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Objective This study aims to analyze the methodological characteristics of qualitative interview studies investigating the public's knowledge and experiences regarding pediatric clinical trials and to provide reference for the design and implementation of similar research in China. Methods We conducted a comprehensive search in CNKI, WanFang Data, Vip Network, PubMed, Embase, APA PsycInfo, CINAHL, and Web of Science databases. We identified all published qualitative interview studies that explored the public's knowledge and experiences related to children's participation in clinical trials up to September 21, 2021. Eight researchers were divided into four groups, with two trained researchers in each group utilizing Note Express(v 3.2) software for pre-screening and data extraction. Literature screening, data extraction, and analysis were performed independently after consistency checks. Disagreements were resolved through team leader decisions after group discussion. The CASP Qualitative Checklist Tool was used to assess study quality, and the extracted data was summarized to develop a classification framework. Results A total of 144 English literature (137 studies) were included. The majority of the studies (80.3%, 110/137) exhibited minimal or no quality concerns. Most studies (54.7%, 75/137) were published from 2015 to 2021. Relevant studies were published in 23 countries, with the United States (37.2%, 51/137) and the United Kingdom (26.3%, 36/137) contributing the most. There were 75.9%(104/137) of studies focusing on actual pediatric clinical trials. The main diseases covered were infectious diseases (28.9%, 35/121) and cancer (22.3%, 27/121). Interventions in clinical trials predominantly involved drug therapy (38.6%, 39/101) and vaccines (14.9%, 15/101). Interviews were conducted by medical staff in hospitals or clinics, with participants mainly recruited from clinical trial subjects (43.0%, 49/114). Most interviewees were parents (79.6%, 109/137). Compensation was often provided in the form of vouchers (46.7%, 21/45). The content of included studies largely centered on parents' perspectives and perceptions of pediatric clinical trial knowledge and processes (27.5%, 78/284). Interviews were mainly performed as semi-structured interviews (75.2%, 103/137) and face-to-face interviews (88.3%, 121/137). Thematic analysis (47.2%, 51/108) and NVivo software (77.6%, 52/67) were commonly used for data analysis. Independent multi-person analysis (46.4%, 52/112) and content verification (77.8%, 21/27) were employed to ensure reliability and credibility. Conclusions Semi-structured in-depth interviews with parents and children using thematic analysis are a prominent research approach. Qualitative interview studies emphasize the clinical characteristics of diseases, including disease types and interventions. Specific attention should be given to perspectives and experiences of children and parents with poor adherence or clinical outcomes. Analyzing potential participants' knowledge, attitudes, and experiences can provide references for improving future trial design and quality.

Aim: The aim of this study was to investigate whether multimodal analgesia can decrease postoperative opioid usage in patients undergoing shoulder arthroscopy., Methods: Patients diagnosed with subacromial impingement syndrome who underwent acromioplasty at our institution between October 2022 and November 2023 were retrospectively analyzed. Patients were divided into an observation group and a control group based on postoperative pain management methods. The control group received intravenous self-controlled electronic analgesia (sufentanil injection 1 μg/kg + butorphanol injection 4 mg + 0.9% NaCl injection to 100 mL), while the observation group received multimodal analgesia (ropivacaine subacromial pump 3 mL/h, combined with oral celecoxib and acetaminophen). Visual Analog Scale (VAS) scores were recorded preoperatively and at various postoperative time points, and opioid usage, length of hospital stay, and analgesia-related complications within 1 week postoperatively were compared between groups. The 36-item Short Form Health Survey (SF-36) scores and the Constant-Murley score (CMS), were also assessed 1 day and 1 week after treatment., Results: One hundred thirty-two patients were included in the study, 66 in the observation group and 66 in the control group. In the control group, there were 46 males and 20 females, with a mean age of 55.47 ± 11.42 years and in the observation group 44 males and 22 females, with a mean age of 56.13 ± 12.19 years The observation group consistently reported significantly lower pain intensity compared to the control group at 8 h (T1), 24 (T2), and 48 h (T3) after surgery (p < 0.05). Additionally, the observation group exhibited significantly lower opioid usage and complication rates compared to the control group (p < 0.05). SF-36 scores and CMS scores were significantly higher in the observation group 1 week after treatment compared to the control group (p < 0.05)., Conclusions: Following shoulder arthroscopy, multimodal analgesia effectively reduces opioid consumption, lowers complication rates, and provides effective short-term pain relief. This approach carries significant implications for improving patient outcomes.

OBJECTIVE: To summarize the therapeutic experience of 24 patients of traumatic head injuries with GCS score of 3. METHODS: Twenty-four most severely head-injured patients with GCS score of 3 who were admitted to our department from Jan 1995 to Mar 1998 were retrospectively analyzed. RESULTS: Twelve cases (50.0%) survived, of which 7 cases (29.2%) had good recovery or moderate disability and 5 cases with severe deficits (20.8%), and the other 12 died (50.0%) after therapy. CONCLUSIONS: The prognosis of most severely head-injured patients with GCS score of 3 could be improved by early intracranial hematoma removal with large decompressive craniotomies, early moderate hypothermia therapy, early assistant ventilation and effective prevention and treatment of complications.

OBJECTIVE: To investigate the protective effects of mild hypothermia (33-35 degrees C) on the outcome of patients with severe traumatic brain injury (TBI) (GCS<8). METHODS: Patients in the mild hypothermia group were cooled to 33-35 degrees C by cooling blanket with muscular relaxant, and patients in the normothermia group were maintained at 37-38 degrees C. RESULTS: The result showed that the mortality was 26.1% (6/23) in the mild hypothermia group and 58.3% (14/24) in the normothermia group respectively (P<0.05). The mild hypothermia also markedly reduced intracranial pressure (P<0.01 and inhibited hyperglycermia (P<0.05). No significant side-effects were found during hypothermic treatment. CONCLUSIONS: Our clinical data have demonstrated that mild hypothermia is a useful method for management of patients with severe traumatic brain injury.