orthopaedic DAs. The short DA outperformed the long DA with regard to knowledge scores and was comparable with respect to other outcomes. The surgeons reported high satisfaction and normal visit duration with both DAs.Clinical Relevance: Surgeons need to ensure that patients with osteoarthritis are well-informed and have a clear preference regarding whether to undergo hip or knee replacement surgery. The DAs used in this study may help surgeons involve patients in elective surgery decisions and meet the requirements of informed consent. [ABSTRACT FROM AUTHOR]

Volatile solid additives have attracted increasing attention in optimizing the morphology and improving the performance of currently dominated non‐fullerene acceptor‐based organic solar cells (OSCs). However, the underlying principles governing the rational design of volatile solid additives remain elusive. Herein, a series of efficient volatile solid additives are successfully developed by the crossbreeding effect of chalcogenation and iodination for optimizing the morphology and improving the photovoltaic performances of OSCs. Five benzene derivatives of 1,4‐dimethoxybenzene (DOB), 1‐iodo‐4‐methoxybenzene (OIB), 1‐iodo‐4‐methylthiobenzene (SIB), 1,4‐dimethylthiobenzene (DSB) and 1,4‐diiodobenzene (DIB) are systematically studied, where the widely used DIB is used as the reference. The effect of chalcogenation and iodination on the overall property is comprehensively investigated, which indicates that the versatile functional groups provided various types of noncovalent interactions with the host materials for modulating the morphology. Among them, SIB with the combination of sulphuration and iodination enabled more appropriate interactions with the host blend, giving rise to a highly ordered molecular packing and more favorable morphology. As a result, the binary OSCs based on PM6:L8‐BO and PBTz‐F:L8‐BO as well as the ternary OSCs based on PBTz‐F:PM6:L8‐BO achieved impressive high PCEs of 18.87%, 18.81% and 19.68%, respectively, which are among the highest values for OSCs. [ABSTRACT FROM AUTHOR]

A double‐fibril network of the photoactive layer morphology is recognized as an ideal structure facilitating exciton diffusion and charge carrier transport for high‐performance organic solar cells (OSCs). However, in the layer‐by‐layer processed OSCs (LbL‐OSCs), polymer donors and small molecule acceptors (SMAs) are separately deposited, and it is challenging to realize a fibril network of pure SMAs with the absence of tight interchain entanglement as polymers. In this work, crystalline small molecule donors (SMDs), named TDZ‐3TR and SeDZ‐3TR, were designed and introduced into the L8‐BO acceptor solution, forcing the phase separation and molecular fibrilization. SeDZ‐3TR showed higher crystallinity and lower miscibility with L8‐BO acceptor than TDZ‐3TR, enabling more driving force to favor the phase separation and better molecular fibrilization of L8‐BO. On the other hand, two donor polymers of PM6 and D18 with different fibril widths and lengths were put together to optimize the fibril network of the donor layer. The simultaneously optimization of the acceptor and donor layers resulted in a more ideal double‐fibril network of the photoactive layer and an impressive power conversion efficiency (PCE) of 19.38 % in LbL‐OSCs. [ABSTRACT FROM AUTHOR]

A double‐fibril network of the photoactive layer morphology is recognized as an ideal structure facilitating exciton diffusion and charge carrier transport for high‐performance organic solar cells (OSCs). However, in the layer‐by‐layer processed OSCs (LbL‐OSCs), polymer donors and small molecule acceptors (SMAs) are separately deposited, and it is challenging to realize a fibril network of pure SMAs with the absence of tight interchain entanglement as polymers. In this work, crystalline small molecule donors (SMDs), named TDZ‐3TR and SeDZ‐3TR, were designed and introduced into the L8‐BO acceptor solution, forcing the phase separation and molecular fibrilization. SeDZ‐3TR showed higher crystallinity and lower miscibility with L8‐BO acceptor than TDZ‐3TR, enabling more driving force to favor the phase separation and better molecular fibrilization of L8‐BO. On the other hand, two donor polymers of PM6 and D18 with different fibril widths and lengths were put together to optimize the fibril network of the donor layer. The simultaneously optimization of the acceptor and donor layers resulted in a more ideal double‐fibril network of the photoactive layer and an impressive power conversion efficiency (PCE) of 19.38 % in LbL‐OSCs. [ABSTRACT FROM AUTHOR]

Most studies on Chinese dormitories are carried out in summer, while few focus on a transition season or winter. This study evaluated the air quality of a student dormitory in a university in the Beijing area by using a questionnaire survey and on-site measurements. The CO2 concentration was used as an indoor air quality evaluation index to characterize the freshness of the air, and different window opening conditions in the dormitory were simulated, with corresponding improvement plans proposed. The results of this study revealed that the air quality and thermal comfort of the student dormitories during a transition season and winter fell short of expectations. According to the survey, students who opened their windows frequently had a better subjective perception of the air quality. However, due to the large temperature difference between day and night, more than 80% of the students felt too cold when opening the windows. For daytime conditions, the area of unilateral ventilation window opening should not be less than 0.39 m2, the area of bilateral ventilation window opening should not be less than 0.13 m2, and the time taken to close the windows and doors should not exceed the maximum ventilation interval. Empirical equations were fitted for nighttime conditions based on the CO2 concentration, number of people in the room, and window opening area, resulting in a reasonable window opening area of 0.349 m2~0.457 m2. In sum, this study assessed the air quality status within typical university dormitories across varying seasons, gaining a clear understanding of how different ventilation strategies and occupant densities influence air freshness and thermal comfort. Based on these insights, a practical and optimized window area recommendation was formulated to enhance the indoor environmental quality in these dormitories. [ABSTRACT FROM AUTHOR]

Here, we report a simple, alternative route towards high-mobility structures of the small-molecular semiconductor 5,11-bis(triethyl silylethynyl) anthradithiophene that requires one single processing step without the need for any post-deposition processing. The method relies on careful control of the casting temperature of the semiconductor and allows rapid production of transistors with uniform and reproducible device performance over large areas. [ABSTRACT FROM AUTHOR]

Controlling the nanoparticle‐cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle‐cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling‐induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell‐membrane interaction holds great potential in nanoparticle‐based biomedical applications. [ABSTRACT FROM AUTHOR]

Controlling the nanoparticle‐cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle‐cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling‐induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell‐membrane interaction holds great potential in nanoparticle‐based biomedical applications. [ABSTRACT FROM AUTHOR]

Employing volatile solid additives have emerged as a promising method to optimize the morphology and improve the performance of organic solar cells (OSCs). However, principles governing the efficient design of solid additives remain elusive. Herein, the programmed fluorination and/or bromination on benzene core to develop efficient additives for OSCs is reported. The programmed fluorination and/or bromination endow the five halogen benzene derivatives, 1,3,5‐trifluorobenzene, hexafluorobenzene, 1,3,5‐tribromo‐2,4,6‐trifluorobenzene (TFTB), 1,3,5‐tribromobenzene, and hexabromobenzene, with different melting and boiling points, volatility, as well as interactions with the host blend. Studies indicate that the additives with extremely high and low volatility are almost powerless and even detrimental to the morphology evolution. Among them, the combination of fluorine and bromine atoms on TFTB not only enables the more appropriate m.p./b.p. and volatility, but also exerts stronger molecular interactions with the host blend, giving rise to higher ordered molecular packing and more favorable morphology. Importantly, TFTB exhibits good universality to optimize the performances of OSCs with high power conversion efficiencies (PCEs; over 18%) in a group of binary blend systems, and an impressive PCE of 19.43% in the ternary PBTz‐F:PM6:L8‐BO system. [ABSTRACT FROM AUTHOR]

Organic semiconductors consist of a conjugated backbone and flexible sidechains. Compared to the meticulous design of backbones, less attention has been paid to the investigation of sidechains, in particular their spatial orientation. Herein, three non‐fullerene acceptors, anti‐PDFC, syn‐PDFC, and PDFC‐Ph, are applied in all‐small‐molecule organic solar cells (ASM‐OSCs) to reveal the varied effects of sidechains on morphology and device performance. With spatially orthogonal alkyl chains, anti‐PDFC and syn‐PDFC show unique bimodal lamellar packing and moderate crystallinity. When blending with an efficient binary BTR‐Cl/Y6 system, anti‐PDFC as well as syn‐PDFC not only form their own crystal phase but also improve the packing order of BTR‐Cl, consequently enhancing the power conversion efficiency (PCE) of ternary ASM‐OSC to be 14.56%. However, although PDFC‐Ph has an identical backbone with anti‐PDFC, the alternated sidechains make it relatively amorphous, which is prone to damage the original packing of the host donor/acceptor, and thus deteriorating the device performance. When PC71BM is added to optimize the morphology further, the triple‐acceptor device involving anti‐PDFC realizes a PCE of 15.67%, which is among the best efficiencies in ASM‐OSCs. This study demonstrates that a multi‐dimensional sidechain can optimize the morphology of a bulk heterojunction as effective as a conjugated backbone. [ABSTRACT FROM AUTHOR]

A moderately strong correlation was also seen between the total PERMA score and the personal accomplishment component of MBI among residents ( I r i = 0.51). We hypothesized that resident well-being would be lower compared with faculty scores and that the PERMA and MBI models would correlate inversely given the focus on measuring positive versus negative aspects of well-being. Overall, no correlation between the two models was found; however, in the subgroup analyses of residents only, a statistically significant inverse relationship was found between the positive emotion (P) of PERMA and the emotional exhaustion (EE) of MBI. Individual items are assessed on a 0-5 scale with 0 correlating with "never" and 5 with "always".[7], [9] We assessed the mean PERMA score, and the individual domain scores (P, E, R, M, and A) across residents and faculty at pre-survey completion. [Extracted from the article]

Liquid chromophores constitute a rare but intriguing class of molecules that are in high demand for the design of luminescent inks, liquid semiconductors, and solar energy storage materials. The most common way to achieve liquid chromophores involves the introduction of long alkyl chains, which, however, significantly reduces the chromophore density. Here, strategy is presented that allows for the preparation of liquid chromophores with a minimal increase in molecular weight, using the important class of perylenes as an example. Two synergistic effects are harnessed: (1) the judicious positioning of short alkyl substituents, and (2) equimolar mixing, which in unison results in a liquid material. A series of 1‐alkyl perylene derivatives is synthesized and it is found that short ethyl or butyl chains reduce the melting temperature from 278 °C to as little as 70 °C. Then, two low‐melting derivatives are mixed, which results in materials that do not crystallize due to the increased configurational entropy of the system. As a result, liquid chromophores with the lowest reported molecular weight increase compared to the neat chromophore are obtained. The mixing strategy is readily applicable to other π‐conjugated systems and, hence, promises to yield a wide range of low molecular weight liquid chromophores. A perylene blend, liquid at room temperature, was achieved by mixing two derivatives with similar photophysical properties. The resulting material is the liquid chromophore with the smallest weight increase due to solubilizing substituents presently known. The analysis suggests that the approach of thermodynamic mixing is general, and hence, applicable to any parent compound, yielding liquid chromophores with a minimal weight increase. [ABSTRACT FROM AUTHOR]

Background: A growing body of researches indicate that the disrupted expression of long non-coding RNA (lncRNA) is linked to a range of human disorders. Therefore, the effective prediction of lncRNA-disease association (LDA) can not only suggest solutions to diagnose a condition but also save significant time and labor costs. Method: In this work, we proposed a novel LDA predicting algorithm based on graph convolutional network and transformer, named GCNFORMER. Firstly, we integrated the intraclass similarity and interclass connections between miRNAs, lncRNAs and diseases, and built a graph adjacency matrix. Secondly, to completely obtain the features between various nodes, we employed a graph convolutional network for feature extraction. Finally, to obtain the global dependencies between inputs and outputs, we used a transformer encoder with a multiheaded attention mechanism to forecast lncRNA-disease associations. Results: The results of fivefold cross-validation experiment on the public dataset revealed that the AUC and AUPR of GCNFORMER achieved 0.9739 and 0.9812, respectively. We compared GCNFORMER with six advanced LDA prediction models, and the results indicated its superiority over the other six models. Furthermore, GCNFORMER's effectiveness in predicting potential LDAs is underscored by case studies on breast cancer, colon cancer and lung cancer. Conclusions: The combination of graph convolutional network and transformer can effectively improve the performance of LDA prediction model and promote the in-depth development of this research filed. [ABSTRACT FROM AUTHOR]

Injectable implants with the ability to form in situ are one of the most promising carriers for the delivery of chemotherapeutic drugs to tumor sites. We have reported a novel injectable in situ-forming implant system composed of n-butyl-2-cyanoacrylate (NBCA), ethyl oleate, along with the sol-gel phase transition. The chemotherapeutic drug-loaded injectable NBCA ethyl oleate implant (INEI) exhibited excellent therapeutic efficacy for local chemotherapy. Herein, we utilize this INEI to carry N, N′-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide) (TE-C-5003), which is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, to treat the lung cancer mice model. The in vitro experiment shows that TE-C-5003 has a good anti-tumor effect on lung cancer (IC50 = 0.7022 µM for A549; IC50 = 0.6844 µM for NCL-H1299) and breast cancer (IC50 = 0.4128 µM for MCF-7; IC50 = 0.5965 µM for MDA-MB-231). Anti-tumor experiments in animal models showed that the average growth inhibition rate of xenografted human lung cancer cells by the TE-C-5003-loaded INEI (40% NBCA) was 68.23%, which is far more than TC-E-5003 alone (31.76%). Our study further confirms that INEI is an effective technique to improve the anti-tumor effect. The druggability of small molecule compounds can be improved with the help of the mentioned technology. Also, TC-E-5003 may be developed as a broad spectrum anti-tumor drug. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a neurodegenerative disease with an annual incidence increase that poses significant health risks to people. However, the pathogenesis of AD is still unclear. Autophagy, as an intracellular mechanism can degrade damaged cellular components and abnormal proteins, which is closely related to AD pathology. The goal of this work is to uncover the intimate association between autophagy and AD, and to mine potential autophagy-related AD biomarkers by identifying key differentially expressed autophagy genes (DEAGs) and exploring the potential functions of these genes. GSE63061 and GSE140831 gene expression profiles of AD were downloaded from the Gene Expression Omnibus (GEO) database. R language was used to standardize and differentially expressed genes (DEGs) of AD expression profiles. A total of 259 autophagy-related genes were discovered through the autophagy gene databases ATD and HADb. The differential genes of AD and autophagy genes were integrated and analyzed to screen out DEAGs. Then the potential biological functions of DEAGs were predicted, and Cytoscape software was used to detect the key DEAGs. There were ten DEAGs associated with the AD development, including nine up-regulated genes (CAPNS1, GAPDH, IKBKB, LAMP1, LAMP2, MAPK1, PRKCD, RAB24, RAF1) and one down-regulated gene (CASP1). The correlation analysis reveals the potential correlation among 10 core DEAGs. Finally, the significance of the detected DEAGs expression was verified, and the value of DEAGs in AD pathology was detected by the receiver operating characteristic curve. The area under the curve values indicated that ten DEAGs are potentially valuable for the study of the pathological mechanism and may become biomarkers of AD. This pathway analysis and DEAG screening in this study found a strong association between autophagy-related genes and AD, providing new insights into the pathological progression of AD. Exploring the relationship between autophagy and AD: analysis of genes associated with autophagy in pathological mechanisms of AD using bioinformatics. 10 autophagy-related genes play an important role in the pathological mechanisms of AD. [ABSTRACT FROM AUTHOR]

Combining targeted tumor therapy with tissue regeneration represents a promising strategy for synergistic tumor therapy. In this study, a multifunctional living material is constructed with human‐derived adipose stem cells (hADSCs) and antibody‐modified hydroxyapatite nanorods (nHAP) for targeted drug delivery and bone regeneration following surgery. The living material delivers the therapeutics to the tumor site efficiently based on the strength of the inherent tumor tropism of hADSCs. The bioconjugation of nHAP with hADSCs via specific antibody modification is found to be biocompatible, even when loaded with the chemotherapeutic drug doxorubicin (Dox). The endocytosis of nHAP stimulates the osteogenic differentiation of hADSCs, promoting bone tissue regeneration. Moreover, the antibody‐modified nHAP‐hADSC conjugate exhibits targeted tumor delivery, which is further facilitated by pH‐triggered release of Dox, inducing apoptosis of tumor cells with low toxicity to healthy tissues. Therefore, the present study provides a general strategy for engineering living materials to achieve targeted tumor therapy and bone tissue regeneration after surgery, which can be extended to other disease types. [ABSTRACT FROM AUTHOR]

Due to the unwarranted lifespan and differentiation, applying neural stem cells (NSCs) in spinal cord injury (SCI) remains challenging. In this study, 3D bioactive hydroxyapatite (HAp) nanobelt haystack‐mouse NSC (mNSC) hybrid spheroids are customized in which the specific nanobelt haystack framework provided the structural function of hypoxia alleviation in the spherical core and biological process of neural differentiation promotion. Commodified with superparamagnetic ferroferric oxide (Fe3O4) nanoparticles and a polydopamine (PDA) coating, the HAp nanobelts are endowed with magnetic field‐driven properties and enhanced cell‐nanobelt adhesion. The engineered bioresponsive 3D nanobelt haystack‐mNSC hybrid spheroids effectively repair SCI in vivo, showing new potential for stem cell therapy by incorporating nanomaterials in 3D culture based on cell‐material interactions. [ABSTRACT FROM AUTHOR]

A facile strategy was developed here to improve the film quality of nickel‐based hole transporting layer (HTL) for efficient organic solar cell (OSC) applications. To prevent the agglomeration of Ni(NO3)2 during film deposition, acetylacetonate was added into the precursor solution, which led to the formation of an amorphous and glass‐like state. After thermal annealing (TA) treatment, the film‐forming ability could be further improved. The additional UV‐ozone (UVO) treatment continuously improved the film quality and increased the work function and conductivity of such HTL. The resulting TA & UVO modified Ni(NO3)2 & Hacac HTL produced highly efficient organic solar cells with exciting power conversion efficiencies of 18.42 % and 19.02 % for PM6 : BTP‐eC9 and D18 : BTP‐Th devices, respectively, much higher than the control PEDOT : PSS devices. [ABSTRACT FROM AUTHOR]

A facile strategy was developed here to improve the film quality of nickel‐based hole transporting layer (HTL) for efficient organic solar cell (OSC) applications. To prevent the agglomeration of Ni(NO3)2 during film deposition, acetylacetonate was added into the precursor solution, which led to the formation of an amorphous and glass‐like state. After thermal annealing (TA) treatment, the film‐forming ability could be further improved. The additional UV‐ozone (UVO) treatment continuously improved the film quality and increased the work function and conductivity of such HTL. The resulting TA & UVO modified Ni(NO3)2 & Hacac HTL produced highly efficient organic solar cells with exciting power conversion efficiencies of 18.42 % and 19.02 % for PM6 : BTP‐eC9 and D18 : BTP‐Th devices, respectively, much higher than the control PEDOT : PSS devices. [ABSTRACT FROM AUTHOR]

A desired morphology is essential for achieving efficient polymer solar cells. Donors and acceptors with appropriate crystallization can lead to a suitable phase-separated morphology for effective photocurrent generation process. Inspired by the success of Y6 acceptors and the 2D side chain engineering on popular polymer donors and small molecule acceptors, the usage of unique 2D 3,4-ethylene dioxythiophene (EDOT) side chains on Y6 to regulate its crystallinity, compatibility, and thus the related blend morphology is explored. In this study, two molecules of BTP-EDOT-4F and BTP-EDOT-4Cl with such unique 2D EDOT side chains are designed and synthesized. Due to the advantage of EDOT side chain, when these molecules are blended with PM6, the decent power conversion efficiencies (PCEs) of 16.78% and 15.87% are obtained. Furthermore, BTP-EDOT-4F is selected as the third component and added into PM6:L8-BO binary system to form ternary blends. The optimized crystallinity, compatibility, and morphology of such ternary blend are discovered in the presence of BTP-EDOT-4F, which enables efficient exciton dissociation and charge transport as well as decreased recombination, resulting in higher short circuit current density Jsc) and fill factor. Finally, the outstanding PCE of 18.56% is achieved in ternary blends containing PM6, L8-BO, and BTP-EDOT-4F. [ABSTRACT FROM AUTHOR]

Background Men who have sex with men (MSM) on antiretroviral therapy (ART) are at risk for multimorbidity as life expectancy increases. Simulation models can project population sizes and age distributions to assist with health policy planning. Methods We populated the CEPAC-US model with CDC data to project the HIV epidemic among MSM in the United States. The PEARL model was predominantly informed by NA-ACCORD data (20092017). We compared projected population sizes and age distributions of MSM receiving ART (20212031) and investigated how parameters and assumptions affected results. Results We projected an aging and increasing population of MSM on ART: CEPAC-US, mean age 48.6 (SD 13.7) years in 2021 versus 53.9 (SD 15.0) years in 2031; PEARL, 46.7 (SD 13.2) years versus 49.2 (SD 14.6) years. We projected 548 800 MSM on ART (147 020 65 years) in 2031 (CEPAC-US) and 599 410 (113 400 65 years) (PEARL). Compared with PEARL, CEPAC-US projected a smaller population of MSM on ART by 2031 and a slower increase in population size, driven by higher estimates of disengagement in care and mortality. Conclusions Findings from two structurally distinct microsimulation models suggest that the MSM population receiving ART in the United States will increase and age over the next decade. Subgroup-specific data regarding engagement in care and mortality can improve projections and inform health care policy planning. [ABSTRACT FROM AUTHOR]

The article focuses on the residency program called Clinical Learning Environment Review (CLER) by the organization Accreditation Council of Graduate Medical Education (ACGME). Topics discussed include experiences of residents who completed the course, with subjects such as work life balance, information processing, and self confidence.

Constructing terpolymer has attracted increasing attention as a strategy to improve the performance of polymer solar cell. Terpolymer usually offers an opportunity to lower the frontier molecular orbital energy level, introduces additional absorption band and sometimes optimizes the morphology of the active blend. Generally, the additional segment in terpolymer backbone inevitably introduces backbone disorder, which causes entropy rises. However, selecting a suitable dipole unit introduces extra driving forces for crystallization by enhancing intermolecular interactions. This provides a handy knob for tradeoff between intermolecular interaction and backbone disorder, thus regulating the blend morphology. Herein, a high dipole and electron‐deficient group of pyrrolo[3,4‐f]benzotriazole‐5,7(6H)‐dione (TzBI) is incorporated into the high‐performance donor polymer and a series of terpolymers with different content of TzBI are designed. As expected, the morphology is optimized gradually for improving charge generation and charge transport, also suppressing charge recombination. The champion device with 10% TzBI exhibited a power conversion efficiency (PCE) of 18.36%, which is 5% increase compared to the controlled device. This study presents a charming terpolymer strategy by highly electron‐deficient and high dipole segment to realize a tradeoff between intermolecular interaction and backbone disorder, facilitating the optimization of morphology and elevation of fill factor and device efficiency. [ABSTRACT FROM AUTHOR]

Side‐chain engineering with heteroatoms is not only effective in tuning frontier molecular orbitals, but also possible for forming secondary bonds which can be utilized to planarize the molecular backbone, hence, improving the photon absorption as well as charge‐transport abilities of polymer solar‐cell (PSC) materials. Herein, two types of unconventional side chains, namely carboxylate and carbamate, containing various heteroatoms are introduced to the thiophene bridges in high performance benzodithiophene (BDT) based donor polymers to from the novel polymers PTzTz‐C and PTzTz‐N, respectively. In these polymers, non‐covalent O⋅⋅⋅S and N⋅⋅⋅H interactions induce a high tendency to aggregation. In a ternary‐blend PSC with PTzTz‐N added to the high‐performance D18 : BTP‐eC9 blend, complimentary absorption and improved thin‐film morphology were observed with a top power conversion efficiency of 18.76 %, which is an improvement of almost 5 % over the D18 : BTP‐eC9 binary blends. [ABSTRACT FROM AUTHOR]

Side‐chain engineering with heteroatoms is not only effective in tuning frontier molecular orbitals, but also possible for forming secondary bonds which can be utilized to planarize the molecular backbone, hence, improving the photon absorption as well as charge‐transport abilities of polymer solar‐cell (PSC) materials. Herein, two types of unconventional side chains, namely carboxylate and carbamate, containing various heteroatoms are introduced to the thiophene bridges in high performance benzodithiophene (BDT) based donor polymers to from the novel polymers PTzTz‐C and PTzTz‐N, respectively. In these polymers, non‐covalent O⋅⋅⋅S and N⋅⋅⋅H interactions induce a high tendency to aggregation. In a ternary‐blend PSC with PTzTz‐N added to the high‐performance D18 : BTP‐eC9 blend, complimentary absorption and improved thin‐film morphology were observed with a top power conversion efficiency of 18.76 %, which is an improvement of almost 5 % over the D18 : BTP‐eC9 binary blends. [ABSTRACT FROM AUTHOR]

Silicon-derived biomaterials are conducive to regulating the fate of osteo-related stem cells, while their effects on the osteogenic differentiation of human adipose-derived stem cells (hADSCs) remain inconclusive. Mesoporous silica (mSiO2) is synthesized in a facile route that exhibited the capability of promoting osteogenic differentiation of hADSCs. The metabolism of SiO2 in cells is proposed according to the colocalization fluorescence analysis between lysosomes and nanoparticles. The released silicon elements promote osteogenic differentiation. The detection of secretory proteins through numerous parallel experiments performed via a microfluidic chip confirms the positive effect of SiO2 on the osteogenic differentiation of hADSCs. Moreover, constructed with superparamagnetic iron oxide (Fe3O4), the magnetic nanoparticles (MNPs) of Fe3O4@mSiO2 endow the cells with magnetic resonance imaging (MRI) properties. The MNP-regulated osteogenic differentiation of autologous adipose-derived stem cells provides considerable clinical application prospects for stem cell therapy of bone tissue repair with an effective reduction in immune rejection. [ABSTRACT FROM AUTHOR]

Microsecond pulsed electric fields (PEF) have previously been used for various tumour therapies, such as gene therapy, electrochemotherapy and irreversible electroporation (IRE), due to its demonstrated ability. However, recently nanosecond pulsed electric fields (nsPEF) have also been used as a potential tumor therapy via inducing cell apoptosis or immunogenic cell death to prevent recurrence and metastasis by interacting with intracellular organelles. A large proportion of the existing in-vitro studies of nsPEF on cells also suggests cell necrosis and swelling/blebbing can be induced, but the replicability and potential for other effects on cells suggesting a complicated process which requires further investigation. Therefore, this study investigated the effects of pulse width and intensity of nsPEF on the murine melanoma cells (B16) and normal murine fibroblast cells (L929) through electromagnetic simulation and in-vitro experiments. Through examining the evolution patterns of potential difference and electric fields on the intracellular compartments, the simulation has shown a differential effect of nsPEF on normal and cancerous skin cells, which explains well the results observed in the reported experiments. In addition, the modelling has provided a clear evidence that a few hundreds of ns PEF may have caused a mixed mode of effects, i.e. a 'cocktail effect', including cell electroporation and IRE due to an over their threshold voltage induced on the plasma membrane, as well as cell apoptosis and other biological effects caused by its interaction with the intracellular compartments. The in-vitro experiments in the pulse range of the hundreds of nanoseconds showed a possible differential cytotoxicity threshold of electric field intensity between B16 cells and L929 cells. [ABSTRACT FROM AUTHOR]

Despite remarkable breakthrough made by virtue of "polymerized small‐molecule acceptor (PSMA)" strategy recently, the limited selection pool of high‐performance polymer acceptors and long‐standing challenge in morphology control impede their further developments. Herein, three PSMAs of PYDT‐2F, PYDT‐3F, and PYDT‐4F are developed by introducing different fluorine atoms on the end groups and/or bithiophene spacers to fine‐tune their optoelectronic properties for high‐performance PSMAs. The PSMAs exhibit narrow bandgap and energy levels that match well with PM6 donor. The fluorination promotes the crystallization of the polymer chain for enhanced electron mobility, which is further improved by following n‐doping with benzyl viologen additive. Moreover, the miscibility is also improved by introducing more fluorine atoms, which promotes the intermixing with PM6 donor. Among them, PYDT‐3F exhibits well‐balanced high crystallinity and miscibility with PM6 donor; thus, the layer‐by‐layer processed PM6/PYDT‐3F film obtains an optimal nanofibril morphology with submicron length and ≈23 nm width of fibrils, facilitating the charge separation and transport. The resulting PM6/PYDT‐3F devices realizes a record high power conversion efficiency (PCE) of 17.41% and fill factor of 77.01%, higher than the PM6/PYDT‐2F (PCE = 16.25%) and PM6/PYDT‐4F (PCE = 16.77%) devices. [ABSTRACT FROM AUTHOR]

Supplemental Digital Content is Available in the Text. Background: The Botswana Combination Prevention Project tested the impact of combination prevention (CP) on HIV incidence in a community-randomized trial. Each trial arm had ∼55,000 people, 26% HIV prevalence, and 72% baseline ART coverage. Results showed intensive testing and linkage campaigns, expanded antiretroviral treatment (ART), and voluntary male medical circumcision referrals increased coverage and decreased incidence over ∼29 months of follow-up. We projected lifetime clinical impact and cost-effectiveness of CP in this population. Setting: Rural and periurban communities in Botswana. Methods: We used the Cost-Effectiveness of Preventing AIDS Complications model to estimate lifetime health impact and cost of (1) earlier ART initiation and (2) averting an HIV infection, which we applied to incremental ART initiations and averted infections calculated from trial data. We determined the incremental cost-effectiveness ratio [US$/quality-adjusted life-years (QALY)] for CP vs. standard of care. Results: In CP, 1418 additional people with HIV initiated ART and an additional 304 infections were averted. For each additional person started on ART, life expectancy increased 0.90 QALYs and care costs increased by $869. For each infection averted, life expectancy increased 2.43 QALYs with $9200 in care costs saved. With CP, an additional $1.7 million were spent on prevention and $1.2 million on earlier treatment. These costs were mostly offset by decreased care costs from averted infections, resulting in an incremental cost-effectiveness ratio of $79 per QALY. Conclusions: Enhanced HIV testing, linkage, and early ART initiation improve life expectancy, reduce transmission, and can be cost-effective or cost-saving in settings like Botswana. [ABSTRACT FROM AUTHOR]

A benzodithiophene-free donor polymer was designed for enabling 19.36% efficiency green-solvent-processable organic solar cells (OSCs), which is the highest value for OSCs processed by halogen-free solvents. [Display omitted] • A high molecular weight benzodithiophene-free donor polymer of PDTP-BDD was developed for organic solar cells. • The layer-by-layer processing of PDTP-BDD based devices in halogen-free solvents was studied. • The champion power conversion efficiency of 19.36% was achieved finally. In this work, a newly benzodithiophene-free D-A polymer donor, named PDTP-BDD, was developed for realizing green-solvent processed high-performance OSCs. By bridging two electron-rich unit of dithieno[3,2-b:2′,3′-d]pyridin-5(4H)-one (DTP) and electron-deficient benzo[1,2-c:4,5c′]dithiophene-4,8-dione (BDD) with thiophene units, PDTP-BDD possesses high absorption in the short wavelength range and a deep HOMO energy level. The rigid building blocks also make PDTP-BDD has strong aggregation and poor solubility in common halogen-free solvents (such as o -xylene) at room temperature, but it is readily dissolved and disaggregated at high temperature (120 °C). After cooling down to a lower temperature (60 °C), PDTP-BDD self-assembled and pre-aggregated slowly in the solution at a long time. By employing a delayed processing strategy in the layer-by-layer processed OSCs (LbL-OSCs), an optimized fibril network of the underling layer was realized, enabling the permeation of acceptor into the donor network. The optimized PDTP-BDD/L8-BO-based LbL-OSCs realized a high PCE of 18.42 %. By adding a small amount of D18 to further optimize the PDTP-BDD fibril network, an impressive PCE of 19.36 % was achieved finally in the resulting ternary LbL-OSCs, which is the highest value for OSCs processed by halogen-free solvents. [ABSTRACT FROM AUTHOR]

The chalcogen effect was investigated on the absorption, energy level and intermolecular interaction of nonfused-ring electron acceptors, which presented TTS-4F containing sulfur substituted side chains to achieve a champion PCE of 14.74% in organic solar cells. [Display omitted] • Nonfused-ring electron acceptors (NFREAs) based on chalcogen substituted side chains were developed. • The chalcogen effect on the photovoltaic property of NFREAs was investigated. • The champion power conversion efficiency 14.74% was achieved finally. Fused-ring electron acceptors (FREAs) are the current working horse for the top performing organic solar cells (OSCs). Nevertheless, these FREAs surfer from high synthetic complexity, production costs and poor scalability, hindering their industrialization. Developing nonfused-ring electron acceptors (NFREAs) is a more feasible alternative solution towards future photovoltaic applications. In this work, a series of NFREAs have been designed and synthesized by introducing chalcogen atoms on the side chains for OSCs. The introduced chalcogen atoms (O, S, and Se) not only modulated the energy levels but also finely tuned the intermolecular interactions. Especially, the formed S‧‧‧S and Se‧‧‧Se intermolecular interactions in TTS-4F and TTSe-4F resulted in higher molecular crystallinity than TTO-4F. Unexpectedly, the strong Se‧‧‧Se interactions also led the aggregation of TTSe-4F and formation of large domains in the PM6:TTSe-4F blend. The moderate S‧‧‧S interactions in TTS-4F enabled an optimal phase separation with more ideal nano fibrils distributed in the PM6:TTS-4F blend, facilitating the charge separation and transport. As a result, TTS-4F based devices achieved a champion power conversion efficiency (PCE) of 14.74%, higher than the TTO-4F (8.76%) and TTSe-4F (11.56%) based devices. [ABSTRACT FROM AUTHOR]

Background: Coaching has been shown to improve resident well-being; however, not all benefit equally. Objective: Assess predictors of changes in resident physician well-being and burnout in a multisite implementation of a Professional Development Coaching Program. Design: Pre- and post-implementation surveys administered to participant cohorts at implementation sites in their intern year. Effect size was calculated comparing pre- and post-intervention paired data. Participants: In total, 272 residents in their intern year at five internal medicine residency programs (Boston Medical Center, University Hospitals Cleveland Medical Center, Duke University, Emory University, Massachusetts General Hospital). Analyses included 129 residents with paired data. Interventions: Interns were paired with a faculty coach trained in positive psychology and coaching skills and asked to meet quarterly with coaches. Main Measures: Primary outcomes included Maslach Burnout Inventory depersonalization (DP) and emotional exhaustion (EE) subscales, and the PERMA well-being scale. Key predictors included site, demographics, intolerance of uncertainty, hardiness-resilience, gratitude, and coping. Program moderators included were reflection, goal setting, and feedback. Key Results: Well-being (PERMA) changed from baseline to follow-up in all participants; females showed a decline and males an increase (−1.41 vs..83, p = 0.04). Self-reflection was associated with positive change in PERMA (mean positive change 1.93, p = 0.009). Burnout (EE) declined in non-Hispanic white residents vs. Black/Asian/Hispanic/other residents (−1.86, p = 0.021). Burnout improved with increased goal setting. Conclusion: Coaching programs should consider tailored approaches to support residents whose well-being is impacted by gender and/or race, and who have higher intolerance of uncertainty and lower resilience at baseline. Coaching skills of goal setting and reflection may positively affect interns and teach coping skills. [ABSTRACT FROM AUTHOR]

Since 2012, cervical cancer screening guidelines allow for choice of screening test for women age 30-65 years (i.e., Pap every 3 years or Pap with human papillomavirus co-testing every 5 years). Intended to give patients and providers options, this flexibility reflects a trend in the growing complexity of screening guidelines. Our objective was to characterize variation in cervical screening at the individual, provider, clinic/facility, and healthcare system levels. The analysis included 296,924 individuals receiving screening from 3626 providers at 136 clinics/facilities in three healthcare systems, 2010 to 2017. Main outcome was receipt of co-testing vs. Pap alone. Co-testing was more common in one healthcare system before the 2012 guidelines (adjusted odds ratio (AOR) of co-testing at the other systems relative to this system 0.00 and 0.50) but was increasingly implemented over time in a second with declining uptake in the third (2017: AORs shifted to 7.32 and 0.01). Despite system-level differences, there was greater heterogeneity in receipt of co-testing associated with providers than clinics/facilities. In the three healthcare systems, providers in the highest quartile of co-testing use had an 8.35, 8.81, and 25.05-times greater odds of providing a co-test to women with the same characteristics relative to the lowest quartile. Similarly, clinics/ facilities in the highest quartile of co-testing use had a 4.20, 3.14, and 6.56-times greater odds of providing a co-test relative to the lowest quartile. Variation in screening test use is associated with health system, provider, and clinic/facility levels even after accounting for patient characteristics. [ABSTRACT FROM AUTHOR]

• Planar propeller-like PDIs were synthesized by noncovalent interactions. • Thiophene and nitrogen annulations were applied to PDI arms with increasing photovoltaic property. • Fine tuning the noncovalent interaction strength promoted PCEs reaching 10.52%. The development of non-fullerene small molecule acceptors enabled fast increasing top power conversion efficiency of polymer solar cells (PSCs). Perylene diimide (PDI) derivatives are among the most promising non-fullerene small molecule acceptors for their relatively straightforward accessible PDI chromophores readily deliver high electron mobility and intensive photon absorption in visible range. In this work, we demonstrated noncovalent interaction as a third strategy of connecting the PDI arms to the center core of propeller-like PDI derivatives other than flexible and all fused linkages through designing and synthesizing two novel PDI derivatives. Thiophene-annulated PDI arms were connected to a small electron withdrawing 1,3,5-triazine center core where N⋯S noncovalent conformational locks restricted the distortion of molecules. Fine tuning of the aggregation tendency of the PDI derivative by introducing N-annulation at the outer bay position of each PDI arms which achieved an outstanding power conversion efficiency reaching 10.52%, which is one of the top PCEs of PDI-based PSCs. [ABSTRACT FROM AUTHOR]

Deep neural networks (DNNs) have evolved as a beneficial machine learning method that has been successfully used in various applications. Currently, DNN is a superior technique of extracting information from massive sets of data in a self-organized method. DNNs have different structures and parameters, which are usually produced for particular applications. Nevertheless, the training procedures of DNNs can be protracted depending on the given application and the size of the training set. Further, determining the most precise and practical structure of a deep learning method in a reasonable time is a possible problem related to this procedure. Meta-heuristics techniques, such as swarm intelligence (SI) and evolutionary computing (EC), represent optimization frames with specific theories and objective functions. These methods are adjustable and have been demonstrated their effectiveness in various applications; hence, they can optimize the DNNs models. This paper presents a comprehensive survey of the recent optimization methods (i.e., SI and EC) employed to enhance DNNs performance on various tasks. This paper also analyzes the importance of optimization methods in generating the optimal hyper-parameters and structures of DNNs in taking into consideration massive-scale data. Finally, several potential directions that still need improvements and open problems in evolutionary DNNs are identified. [ABSTRACT FROM AUTHOR]