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31 results on '"Yu, Valen Zhuoyou"'

1. ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma

Author

Yu, Valen Zhuoyou, So, Shan Shan, Lung, Bryan Chee-chad, Hou, George Zhaozheng, Wong, Carissa Wing-yan, Chow, Larry Ka-yue, Chung, Michael King-yung, Wong, Ian Yu-hong, Wong, Claudia Lai-yin, Chan, Desmond Kwan-kit, Chan, Fion Siu-yin, Law, Betty Tsz-ting, Xu, Kaiyan, Tan, Zack Zhen, Lam, Ka-on, Lo, Anthony Wing-ip, Lam, Alfred King-yin, Kwong, Dora Lai-wan, Ko, Josephine Mun-yee, Dai, Wei, Law, Simon, and Lung, Maria Li

Published
2024
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2. ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma

Author

Yu, Valen Zhuoyou, primary, So, Shan Shan, additional, Lung, Bryan Chee-chad, additional, Hou, George Zhaozheng, additional, Wong, Carissa Wing-yan, additional, Chow, Larry Ka-yue, additional, Chung, Michael King-yung, additional, Wong, Ian Yu-hong, additional, Wong, Claudia Lai-yin, additional, Chan, Desmond Kwan-kit, additional, Chan, Fion Siu-yin, additional, Law, Betty Tsz-ting, additional, Xu, Kaiyan, additional, Tan, Zack Zhen, additional, Lam, Ka-on, additional, Lo, Anthony Wing-ip, additional, Lam, Alfred King-yin, additional, Kwong, Dora Lai-wan, additional, Ko, Josephine Mun-yee, additional, Dai, Wei, additional, Law, Simon, additional, and Lung, Maria Li, additional

Published
2024
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3. Multigene Profiling of Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma Identifies Prognostic Cancer Driver Genes Associated with Epithelial-Mesenchymal-Transition Progression and Chemoresistance

Author

Tan, Zhen, primary, Ko, Josephine Mun-Yee, additional, Yu, Valen Zhuoyou, additional, Lam, Ka-On, additional, Kwong, Dora Lai-Wan, additional, Wong, Ian Yu-Hong, additional, Chan, Fion Siu-Yin, additional, Wong, Claudia Lai-Yin, additional, Chan, Kwan-Kit, additional, Law, Tsz-Ting, additional, Choy, Faith Sin-Fai, additional, Ng, Hoi-Yan, additional, Law, Simon Ying-Kit, additional, and Lung, Maria Li, additional

Published
2023
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4. 198. MODELING CANCER CACHEXIA USING PATIENT TUMOR ORGANOID-DERIVED XENOGRAFTS IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Author

Lung, Bryan Chee-chad, primary, Yu, Valen Zhuoyou, additional, Wong, Ian Yu-hong, additional, Wong, Claudia Lai-yin, additional, Chan, Desmond Kwan-kit, additional, Chan, Fion Siu-yin, additional, Law, Betty Tsz-ting, additional, Lam, Ka-on, additional, Kwong, Dora Lai-wan, additional, Lo, Anthony Wing-ip, additional, Law, Simon, additional, and Lung, Maria Li, additional

Published
2023
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5. Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci

Author

Ning, Lvwen, Ko, Josephine Mun-Yee, Yu, Valen Zhuoyou, Ng, Hoi Yan, Chan, Candy King-Chi, Tao, Lihua, Lam, Shiu-Yeung, Leong, Merrin Man-Long, Ngan, Roger Kai-Cheong, Kwong, Dora Lai-Wan, Lee, Anne Wing-Mui, Ng, Wai-Tong, Cheng, Ashley, Tung, Stewart, Lee, Victor Ho-Fun, Lam, Ka-On, Kwan, Chung-Kong, Li, Wing-Sum, Yau, Stephen, Bei, Jin-Xin, and Lung, Maria Li

Published
2020
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6. Abstract 2611: p63 constrains cancer cell transposable element expressions and viral mimicry response to sustain esophageal cancer development and indicates therapeutic vulnerability

Author

Yu, Valen Zhuoyou, primary, So, Shan Shan, additional, Lung, Bryan Chee-Chad, additional, Wong, Carissa Wing-Yan, additional, Wong, Ian Yu-Hong, additional, Wong, Claudia Lai-Yin, additional, Chan, Desmond Kwan-Kit, additional, Chan, Fion Siu-Yin, additional, Law, Betty Tsz-Ting, additional, Lam, Ka-On, additional, Lo, Anthony Wing-Ip, additional, Ko, Josephine Mum-Yee, additional, Dai, Wei, additional, Lam, Alfred King-Yin, additional, Kwong, Dora Lai-Wan, additional, Law, Simon, additional, and Lung, Maria Li, additional

Published
2023
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8. Abstract 363: Modelling cancer cachexia using a comprehensive panel of heterogeneous esophageal squamous cell carcinoma xenografts for therapeutic application

Author

Chee-chad Lung, Bryan, primary, Yu, Valen Zhuoyou, additional, Yu-hong Wong, Ian, additional, Lai-yin Wong, Claudia, additional, Kwan-kit Chan, Desmond, additional, Siu-yin Chan, Fion, additional, Tsz-ting Law, Betty, additional, Lam, Ka-on, additional, Lai-wan Kwong, Dora, additional, Wing-ip Lo, Anthony, additional, Law, Simon, additional, and Lung, Maira Li, additional

Published
2023
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27. Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells

Author

Yu, Valen Zhuoyou, primary, Wong, Victor Chun-Lam, additional, Dai, Wei, additional, Ko, Josephine Mun-Yee, additional, Lam, Alfred King-Yin, additional, Chan, Kwok Wah, additional, Samant, Rajeev S., additional, Lung, Hong Lok, additional, Shuen, Wai Ho, additional, Law, Simon, additional, Chan, Yuen Piu, additional, Lee, Nikki Pui-Yue, additional, Tong, Daniel King Hung, additional, Law, Tsz Ting, additional, Lee, Victor Ho-Fun, additional, and Lung, Maria Li, additional

Published
2015
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29. Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma.

Author

Ana Choi, Sheyne Sta, Ko, Josephine Mun-Yee, Yu, Valen Zhuoyou, Ning, Lvwen, and Lung, Maria Li

Subjects
TRETINOIN, ZINC-finger proteins, SQUAMOUS cell carcinoma, KERATINOCYTE differentiation, CELL growth, ESOPHAGEAL cancer, CELL differentiation
Abstract

Esophageal squamous cell carcinoma (ESCC) is a deadly squamous cell carcinoma (SCC) of the esophagus. Development of SCCs is associated with the deregulation of the squamous cell lineage program and/or keratinocyte terminal differentiation by genomic and genetic aberrations; thus, these processes must be tightly controlled to maintain normal squamous cell development. Zinc finger protein 750 (ZNF750) is a gene involved in keratinocyte terminal differentiation and is frequently mutated and putatively silenced in ESCC, which implicates its function as a potential differentiation-related suppressor of ESCC. The present study aimed to elucidate the relationship between ZNF750 function to induce keratinocyte differentiation and tumor suppression in ESCC. The results demonstrated that chemical manipulation of esophageal keratinocyte differentiation in mouse normal esophageal epithelial organoids (mNEEO) implicated the involvement of the mouse homologue of ZNF750, Zfp750, in keratinocyte differentiation in premalignant cells. Bioinformatics analyses of data from high ZNF750-expressing ESCC tumors obtained from public databases and ZNF750-overexpressing ESCC cells compared with low ZNF750-expressing ESCC tumors and GFP-expressing ESCC cells, respectively, revealed enrichment of keratinocyte differentiation-related gene sets in these samples. Finally, the induction through to terminal differentiation of the keratinocyte by all-trans retinoic acid on parental ESCC cell lines led to the upregulation of the terminal differentiation marker Involucrin and a decrease in cell viability similar to that observed in ZNF750-overexpressing ESCC cells. The results of the present study demonstrated a functional link between the ability of ZNF750 to induce cell differentiation through to terminal differentiation and its function as a growth suppressor in ESCC. This study provides improved understanding of the role of ZNF750, a frequently mutated differentiation-related gene in ESCC, and its effects in ESCC pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2021

30. Gain-of-function hot spot mutant p53R248Qregulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma

Author

Yu, Valen Zhuoyou, So, Shan Shan, and Lung, Maria Li

Abstract

•Majority of the missense p53 mutants are functionally dispensable in ESCC.•P53 hot spot mutant p53R248Qexerts specific gain-of-function oncogenic effects in ESCC.•Depletion of p53R248Qsuppresses in vitrocolony formation and cell cycle progression in a three-dimensional extracellular matrix-rich culture model and in vivotumor growth.•P53R248Qregulates the integrin/FAK/ERK signaling axis.•P53R248Qenhances cell proliferation upon glutamine deprivation.

Published
2021
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31. Gain-of-function hot spot mutant p53 R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma.

Author

Yu VZ, So SS, and Lung ML

Abstract

Purpose: TP53, encoding the protein p53, is among the most frequently mutated genes in all cancers. A high frequency of 60 - 90% mutations is seen in esophageal squamous cell carcinoma (ESCC) patients. Certain p53 mutants show gain-of-function (GoF) oncogenic features unrelated to its wild type functions., Methods: This study functionally characterized a panel of p53 mutants in individual ESCC cell lines and assayed for GoF oncogenic properties., Results: The ESCC cell line with endogenous p53 R248Q expression showed suppressed tumor growth in an immunocompromised mouse model and suppressed colony growth in in vitro three-dimensional culture, when depleted of the endogenous p53 protein expression. This suppression is accompanied by suppressed cell cycle progression, along with reduced integrin expression and decreased focal adhesion kinase and extracellular-regulated protein kinase signaling and can be compensated by expression of a constitutively active mitogen-activated protein. P53 R248Q enhances cell proliferation upon glutamine deprivation, as compared to other non-GoF mutants., Conclusions: In summary, study of the functional contributions of endogenous p53 mutants identified a novel GoF mechanism through which a specific p53 mutant exerts oncogenic features and contributes to ESCC tumorigenesis., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2021
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