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13 results on '"Yu, Shaokang"'

6. Immune activity score to assess the prognosis, immunotherapy and chemotherapy response in gastric cancer and experimental validation

Author

Wu, Xuan, Zhou, Fengrui, Cheng, Boran, Tong, Gangling, Chen, Minhua, He, Lirui, Li, Zhu, Yu, Shaokang, Wang, Shubin, Lin, Liping, Wu, Xuan, Zhou, Fengrui, Cheng, Boran, Tong, Gangling, Chen, Minhua, He, Lirui, Li, Zhu, Yu, Shaokang, Wang, Shubin, and Lin, Liping

Abstract

Background. Gastric cancer (GC) is an extremely heterogeneous malignancy with a complex tumor microenvironment (TME) that contributes to unsatisfactory prognosis. Methods. The overall activity score for assessing the immune activity of GC patients was developed based on cancer immune cycle activity index in the Tracking Tumor Immunophenotype (TIP). Genes potentially affected by the overall activity score were screened using weighted gene co-expression network analysis (WGCNA). Based on the expression profile data of GC in The Cancer Genome Atlas (TCGA) database, COX analysis was applied to create an immune activity score (IAS). Differences in TME activity in the IAS groups were analyzed. We also evaluated the value of IAS in estimating immunotherapy and chemotherapy response based on immunotherapy cohort. Gene expression in IAS model and cell viability were determined by real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) and Cell Counting Kit-8 (CCK-8) assay, respectively. Results. WGCAN analysis screened 629 overall activity score-related genes, which were mainly associated with T cell response and B cell response. COX analysis identified AKAP5, CTLA4, LRRC8C, AOAH-IT1, NPC2, RGS1 and SLC2A3 as critical genes affecting the prognosis of GC, based on which the IAS was developed. Further RT-qPCR analysis data showed that the expression of AKAP5 and CTLA4 was downregulated, while that of LRRC8C, AOAH-IT1, NPC2, RGS1 and SLC2A3 was significantly elevated in GC cell lines. Inhibition of AKAP5 increased cell viability but siAOAH-IT1 promoted viability of GC cells. IAS demonstrated excellent robustness in predicting immunotherapy outcome and GC prognosis, with low-IAS patients having better prognosis and immunotherapy. In addition, resistance to Erlotinib, Rapamycin, MG- 132, Cyclopamine, AZ628, and Sorafenib was reduced in patients with low IAS. Conclusion. IAS was a reliable prognostic indicator. ForGCpatients, IAS showed excel- lent robustness in predic

Published
2023

12. Enumeration And Characterization Of Circulating Tumor Cells And Its Application In Advanced Gastric Cancer

Author

Cheng,Boran, Tong,Gangling, Wu,Xuan, Cai,Wenwu, Li,Zhu, Tong,Zhongyi, He,Lirui, Yu,Shaokang, and Wang,Shubin

Subjects
OncoTargets and Therapy
Abstract

Boran Cheng,1,* Gangling Tong,1,* Xuan Wu,1,* Wenwu Cai,2,* Zhu Li,1,* Zhongyi Tong,2 Lirui He,1 Shaokang Yu,1 Shubin Wang1 1Department of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province 518036, People’s Republic of China; 2Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province 410011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Boran Cheng; Shubin WangDepartment of Oncology, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong Province 518036, People’s Republic of ChinaTel +86 755 135-3093-5356Fax +86 755-8392-3333Email BRcheng@whu.edu.cn; Shubinwang@aliyun.comBackground: Advanced gastric cancer (aGC) has a high global incidence and a high mortality rate and because of its high malignancy and heterogeneity, the existing methods for prognosis are limited, and a new treatment model is necessary. Circulating tumor cells (CTCs) could be considered as a “liquid biopsy” for tumor diagnosis and for monitoring treatment responses and predicting clinical outcome. Clinical studies support the efficacy of programmed cell death 1 (PD-1) immunotherapy in a subset of aGC.Methods: Cell capture efficiency, as described by the CanPatrol CTC enrichment technique, was validated using artificial blood samples as well as blood samples from 32 aGC patients. Clinicopathologic data of patients were collected from the hospital information system. We used CanPatrol for CTC isolation, classification, and clinical analysis.Results: A cell capture efficiency of >80% was achieved. Significant correlation was observed between CTC enumeration and clinicopathology parameters, including the Lauren classification (r=0.470, P=0.008), perineural invasion (r=0.393, P=0.029), TNM stage (r=0.740, P

Published
2019

13. Facile synthesis of hierarchical porous ZnMn2O4 rugby-balls on Ni foam for lithium-ion batteries with enhanced electrochemical properties.

Author

Ren, Na, Jiu, Hongfang, Jiang, LiYa, Zhang, Qing, Yu, Shaokang, Gao, Yuying, Gao, Zhonghao, and Zhang, Lixin

Subjects
*LITHIUM-ion batteries, *ANNEALING of metals, *CURRENT density (Electromagnetism), *SPINEL group crystallography, *POROUS electrodes
Abstract

Hierarchical porous ZnMn 2 O 4 rugby-balls on Ni foam were first synthesized via a hydrothermal method and then an annealing process. The ZnMn 2 O 4 rugby-balls were composed of interconnected nanosheets of about 25 nm. The growth mechanism is also proposed. In addition, the unique structure of hierarchical porous ZnMn 2 O 4 rugby-balls on Ni foam exhibited superior electrochemical performances including high specific capacity, long cyclic stability and good rate capability. At a constant current density of 100 mA g −1 , the initial discharge and charge capacities were 1584 mAh g −1 and 1114 mAh g −1 respectively, after 100 cycles, the reversible capacity could remain 614 mAh g −1 . These results demonstrate great potential of hierarchical porous ZnMn 2 O 4 rugby-balls on Ni foam in advanced LIBs. Furthermore, this method may provide a novel route for the synthesis of a series of hierarchical porous ternary spinel oxides rugby-balls. [ABSTRACT FROM AUTHOR]

Published
2018
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