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Drug use is a worldwide issue, and how to treat it is even a greater challenge. It is important for drug dependences to receive interventions and treatments in time. Before receiving treatments, an effective screening or diagnosis assessment is necessary, and patients should have an assessment to understand the severity of drug use–related disorders. For more than 40 years, the instruments to assess the severity of drug dependence have been developed well, and different quantitative methods can cover almost every field of the symptoms in different periods and stages of drug addiction. This chapter reviews more than 20 drug dependence screening and diagnosis assessments and different types of treatments. These quantitative assessments can provide drug dependences a comprehensive diagnosis of their drug use–related disorders. The treatments should be designed for different level of drug dependence.