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322 results on '"Yuan, Baohong"'

3. In vivo ultrasound-switchable fluorescence imaging

Author

Yao, Tingfeng, Yu, Shuai, Liu, Yang, and Yuan, Baohong

Subjects
Physics - Biological Physics, Physics - Optics
Abstract

Ultrasound-switchable fluorescence (USF) imaging was recently developed to overcome the limitation of the poor spatial resolution of the conventional fluorescence imaging in centimeter-deep tissue. However, in vivo USF imaging has not been achieved so far because of the lack of stable near-infrared contrast agents in a biological environment and the lack of data about their biodistributions. In this study, for the first time, we achieved in vivo USF imaging successfully in mice with high resolution. USF imaging in porcine heart tissue and mouse breast tumor via local injections were studied and demonstrated. In vivo and ex vivo USF imaging of the mouse spleen via intravenous injections was also successfully achieved. The results showed that the USF contrast agent adopted in this study was very stable in a biological environment, and it was mainly accumulated into the spleen of the mice. All the results of USF imaging were validated by a commercial micro-CT., Comment: 14 pages, 6 figures

Published
2018

7. Centimeter-deep tissue fluorescence microscopic imaging with high signal-to-noise ratio and picomole sensitivity

Author

Cheng, Bingbing, Bandi, Venugopal, Wei, Ming-Yuan, Pei, Yanbo, DSouza, Francis, Nguyen, Kytai T., Hong, Yi, Tang, Liping, and Yuan, Baohong

Subjects
Physics - Optics, Physics - Medical Physics
Abstract

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in tissue. In this study, for the first time this goal has been achieved in 3-centimeter deep tissue with high signal-to-noise ratio (SNR) and picomole sensitivity under radiation safety thresholds. These results are demonstrated not only in tissue-mimic phantoms but also in actual tissues, such as porcine muscle, ex vivo mouse liver, ex vivo spleen, and in vivo mouse tissue. These results are achieved based on three unique technologies: excellent near infrared ultrasound-switchable fluorescence (USF) contrast agents, a sensitive USF imaging system, and an effective correlation method. Multiplex USF fluorescence imaging is also achieved. It is useful to simultaneously image multiple targets and observe their interactions. This work opens the door for future studies of centimeter-deep tissue fluorescence microscopic imaging.

Published
2015
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34. A cost-efficient frequency domain fluorescence lifetime measurement system

Author

Yuan, Baohong, McClellan, Samantha R., Mifgai, Bandar Al- F., Growney, Emily A., and Komolafe, Olamide A.

Subjects
Fluorescence -- Measurement, Time -- Systems and standards, Time -- Methods, Time -- Testing, Physics
Abstract

A cost-efficient frequency domain system for measuring nanosecond fluorescence lifetime has been designed and tested. In this design, function generators are adopted to directly modulate a light-emitting diode at radio frequencies. A heterodyne detection technique is used to reduce the bandwidth of the system and to improve the signal-to-noise ratio. A fluorescence lifetime close to 2 ns was measured and verified by comparison with the results from a broadband lock-in amplifier. The total cost of the system is reasonable for undergraduate laboratories, which enables students to gain hands-on experience in designing and constructing a nanosecond fluorescence lifetime measurement system. Some suggestions for conducting the measurement with a limited budget are provided. [c] 2010 American Association of Physics Teachers. [DOI: 10.1119/1.3224765]

Published
2010
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38. Theory of space-charge field with a moving fringe in photorefractive polymers

Author

Yuan, Baohong, Sun, Xiudong, Zhou, Zhongxiang, Li, Yan, Jiang, Yongyuan, and Hou, Chunfeng

Subjects
Diffraction gratings -- Research, Photorefractive materials -- Research, Physics -- Research, Polymers -- Research, Physics
Abstract

Research describing the theory of moving gratings in photorefractive polymer materials is presented. The effect of total intensity on gain coefficients is explained by the relation between space charge field and experimental parameters.

Published
2001

48. Kinetics of the formation of space-charge field in photorefractive polymers

Author

Yuan, Baohong, Sun, Xiudong, Hou, Chunfeng, Li, Yan, Zhou, Zhongxiang, Jiang, Yongyuan, and Li, Chunfei

Subjects
Photorefractive materials -- Research, Physics -- Research, Physics
Abstract

Research describing the formation of space-charge fields in photorefractive polymer materials is presented. In particular a derivation of the dynamic differential equation for such fields is developed with reference to the previous work of Schildkraut.

Published
2000

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