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Daohong Chen, Qian Zeng, Lu Liu, Ziyang Zhou, Wenchuan Qi, Shuguang Yu, Ling Zhao Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Ling Zhao; Shuguang Yu, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, No. 37, Twelve Bridge Road, Chengdu, Sichuan Province, People’s Republic of China, Email zhaoling@cdutcm.edu.cn; ysg@cdutcm.edu.cnBackground: The pathogenesis of chronic obstructive pulmonary disease (COPD) has been studied in relation to the microbiome, providing space for more targeted interventions and new treatments. Numerous papers on the COPD microbiome have been reported in the last 10 years, yet few publications have used bibliometric methods to evaluate this area.Methods: We searched the Web of Science Core Collection for all original research articles in the field of COPD microbiome from January 2011 to August 2022 and used CiteSpace for visual analysis.Results: A total of 505 relevant publications were obtained, and the number of global publications in this field is steadily increasing every year, with China and the USA occupying the first two spots in international publications. Imperial College London and the University of Leicester produced the most publications. Brightling C from the UK was the most prolific writer, while Huang Y and Sze M from the USA were first and second among the authors cited. The American Journal of Respiratory and Critical Care Medicine had the highest frequency of citations. The top 10 institutions, cited authors and journals are mostly from the UK and the US. In the ranking of citations, the first article was a paper published by Sze M on changes in the lung tissue’s microbiota in COPD patients. The keywords “exacerbation”, “gut microbiota”, “lung microbiome”, “airway microbiome”, “bacterial colonization”, and “inflammation” were identified as cutting-edge research projects for 2011– 2022.Conclusion: Based on the visualization results, in the future, we can use the gut–lung axis as the starting point to explore the immunoinflammatory mechanism of COPD, and study how to predict the effects of different treatments of COPD by identifying the microbiota, and how to achieve the optimal enrichment of beneficial bacteria and the optimal consumption of harmful bacteria to improve COPD.Keywords: COPD, microbiome, bibliometric analysis, CiteSpace, gut microbiome, respiratory microbiome, bacterial colonization

Additional file 1 Supplementary Table 1. Quality preprocessing of transcriptome sequencing data.

Highlights • This study is a community-based RCT. • This study provides scientific-based evidence on the effects and safety of herbal medicines during COVID-19 Pandemic., Background : Since the declaration of COVID-19 as a global pandemic by the World Health Organization, countries are struggling with a shortage of medical capacities. It would be essential if the risk for preventable comorbidities, such as the common cold, can be reduced or prevented, so that the scarce medical resources and facilities can be focused on COVID-19. Purpose : To evaluate the effects of two herbal medicines (Jinhao artemisia antipyretic granules and Huoxiangzhengqi oral liquids) in reducing the risk of the common cold in community-dwelling residents in China during the COVID-19 outbreak. Study Design : An open-label, parallel-group, controlled, cluster-randomized trial, was conducted in Chengdu, China. Methods : A total of 22,065 participants from 11 communities were recruited during a period of 1 month. The trial started on 30 January and participants were followed up till 29 February 2020. Participants were randomly assigned to receive either a five-day herbal medicine therapy plus a reference manual for Health Infection Prevention and Control or the reference manual if they were allocated to the control group. The primary endpoint was the occurrence of patient-reported common cold symptoms. The secondary endpoint was the time in days from the receipt of herbal drugs/reference manual and the occurrence of the common cold symptoms. Results : Use of herbal medicine reduced the risk of the common cold by 89.6% (95% CI, 52.9% to 97.7%) in all community-dwelling residents, and by 94.0% (95% CI, 52.1% to 99.2%) in residents aged between 16 and 59 years old. Sensitivity analyses showed similar results. Conclusion : This community-based RCT found that the use of a herbal medicine therapy (Jinhao artemisia antipyretic granules and Huoxiangzhengqi oral liquids) could significantly reduce the risks of the common cold among community-dwelling residents, suggesting that herbal medicine may be a useful approach for public health intervention to minimize preventable morbidity during COVID-19 outbreak.