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1. Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis

Author

Ren, Lu, Yu, Shandong, Xu, Wilson, Overton, James L, Chiamvimonvat, Nipavan, and Thai, Phung N

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Hypertension, Coronaviruses, Emerging Infectious Diseases, Infectious Diseases, Good Health and Well Being, Adrenergic beta-Antagonists, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, COVID-19, Calcium Channel Blockers, Case-Control Studies, Diuretics, Humans, SARS-CoV-2, COVID-19 Drug Treatment, Antihypertensive drugs, Meta-analysis, Severe acute respiratory syndrome, coronavirus 2, Severe acute respiratory syndrome coronavirus 2, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe association of antihypertensive drugs with the risk and severity of COVID-19 remains unknown.Methods and resultsWe systematically searched PubMed, MEDLINE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and medRxiv for publications before July 13, 2020. Cohort studies and case-control studies that contain information on the association of antihypertensive agents including angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium-channel blockers (CCBs), β-blockers, and diuretics with the risk and severity of COVID-19 were selected. The random or fixed-effects models were used to pool the odds ratio (OR) with 95% confidence interval (CI) for the outcomes. The literature search yielded 53 studies that satisfied our inclusion criteria, which comprised 39 cohort studies and 14 case-control studies. These studies included a total of 2,100,587 participants. We observed no association between prior usage of antihypertensive medications including ACEIs/ARBs, CCBs, β-blockers, or diuretics and the risk and severity of COVID-19. Additionally, when only hypertensive patients were included, the severity and mortality were lower with prior usage of ACEIs/ARBs (overall OR of 0.81, 95% CI 0.66-0.99, p < 0.05 and overall OR of 0.77, 95% CI 0.66-0.91, p < 0.01).ConclusionsTaken together, usage of antihypertensive drugs is not associated with the risk and severity of COVID-19. Based on the current available literature, it is not recommended to abstain from the usage of these drugs in COVID-19 patients.RegistrationThe meta-analysis was registered on OSF (https://osf.io/ynd5g).

Published
2021

2. Assessment of Chloroquine and Hydroxychloroquine Safety Profiles: A Systematic Review and Meta-Analysis

Author

Ren, Lu, Xu, Wilson, Overton, James L, Yu, Shandong, Chiamvimonvat, Nipavan, and Thai, Phung N

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Coronaviruses, Infectious Diseases, Emerging Infectious Diseases, Clinical Research, 6.1 Pharmaceuticals, Good Health and Well Being, chloroquine, hydroxychloroquine, safety profiles, meta-analysis, adverse events, Pharmacology and Pharmaceutical Sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundChloroquine (CQ) and its derivative hydroxychloroquine (HCQ) have recently emerged as potential antiviral and immunomodulatory options for the treatment of 2019 coronavirus disease (COVID-19). To examine the safety profiles of these medications, we systematically evaluated the adverse events (AEs) of these medications from published randomized controlled trials (RCTs).MethodsWe systematically searched MEDLINE, the Cochrane library, the Cochrane Central Register of Controlled Trials (CENTRAL), and the ClinicalTrials.gov for all the RCTs comparing CQ or HCQ with placebo or other active agents, published before June 20, 2020. The random-effects or fixed-effects models were used to pool the risk estimates relative ratio (RR) with 95% confidence interval (CI) for the outcomes.ResultsThe literature search yielded 23 and 19 studies for CQ and HCQ, respectively, that satisfied our inclusion criteria. Of these studies, we performed meta-analysis on 6 studies for CQ and 18 studies for HCQ. We did not limit our analysis to published records involving viral treatment alone; data also included the usage of either CQ or HCQ for the treatment of other diseases. The trials for the CQ consisted of a total of 2,137 participants (n = 1,077 CQ, n = 1,060 placebo), while the trials for HCQ involved 2,675 participants (n = 1,345 HCQ and n = 1,330 control). The overall mild and total AEs were significantly higher in CQ-treated non-COVID-19 patients, HCQ-treated non-COVID-19 patients, and HCQ-treated COVID-19 patients. The AEs were further categorized into four groups and analyses revealed that neurologic, gastrointestinal (GI), dermatologic, and sensory AEs were higher in participants taking CQ compared to placebo, while GI, dermatologic, sensory, and cardiovascular AEs were higher in HCQ-treated COVID-19 patients compared to control patients. Moreover, subgroup analysis suggested higher AEs with respect to dosage and duration in HCQ group. Data were acquired from studies with perceived low risk of bias, so plausible bias is unlikely to seriously affect the main findings of the current study.ConclusionsTaken together, we found that participants taking either CQ or HCQ exhibited more AEs than participants taking placebo or control. Precautionary measures should be taken when using these drugs to treat COVID-19. The meta-analysis was registered on OSF (https://osf.io/jm3d9).RegistrationThe meta-analysis was registered on OSF (https://osf.io/jm3d9).

Published
2020

10. Mean Platelet Volume to Platelet Count Ratio Predicts Left Atrial Stasis in Patients with Non-Valvular Atrial Fibrillation

Author

Liu,Xiaoyan, Yu,Shandong, Liang,Tuo, Chen,Lizhu, Zhang,Heping, Liu,Xiaoyan, Yu,Shandong, Liang,Tuo, Chen,Lizhu, and Zhang,Heping

Abstract

Xiaoyan Liu, Shandong Yu, Tuo Liang, Lizhu Chen, Heping Zhang Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Heping Zhang, Department of Cardiology, Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, Beijing, 100050, People’s Republic of China, Tel +86-10-63138344, Email zhp672003@163.comBackground: The mean platelet volume to platelet count ratio (MPV/PC) has been investigated in the diagnosis, prognosis and risk stratification in several diseases. However, the predictive role of MPV/PC in left atrial stasis (LAS) of non-valvular atrial fibrillation (NVAF) patients remains unknown.Methods: A total of 217 consecutive NVAF patients undergoing transesophageal echocardiogram (TEE) evaluation were retrospectively enrolled. The demographic, clinical, admission laboratory and TEE data were extracted and analyzed. Patients were categorized into those with or without LAS. The associations between the MPV/PC ratio and LAS were assessed by multivariate logistic regression analysis.Results: There were 24.9% (n = 54) patients with LAS according to TEE. Compared with patients without LAS, the MPV/PC ratio was significantly higher in those with LAS (5.6± 1.6 vs 4.8± 1.0, P < 0.001). After multivariable adjustment, higher MPV/PC ratio levels (OR 1.747, 95% CI 1.193– 2.559, P = 0.004) were positively associated with LAS, with the optimal cut-point for LAS prediction of 5.36 (area under the curve, AUC = 0.683, sensitivity 48%, specificity 73%, 95% CI 0.589– 0.777, P < 0.001). The stratification analysis showed that a significant positive correlation between MPV/PC ratio ≥ 5.36 and LAS in patients of male, younger (< 65 years), paroxysmal AF, without history of stroke/TIA, CHA2DS2-VASc score ≥ 2, left atrial diame

Published
2023

12. Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation.

Author

Liu, Xiaoyan, Ren, Lu, Yu, Shandong, Li, Gang, He, Pengkang, Yang, Qiaomei, Wei, Xiaohong, Thai, Phung N., Wu, Lin, and Huo, Yong

Subjects
ATRIAL fibrillation, PROTEIN kinases, SODIUM channels, ATRIAL arrhythmias, PHYSIOLOGY, CALMODULIN, ACTION potentials
Abstract

Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late INa) and Ca2+/calmodulin-dependent protein kinase (CaMKII)-mediated arrhythmogenic activities in β-adrenergic overactivation-associated AF. Monophasic action potential, conduction properties, protein phosphorylation, ion currents and cellular trigger activities were measured from rabbit-isolated hearts, atrial tissue and atrial myocytes, respectively. Isoproterenol (ISO, 1–15 nM) increased atrial conduction inhomogeneity index, phospho-Nav1.5 and phospho-CaMKII protein levels and late INa by 108%, 65%, 135% and 87%, respectively, and induced triggered activities and episodes of AF in all hearts studied (p < 0.05). Sea anemone toxin II (ATX-II, 2 nM) was insufficient to induce any atrial arrhythmias, whereas the propensities of AF were greater in hearts treated with a combination of ATX-II and ISO. Ranolazine, eleclazine and KN-93 abolished ISO-induced AF, attenuated the phosphorylation of Nav1.5 and CaMKII, and reversed the increase of late INa (p < 0.05) in a synergistic mode. Overall, late INa in association with the activation of CaMKII potentiates β-adrenergic stimulation-induced AF and the inhibition of both late INa and CaMKII exerted synergistic anti-arrhythmic effects to suppress atrial arrhythmic activities associated with catecholaminergic activation. This article is part of the theme issue 'The heartbeat: its molecular basis and physiological mechanisms'. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Study of $J/ψ\to p\bar{p}$ and $J/ψ\to n\bar{n}$

Author

BESIII Collaboration, M. Ablikim(Institute of High Energy Physics, Beijing, P. R. China), M. N. Achasov(G.I. Budker Institute of Nuclear Physics SB RAS), D. J. Ambrose(University of Rochester, Rochester, New York, USA), F. F. An(Institute of High Energy Physics, Beijing, P. R. China), Q. An(University of Science and Technology of China, Hefei, P. R. China), Z. H. An(Institute of High Energy Physics, Beijing, P. R. China), J. Z. Bai(Institute of High Energy Physics, Beijing, P. R. China), R. B. Ferroli(INFN Laboratori Nazionali di Frascati, Frascati, Italy), Y. Ban(Peking University, Beijing, P. R. China), J. Becker(Bochum Ruhr-University, Bochum, Germany), N. Berger(Institute of High Energy Physics, Beijing, P. R. China), M. B. Bertani(INFN Laboratori Nazionali di Frascati, Frascati, Italy), J. M. Bian(University of Minnesota, Minneapolis, MN, USA), E. Boger(20, a), O. Bondarenko(KVI/University of Groningen, Groningen, The Netherlands), I. Boyko(Joint Institute for Nuclear Research, Dubna, Russia), R. A. Briere(Carnegie Mellon University, Pittsburgh, PA, USA), V. Bytev(Joint Institute for Nuclear Research, Dubna, Russia), X. Cai(Institute of High Energy Physics, Beijing, P. R. China), A. C. Calcaterra(INFN Laboratori Nazionali di Frascati, Frascati, Italy), G. F. Cao(Institute of High Energy Physics, Beijing, P. R. China), J. F. Chang(Institute of High Energy Physics, Beijing, P. R. China), G. Chelkov(20, a), G. Chen(Institute of High Energy Physics, Beijing, P. R. China), H. S. Chen(Institute of High Energy Physics, Beijing, P. R. China), J. C. Chen(Institute of High Energy Physics, Beijing, P. R. China), M. L. Chen(Institute of High Energy Physics, Beijing, P. R. China), S. J. Chen(Nanjing University, Nanjing, P. R. China), Y. Chen(Institute of High Energy Physics, Beijing, P. R. China), Y. B. Chen(Institute of High Energy Physics, Beijing, P. R. China), H. P. Cheng(Huangshan College, Huangshan, P. R. China), Y. P. Chu(Institute of High Energy Physics, Beijing, P. R. China), D. Cronin-Hennessy(University of Minnesota, Minneapolis, MN, USA), H. L. Dai(Institute of High Energy Physics, Beijing, P. R. China), J. P. Dai(Institute of High Energy Physics, Beijing, P. R. China), D. Dedovich(Joint Institute for Nuclear Research, Dubna, Russia), Z. Y. Deng(Institute of High Energy Physics, Beijing, P. R. China), A. Denig(Johannes Gutenberg University of Mainz, Mainz, Germany), I. Denysenko(20, b), M. Destefanis(University of Turin and INFN, Turin, Italy), W. M. Ding(Shandong University, Jinan, P. R. China), Y. Ding(Liaoning University, Shenyang, P. R. China), L. Y. Dong(Institute of High Energy Physics, Beijing, P. R. China), M. Y. Dong(Institute of High Energy Physics, Beijing, P. R. China), S. X. Du(Zhengzhou University, Zhengzhou, P. R. China), J. Fang(Institute of High Energy Physics, Beijing, P. R. China), S. S. Fang(Institute of High Energy Physics, Beijing, P. R. China), L. Fava(44, c), F. Feldbauer(Bochum Ruhr-University, Bochum, Germany), C. Q. Feng(University of Science and Technology of China, Hefei, P. R. China), C. D. Fu(Institute of High Energy Physics, Beijing, P. R. China), J. L. Fu(Nanjing University, Nanjing, P. R. China), Y. Gao(Tsinghua University, Beijing, P. R. China), C. Geng(University of Science and Technology of China, Hefei, P. R. China), K. Goetzen(GSI Helmholtzcentre for Heavy Ion Research GmbH, Darmstadt, Germany), W. X. Gong(Institute of High Energy Physics, Beijing, P. R. China), W. Gradl(Johannes Gutenberg University of Mainz, Mainz, Germany), M. Greco(University of Turin and INFN, Turin, Italy), M. H. Gu(Institute of High Energy Physics, Beijing, P. R. China), Y. T. Gu(GuangXi University, Nanning, P.R.China), Y. H. Guan(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), A. Q. Guo(Nankai University, Tianjin, P. R. China), L. B. Guo(Nanjing Normal University, Nanjing, P. R. China), Y. P. Guo(Nankai University, Tianjin, P. R. China), Y. L. Han(Institute of High Energy Physics, Beijing, P. R. China), X. Q. Hao(Institute of High Energy Physics, Beijing, P. R. China), F. A. Harris(University of Hawaii, Honolulu, Hawaii, USA), K. L. He(Institute of High Energy Physics, Beijing, P. R. China), M. He(Institute of High Energy Physics, Beijing, P. R. China), Z. Y. He(Nankai University, Tianjin, P. R. China), T. Held(Bochum Ruhr-University, Bochum, Germany), Y. K. Heng(Institute of High Energy Physics, Beijing, P. R. China), Z. L. Hou(Institute of High Energy Physics, Beijing, P. R. China), H. M. Hu(Institute of High Energy Physics, Beijing, P. R. China), J. F. Hu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), T. Hu(Institute of High Energy Physics, Beijing, P. R. China), B. Huang(Institute of High Energy Physics, Beijing, P. R. China), G. M. Huang(Huazhong Normal University, Wuhan, P. R. China), J. S. Huang(Henan Normal University, Xinxiang, P. R. China), X. T. Huang(Shandong University, Jinan, P. R. China), Y. P. Huang(Institute of High Energy Physics, Beijing, P. R. China), T. Hussain(University of the Punjab, Lahore, Pakistan), C. S. Ji(University of Science and Technology of China, Hefei, P. R. China), Q. Ji(Institute of High Energy Physics, Beijing, P. R. China), X. B. Ji(Institute of High Energy Physics, Beijing, P. R. China), X. L. Ji(Institute of High Energy Physics, Beijing, P. R. China), L. K. Jia(Institute of High Energy Physics, Beijing, P. R. China), L. L. Jiang(Institute of High Energy Physics, Beijing, P. R. China), X. S. Jiang(Institute of High Energy Physics, Beijing, P. R. China), J. B. Jiao(Shandong University, Jinan, P. R. China), Z. Jiao(Huangshan College, Huangshan, P. R. China), D. P. Jin(Institute of High Energy Physics, Beijing, P. R. China), S. Jin(Institute of High Energy Physics, Beijing, P. R. China), F. F. Jing(Tsinghua University, Beijing, P. R. China), N. Kalantar-Nayestanaki(KVI/University of Groningen, Groningen, The Netherlands), M. Kavatsyuk(KVI/University of Groningen, Groningen, The Netherlands), W. Kuehn(Universitaet Giessen, Giessen, Germany), W. Lai(Institute of High Energy Physics, Beijing, P. R. China), J. S. Lange(Universitaet Giessen, Giessen, Germany), J. K. C. Leung(The University of Hong Kong, Pokfulam, Hong Kong), C. H. Li(Institute of High Energy Physics, Beijing, P. R. China), Cheng Li(University of Science and Technology of China, Hefei, P. R. China), Cui Li(University of Science and Technology of China, Hefei, P. R. China), D. M. Li(Zhengzhou University, Zhengzhou, P. R. China), F. Li(Institute of High Energy Physics, Beijing, P. R. China), G. Li(Institute of High Energy Physics, Beijing, P. R. China), H. B. Li(Institute of High Energy Physics, Beijing, P. R. China), J. C. Li(Institute of High Energy Physics, Beijing, P. R. China), K. Li(Hangzhou Normal University, Hangzhou, P. R. China), Lei Li(Institute of High Energy Physics, Beijing, P. R. China), N. B. Li(Nanjing Normal University, Nanjing, P. R. China), Q. J. Li(Institute of High Energy Physics, Beijing, P. R. China), S. L. Li(Institute of High Energy Physics, Beijing, P. R. China), W. D. Li(Institute of High Energy Physics, Beijing, P. R. China), W. G. Li(Institute of High Energy Physics, Beijing, P. R. China), X. L. Li(Shandong University, Jinan, P. R. China), X. N. Li(Institute of High Energy Physics, Beijing, P. R. China), X. Q. Li(Nankai University, Tianjin, P. R. China), X. R. Li(Seoul National University, Seoul, Korea), Z. B. Li(Sun Yat-Sen University, Guangzhou, P. R. China), H. Liang(University of Science and Technology of China, Hefei, P. R. China), Y. F. Liang(Sichuan University, Chengdu, P. R. China), Y. T. Liang(Universitaet Giessen, Giessen, Germany), G. R. Liao(Tsinghua University, Beijing, P. R. China), X. T. Liao(Institute of High Energy Physics, Beijing, P. R. China), B. J. Liu(Institute of High Energy Physics, Beijing, P. R. China), C. L. Liu(Carnegie Mellon University, Pittsburgh, PA, USA), C. X. Liu(Institute of High Energy Physics, Beijing, P. R. China), C. Y. Liu(Institute of High Energy Physics, Beijing, P. R. China), F. H. Liu(Shanxi University, Taiyuan, P. R. China), Fang Liu(Institute of High Energy Physics, Beijing, P. R. China), Feng Liu(Huazhong Normal University, Wuhan, P. R. China), H. Liu(Shanxi University, Taiyuan, P. R. China), H. B. Liu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), H. H. Liu(Henan University of Science and Technology, Luoyang, P. R. China), H. M. Liu(Institute of High Energy Physics, Beijing, P. R. China), H. W. Liu(Institute of High Energy Physics, Beijing, P. R. China), J. P. Liu(Wuhan University, Wuhan, P. R. China), Kun Liu(Peking University, Beijing, P. R. China), Kai Liu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), K. Y. Liu(Liaoning University, Shenyang, P. R. China), P. L. Liu(Shandong University, Jinan, P. R. China), S. B. Liu(University of Science and Technology of China, Hefei, P. R. China), X. Liu(Institute of High Energy Physics, Beijing, P. R. China), X. H. Liu(Institute of High Energy Physics, Beijing, P. R. China), Y. B. Liu(Nankai University, Tianjin, P. R. China), Y. Liu(Institute of High Energy Physics, Beijing, P. R. China), Z. A. Liu(Institute of High Energy Physics, Beijing, P. R. China), Zhiqiang Liu(Institute of High Energy Physics, Beijing, P. R. China), Zhiqing Liu(Institute of High Energy Physics, Beijing, P. R. China), H. Loehner(KVI/University of Groningen, Groningen, The Netherlands), G. R. Lu(Henan Normal University, Xinxiang, P. R. China), H. J. Lu(Huangshan College, Huangshan, P. R. China), J. G. Lu(Institute of High Energy Physics, Beijing, P. R. China), Q. W. Lu(Shanxi University, Taiyuan, P. R. China), X. R. Lu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), Y. P. Lu(Institute of High Energy Physics, Beijing, P. R. China), C. L. Luo(Nanjing Normal University, Nanjing, P. R. China), M. X. Luo(Zhejiang University, Hangzhou, P. R. China), T. Luo(University of Hawaii, Honolulu, Hawaii, USA), X. L. Luo(Institute of High Energy Physics, Beijing, P. R. China), M. Lv(Institute of High Energy Physics, Beijing, P. R. China), C. L. Ma(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), F. C. Ma(Liaoning University, Shenyang, P. R. China), H. L. Ma(Institute of High Energy Physics, Beijing, P. R. China), Q. M. Ma(Institute of High Energy Physics, Beijing, P. R. China), S. Ma(Institute of High Energy Physics, Beijing, P. R. China), T. Ma(Institute of High Energy Physics, Beijing, P. R. China), X. Y. Ma(Institute of High Energy Physics, Beijing, P. R. China), Y. Ma(Institute of High Energy Physics, Beijing, P. R. China), F. E. Maas(Helmholtz Institute Mainz, Mainz, Germany), M. Maggiora(University of Turin and INFN, Turin, Italy), Q. A. Malik(University of the Punjab, Lahore, Pakistan), H. Mao(Institute of High Energy Physics, Beijing, P. R. China), Y. J. Mao(Peking University, Beijing, P. R. China), Z. P. Mao(Institute of High Energy Physics, Beijing, P. R. China), J. G. Messchendorp(KVI/University of Groningen, Groningen, The Netherlands), J. Min(Institute of High Energy Physics, Beijing, P. R. China), T. J. Min(Institute of High Energy Physics, Beijing, P. R. China), R. E. Mitchell(Indiana University, Bloomington, Indiana, USA), X. H. Mo(Institute of High Energy Physics, Beijing, P. R. China), C. Morales Morales(Helmholtz Institute Mainz, Mainz, Germany), C. Motzko(Bochum Ruhr-University, Bochum, Germany), N. Yu. Muchnoi(G.I. Budker Institute of Nuclear Physics SB RAS), Y. Nefedov(Joint Institute for Nuclear Research, Dubna, Russia), C. Nicholson(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), I. B. Nikolaev(G.I. Budker Institute of Nuclear Physics SB RAS), Z. Ning(Institute of High Energy Physics, Beijing, P. R. China), S. L. Olsen(Seoul National University, Seoul, Korea), Q. Ouyang(Institute of High Energy Physics, Beijing, P. R. China), S. P. Pacetti(18, d), J. W. Park(Seoul National University, Seoul, Korea), M. Pelizaeus(University of Hawaii, Honolulu, Hawaii, USA), K. Peters(GSI Helmholtzcentre for Heavy Ion Research GmbH, Darmstadt, Germany), J. L. Ping(Nanjing Normal University, Nanjing, P. R. China), R. G. Ping(Institute of High Energy Physics, Beijing, P. R. China), R. Poling(University of Minnesota, Minneapolis, MN, USA), E. Prencipe(Johannes Gutenberg University of Mainz, Mainz, Germany), C. S. J. Pun(The University of Hong Kong, Pokfulam, Hong Kong), M. Qi(Nanjing University, Nanjing, P. R. China), S. Qian(Institute of High Energy Physics, Beijing, P. R. China), C. F. Qiao(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), X. S. Qin(Institute of High Energy Physics, Beijing, P. R. China), Y. Qin(Peking University, Beijing, P. R. China), Z. H. Qin(Institute of High Energy Physics, Beijing, P. R. China), J. F. Qiu(Institute of High Energy Physics, Beijing, P. R. China), K. H. Rashid(University of the Punjab, Lahore, Pakistan), G. Rong(Institute of High Energy Physics, Beijing, P. R. China), X. D. Ruan(GuangXi University, Nanning, P.R.China), A. Sarantsev(20, e), J. Schulze(Bochum Ruhr-University, Bochum, Germany), M. Shao(University of Science and Technology of China, Hefei, P. R. China), C. P. Shen(38, f), X. Y. Shen(Institute of High Energy Physics, Beijing, P. R. China), H. Y. Sheng(Institute of High Energy Physics, Beijing, P. R. China), M. R. Shepherd(Indiana University, Bloomington, Indiana, USA), X. Y. Song(Institute of High Energy Physics, Beijing, P. R. China), S. Spataro(University of Turin and INFN, Turin, Italy), B. Spruck(Universitaet Giessen, Giessen, Germany), D. H. Sun(Institute of High Energy Physics, Beijing, P. R. China), G. X. Sun(Institute of High Energy Physics, Beijing, P. R. China), J. F. Sun(Henan Normal University, Xinxiang, P. R. China), S. S. Sun(Institute of High Energy Physics, Beijing, P. R. China), X. D. Sun(Institute of High Energy Physics, Beijing, P. R. China), Y. J. Sun(University of Science and Technology of China, Hefei, P. R. China), Y. Z. Sun(Institute of High Energy Physics, Beijing, P. R. China), Z. J. Sun(Institute of High Energy Physics, Beijing, P. R. China), Z. T. Sun(University of Science and Technology of China, Hefei, P. R. China), C. J. Tang(Sichuan University, Chengdu, P. R. China), X. Tang(Institute of High Energy Physics, Beijing, P. R. China), E. H. Thorndike(University of Rochester, Rochester, New York, USA), H. L. Tian(Institute of High Energy Physics, Beijing, P. R. China), D. Toth(University of Minnesota, Minneapolis, MN, USA), M. U. Ulrich(Universitaet Giessen, Giessen, Germany), G. S. Varner(University of Hawaii, Honolulu, Hawaii, USA), B. Wang(GuangXi University, Nanning, P.R.China), B. Q. Wang(Peking University, Beijing, P. R. China), K. Wang(Institute of High Energy Physics, Beijing, P. R. China), L. L. Wang(China Center of Advanced Science and Technology, Beijing, P. R. China), L. S. Wang(Institute of High Energy Physics, Beijing, P. R. China), M. Wang(Shandong University, Jinan, P. R. China), P. Wang(Institute of High Energy Physics, Beijing, P. R. China), P. L. Wang(Institute of High Energy Physics, Beijing, P. R. China), Q. Wang(Peking University, Beijing, P. R. China), Q. J. Wang(Institute of High Energy Physics, Beijing, P. R. China), S. G. Wang(Peking University, Beijing, P. R. China), X. F. Wang(Henan Normal University, Xinxiang, P. R. China), X. L. Wang(University of Science and Technology of China, Hefei, P. R. China), Y. D. Wang(University of Science and Technology of China, Hefei, P. R. China), Y. F. Wang(Institute of High Energy Physics, Beijing, P. R. China), Y. Q. Wang(Shandong University, Jinan, P. R. China), Z. Wang(Institute of High Energy Physics, Beijing, P. R. China), Z. G. Wang(Institute of High Energy Physics, Beijing, P. R. China), Z. Y. Wang(Institute of High Energy Physics, Beijing, P. R. China), D. H. Wei(Guangxi Normal University, Guilin, P. R. China), P. Weidenkaff(Johannes Gutenberg University of Mainz, Mainz, Germany), Q. G. Wen(University of Science and Technology of China, Hefei, P. R. China), S. P. Wen(Institute of High Energy Physics, Beijing, P. R. China), M. W. Werner(Universitaet Giessen, Giessen, Germany), U. Wiedner(Bochum Ruhr-University, Bochum, Germany), L. H. Wu(Institute of High Energy Physics, Beijing, P. R. China), N. Wu(Institute of High Energy Physics, Beijing, P. R. China), S. X. Wu(University of Science and Technology of China, Hefei, P. R. China), W. Wu(Nankai University, Tianjin, P. R. China), Z. Wu(Institute of High Energy Physics, Beijing, P. R. China), L. G. Xia(Tsinghua University, Beijing, P. R. China), Z. J. Xiao(Nanjing Normal University, Nanjing, P. R. China), Y. G. Xie(Institute of High Energy Physics, Beijing, P. R. China), Q. L. Xiu(Institute of High Energy Physics, Beijing, P. R. China), G. F. Xu(Institute of High Energy Physics, Beijing, P. R. China), G. M. Xu(Peking University, Beijing, P. R. China), H. Xu(Institute of High Energy Physics, Beijing, P. R. China), Q. J. Xu(Hangzhou Normal University, Hangzhou, P. R. China), X. P. Xu(Soochow University, Suzhou, China), Y. Xu(Nankai University, Tianjin, P. R. China), Z. R. Xu(University of Science and Technology of China, Hefei, P. R. China), F. Xue(Huazhong Normal University, Wuhan, P. R. China), Z. Xue(Institute of High Energy Physics, Beijing, P. R. China), L. Yan(University of Science and Technology of China, Hefei, P. R. China), W. B. Yan(University of Science and Technology of China, Hefei, P. R. China), Y. H. Yan(Hunan University, Changsha, P. R. China), H. X. Yang(Institute of High Energy Physics, Beijing, P. R. China), T. Yang(GuangXi University, Nanning, P.R.China), Y. Yang(Huazhong Normal University, Wuhan, P. R. China), Y. X. Yang(Guangxi Normal University, Guilin, P. R. China), H. Ye(Institute of High Energy Physics, Beijing, P. R. China), M. Ye(Institute of High Energy Physics, Beijing, P. R. China), M. H. Ye(China Center of Advanced Science and Technology, Beijing, P. R. China), B. X. Yu(Institute of High Energy Physics, Beijing, P. R. China), C. X. Yu(Nankai University, Tianjin, P. R. China), J. S. Yu(Lanzhou University, Lanzhou, P. R. China), S. P. Yu(Shandong University, Jinan, P. R. China), C. Z. Yuan(Institute of High Energy Physics, Beijing, P. R. China), W. L. Yuan(Nanjing Normal University, Nanjing, P. R. China), Y. Yuan(Institute of High Energy Physics, Beijing, P. R. China), A. A. Zafar(University of the Punjab, Lahore, Pakistan), A. Z. Zallo(INFN Laboratori Nazionali di Frascati, Frascati, Italy), Y. Zeng(Hunan University, Changsha, P. R. China), B. X. Zhang(Institute of High Energy Physics, Beijing, P. R. China), B. Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), C. C. Zhang(Institute of High Energy Physics, Beijing, P. R. China), D. H. Zhang(Institute of High Energy Physics, Beijing, P. R. China), H. H. Zhang(Sun Yat-Sen University, Guangzhou, P. R. China), H. Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. Zhang(Nanjing Normal University, Nanjing, P. R. China), J. G. Zhang(Henan Normal University, Xinxiang, P. R. China), J. Q. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. W. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. Z. Zhang(Institute of High Energy Physics, Beijing, P. R. China), L. Zhang(Nanjing University, Nanjing, P. R. China), S. H. Zhang(Institute of High Energy Physics, Beijing, P. R. China), T. R. Zhang(Nanjing Normal University, Nanjing, P. R. China), X. J. Zhang(Institute of High Energy Physics, Beijing, P. R. China), X. Y. Zhang(Shandong University, Jinan, P. R. China), Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), Y. H. Zhang(Institute of High Energy Physics, Beijing, P. R. China), Y. S. Zhang(GuangXi University, Nanning, P.R.China), Z. P. Zhang(University of Science and Technology of China, Hefei, P. R. China), Z. Y. Zhang(Wuhan University, Wuhan, P. R. China), G. Zhao(Institute of High Energy Physics, Beijing, P. R. China), H. S. Zhao(Institute of High Energy Physics, Beijing, P. R. China), J. W. Zhao(Institute of High Energy Physics, Beijing, P. R. China), K. X. Zhao(Nanjing Normal University, Nanjing, P. R. China), Lei Zhao(University of Science and Technology of China, Hefei, P. R. China), Ling Zhao(Institute of High Energy Physics, Beijing, P. R. China), M. G. Zhao(Nankai University, Tianjin, P. R. China), Q. Zhao(Institute of High Energy Physics, Beijing, P. R. China), S. J. Zhao(Zhengzhou University, Zhengzhou, P. R. China), T. C. Zhao(Institute of High Energy Physics, Beijing, P. R. China), X. H. Zhao(Nanjing University, Nanjing, P. R. China), Y. B. Zhao(Institute of High Energy Physics, Beijing, P. R. China), Z. G. Zhao(University of Science and Technology of China, Hefei, P. R. China), A. Zhemchugov(20, a), B. Zheng(University of South China, Hengyang, P. R. China), J. P. Zheng(Institute of High Energy Physics, Beijing, P. R. China), Y. H. Zheng(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), Z. P. Zheng(Institute of High Energy Physics, Beijing, P. R. China), B. Zhong(Institute of High Energy Physics, Beijing, P. R. China), J. Zhong(Bochum Ruhr-University, Bochum, Germany), L. Zhou(Institute of High Energy Physics, Beijing, P. R. China), X. K. Zhou(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), X. R. Zhou(University of Science and Technology of China, Hefei, P. R. China), C. Zhu(Institute of High Energy Physics, Beijing, P. R. China), K. Zhu(Institute of High Energy Physics, Beijing, P. R. China), K. J. Zhu(Institute of High Energy Physics, Beijing, P. R. China), S. H. Zhu(Institute of High Energy Physics, Beijing, P. R. China), X. L. Zhu(Tsinghua University, Beijing, P. R. China), X. W. Zhu(Institute of High Energy Physics, Beijing, P. R. China), Y. M. Zhu(Nankai University, Tianjin, P. R. China), Y. S. Zhu(Institute of High Energy Physics, Beijing, P. R. China), Z. A. Zhu(Institute of High Energy Physics, Beijing, P. R. China), J. Zhuang(Institute of High Energy Physics, Beijing, P. R. China), B. S. Zou(Institute of High Energy Physics, Beijing, P. R. China), J. H. Zou(Institute of High Energy Physics, Beijing, P. R. China), and J. X. Zuo(Institute of High Energy Physics, Beijing, P. R. China)

Subjects
hep-ex, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

The decays $J/\psi\to p\bar{p}$ and $J/\psi\to n\bar{n}$ have been investigated with a sample of 225.2 million $J/\psi$ events collected with the BESIII detector at the BEPCII $e^+e^-$ collider. The branching fractions are determined to be $\mathcal{B}(J/\psi\to p\bar{p})=(2.112\pm0.004\pm0.031)\times10^{-3}$ and $\mathcal{B}(J/\psi\to n\bar{n})=(2.07\pm0.01\pm0.17)\times10^{-3}$. Distributions of the angle $\theta$ between the proton or anti-neutron and the beam direction are well described by the form $1+\alpha\cos^2\theta$, and we find $\alpha=0.595\pm0.012\pm0.015$ for $J/\psi\to p\bar{p}$ and $\alpha=0.50\pm0.04\pm0.21$ for $J/\psi\to n\bar{n}$. Our branching-fraction results suggest a large phase angle between the strong and electromagnetic amplitudes describing the $J/\psi\to N\bar{N}$ decay.

Published
2015

23. Observation of Electromagnetic Dalitz decays J/ψ\to P e^+e^

Author

M. AblikimInstitute of High Energy Physics, M. N. Achasov(8, a), X. C. Ai(Institute of High Energy Physics), O. Albayrak(Carnegie Mellon University), M. Albrecht(, Bochum Ruhr-University, Germany), D. J. Ambrose(University of Rochester), F. F. An(Institute of High Energy Physics), Q. An(University of Science and Technology of China), J. Z. Bai(Institute of High Energy Physics), R. Baldini Ferroli(19A), Y. Ban(Peking University), J. V. Bennett(Indiana University), M. Bertani(19A), J. M. Bian(University of Minnesota), E. Boger(21, b), O. Bondarenko(KVI, University of Groningen), I. Boyko(Joint Institute for Nuclear Research), S. Braun(Universitaet Giessen), R. A. Briere(Carnegie Mellon University), H. Cai(Wuhan University), X. Cai(Institute of High Energy Physics), O. Cakir(36A), A. Calcaterra(19A), G. F. Cao(Institute of High Energy Physics), S. A. Cetin(36B), J. F. Chang(Institute of High Energy Physics), G. Chelkov(21, b), G. Chen(Institute of High Energy Physics), H. S. Chen(Institute of High Energy Physics), J. C. Chen(Institute of High Energy Physics), M. L. Chen(Institute of High Energy Physics), S. J. Chen(Nanjing University), X. Chen(Institute of High Energy Physics), X. R. Chen(Lanzhou University), Y. B. Chen(Institute of High Energy Physics), H. P. Cheng(Huangshan College), X. K. Chu(Peking University), Y. P. Chu(Institute of High Energy Physics), D. Cronin-Hennessy(University of Minnesota), H. L. Dai(Institute of High Energy Physics), J. P. Dai(Institute of High Energy Physics), D. Dedovich(Joint Institute for Nuclear Research), Z. Y. Deng(Institute of High Energy Physics), A. Denig(Johannes Gutenberg University of Mainz), I. Denysenko(Joint Institute for Nuclear Research), M. Destefanis(45A,45C), W. M. Ding(Shandong University), Y. Ding(Liaoning University), C. Dong(Nankai university), J. Dong(Institute of High Energy Physics), L. Y. Dong(Institute of High Energy Physics), M. Y. Dong(Institute of High Energy Physics), S. X. Du(Zhengzhou University), J. Z. Fan(Tsinghua University), J. Fang(Institute of High Energy Physics), S. S. Fang(Institute of High Energy Physics), Y. Fang(Institute of High Energy Physics), L. Fava(45B,45C), C. Q. Feng(University of Science and Technology of China), C. D. Fu(Institute of High Energy Physics), J. L. Fu(Nanjing University), O. Fuks(21, b), Q. Gao(Institute of High Energy Physics), Y. Gao(Tsinghua University), C. Geng(University of Science and Technology of China), K. Goetzen(GSI Helmholtzcentre for Heavy Ion Research GmbH), W. X. Gong(Institute of High Energy Physics), W. Gradl(Johannes Gutenberg University of Mainz), M. Greco(45A,45C), M. H. Gu(Institute of High Energy Physics), Y. T. Gu(GuangXi University), Y. H. Guan(Institute of High Energy Physics), A. Q. Guo(Nankai university), L. B. Guo(Nanjing Normal University), T. Guo(Nanjing Normal University), Y. P. Guo(Johannes Gutenberg University of Mainz), Y. L. Han(Institute of High Energy Physics), F. A. Harris(University of Hawaii), K. L. He(Institute of High Energy Physics), M. He(Institute of High Energy Physics), Z. Y. He(Nankai university), T. Held(, Bochum Ruhr-University, Germany), Y. K. Heng(Institute of High Energy Physics), Z. L. Hou(Institute of High Energy Physics), C. Hu(Nanjing Normal University), H. M. Hu(Institute of High Energy Physics), J. F. Hu(Universitaet Giessen), T. Hu(Institute of High Energy Physics), G. M. Huang(Central China Normal University), G. S. Huang(University of Science and Technology of China), H. P. Huang(Wuhan University), J. S. Huang(Henan Normal University), L. Huang(Institute of High Energy Physics), X. T. Huang(Shandong University), Y. Huang(Nanjing University), T. Hussain(University of the Punjab), C. S. Ji(University of Science and Technology of China), Q. Ji(Institute of High Energy Physics), Q. P. Ji(Nankai university), X. B. Ji(Institute of High Energy Physics), X. L. Ji(Institute of High Energy Physics), L. L. Jiang(Institute of High Energy Physics), L. W. Jiang(Wuhan University), X. S. Jiang(Institute of High Energy Physics), J. B. Jiao(Shandong University), Z. Jiao(Huangshan College), D. P. Jin(Institute of High Energy Physics), S. Jin(Institute of High Energy Physics), T. Johansson(Uppsala University), N. Kalantar-Nayestanaki(KVI, University of Groningen), X. L. Kang(Institute of High Energy Physics), X. S. Kang(Nankai university), M. Kavatsyuk(KVI, University of Groningen), B. Kloss(Johannes Gutenberg University of Mainz), B. Kopf(, Bochum Ruhr-University, Germany), M. Kornicer(University of Hawaii), W. Kuehn(Universitaet Giessen), A. Kupsc(Uppsala University), W. Lai(Institute of High Energy Physics), J. S. Lange(Universitaet Giessen), M. Lara(Indiana University), P. Larin(Helmholtz Institute Mainz), M. Leyhe(, Bochum Ruhr-University, Germany), C. H. Li(Institute of High Energy Physics), Cheng Li(University of Science and Technology of China), Cui Li(University of Science and Technology of China), D. Li(Hunan University), D. M. Li(Zhengzhou University), F. Li(Institute of High Energy Physics), G. Li(Institute of High Energy Physics), H. B. Li(Institute of High Energy Physics), J. C. Li(Institute of High Energy Physics), K. Li(Shandong University), Lei Li(Institute of High Energy Physics), P. R. Li(University of Chinese Academy of Sciences), Q. J. Li(Institute of High Energy Physics), T. Li(Shandong University), W. D. Li(Institute of High Energy Physics), W. G. Li(Institute of High Energy Physics), X. L. Li(Shandong University), X. N. Li(Institute of High Energy Physics), X. Q. Li(Nankai university), Z. B. Li(Sun Yat-Sen University), H. Liang(University of Science and Technology of China), Y. F. Liang(Sichuan University), Y. T. Liang(Universitaet Giessen), D. X. Lin(Helmholtz Institute Mainz), B. J. Liu(Institute of High Energy Physics), C. L. Liu(Carnegie Mellon University), C. X. Liu(Institute of High Energy Physics), F. H. Liu(Shanxi University), Fang Liu(Institute of High Energy Physics), Feng Liu(Central China Normal University), H. B. Liu(GuangXi University), H. H. Liu(Henan University of Science and Technology), H. M. Liu(Institute of High Energy Physics), J. Liu(Institute of High Energy Physics), J. P. Liu(Wuhan University), K. Liu(Tsinghua University), K. Y. Liu(Liaoning University), P. L. Liu(Shandong University), Q. Liu(University of Chinese Academy of Sciences), S. B. Liu(University of Science and Technology of China), X. Liu(Institute of High Energy Physics), Y. B. Liu(Nankai university), Z. A. Liu(Institute of High Energy Physics), Zhiqiang Liu(Institute of High Energy Physics), Zhiqing Liu(Johannes Gutenberg University of Mainz), H. Loehner(KVI, University of Groningen), X. C. Lou(1, c), G. R. Lu(Henan Normal University), H. J. Lu(Huangshan College), H. L. Lu(Institute of High Energy Physics), J. G. Lu(Institute of High Energy Physics), X. R. Lu(University of Chinese Academy of Sciences), Y. Lu(Institute of High Energy Physics), Y. P. Lu(Institute of High Energy Physics), C. L. Luo(Nanjing Normal University), M. X. Luo(Zhejiang University), T. Luo(University of Hawaii), X. L. Luo(Institute of High Energy Physics), M. Lv(Institute of High Energy Physics), F. C. Ma(Liaoning University), H. L. Ma(Institute of High Energy Physics), Q. M. Ma(Institute of High Energy Physics), S. Ma(Institute of High Energy Physics), T. Ma(Institute of High Energy Physics), X. Y. Ma(Institute of High Energy Physics), F. E. Maas(Helmholtz Institute Mainz), M. Maggiora(45A,45C), Q. A. Malik(University of the Punjab), Y. J. Mao(Peking University), Z. P. Mao(Institute of High Energy Physics), J. G. Messchendorp(KVI, University of Groningen), J. Min(Institute of High Energy Physics), T. J. Min(Institute of High Energy Physics), R. E. Mitchell(Indiana University), X. H. Mo(Institute of High Energy Physics), Y. J. Mo(Central China Normal University), H. Moeini(KVI, University of Groningen), C. Morales Morales(Helmholtz Institute Mainz), K. Moriya(Indiana University), N. Yu. Muchnoi(8, a), H. Muramatsu(University of Minnesota), Y. Nefedov(Joint Institute for Nuclear Research), I. B. Nikolaev(8, a), Z. Ning(Institute of High Energy Physics), S. Nisar(COMSATS Institute of Information Technology), X. Y. Niu(Institute of High Energy Physics), S. L. Olsen(Seoul National University), Q. Ouyang(Institute of High Energy Physics), S. Pacetti(19B), M. Pelizaeus(, Bochum Ruhr-University, Germany), H. P. Peng(University of Science and Technology of China), K. Peters(GSI Helmholtzcentre for Heavy Ion Research GmbH), J. L. Ping(Nanjing Normal University), R. G. Ping(Institute of High Energy Physics), R. Poling(University of Minnesota), N. Q.(Wuhan University), M. Qi(Nanjing University), S. Qian(Institute of High Energy Physics), C. F. Qiao(University of Chinese Academy of Sciences), L. Q. Qin(Shandong University), X. S. Qin(Institute of High Energy Physics), Y. Qin(Peking University), Z. H. Qin(Institute of High Energy Physics), J. F. Qiu(Institute of High Energy Physics), K. H. Rashid(University of the Punjab), C. F. Redmer(Johannes Gutenberg University of Mainz), M. Ripka(Johannes Gutenberg University of Mainz), G. Rong(Institute of High Energy Physics), X. D. Ruan(GuangXi University), A. Sarantsev(21, d), K. Schoenning(Uppsala University), S. Schumann(Johannes Gutenberg University of Mainz), W. Shan(Peking University), M. Shao(University of Science and Technology of China), C. P. Shen(Beihang University), X. Y. Shen(Institute of High Energy Physics), H. Y. Sheng(Institute of High Energy Physics), M. R. Shepherd(Indiana University), W. M. Song(Institute of High Energy Physics), X. Y. Song(Institute of High Energy Physics), S. Spataro(45A,45C), B. Spruck(Universitaet Giessen), G. X. Sun(Institute of High Energy Physics), J. F. Sun(Henan Normal University), S. S. Sun(Institute of High Energy Physics), Y. J. Sun(University of Science and Technology of China), Y. Z. Sun(Institute of High Energy Physics), Z. J. Sun(Institute of High Energy Physics), Z. T. Sun(University of Science and Technology of China), C. J. Tang(Sichuan University), X. Tang(Institute of High Energy Physics), I. Tapan(36C), E. H. Thorndike(University of Rochester), D. Toth(University of Minnesota), M. Ullrich(Universitaet Giessen), I. Uman(36B), G. S. Varner(University of Hawaii), B. Wang(Nankai university), D. Wang(Peking University), D. Y. Wang(Peking University), K. Wang(Institute of High Energy Physics), L. L. Wang(Institute of High Energy Physics), L. S. Wang(Institute of High Energy Physics), M. Wang(Shandong University), P. Wang(Institute of High Energy Physics), P. L. Wang(Institute of High Energy Physics), Q. J. Wang(Institute of High Energy Physics), S. G. Wang(Peking University), W. Wang(Institute of High Energy Physics), X. F. Wang(Tsinghua University), Y. D. Wang(19A), Y. F. Wang(Institute of High Energy Physics), Y. Q. Wang(Johannes Gutenberg University of Mainz), Z. Wang(Institute of High Energy Physics), Z. G. Wang(Institute of High Energy Physics), Z. H. Wang(University of Science and Technology of China), Z. Y. Wang(Institute of High Energy Physics), D. H. Wei(Guangxi Normal University), J. B. Wei(Peking University), P. Weidenkaff(Johannes Gutenberg University of Mainz), S. P. Wen(Institute of High Energy Physics), M. Werner(Universitaet Giessen), U. Wiedner(, Bochum Ruhr-University, Germany), M. Wolke(Uppsala University), L. H. Wu(Institute of High Energy Physics), N. Wu(Institute of High Energy Physics), Z. Wu(Institute of High Energy Physics), L. G. Xia(Tsinghua University), Y. Xia(Hunan University), D. Xiao(Institute of High Energy Physics), Z. J. Xiao(Nanjing Normal University), Y. G. Xie(Institute of High Energy Physics), Q. L. Xiu(Institute of High Energy Physics), G. F. Xu(Institute of High Energy Physics), L. Xu(Institute of High Energy Physics), Q. J. Xu(Hangzhou Normal University), Q. N. Xu(University of Chinese Academy of Sciences), X. P. Xu(Soochow University), Z. Xue(Institute of High Energy Physics), L. Yan(University of Science and Technology of China), W. B. Yan(University of Science and Technology of China), W. C. Yan(University of Science and Technology of China), Y. H. Yan(Hunan University), H. X. Yang(Institute of High Energy Physics), L. Yang(Wuhan University), Y. Yang(Central China Normal University), Y. X. Yang(Guangxi Normal University), H. Ye(Institute of High Energy Physics), M. Ye(Institute of High Energy Physics), M. H. Ye(China Center of Advanced Science and Technology), B. X. Yu(Institute of High Energy Physics), C. X. Yu(Nankai university), H. W. Yu(Peking University), J. S. Yu(Lanzhou University), S. P. Yu(Shandong University), C. Z. Yuan(Institute of High Energy Physics), W. L. Yuan(Nanjing University), Y. Yuan(Institute of High Energy Physics), A. Yuncu(36B), A. A. Zafar(University of the Punjab), A. Zallo(19A), S. L. Zang(Nanjing University), Y. Zeng(Hunan University), B. X. Zhang(Institute of High Energy Physics), B. Y. Zhang(Institute of High Energy Physics), C. Zhang(Nanjing University), C. B. Zhang(Hunan University), C. C. Zhang(Institute of High Energy Physics), D. H. Zhang(Institute of High Energy Physics), H. H. Zhang(Sun Yat-Sen University), H. Y. Zhang(Institute of High Energy Physics), J. J. Zhang(Institute of High Energy Physics), J. Q. Zhang(Institute of High Energy Physics), J. W. Zhang(Institute of High Energy Physics), J. Y. Zhang(Institute of High Energy Physics), J. Z. Zhang(Institute of High Energy Physics), S. H. Zhang(Institute of High Energy Physics), X. J. Zhang(Institute of High Energy Physics), X. Y. Zhang(Shandong University), Y. Zhang(Institute of High Energy Physics), Y. H. Zhang(Institute of High Energy Physics), Z. H. Zhang(Central China Normal University), Z. P. Zhang(University of Science and Technology of China), Z. Y. Zhang(Wuhan University), G. Zhao(Institute of High Energy Physics), J. W. Zhao(Institute of High Energy Physics), Lei Zhao(University of Science and Technology of China), Ling Zhao(Institute of High Energy Physics), M. G. Zhao(Nankai university), Q. Zhao(Institute of High Energy Physics), Q. W. Zhao(Institute of High Energy Physics), S. J. Zhao(Zhengzhou University), T. C. Zhao(Institute of High Energy Physics), X. H. Zhao(Nanjing University), Y. B. Zhao(Institute of High Energy Physics), Z. G. Zhao(University of Science and Technology of China), A. Zhemchugov(21, b), B. Zheng(University of South China), J. P. Zheng(Institute of High Energy Physics), Y. H. Zheng(University of Chinese Academy of Sciences), B. Zhong(Nanjing Normal University), L. Zhou(Institute of High Energy Physics), Li Zhou(Nankai university), X. Zhou(Wuhan University), X. K. Zhou(University of Chinese Academy of Sciences), X. R. Zhou(University of Science and Technology of China), X. Y. Zhou(Institute of High Energy Physics), K. Zhu(Institute of High Energy Physics), K. J. Zhu(Institute of High Energy Physics), S. H. Zhu(Institute of High Energy Physics), X. L. Zhu(Tsinghua University), Y. C. Zhu(University of Science and Technology of China), Y. S. Zhu(Institute of High Energy Physics), Z. A. Zhu(Institute of High Energy Physics), J. Zhuang(Institute of High Energy Physics), B. S. Zou(Institute of High Energy Physics), and J. H. Zou(Institute of High Energy Physics)

Subjects
hep-ex, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment, Nuclear Experiment, Astrophysics::Galaxy Astrophysics
Abstract

Based on a sample of (225.3\pm2.8)\times 10^{6} J/\psi events collected with the BESIII detector, the electromagnetic Dalitz decays of J/\psi \to P e^+e^-(P=\eta'/\eta/\pi^0) are studied. By reconstructing the pseudoscalar mesons in various decay modes, the decays J/\psi \to \eta' e^+e^-, J/\psi \to \eta e^+e^- and J/\psi \to \pi^0 e^+e^- are observed for the first time. The branching fractions are determined to be \mathcal{B}(J/\psi\to \eta' e^+e^-) = (5.81\pm0.16\pm0.31)\times10^{-5}, \mathcal{B}(J/\psi\to \eta e^+e^-) = (1.16\pm0.07\pm0.06)\times10^{-5}, and \mathcal{B}(J/\psi\to \pi^0 e^+e^-)=(7.56\pm1.32\pm0.50)\times10^{-7}, where the first errors are statistical and the second ones systematic.

Published
2015

24. Two-photon widths of the $χ_{c0, 2}$ states and helicity analysis for $χ_{c2}\arγγ$}

Author

BESIII Collaboration, M. Ablikim(Institute of High Energy Physics, Beijing, P. R. China), M. N. Achasov(G.I. Budker Institute of Nuclear Physics SB RAS), D. J. Ambrose(University of Rochester, Rochester, New York, USA), F. F. An(Institute of High Energy Physics, Beijing, P. R. China), Q. An(University of Science and Technology of China, Hefei, P. R. China), Z. H. An(Institute of High Energy Physics, Beijing, P. R. China), J. Z. Bai(Institute of High Energy Physics, Beijing, P. R. China), R. B. Ferroli(INFN Laboratori Nazionali di Frascati, Frascati, Italy), Y. Ban(Peking University, Beijing, P. R. China), J. Becker(Bochum Ruhr-University, Bochum, Germany), N. Berger(Institute of High Energy Physics, Beijing, P. R. China), M. B. Bertani(INFN Laboratori Nazionali di Frascati, Frascati, Italy), J. M. Bian(University of Minnesota, Minneapolis, MN, USA), E. Boger(20, a), O. Bondarenko(KVI/University of Groningen, Groningen, The Netherlands), I. Boyko(Joint Institute for Nuclear Research, Dubna, Russia), R. A. Briere(Carnegie Mellon University, Pittsburgh, PA, USA), V. Bytev(Joint Institute for Nuclear Research, Dubna, Russia), X. Cai(Institute of High Energy Physics, Beijing, P. R. China), A. C. Calcaterra(INFN Laboratori Nazionali di Frascati, Frascati, Italy), G. F. Cao(Institute of High Energy Physics, Beijing, P. R. China), J. F. Chang(Institute of High Energy Physics, Beijing, P. R. China), G. Chelkov(20, a), G. Chen(Institute of High Energy Physics, Beijing, P. R. China), H. S. Chen(Institute of High Energy Physics, Beijing, P. R. China), J. C. Chen(Institute of High Energy Physics, Beijing, P. R. China), M. L. Chen(Institute of High Energy Physics, Beijing, P. R. China), S. J. Chen(Nanjing University, Nanjing, P. R. China), Y. Chen(Institute of High Energy Physics, Beijing, P. R. China), Y. B. Chen(Institute of High Energy Physics, Beijing, P. R. China), H. P. Cheng(Huangshan College, Huangshan, P. R. China), Y. P. Chu(Institute of High Energy Physics, Beijing, P. R. China), D. Cronin-Hennessy(University of Minnesota, Minneapolis, MN, USA), H. L. Dai(Institute of High Energy Physics, Beijing, P. R. China), J. P. Dai(Institute of High Energy Physics, Beijing, P. R. China), D. Dedovich(Joint Institute for Nuclear Research, Dubna, Russia), Z. Y. Deng(Institute of High Energy Physics, Beijing, P. R. China), A. Denig(Johannes Gutenberg University of Mainz, Mainz, Germany), I. Denysenko(20, b), M. Destefanis(University of Turin and INFN, Turin, Italy), W. M. Ding(Shandong University, Jinan, P. R. China), Y. Ding(Liaoning University, Shenyang, P. R. China), L. Y. Dong(Institute of High Energy Physics, Beijing, P. R. China), M. Y. Dong(Institute of High Energy Physics, Beijing, P. R. China), S. X. Du(Zhengzhou University, Zhengzhou, P. R. China), J. Fang(Institute of High Energy Physics, Beijing, P. R. China), S. S. Fang(Institute of High Energy Physics, Beijing, P. R. China), L. Fava(44, c), F. Feldbauer(Bochum Ruhr-University, Bochum, Germany), C. Q. Feng(University of Science and Technology of China, Hefei, P. R. China), C. D. Fu(Institute of High Energy Physics, Beijing, P. R. China), J. L. Fu(Nanjing University, Nanjing, P. R. China), Y. Gao(Tsinghua University, Beijing, P. R. China), C. Geng(University of Science and Technology of China, Hefei, P. R. China), K. Goetzen(GSI Helmholtzcentre for Heavy Ion Research GmbH, Darmstadt, Germany), W. X. Gong(Institute of High Energy Physics, Beijing, P. R. China), W. Gradl(Johannes Gutenberg University of Mainz, Mainz, Germany), M. Greco(University of Turin and INFN, Turin, Italy), M. H. Gu(Institute of High Energy Physics, Beijing, P. R. China), Y. T. Gu(GuangXi University, Nanning, P.R.China), Y. H. Guan(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), A. Q. Guo(Nankai University, Tianjin, P. R. China), L. B. Guo(Nanjing Normal University, Nanjing, P. R. China), Y. P. Guo(Nankai University, Tianjin, P. R. China), Y. L. Han(Institute of High Energy Physics, Beijing, P. R. China), X. Q. Hao(Institute of High Energy Physics, Beijing, P. R. China), F. A. Harris(University of Hawaii, Honolulu, Hawaii, USA), K. L. He(Institute of High Energy Physics, Beijing, P. R. China), M. He(Institute of High Energy Physics, Beijing, P. R. China), Z. Y. He(Nankai University, Tianjin, P. R. China), T. Held(Bochum Ruhr-University, Bochum, Germany), Y. K. Heng(Institute of High Energy Physics, Beijing, P. R. China), Z. L. Hou(Institute of High Energy Physics, Beijing, P. R. China), H. M. Hu(Institute of High Energy Physics, Beijing, P. R. China), J. F. Hu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), T. Hu(Institute of High Energy Physics, Beijing, P. R. China), B. Huang(Institute of High Energy Physics, Beijing, P. R. China), G. M. Huang(Huazhong Normal University, Wuhan, P. R. China), J. S. Huang(Henan Normal University, Xinxiang, P. R. China), X. T. Huang(Shandong University, Jinan, P. R. China), Y. P. Huang(Institute of High Energy Physics, Beijing, P. R. China), T. Hussain(University of the Punjab, Lahore, Pakistan), C. S. Ji(University of Science and Technology of China, Hefei, P. R. China), Q. Ji(Institute of High Energy Physics, Beijing, P. R. China), X. B. Ji(Institute of High Energy Physics, Beijing, P. R. China), X. L. Ji(Institute of High Energy Physics, Beijing, P. R. China), L. K. Jia(Institute of High Energy Physics, Beijing, P. R. China), L. L. Jiang(Institute of High Energy Physics, Beijing, P. R. China), X. S. Jiang(Institute of High Energy Physics, Beijing, P. R. China), J. B. Jiao(Shandong University, Jinan, P. R. China), Z. Jiao(Huangshan College, Huangshan, P. R. China), D. P. Jin(Institute of High Energy Physics, Beijing, P. R. China), S. Jin(Institute of High Energy Physics, Beijing, P. R. China), F. F. Jing(Tsinghua University, Beijing, P. R. China), N. Kalantar-Nayestanaki(KVI/University of Groningen, Groningen, The Netherlands), M. Kavatsyuk(KVI/University of Groningen, Groningen, The Netherlands), W. Kuehn(Universitaet Giessen, Giessen, Germany), W. Lai(Institute of High Energy Physics, Beijing, P. R. China), J. S. Lange(Universitaet Giessen, Giessen, Germany), J. K. C. Leung(The University of Hong Kong, Pokfulam, Hong Kong), C. H. Li(Institute of High Energy Physics, Beijing, P. R. China), Cheng Li(University of Science and Technology of China, Hefei, P. R. China), Cui Li(University of Science and Technology of China, Hefei, P. R. China), D. M. Li(Zhengzhou University, Zhengzhou, P. R. China), F. Li(Institute of High Energy Physics, Beijing, P. R. China), G. Li(Institute of High Energy Physics, Beijing, P. R. China), H. B. Li(Institute of High Energy Physics, Beijing, P. R. China), J. C. Li(Institute of High Energy Physics, Beijing, P. R. China), K. Li(Hangzhou Normal University, Hangzhou, P. R. China), Lei Li(Institute of High Energy Physics, Beijing, P. R. China), N. B. Li(Nanjing Normal University, Nanjing, P. R. China), Q. J. Li(Institute of High Energy Physics, Beijing, P. R. China), S. L. Li(Institute of High Energy Physics, Beijing, P. R. China), W. D. Li(Institute of High Energy Physics, Beijing, P. R. China), W. G. Li(Institute of High Energy Physics, Beijing, P. R. China), X. L. Li(Shandong University, Jinan, P. R. China), X. N. Li(Institute of High Energy Physics, Beijing, P. R. China), X. Q. Li(Nankai University, Tianjin, P. R. China), X. R. Li(Seoul National University, Seoul, Korea), Z. B. Li(Sun Yat-Sen University, Guangzhou, P. R. China), H. Liang(University of Science and Technology of China, Hefei, P. R. China), Y. F. Liang(Sichuan University, Chengdu, P. R. China), Y. T. Liang(Universitaet Giessen, Giessen, Germany), G. R. Liao(Tsinghua University, Beijing, P. R. China), X. T. Liao(Institute of High Energy Physics, Beijing, P. R. China), B. J. Liu(Institute of High Energy Physics, Beijing, P. R. China), C. L. Liu(Carnegie Mellon University, Pittsburgh, PA, USA), C. X. Liu(Institute of High Energy Physics, Beijing, P. R. China), C. Y. Liu(Institute of High Energy Physics, Beijing, P. R. China), F. H. Liu(Shanxi University, Taiyuan, P. R. China), Fang Liu(Institute of High Energy Physics, Beijing, P. R. China), Feng Liu(Huazhong Normal University, Wuhan, P. R. China), H. Liu(Shanxi University, Taiyuan, P. R. China), H. B. Liu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), H. H. Liu(Henan University of Science and Technology, Luoyang, P. R. China), H. M. Liu(Institute of High Energy Physics, Beijing, P. R. China), H. W. Liu(Institute of High Energy Physics, Beijing, P. R. China), J. P. Liu(Wuhan University, Wuhan, P. R. China), Kun Liu(Peking University, Beijing, P. R. China), Kai Liu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), K. Y. Liu(Liaoning University, Shenyang, P. R. China), P. L. Liu(Shandong University, Jinan, P. R. China), S. B. Liu(University of Science and Technology of China, Hefei, P. R. China), X. Liu(Institute of High Energy Physics, Beijing, P. R. China), X. H. Liu(Institute of High Energy Physics, Beijing, P. R. China), Y. B. Liu(Nankai University, Tianjin, P. R. China), Y. Liu(Institute of High Energy Physics, Beijing, P. R. China), Z. A. Liu(Institute of High Energy Physics, Beijing, P. R. China), Zhiqiang Liu(Institute of High Energy Physics, Beijing, P. R. China), Zhiqing Liu(Institute of High Energy Physics, Beijing, P. R. China), H. Loehner(KVI/University of Groningen, Groningen, The Netherlands), G. R. Lu(Henan Normal University, Xinxiang, P. R. China), H. J. Lu(Huangshan College, Huangshan, P. R. China), J. G. Lu(Institute of High Energy Physics, Beijing, P. R. China), Q. W. Lu(Shanxi University, Taiyuan, P. R. China), X. R. Lu(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), Y. P. Lu(Institute of High Energy Physics, Beijing, P. R. China), C. L. Luo(Nanjing Normal University, Nanjing, P. R. China), M. X. Luo(Zhejiang University, Hangzhou, P. R. China), T. Luo(University of Hawaii, Honolulu, Hawaii, USA), X. L. Luo(Institute of High Energy Physics, Beijing, P. R. China), M. Lv(Institute of High Energy Physics, Beijing, P. R. China), C. L. Ma(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), F. C. Ma(Liaoning University, Shenyang, P. R. China), H. L. Ma(Institute of High Energy Physics, Beijing, P. R. China), Q. M. Ma(Institute of High Energy Physics, Beijing, P. R. China), S. Ma(Institute of High Energy Physics, Beijing, P. R. China), T. Ma(Institute of High Energy Physics, Beijing, P. R. China), X. Y. Ma(Institute of High Energy Physics, Beijing, P. R. China), Y. Ma(Institute of High Energy Physics, Beijing, P. R. China), F. E. Maas(Helmholtz Institute Mainz, Mainz, Germany), M. Maggiora(University of Turin and INFN, Turin, Italy), Q. A. Malik(University of the Punjab, Lahore, Pakistan), H. Mao(Institute of High Energy Physics, Beijing, P. R. China), Y. J. Mao(Peking University, Beijing, P. R. China), Z. P. Mao(Institute of High Energy Physics, Beijing, P. R. China), J. G. Messchendorp(KVI/University of Groningen, Groningen, The Netherlands), J. Min(Institute of High Energy Physics, Beijing, P. R. China), T. J. Min(Institute of High Energy Physics, Beijing, P. R. China), R. E. Mitchell(Indiana University, Bloomington, Indiana, USA), X. H. Mo(Institute of High Energy Physics, Beijing, P. R. China), C. Morales Morales(Helmholtz Institute Mainz, Mainz, Germany), C. Motzko(Bochum Ruhr-University, Bochum, Germany), N. Yu. Muchnoi(G.I. Budker Institute of Nuclear Physics SB RAS), Y. Nefedov(Joint Institute for Nuclear Research, Dubna, Russia), C. Nicholson(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), I. B. Nikolaev(G.I. Budker Institute of Nuclear Physics SB RAS), Z. Ning(Institute of High Energy Physics, Beijing, P. R. China), S. L. Olsen(Seoul National University, Seoul, Korea), Q. Ouyang(Institute of High Energy Physics, Beijing, P. R. China), S. P. Pacetti(18, d), J. W. Park(Seoul National University, Seoul, Korea), M. Pelizaeus(University of Hawaii, Honolulu, Hawaii, USA), K. Peters(GSI Helmholtzcentre for Heavy Ion Research GmbH, Darmstadt, Germany), J. L. Ping(Nanjing Normal University, Nanjing, P. R. China), R. G. Ping(Institute of High Energy Physics, Beijing, P. R. China), R. Poling(University of Minnesota, Minneapolis, MN, USA), E. Prencipe(Johannes Gutenberg University of Mainz, Mainz, Germany), C. S. J. Pun(The University of Hong Kong, Pokfulam, Hong Kong), M. Qi(Nanjing University, Nanjing, P. R. China), S. Qian(Institute of High Energy Physics, Beijing, P. R. China), C. F. Qiao(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), X. S. Qin(Institute of High Energy Physics, Beijing, P. R. China), Y. Qin(Peking University, Beijing, P. R. China), Z. H. Qin(Institute of High Energy Physics, Beijing, P. R. China), J. F. Qiu(Institute of High Energy Physics, Beijing, P. R. China), K. H. Rashid(University of the Punjab, Lahore, Pakistan), G. Rong(Institute of High Energy Physics, Beijing, P. R. China), X. D. Ruan(GuangXi University, Nanning, P.R.China), A. Sarantsev(20, e), J. Schulze(Bochum Ruhr-University, Bochum, Germany), M. Shao(University of Science and Technology of China, Hefei, P. R. China), C. P. Shen(38, f), X. Y. Shen(Institute of High Energy Physics, Beijing, P. R. China), H. Y. Sheng(Institute of High Energy Physics, Beijing, P. R. China), M. R. Shepherd(Indiana University, Bloomington, Indiana, USA), X. Y. Song(Institute of High Energy Physics, Beijing, P. R. China), S. Spataro(University of Turin and INFN, Turin, Italy), B. Spruck(Universitaet Giessen, Giessen, Germany), D. H. Sun(Institute of High Energy Physics, Beijing, P. R. China), G. X. Sun(Institute of High Energy Physics, Beijing, P. R. China), J. F. Sun(Henan Normal University, Xinxiang, P. R. China), S. S. Sun(Institute of High Energy Physics, Beijing, P. R. China), X. D. Sun(Institute of High Energy Physics, Beijing, P. R. China), Y. J. Sun(University of Science and Technology of China, Hefei, P. R. China), Y. Z. Sun(Institute of High Energy Physics, Beijing, P. R. China), Z. J. Sun(Institute of High Energy Physics, Beijing, P. R. China), Z. T. Sun(University of Science and Technology of China, Hefei, P. R. China), C. J. Tang(Sichuan University, Chengdu, P. R. China), X. Tang(Institute of High Energy Physics, Beijing, P. R. China), E. H. Thorndike(University of Rochester, Rochester, New York, USA), H. L. Tian(Institute of High Energy Physics, Beijing, P. R. China), D. Toth(University of Minnesota, Minneapolis, MN, USA), M. U. Ulrich(Universitaet Giessen, Giessen, Germany), G. S. Varner(University of Hawaii, Honolulu, Hawaii, USA), B. Wang(GuangXi University, Nanning, P.R.China), B. Q. Wang(Peking University, Beijing, P. R. China), K. Wang(Institute of High Energy Physics, Beijing, P. R. China), L. L. Wang(China Center of Advanced Science and Technology, Beijing, P. R. China), L. S. Wang(Institute of High Energy Physics, Beijing, P. R. China), M. Wang(Shandong University, Jinan, P. R. China), P. Wang(Institute of High Energy Physics, Beijing, P. R. China), P. L. Wang(Institute of High Energy Physics, Beijing, P. R. China), Q. Wang(Peking University, Beijing, P. R. China), Q. J. Wang(Institute of High Energy Physics, Beijing, P. R. China), S. G. Wang(Peking University, Beijing, P. R. China), X. F. Wang(Henan Normal University, Xinxiang, P. R. China), X. L. Wang(University of Science and Technology of China, Hefei, P. R. China), Y. D. Wang(University of Science and Technology of China, Hefei, P. R. China), Y. F. Wang(Institute of High Energy Physics, Beijing, P. R. China), Y. Q. Wang(Shandong University, Jinan, P. R. China), Z. Wang(Institute of High Energy Physics, Beijing, P. R. China), Z. G. Wang(Institute of High Energy Physics, Beijing, P. R. China), Z. Y. Wang(Institute of High Energy Physics, Beijing, P. R. China), D. H. Wei(Guangxi Normal University, Guilin, P. R. China), P. Weidenkaff(Johannes Gutenberg University of Mainz, Mainz, Germany), Q. G. Wen(University of Science and Technology of China, Hefei, P. R. China), S. P. Wen(Institute of High Energy Physics, Beijing, P. R. China), M. W. Werner(Universitaet Giessen, Giessen, Germany), U. Wiedner(Bochum Ruhr-University, Bochum, Germany), L. H. Wu(Institute of High Energy Physics, Beijing, P. R. China), N. Wu(Institute of High Energy Physics, Beijing, P. R. China), S. X. Wu(University of Science and Technology of China, Hefei, P. R. China), W. Wu(Nankai University, Tianjin, P. R. China), Z. Wu(Institute of High Energy Physics, Beijing, P. R. China), L. G. Xia(Tsinghua University, Beijing, P. R. China), Z. J. Xiao(Nanjing Normal University, Nanjing, P. R. China), Y. G. Xie(Institute of High Energy Physics, Beijing, P. R. China), Q. L. Xiu(Institute of High Energy Physics, Beijing, P. R. China), G. F. Xu(Institute of High Energy Physics, Beijing, P. R. China), G. M. Xu(Peking University, Beijing, P. R. China), H. Xu(Institute of High Energy Physics, Beijing, P. R. China), Q. J. Xu(Hangzhou Normal University, Hangzhou, P. R. China), X. P. Xu(Soochow University, Suzhou, China), Y. Xu(Nankai University, Tianjin, P. R. China), Z. R. Xu(University of Science and Technology of China, Hefei, P. R. China), F. Xue(Huazhong Normal University, Wuhan, P. R. China), Z. Xue(Institute of High Energy Physics, Beijing, P. R. China), L. Yan(University of Science and Technology of China, Hefei, P. R. China), W. B. Yan(University of Science and Technology of China, Hefei, P. R. China), Y. H. Yan(Hunan University, Changsha, P. R. China), H. X. Yang(Institute of High Energy Physics, Beijing, P. R. China), T. Yang(GuangXi University, Nanning, P.R.China), Y. Yang(Huazhong Normal University, Wuhan, P. R. China), Y. X. Yang(Guangxi Normal University, Guilin, P. R. China), H. Ye(Institute of High Energy Physics, Beijing, P. R. China), M. Ye(Institute of High Energy Physics, Beijing, P. R. China), M. H. Ye(China Center of Advanced Science and Technology, Beijing, P. R. China), B. X. Yu(Institute of High Energy Physics, Beijing, P. R. China), C. X. Yu(Nankai University, Tianjin, P. R. China), J. S. Yu(Lanzhou University, Lanzhou, P. R. China), S. P. Yu(Shandong University, Jinan, P. R. China), C. Z. Yuan(Institute of High Energy Physics, Beijing, P. R. China), W. L. Yuan(Nanjing Normal University, Nanjing, P. R. China), Y. Yuan(Institute of High Energy Physics, Beijing, P. R. China), A. A. Zafar(University of the Punjab, Lahore, Pakistan), A. Z. Zallo(INFN Laboratori Nazionali di Frascati, Frascati, Italy), Y. Zeng(Hunan University, Changsha, P. R. China), B. X. Zhang(Institute of High Energy Physics, Beijing, P. R. China), B. Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), C. C. Zhang(Institute of High Energy Physics, Beijing, P. R. China), D. H. Zhang(Institute of High Energy Physics, Beijing, P. R. China), H. H. Zhang(Sun Yat-Sen University, Guangzhou, P. R. China), H. Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. Zhang(Nanjing Normal University, Nanjing, P. R. China), J. G. Zhang(Henan Normal University, Xinxiang, P. R. China), J. Q. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. W. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), J. Z. Zhang(Institute of High Energy Physics, Beijing, P. R. China), L. Zhang(Nanjing University, Nanjing, P. R. China), S. H. Zhang(Institute of High Energy Physics, Beijing, P. R. China), T. R. Zhang(Nanjing Normal University, Nanjing, P. R. China), X. J. Zhang(Institute of High Energy Physics, Beijing, P. R. China), X. Y. Zhang(Shandong University, Jinan, P. R. China), Y. Zhang(Institute of High Energy Physics, Beijing, P. R. China), Y. H. Zhang(Institute of High Energy Physics, Beijing, P. R. China), Y. S. Zhang(GuangXi University, Nanning, P.R.China), Z. P. Zhang(University of Science and Technology of China, Hefei, P. R. China), Z. Y. Zhang(Wuhan University, Wuhan, P. R. China), G. Zhao(Institute of High Energy Physics, Beijing, P. R. China), H. S. Zhao(Institute of High Energy Physics, Beijing, P. R. China), J. W. Zhao(Institute of High Energy Physics, Beijing, P. R. China), K. X. Zhao(Nanjing Normal University, Nanjing, P. R. China), Lei Zhao(University of Science and Technology of China, Hefei, P. R. China), Ling Zhao(Institute of High Energy Physics, Beijing, P. R. China), M. G. Zhao(Nankai University, Tianjin, P. R. China), Q. Zhao(Institute of High Energy Physics, Beijing, P. R. China), S. J. Zhao(Zhengzhou University, Zhengzhou, P. R. China), T. C. Zhao(Institute of High Energy Physics, Beijing, P. R. China), X. H. Zhao(Nanjing University, Nanjing, P. R. China), Y. B. Zhao(Institute of High Energy Physics, Beijing, P. R. China), Z. G. Zhao(University of Science and Technology of China, Hefei, P. R. China), A. Zhemchugov(20, a), B. Zheng(University of South China, Hengyang, P. R. China), J. P. Zheng(Institute of High Energy Physics, Beijing, P. R. China), Y. H. Zheng(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), Z. P. Zheng(Institute of High Energy Physics, Beijing, P. R. China), B. Zhong(Institute of High Energy Physics, Beijing, P. R. China), J. Zhong(Bochum Ruhr-University, Bochum, Germany), L. Zhou(Institute of High Energy Physics, Beijing, P. R. China), X. K. Zhou(Graduate University of Chinese Academy of Sciences, Beijing, P. R. China), X. R. Zhou(University of Science and Technology of China, Hefei, P. R. China), C. Zhu(Institute of High Energy Physics, Beijing, P. R. China), K. Zhu(Institute of High Energy Physics, Beijing, P. R. China), K. J. Zhu(Institute of High Energy Physics, Beijing, P. R. China), S. H. Zhu(Institute of High Energy Physics, Beijing, P. R. China), X. L. Zhu(Tsinghua University, Beijing, P. R. China), X. W. Zhu(Institute of High Energy Physics, Beijing, P. R. China), Y. M. Zhu(Nankai University, Tianjin, P. R. China), Y. S. Zhu(Institute of High Energy Physics, Beijing, P. R. China), Z. A. Zhu(Institute of High Energy Physics, Beijing, P. R. China), J. Zhuang(Institute of High Energy Physics, Beijing, P. R. China), B. S. Zou(Institute of High Energy Physics, Beijing, P. R. China), J. H. Zou(Institute of High Energy Physics, Beijing, P. R. China), and J. X. Zuo(Institute of High Energy Physics, Beijing, P. R. China)

Subjects
hep-ex, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

Based on a data sample of 106 M $\psi^{\prime}$ events collected with the BESIII detector, the decays $\psi^{\prime}\ar\gamma\chi_{c0, 2}$,$\chi_{c0, 2}\ar\gamma\gamma$ are studied to determine the two-photon widths of the $\chi_{c0, 2}$ states. The two-photon decay branching fractions are determined to be ${\cal B}(\chi_{c0}\ar\gamma\gamma) = (2.24\pm 0.19\pm 0.12\pm 0.08)\times 10^{-4}$ and ${\cal B}(\chi_{c2}\ar\gamma\gamma) = (3.21\pm 0.18\pm 0.17\pm 0.13)\times 10^{-4}$. From these, the two-photon widths are determined to be $\Gamma_{\gamma \gamma}(\chi_{c0}) = (2.33\pm0.20\pm0.13\pm0.17)$ keV, $\Gamma_{\gamma \gamma}(\chi_{c2}) = (0.63\pm0.04\pm0.04\pm0.04)$ keV, and $\cal R$ $=\Gamma_{\gamma \gamma}(\chi_{c2})/\Gamma_{\gamma \gamma}(\chi_{c0})=0.271\pm 0.029\pm 0.013\pm 0.027$, where the uncertainties are statistical, systematic, and those from the PDG ${\cal B}(\psi^{\prime}\ar\gamma\chi_{c0,2})$ and $\Gamma(\chi_{c0,2})$ errors, respectively. The ratio of the two-photon widths for helicity $\lambda=0$ and helicity $\lambda=2$ components in the decay $\chi_{c2}\ar\gamma\gamma$ is measured for the first time to be $f_{0/2} =\Gamma^{\lambda=0}_{\gamma\gamma}(\chi_{c2})/\Gamma^{\lambda=2}_{\gamma\gamma}(\chi_{c2}) = 0.00\pm0.02\pm0.02$.

Published
2015

25. Late sodium current associated cardiac electrophysiological and mechanical dysfunction.

Author

Yu, Shandong, Li, Gang, Huang, Christopher L.-H., Lei, Ming, and Wu, Lin

Subjects
*ELECTROPHYSIOLOGY, *HEART function tests, *HEART cells, *ARRHYTHMIA, *HEART ventricles
Abstract

Late sodium current (INaL) is a small sustained inward current observed during the cardiac action potential plateau phase following decay of the early peak INa. The endogenous INaL is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced INa,L occurs in long QT syndrome 3 (LQTS 3) patients, and under a number of pathological and pharmacological cardiovascular conditions, including bradycardia, myocardial ischemia, reperfusion injury, and heart failure. It may there play important roles in arrhythmogenesis and mechanical dysfunction. Experimental and clinical research suggests that INaL inhibition may prevent and treat cardiac arrhythmias and improve ventricular pump function. Selective INa,L inhibitors, exemplified by ranolazine, GS-967 and GS-458967 have little or no effect on peak sodium current and/or IKr, and carry no or minimal pro-arrhythmic risk compared to those associated with administration of classical class I or III antiarrhythmic drugs, particularly in patients with ischemic heart disease. This increased understanding of INaL may be encouraging to clinicians in use of INaL inhibitors to treat cardiac arrhythmias and mechanical dysfunction directly associated with enhanced INaL such as LQTS type 3, and myocardial ischemia. This review discusses the roles of endogenous and enhanced INaL in arrhythmogenesis and mechanical dysfunction, and the basic and clinical research of INaL inhibitors. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Smilacis Glabrae Rhizoma Reduces Oxidative Stress Caused by Hyperuricemia via Upregulation of Catalase.

Author

Hong, Quan, Yu, Shandong, Mei, Yan, YangLv, Yang, Chen, Dapeng, Wang, Yuanda, Geng, Wenjia, Wu, Di, Cai, Guangyan, and Chen, Xiangmei

Subjects
*HYPERURICEMIA, *OXIDATIVE stress, *CHINESE medicine, *CATALASE, *ENDOTHELIAL cells, *REACTIVE oxygen species, *THERAPEUTICS
Abstract

Background/Aims: Reports have suggested that the traditional Chinese medicine Smilacis Glabrae Rhizoma attenuates hyperuricemia, but its mechanism is unclear. Our previous study demonstrated that uric acid could induce the generation of reactive oxygen species(ROS), which subsequently cause endothelial dysfunction. Therefore, we focused on the oxidative stress process. In this study, we would use LC-MS and bioinformatic analysis to investigate the underlying mechanism. Methods: We utilized LC-MS to reveal the differential protein expression in the kidneys of rats in the hyperuricemia group and the Smilacis Glabrae Rhizoma treatment group and then subjected the differentially expressed proteins to bioinformatic analysis. We also determined the serum ROS level of the two groups. According the above results, we built our hypothesis and performed in vitro experiments to validate this hypothesis. Results: We found that catalase was upregulated in the group treated with Smilacis Glabrae Rhizoma, and the level of reactive oxygen species was higher in the hyperuricemia group. Thus, we speculated that Smilacis Glabrae Rhizoma could alleviate oxidative stress by upregulating catalase. In vitro experiments, we found that high concentrations of uric acid reduced catalase expression in endothelial cells, which was alleviated by Smilacis Glabrae Rhizoma and resulted in a reduction of reactive oxygen species. Knockdown of catalase led to an increase in reactive oxygen species. Conclusion: We demonstrated that Smilacis Glabrae Rhizoma could alleviate the oxidative stress caused by hyperuricemia by upregulating catalase expression. This finding could represent a new application for Smilacis Glabrae Rhizoma in the treatment of hyperuricemia. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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36. Assessment of Hydroxychloroquine and Chloroquine Safety Profiles: A Systematic Review and Meta-Analysis.

Author

Ren L, Xu W, Overton JL, Yu S, Chiamvimonvat N, and Thai PN

Abstract

Background: Recently, chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) have emerged as potential antiviral and immunomodulatory options for the treatment of 2019 coronavirus disease (COVID-19). To examine the safety profiles of these medications, we systematically evaluated the adverse events (AEs) of these medications from published randomized controlled trials (RCTs)., Methods: We systematically searched PubMed, MEDLINE, Cochrane, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, and the ClinicalTrials.gov for all the RCTs comparing CQ or HCQ with placebo or other active agents, published before March 31, 2020. The random-effects or fixed-effects models were used to pool the risk estimates relative ratio (RR) with 95% confidence interval (CI) for the outcomes., Results: The literature search yielded 23 and 17 studies for CQ and HCQ, respectively, that satisfied our inclusion criteria. Of these studies, we performed meta-analysis on the ones that were placebo-controlled, which included 6 studies for CQ and 14 studies for HCQ. We did not limit our analysis to published reports involving viral treatment alone; data also included the usage of either CQ or HCQ for the treatment of other diseases. The trials for the CQ consisted of a total of 2,137 participants (n=1,077 CQ, n=1,060 placebo), while the trials for HCQ involved 1,096 participants (n=558 HCQ and n=538 placebo). The overall mild or total AEs were statistically higher comparing CQ or HCQ to placebo. The AEs were further categorized into four groups and analyses revealed that neurologic, gastrointestinal, dermatologic, and ophthalmic AEs were higher in participants taking CQ compared to placebo. Although this was not evident in HCQ treated groups, further analyses suggested that there were more AEs attributed to other organ system that were not included in the categorized meta-analyses. Additionally, meta-regression analyses revealed that total AEs was affected by dosage for the CQ group., Conclusions: Taken together, we found that participants taking either CQ or HCQ have more AEs than participants taking placebo. Precautionary measures should be taken when using these drugs to treat COVID-19.

Published
2020
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