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4 results on '"Yu-Yuan Han"'

1. Causal relationships between gut microbiota and programmed cell death protein 1/programmed cell death-ligand 1: A bidirectional Mendelian randomization study

Author

Yu-Feng Huang, Wei-Ming Zhang, Zhi-Song Wei, Huan Huang, Qi-Yan Mo, Dan-Li Shi, Lu Han, Yu-Yuan Han, Si-Kai Nong, and Guo-Xiang Lin

Subjects
PD-1/PD-L1, gut microbiota, bidirectional Mendelian randomization, pQTL, causality, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundMultiple clinical studies have indicated that the gut microbiota influences the effects of immune checkpoint blockade (ICB) therapy comprising PD-1/PD-L1 inhibitors, but the causal relationship is unclear. Because of numerous confounders, many microbes related to PD-1/PD-L1 have not been identified. This study aimed to determine the causal relationship between the microbiota and PD-1/PD-L1 and identify possible biomarkers for ICB therapy.MethodWe used bidirectional two-sample Mendelian randomization with two different thresholds to explore the potential causal relationship between the microbiota and PD-1/PD-L1 and species-level microbiota GWAS to verify the result.ResultIn the primary forward analysis, genus_Holdemanella showed a negative correlation with PD-1 [βIVW = -0.25; 95% CI (-0.43 to -0.07); PFDR = 0.028] and genus_Prevotella9 showed a positive correlation with PD-1 [βIVW = 0.2; 95% CI (0.1 to 0.4); PFDR = 0.027]; order_Rhodospirillales [βIVW = 0.2; 95% CI (0.1 to 0.4); PFDR = 0.044], family_Rhodospirillaceae [βIVW = 0.2; 95% CI (0 to 0.4); PFDR = 0.032], genus_Ruminococcaceae_UCG005 [βIVW = 0.29; 95% CI (0.08 to 0.5); PFDR = 0.028], genus_Ruminococcus_gnavus_group [βIVW = 0.22; 95% CI (0.05 to 0.4); PFDR = 0.029], and genus_Coprococcus_2 [βIVW = 0.4; 95% CI (0.1 to 0.6); PFDR = 0.018] were positively correlated with PD-L1; and phylum_Firmicutes [βIVW = -0.3; 95% CI (-0.4 to -0.1); PFDR = 0.031], family_ClostridialesvadinBB60group [βIVW = -0.31; 95% CI (-0.5 to -0.11), PFDR = 0.008], family_Ruminococcaceae [βIVW = -0.33; 95% CI (-0.58 to -0.07); PFDR = 0.049], and genus_Ruminococcaceae_UCG014 [βIVW = -0.35; 95% CI (-0.57 to -0.13); PFDR = 0.006] were negatively correlated with PD-L1. The one significant species in further analysis was species_Parabacteroides_unclassified [βIVW = 0.2; 95% CI (0-0.4); PFDR = 0.029]. Heterogeneity (P > 0.05) and pleiotropy (P > 0.05) analyses confirmed the robustness of the MR results.

Published
2023
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2. A meta-analysis of prognosis difference between adolescent and adult nasopharyngeal carcinoma

Author

Yu yuan Han

Abstract

Review question / Objective: Clinical trials for young patients with nasopharyngeal carcinoma are very limited. because of the rarity of nasopharyngeal carcinoma in young patients, oncologists are forced to follow treatment guidelines developed for adults for adolescent nasopharyngeal carcinoma patients. This study examines the differences in outcomes between adolescent and adult nasopharyngeal carcinoma patients treated with the same regimen and has clinical implications for the treatment of adolescent nasopharyngeal carcinoma patients. P : Patients with nasopharyngeal carcinoma. I : Adolescents. C : Adults. O : 5-year overall survival (OS). S : case-control study. Condition being studied: Nasopharyngeal carcinoma. Clinical trials for young patients with nasopharyngeal carcinoma are very limited. because of the rarity of nasopharyngeal carcinoma in young patients, oncologists are forced to follow treatment guidelines developed for adults for adolescent nasopharyngeal carcinoma patients. This study examines the differences in outcomes between adolescent and adult nasopharyngeal carcinoma patients treated with the same regimen and has clinical implications for the treatment of adolescent nasopharyngeal carcinoma patients.

Published
2022
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3. Predictive Value of Some Inflammatory Indexes in the Survival and Toxicity of Nasopharyngeal Carcinoma

Author

Kai-Hua Chen, Yu-Yuan Han, Xiao-Dong Zhu, Man-Ru Lin, Li Chen, Ying Guan, and Si-Kai Nong

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Receiver operating characteristic, business.industry, Incidence (epidemiology), medicine.disease, Predictive value, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Nasopharyngeal carcinoma, 030220 oncology & carcinogenesis, Internal medicine, Toxicity, medicine, Cutoff, Prospective cohort study, business, Survival rate
Abstract

Objective The present study aimed to investigate the predictive value of some inflammatory indexes, such as the ratio of C-reactive protein-to-albumin (CAR), high-sensitivity C-reactive protein-to-albumin (HCAR), C-reactive protein-to-lymphocyte (CLR), and high-sensitivity C-reactive protein-to-lymphocyte (HCLR) in the survival and toxicity of nasopharyngeal carcinoma and provide reference for the development of treatment. Methods A retrospective analysis was conducted on 162 patients from 2013 to 2018. The value of the indexes before the treatment was calculated. SPSS 25.0 software was used for the analysis, and the cutoff values of the indexes were determined by the receiver operating characteristic curve (ROC). The prognostic value of the indexes was evaluated according to the overall survival rate (OS), progression-free survival rate (PFS), and the incidence of toxic side effects. Results The index CLR was found to be the predictor of mortality of nasopharyngeal carcinoma but not the indicator for toxicity. Conclusion The index CLR can be used for risk-stratification. However, whether the risk-stratification treatment based on these indicators can improve the prognosis subsequently needs further prospective study.

Published
2020
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4. Predictive Value of Some Inflammatory Indexes in the Survival and Toxicity of Nasopharyngeal Carcinoma

Author

Yu-Yuan, Han, Kai-Hua, Chen, Ying, Guan, Li, Chen, Man-Ru, Lin, Si-Kai, Nong, and Xiao-Dong, Zhu

Subjects
C-reactive protein/lymphocyte ratio, nasopharyngeal carcinoma, C-reactive protein/albumin ratio, high-sensitivity C-reactive protein/lymphocyte ratio, toxicity, survival, high-sensitivity C-reactive protein/albumin ratio, Original Research
Abstract

Objective The present study aimed to investigate the predictive value of some inflammatory indexes, such as the ratio of C-reactive protein-to-albumin (CAR), high-sensitivity C-reactive protein-to-albumin (HCAR), C-reactive protein-to-lymphocyte (CLR), and high-sensitivity C-reactive protein-to-lymphocyte (HCLR) in the survival and toxicity of nasopharyngeal carcinoma and provide reference for the development of treatment. Methods A retrospective analysis was conducted on 162 patients from 2013 to 2018. The value of the indexes before the treatment was calculated. SPSS 25.0 software was used for the analysis, and the cutoff values of the indexes were determined by the receiver operating characteristic curve (ROC). The prognostic value of the indexes was evaluated according to the overall survival rate (OS), progression-free survival rate (PFS), and the incidence of toxic side effects. Results The index CLR was found to be the predictor of mortality of nasopharyngeal carcinoma but not the indicator for toxicity. Conclusion The index CLR can be used for risk-stratification. However, whether the risk-stratification treatment based on these indicators can improve the prognosis subsequently needs further prospective study.

Published
2020

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