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Background: Human olfactory receptors (ORs) account for approximately 60% of all human G protein-coupled receptors. The functions of ORs extend beyond olfactory perception and have garnered significant attention in tumor biology. However, a comprehensive pan-cancer analysis of ORs in human cancers is lacking. Methods: Using data from public databases, such as HPA, TCGA, GEO, GTEx, TIMER2, TISDB, UALCAN, GEPIA2, and GSCA, this study investigated the role of olfactory receptor family 7 subfamily A member 5 (OR7A5) in various cancers. Functional analysis of OR7A5 in LGG and GBM was performed using the CGGA database. Molecular and cellular experiments were performed to validate the expression and biological function of OR7A5 in gliomas. Results: The results revealed heightened OR7A5 expression in certain tumors, correlating with the expression levels of immune checkpoints and immune infiltration. In patients with gliomas, the expression levels of OR7A5 were closely associated with adverse prognosis, 1p/19p co-deletion status, and wild-type IDH status. Finally, in vitro experiments confirmed the inhibitory effect of OR7A5 knockdown on the proliferative capacity of glioma cells and on the expression levels of proteins related to lipid metabolism. Conclusion: This study establishes OR7A5 as a novel biomarker, potentially offering a novel therapeutic target for gliomas. [ABSTRACT FROM AUTHOR]

Hydrogen storage in MgH2 is an ideal solution for realizing the safe storage of hydrogen. High operating temperature, however, is required for hydrogen storage of MgH2 induced by high thermodynamic stability and kinetic barrier. Herein, flower‐like microspheres uniformly constructed by N‐doped TiO2 nanosheets coated with TiN nanoparticles are fabricated to integrate the light absorber and thermo‐chemical catalysts at a nanometer scale for driving hydrogen storage of MgH2 using solar energy. N‐doped TiO2 is in situ transformed into TiNxOy and Ti/TiH2 uniformly distributed inside of TiN matrix during cycling, in which TiN and Ti/TiHx pairs serve as light absorbers that exhibit strong localized surface plasmon resonance effect with full‐spectrum light absorbance capability. On the other hand, it is theoretically and experimentally demonstrated that the intimate interface between TiH2 and MgH2 can not only thermodynamically and kinetically promote H2 desorption from MgH2 but also simultaneously weaken Ti─H bonds and hence in turn improve H2 desorption from the combination of weakened Ti─H and Ti─H bonds. The uniform integration of photothermal and catalytic effect leads to the direct action of localized heat generated from TiN on initiating the catalytic effect in realizing hydrogen storage of MgH2 with a capacity of 6.1 wt.% under 27 sun. [ABSTRACT FROM AUTHOR]

SnO2 has been extensively investigated as an anode material for sodium‐ion batteries (SIBs) and potassium‐ion batteries (PIBs) due to its high Na/K storage capacity, high abundance, and low toxicity. However, the sluggish reaction kinetics, low electronic conductivity, and large volume changes during charge and discharge hinder the practical applications of SnO2‐based electrodes for SIBs and PIBs. Engineering rational structures with fast charge/ion transfer and robust stability is important to overcoming these challenges. Herein, S‐doped SnO2 (S–SnO2) quantum dots (QDs) (≈3 nm) encapsulated in an N, S codoped carbon fiber networks (S–SnO2–CFN) are rationally fabricated using a sequential freeze‐drying, calcination, and S‐doping strategy. Experimental analysis and density functional theory calculations reveal that the integration of S–SnO2 QDs with N, S codoped carbon fiber network remarkably decreases the adsorption energies of Na/K atoms in the interlayer of SnO2–CFN, and the S doping can increase the conductivity of SnO2, thereby enhancing the ion transfer kinetics. The synergistic interaction between S–SnO2 QDs and N, S codoped carbon fiber network results in a composite with fast Na+/K+ storage and extraordinary long‐term cyclability. Specifically, the S–SnO2–CFN delivers high rate capacities of 141.0 mAh g−1 at 20 A g−1 in SIBs and 102.8 mAh g−1 at 10 A g−1 in PIBs. Impressively, it delivers ultra‐stable sodium storage up to 10,000 cycles at 5 A g−1 and potassium storage up to 5000 cycles at 2 A g−1. This study provides insights into constructing metal oxide‐based carbon fiber network structures for high‐performance electrochemical energy storage and conversion devices. [ABSTRACT FROM AUTHOR]