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12 results on '"Yu, Qixiang"'

1. Laboratory determination method and application of sensitive index and critical value for coal roadway outburst prediction

Author

JIANG Chenglin, YU Qixiang, ZHANG Chaojie

Subjects
coal and gas outburst, outburst prediction, sensitive index, outburst simulation, relative sensitivity, Mining engineering. Metallurgy, TN1-997
Abstract

Aiming at the shortcomings of the “three-rate method” in determining the sensitive indicators for coal roadway outburst prediction and the threat of outburst to personnel during detection, in this paper, a laboratory method for determining the sensitive index and critical value of coal roadway outburst prediction is presented. According to the principle that the apparent density and moisture of simulated soft stratification are consistent with the original coal seam in the field, the forming pressure and pressing steps of simulated soft stratification were determined. Then filling the simulated soft layer with low pressure and high pressure gas, drilling and measuring various coal roadway outburst prediction indexes respectively, the relative sensitivity of each predictor is known and one of the highest predictors of sensitivity can be obtained. Through outburst simulation or measuring the initial release gas expansion energy, the critical value of the index can be determined. Through the application in the coal mine site, it is proved that the prediction index and critical value obtained by this method are effective, and can be directly used in the field coal roadway prediction.

Published
2021
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11. Modulation of neuronal activity of cerebellar fastigial nucleus by locus coeruleus stimulation in the rat

Author

Yu Qixiang, Wang Jian-jun, Cheng Hong, Li Hong-Zhao, and Wang Tao

Subjects
Multidisciplinary, Chemistry, Stimulation, Pharmacology, Inhibitory postsynaptic potential, medicine.anatomical_structure, Phentolamine, nervous system, medicine, Excitatory postsynaptic potential, Premovement neuronal activity, Locus coeruleus, Nucleus, Fastigial nucleus, medicine.drug
Abstract

The effects of stimulating locus coeruleus (LC) on neuronal activity of cerebellar fastigii nucleus (FN) was investigated. Stimulation of LC elicited inhibitory, excitatory and biphasic (inhibition-excitation) responses from FN cells. The majority of responsive cells showed an inhibitory response with a latency of less than 10 ms. Injection of a adrenoreceptor antagonists phentolamine (iV) could block the inhibitory response of FN cells to the LC stimulation, but propranolol (IV), a β adrenoreceptor antagonist, could not. These results suggest that LC-cerebellar noradrenergic afferent fibers may be involved in the cerebellar sensorimotor integration process by exerting their modulatory action on the cerebellar nuclear cells’ activities.

Published
1998

12. Abstract 13072: Association Between Baseline Lipoprotein(a) and Five-Year Outcomes in Patients Underwent Coronary Artery Bypass Grafting: A Post-Hoc Analysis of DACAB Trial

Author

Yu, Qixiang, Zhou, Yanzai, Zhang, Wei, Zhao, Qiang, and Zhu, Yunpeng

Abstract

Introduction:Serum lipoprotein(a) [Lp(a)] is genetically determined and has been proposed to be associated with coronary artery lesion severity and clinical outcomes in coronary artery disease (CAD). But some researches suggested heterogeneous effects and marked variations of Lp(a) level between ethnic groups. The aim of this study was to investigate the impact of baseline Lp(a) on five-year clinical outcomes in Chinese population who underwent coronary artery bypass grafting (CABG).Methods:We performed a post-hoc analysis of the DACAB trial (NCT02201771), in which patients aged 18 to 80 years, male or female, underwent primary, isolated and elective CABG, were randomly assigned to receive different antiplatelet treatments. Serum Lp(a) was obtained and analyzed in 270/272 patients of one single center. The primary outcome was major adverse cardiovascular events (MACE). MACE-5 included all-cause death, myocardial infarction, stroke, repeated revascularization and rehospitalization for unstable angina, and MACE-3 included cardiovascular death, myocardial infarction, and stroke. The mean follow-up reached 59.4±9.4 months.Results:The baseline characteristics were generally comparable. High Lp(a) level was identified in 71 (26.3%) (cut-off ≥30mg/dL) and 33 (12.2%) (cut-off ≥50mg/dL) patients, respectively. During 5-year follow-up, MACE-5 reported in high and low Lp(a) group were 34.2% vs 28.8% when the cut-off value was 30mg/dL (hazard ratio [HR], 1.11; 95% CI, 0.69-1.78, p=0.66). While the cut-off value was 50mg/dL, MACE-5 reported in high and low Lp(a) group were 39.4% vs 28.9% (HR, 1.32; 95% CI, 0.73-2.38, p=0.36). Similar results were observed in MACE-3 (Cut-off value 30mg/dL: 24.2% vs 21.9%, HR 1.08, p=0.78; Cut-off value 50mg/dL: 27.3% vs 21.8%, HR 1.24, p=0.56). No statistical significant difference was achieved between the two groups.Conclusions:In this single center post-hoc analysis, baseline Lp(a) level ≥30mg/dL or ≥50mg/dL had no statistical significant association with 5-year MACE in post-CABG Chinese population. But higher baseline Lp(a) levels seem to be associated with more MACE in longer follow-up. Larger sample size from multicenter are needed to confirm our findings.

Published
2021
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