14 results on '"Yu-chan Huang"'
Search Results
2. Clinical characteristics and risk factors in patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases
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Xiao-hua Yu, Yu-wei Liao, Ling Rong, Bi-gui Chen, Run-jun Li, Guang-kuan Zeng, Li-li Liu, Yan-bin Cao, Jian-lian Liang, Bai-ru Lai, Yan-qing Zeng, Yu-chan Huang, and Li-ye Yang
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SARS-CoV-2 ,Omicron variant ,clinical characteristics ,China ,cardiovascular diseases ,Medicine (General) ,R5-920 - Abstract
ObjectiveTo investigate the clinical characteristics and risk factors of patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases.MethodsA retrospective analysis of general clinical data was conducted on patients with SARS-CoV-2 omicron infection complicated with hypertension, coronary heart disease, and heart failure admitted to one hospital in Guangdong Province from December 1, 2022, to February 28, 2023. Clinical symptoms, laboratory tests, imaging examinations, treatment, and clinical outcomes were collected. Multivariate logistic regression analysis was used to analyze the risk factors for mortality in patients with SARS-CoV-2 Omicron variant infection complicated with cardiovascular diseases. ROC curves were drawn to evaluate the predictive value of CRP, D-dimer, and CK-MB in predicting the risk of death.ResultsA total of 364 confirmed cases were included, divided into the asymptomatic group, mild to moderate group, and severe to critically ill group based on the symptoms of COVID-19. There were 216 males (59.34%) and 148 females (40.66%), with a median age of 75 years. The differences between the three groups in terms of sex and age were statistically significant (p
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- 2024
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3. Molecular epidemiological investigation of G6PD deficiency in Yangjiang region, western Guangdong province
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Hong-Feng Liang, Yan-Bin Cao, Fen Lin, Yi-Kang Yang, Yu-Wei Liao, Wei-Hao Ou, Jin-Ling Chen, Yan-Qing Zeng, Yu-Chan Huang, Guang-Kuan Zeng, Zhi-Xiao Chen, Jing-Wei Situ, Jin-Xiu Yao, and Li-Ye Yang
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G6PD deficiency ,G6PD mutation ,DNA sequence ,China ,gene variant ,Genetics ,QH426-470 - Abstract
Objectives: The prevalence of G6PD deficiency has not been reported in Yangjiang, a western city in Guangdong province. This study aims to investigate the molecular characteristics of G6PD deficiency in this region.Methods: Blood samples were collected from adults at a local hospital to screen for G6PD deficiency. The deficient samples were subjected to further analysis using PCR and reverse dot blot to determine the specific G6PD variants.Results: Among the 3314 male subjects, 250 cases of G6PD deficiency were found using the G6PD enzyme quantitative assay, resulting in a prevalence of 7.54% (250/3314) in the Yangjiang region. The prevalence of G6PD deficiency in females was 3.42% (176/5145). Out of the 268 cases of G6PD deficiency tested for G6PD mutations, reverse dot blot identified 20 different G6PD variants. The most common G6PD variant was c.1388G>A (81/268), followed by c.1376G>T (48/268), c.95A>G (32/268), c.1024C>T (9/268), c.392G>T (7/268), and c.871G>A/c.1311C>T (6/268). It was observed that c.871G>A was always linked to the polymorphism of c.1311C>T in this population.Conclusion: This investigation into G6PD deficiency in this area is expected to significantly improve our understanding of the prevalence and molecular characterization of this condition.
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- 2024
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4. The clinical characteristics of COVID-19 omicron variant infection in pregnant women and their neonates
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Li-Li Liu, Lv-Hua Lin, Fen Lin, Yi-Kang Yang, Chun-Fan Lin, Lin Zhang, Yu-Chan Huang, Yu-Wei Liao, Yan-Qing Zeng, Guang-Kuan Zeng, Yan-Bin Cao, Rui-Zhen Zhu, and Li-Ye Yang
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COVID-19 ,omicron variant ,pregnant women ,neonate ,China ,Medicine (General) ,R5-920 - Abstract
ObjectiveThe objective of this study was to analyze the clinical characteristics of pregnant women infected with the COVID-19 omicron variant and their neonates during the outbreak in Guangdong province, China.MethodsThe clinical data of pregnant women infected with the COVID-19 omicron variant and their neonates were retrospectively collected from two hospitals in Guangdong province. Information recorded included age of mother, date of birth, sex, weight at birth, mode of delivery, gestational age, feeding mode, Apgar score, signs, medical records, underlying comorbidities and laboratory results. The presence of SARS-CoV-2 viral RNA was tested using an real-time PCR assay.ResultsSeventy-nine pregnant women infected with COVID-19 omicron variant and their 68 neonates were included in this study. The vast majority (86.1%) of pregnant women was in their third trimester of pregnancy, and only 11 cases (15%) were in the first or second trimester. Of 79 pregnant women, 39 cases were asymptomatic at the time of infection, and 40 mothers presented with mild manifestations of COVID-19. The most common symptoms were fever (92.5%, 37/40) and cough (57.5%, 21/40). All of pregnant women did not receive chest computed tomography (CT) scan or X-ray. No pregnant woman developed severe pneumonia. A total of 68 neonates (3 set of twins) from 65 mothers with COVID-19 were reviewed. Among women who delivered, 34 cases underwent cesarean section, 31 cases underwent vaginal delivery. According to the timing of birth, there were 10 (14.7%) preterm neonates. Two babies were born dead (intrauterine fetal death after 22 weeks of gestation). Of the live babies born (66 cases) from mothers with COVID-19, 9 newborns were lower weight, and one preterm case was born with respiratory distress and intubated, he recovered and developed normally. SARS-CoV-2 nucleic acid testing was conducted on 41 neonates daily after birth, with only one neonate testing positive for SARS-CoV-2 infection on the third day after birth. The infected neonate exhibited typical fever and acute respiratory tract syndrome but ultimately had a good prognosis, recovering after 5 days of treatment.ConclusionAlthough preliminary data suggests the risk of severe maternal and fetal complications from Omicron variant infection during pregnancy is lower than previous variants and Delta variant. Our study, which was conducted on a limited population sample, indicates that there is a possibility of severe complications, such as stillbirth, occurring in some fetal cases. These findings emphasize the need for continued attention from obstetricians.
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- 2023
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5. Etiology analysis and G6PD deficiency for term infants with jaundice in Yangjiang of western Guangdong
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Yi-Kang Yang, Chun-Fan Lin, Fen Lin, Zi-Kai Chen, Yu-Wei Liao, Yu-Chan Huang, Bei-Ru Xiao, Shan-Hua Huang, Yu-Mei Xu, Yue-E. Chen, Yan-Bin Cao, and Li-Ye Yang
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neonatal hyperbilirubinemia ,neonatal jaundice ,etiology ,G6PD deficiency ,hemolysis ,Pediatrics ,RJ1-570 - Abstract
ObjectiveGlucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. The aim of this study is to evaluate the risk factors associated with hyperbilirubinemia in infants from the western part of Guangdong Province, and to assess the contribution of G6PD deficiency to neonatal jaundice.MethodsThe term infants with neonatal hyperbilirubinemia in People's Hospital of Yangjiang from June 2018 to July 2022 were recruited for the retrospective analysis. All the infants underwent quantitative detection of the G6PD enzyme. The etiology was determined through laboratory tests and clinical manifestations.ResultsOut of 1,119 term infants, 435 cases presented with jaundice. For the etiology analysis, infection was responsible for 16.09% (70/435), G6PD deficiency accounted for 9.66% (42/435), of which 3 were complicated with acute bilirubin encephalopathy), bleeding accounted for 8.05% (35/435), hemolytic diseases accounted for 3.45% (15/435), and breast milk jaundice accounted for 2.53% (11/435). One case (0.23%) was attributed to congenital hypothyroidism, multiple etiologies accounted for 22.3% (97/435), and 35.63% (155/435) were of unknown etiology. Of the jaundiced infants, 19.54% (85/435) had G6PD deficiency, while only 10.23% (70/684) of non-jaundiced infants had G6PD deficiency; this difference was found to be statistically significant (P G, c.392G > T, c.1024C > T, c.1311C > T, c.1376G > T, c.1388G > A, c.871G > A/c.1311C > T, c.392G > T/c.1388G > A, and c.1376G > T/c.1311C > T.65iciencyConclusionIn newborns in Yangjiang, G6PD deficiency, infection, and neonatal hemolytic disease were identified as the main causes of hyperbilirubinemia and acute bilirubin encephalopathy. Specifically, Hemolytic factors in infants with G6PD deficiency may lead to reduced hemoglobin and increased bilirubin levels in jaundiced infants.
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- 2023
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6. Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases
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Yi-Kang Yang, Fen Lin, Jian-Feng Lin, Chun-Fan Lin, Li-Li Liu, Yu-Bin Ma, Xian-Yao Wang, Yu-Wei Liao, Yu-Chan Huang, Guang-Kuan Zeng, Bei-Ru Xiao, Shan-Hua Huang, Yu-Mei Xu, Yue-E Chen, Yan-Bin Cao, and Li-Ye Yang
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COVID-19 ,omicron ,neonate ,China ,prognosis ,SARS-CoV-2 ,Pediatrics ,RJ1-570 - Abstract
ObjectiveTo analyze the clinical characteristics of neonatal infection during the outbreak of COVID-19 omicron variant in Guangdong province of China.MethodThe clinical data of neonates infected with COVID-19 omicron variant were collected from three hospitals of Guangdong province, their epidemiological history, clinical manifestation and prognosis were summarized.ResultsFrom December 12, 2022 to January 15, 2023, a total of 52 neonates with COVID-19 infection were identified across three hospitals in Guangdong Province, including 34 males and 18 females. The age of diagnosis was 18.42 ± 6.32 days. 24 cases had clear contact history with adults who were suspected to be infected with COVID-19. The most common clinical manifestation was fever (43/52, 82.7%), the duration of fever was 1–8 days. The other clinical manifestations were cough (27/52, 51.9%), rales (21/52, 40.4%), nasal congestion (10/52, 19.2%), shortness of breath (2/52, 3.8%), and vomiting (4/52, 7.7%). C-reactive protein was only increased in 3 cases. Chest radiological examination was performed in 42 neonates, twenty-three cases showed abnormal chest radiographic findings, including ground-glass opacity and consolidation. Fifty cases were admitted with COVID-19 presentation, two cases were admitted for jaundice. The hospital stay was 6.59 ± 2.77 days. The clinical classification included 3 cases of severe COVID-19 and one critical case. Fifty-one cases were cured and discharged after general treatment, and one critical case with respiratory failure was intubated and transferred to another hospital.ConclusionThe COVID-19 omicron variant infection in neonates is usually mild. The clinical manifestation and laboratory results are not specific, and the short-term prognosis is good.
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- 2023
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7. Modeling and Parameter Identification of a Consumer-used Skillet Heating System.
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Chao-Chung Peng, Min-Che Tsai, and Yu-Chan Huang
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- 2022
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8. Star Poly(N-isopropylacrylamide) Tethered to Polyhedral Oligomeric Silsesquioxane (POSS) Nanoparticles by a Combination of ATRP and Click Chemistry
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Shiao-Wei Kuo, Jem-Kun Chen, Feng-Chih Chang, Fu-Hsiang Ko, Yu-Chan Huang, Shih-Kang Fan, Chih-Wei Chu, and Jing-Long Hong
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chemistry.chemical_classification ,Materials science ,Article Subject ,Atom-transfer radical-polymerization ,Polymer ,Lower critical solution temperature ,Silsesquioxane ,chemistry.chemical_compound ,chemistry ,lcsh:Technology (General) ,Polymer chemistry ,Propargyl ,Click chemistry ,Copolymer ,Poly(N-isopropylacrylamide) ,lcsh:T1-995 ,General Materials Science - Abstract
New star poly(N-isopropylacrylamide)-b-polyhedral oligomeric silsesquioxane (PNIPAm-b-POSS) copolymers were synthesized from octa-azido functionalized POSS (N3-POSS) and alkyne-PNIPAm, which was prepared using an alkyne-functionalized atom transfer radical polymerization (ATRP) initiator (propargyl 2-bromo-2-methylpropionamide), via click chemistry. These star PNIPAm-b-POSS copolymers undergo a sharp coil-globule transition in water at above 32°C changing from a hydrophilic state below this temperature to a hydrophobic state above it, which is similar to linear PNIPAm homopolymers. More interestingly, we found that these star polymers exhibited strong blue photoluminescence in water above a lower critical solution temperature (LCST). This photoluminescence was likely due to the constrained geometric freedom and relatively rigid structure caused by intramolecular hydrogen bonding within the star PNIPAm polymers, which exhibit an intrinsic fluorescent behavior.
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- 2012
9. Second harmonic generation imaging – A new method for unraveling molecular information of starch
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Chen Han Huang, Chien-Sheng Liao, Yu Yi Tzeng, Zong Yan Zhuo, Jiun Yann Yu, Hsi-Mei Lai, Wen Lo, Chen-Yuan Dong, Shi-Wei Chu, Hsiang-Chen Chui, and Yu Chan Huang
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Optics and Photonics ,Microscopy, Confocal ,Materials science ,Starch ,Amylopectin ,Second-harmonic imaging microscopy ,Nonlinear optics ,Second-harmonic generation ,Oryza ,Centrosymmetry ,Polarization (waves) ,chemistry.chemical_compound ,Crystallography ,Imaging, Three-Dimensional ,chemistry ,Structural Biology ,Chemical physics ,Anisotropy ,Amylose - Abstract
We present a new method, second harmonic generation (SHG) imaging for the study of starch structure. SHG imaging can provide the structural organization and molecular orientation information of bio-tissues without centrosymmetry. In recent years, SHG has proven its capability in the study of crystallized bio-molecules such as collagen and myosin. Starch, the most important food source and a promising future energy candidate, has, for a decade, been shown to exhibit strong SHG response. By comparing SHG intensity from different starch species, we first identified that the SHG-active molecule is amylopectin, which accounts for the crystallinity in starch granules. With the aid of SHG polarization anisotropy, we extracted the complete χ(2) tensor of amylopectin, which reflects the underlying molecular details. Through χ(2) tensor analysis, three-dimensional orientation and packing symmetry of amylopectin are determined. The helical angle of the double-helix in amylopectin is also deduced from the tensor, and the value corresponds well to previous X-ray studies, further verifying amylopectin as SHG source. It is noteworthy that the nm-sized structure of amylopectin inside a starch granule can be determined by this far-field optical method with 1-μm excitation wavelength. Since SHG is a relatively new tool for plant research, a detailed understanding of SHG in starch structure will be useful for future high-resolution imaging and quantitative analyses for food/energy applications.
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- 2010
10. Noodle quality affected by different cereal starches
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Hsi-Mei Lai and Yu-Chan Huang
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chemistry.chemical_classification ,Waxy corn ,Absorption of water ,biology ,Starch ,viruses ,food and beverages ,Polysaccharide ,biology.organism_classification ,Maize starch ,chemistry.chemical_compound ,chemistry ,Amylose ,Amylopectin ,Food science ,Potato starch ,Food Science - Abstract
To investigate the effects of starch characteristics on the quality of noodle making, white salted noodles (WSN) made from reconstituted flours, in which the wheat starch was substituted by different cereal starches, including waxy and non-waxy rice starches, waxy wheat starch and waxy corn starch, were prepared. The rheological properties of raw WSN were mainly influenced by the size of starch granules, where the small starch granules, such as for rice starches, exhibited high amounts of water absorption during dough preparation and a dense packing of starch granules inside a thin gluten-strand network. The rheological properties of cooked WSN were mainly dominated by the amylose content and fine structure of the amylopectin, which resulted in the differences in water absorption and cooking time required for cooked WSN.
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- 2010
11. Characteristics of the starch fine structure and pasting properties of waxy rice during storage
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Yu-Chan Huang and Hsi-Mei Lai
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Starch ,Flour ,Rice flour ,Analytical Chemistry ,Hydrolysis ,chemistry.chemical_compound ,Botany ,medicine ,Amylase ,Food science ,Low amylase ,biology ,Molecular Structure ,Viscosity ,Temperature ,food and beverages ,Oryza ,General Medicine ,chemistry ,Food Storage ,Amylopectin ,biology.protein ,Starch granule ,Swelling ,medicine.symptom ,Food Science - Abstract
Two waxy rice (TNW1 and TCSW1, exhibiting high and low amylase activity, respectively), were stored at 4 and 17 °C (polished rice) and at room temperature (paddy rice) for 15 months. The fine structure of starch isolated from the aged rice and the pasting properties of starch and rice flour were studied. After storage, the percentage of short amylopectin (AP) chains increased in TNW1, and no uniform changing pattern was observed in the chain-length (CL) distribution of TCSW1. The viscosity of starch isolated from the aged rice increased as the storage temperature and duration increased. We hypothesised that this increase was due to the hydrolysis of AP by endogenous amylase and the generation of small clusters during storage, which caused the simple dissociation of AP and a high swelling degree of starch granules during gelatinisation. Factor analysis of the first two factors associated with the characteristics of viscograms and the CL of AP explained 72% of the total variation.
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- 2013
12. [Intention survey of target population with regard to H1N1 influenza vaccination]
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Min, Lu, Luo-dan, Suo, Li, Lu, Liang, Miao, Wen-yan, Ji, Dong-lei, Liu, Rui, Ma, Yu-chan, Huang, and Jiang, Wu
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Male ,China ,Health Services Needs and Demand ,Influenza A Virus, H1N1 Subtype ,Influenza Vaccines ,Pregnancy ,Influenza, Human ,Vaccination ,Medical Staff ,Humans ,Female ,Intention ,Students - Published
- 2012
13. The involvement of guanylyl cyclase‐G in intestinal ischemia and reperfusion‐induced jejunal apoptosis in mice
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Ruey‐Bing Yang, Chun‐Hong Lai, Hui‐Chen Lo, and Yu‐Chan Huang
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Apoptosis ,Chemistry ,Intestinal ischemia ,Genetics ,Pharmacology ,Molecular Biology ,Biochemistry ,Biotechnology ,Guanylate cyclase - Published
- 2010
14. Epidemiological and genetic diversity of Staphylococcus aureus causing bloodstream infection in Shanghai, 2009-2011.
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Xu Chen, Wen-Kui Wang, Li-Zhong Han, Ying Liu, Hong Zhang, Jin Tang, Qing-Zhong Liu, Yu-Chan Huangfu, and Yu-Xing Ni
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Medicine ,Science - Abstract
OBJECTIVES: Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) has been an important pathogen causing bloodstream infections. Our study aimed to investigate the epidemiological and genetic diversity of clinical S. aureus isolates from patients with bloodstream infection in four hospitals of Shanghai from 2009 to 2011. METHODS: A collection of S. aureus isolates causing bloodstream infection from four hospitals in the central part of Shanghai was carried out. Antimicrobial susceptibility testings of collected isolates were performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, and spa-type, multi-locus sequence typing, agr type and toxin gene profiling were performed to explore the molecular diversity. Moreover, MRSA strains were also characterized by Staphylococcal cassette chromosome mec (SCCmec) typing. RESULTS: The drugs such as linezolid, teicoplanin and vancomycin were efficacious for treating S. aureus including MRSA bloodstream infection. Methicillin-sensitive Staphylococcus aureus (MSSA) strains displayed distinct diversity in molecular characterization and toxin genes, and three virulent MSSA strains encoding at least five toxins were detected. Five community-associated MRSA (CA-MRSA) strains were found, but the majority (88.7%) of MRSA strains belonged to two epidemic clones (ST239-MRSA- III and ST5-MRSA- II) with different toxin gene profiles among patients with bloodstream infection. CONCLUSIONS: Healthcare-associated MRSA (HA-MRSA) strains were still the main pathogen causing bloodstream infections in spite of the emergence of CA-MRSA strains in hospital setting.
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- 2013
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